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The map label for this gene is uhpC

Identifier: 30064980

GI number: 30064980

Start: 3869169

End: 3870488

Strand: Reverse

Name: uhpC

Synonym: S3974

Alternate gene names: 30064980

Gene position: 3870488-3869169 (Counterclockwise)

Preceding gene: 30064981

Following gene: 30064979

Centisome position: 84.15

GC content: 55.15

Gene sequence:

>1320_bases
ATGTTGCCGTTTCTGAAAGCGCCTGCCGATGCGCCATTAATGACTGATAAACATGAAATTGATGCCCGTTATCGCTACTG
GCGTCGGCATATTCTGCTGACCATCTGGCTGGGTTACGCGCTGTTTTACTTCACGCGGAAAAGTTTTAACGCCGCGGTAC
CAGAAATCCTTGCTAACGGCGTGCTCAGCCGTAGCGATATCGGCCTGTTAGCGACCCTGTTTTACATTACTTACGGCGTG
TCGAAGTTTGTCTCCGGCATTGTCAGCGATCGCTCAAATGCCCGTTATTTTATGGGGATAGGGCTTATCGCCACGGGCAT
CATGAACATTCTGTTTGGCTTCTCGACGTCGCTATGGGCGTTTGCCGTGCTCTGGGTGCTGAACGCCTTTTTCCAGGGCT
GGGGTTCACCGGTGTGTGCGCGTCTGTTAACGGCCTGGTATTCACGTACCGAGCGCGGCGGTTGGTGGGCATTATGGAAC
ACGGCGCATAACGTCGGCGGCGCACTCATTCCCATTGTGATGGCAGCGAGCGCGCTGCATTACGGCTGGCGTGCCGGGAT
GATGATTGCTGGTTGTATGGCGATAGTCGTGGGGATTTTTCTCTGCTGGCGGCTACGCGATCGCCCGCAGGCGTTAGGTT
TACCGGCGGTCGGTGAATGGCGGCACGACGCGCTGGAAATTGCTCAACAACAAGAAGGGGCAGGGTTGACGCGTAAAGAG
ATCCTCACCAAATATGTGTTGCTGAATCCGTATATCTGGCTGCTTTCGTTTTGCTATGTGCTGGTCTATGTGGTCCGGGC
GGCGATCAACGACTGGGGCAATTTGTATATGTCCGAGACGCTGGGCGTCGATCTGGTCACGGCGAATACGGCAGTGACGA
TGTTTGAACTGGGCGGATTTATCGGTGCGCTGGTAGCCGGTTGGGGCTCGGACAAATTGTTTAACGGCAACCGTGGGCCG
ATGAATTTGATTTTCGCCGCCGGAATTTTGCTTTCAGTCGGCTCGCTGTGGCTGATGCCATTTGCCAGCTACGTGATGCA
GGCAACCTGCTTCTTCACCATTGGTTTTTTTGTCTTTGGCCCGCAGATGTTAATTGGTATGGCGGCGGCAGAGTGTTCCC
ACAAAGAGGCGGCAGGGGCGGCGACGGGGTTTGTCGGCTTGTTTGCTTATCTGGGGGCGTCGCTTGCTGGTTGGCCGCTG
GCGAAAGTGCTCGATACCTGGCACTGGAGCGGATTTTTTGTGGTTATCTCTATCGCTGCCGGGATTTCCGCACTGCTGTT
ACTGCCCTTTTTGAACGCCCAGACACCGCGTGAAGCGTGA

Upstream 100 bases:

>100_bases
CGAGCGCGTAACGGCGCTGGGCGGCACATTACACATTTCCTGTCTGCACGGCACGCGTGTCAGCGTTTCTCTACCTCAAC
GTTATGTCTAAGGTTCGATG

Downstream 100 bases:

>100_bases
TGCATCTCACCTTTTCACTTCATATCCGGCAAAACTAAGAAATTTTCCAGGTTTTTCTTGGACGCTATCTCAGGCCTGAT
TTGCTGCTGATTTTTACAAT

Product: regulatory protein UhpC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MLPFLKAPADAPLMTDKHEIDARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGV
SKFVSGIVSDRSNARYFMGIGLIATGIMNILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWN
TAHNVGGALIPIVMAASALHYGWRAGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQEGAGLTRKE
ILTKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLFNGNRGP
MNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPL
AKVLDTWHWSGFFVVISIAAGISALLLLPFLNAQTPREA

Sequences:

>Translated_439_residues
MLPFLKAPADAPLMTDKHEIDARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGV
SKFVSGIVSDRSNARYFMGIGLIATGIMNILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWN
TAHNVGGALIPIVMAASALHYGWRAGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQEGAGLTRKE
ILTKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLFNGNRGP
MNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPL
AKVLDTWHWSGFFVVISIAAGISALLLLPFLNAQTPREA
>Mature_439_residues
MLPFLKAPADAPLMTDKHEIDARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGV
SKFVSGIVSDRSNARYFMGIGLIATGIMNILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWN
TAHNVGGALIPIVMAASALHYGWRAGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQEGAGLTRKE
ILTKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLFNGNRGP
MNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPL
AKVLDTWHWSGFFVVISIAAGISALLLLPFLNAQTPREA

Specific function: UhpC is required for uhpT expression, it may act jointly with the uhpB signaling protein [H]

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family [H]

Homologues:

Organism=Homo sapiens, GI256219598, Length=436, Percent_Identity=30.045871559633, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI4503847, Length=436, Percent_Identity=30.045871559633, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI256219483, Length=436, Percent_Identity=30.045871559633, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI256219543, Length=449, Percent_Identity=28.7305122494432, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI256219564, Length=366, Percent_Identity=27.8688524590164, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI46361976, Length=390, Percent_Identity=22.8205128205128, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI14150047, Length=291, Percent_Identity=22.3367697594502, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI38093649, Length=470, Percent_Identity=25.1063829787234, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI223717983, Length=470, Percent_Identity=25.1063829787234, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI87082310, Length=439, Percent_Identity=99.3166287015945, Blast_Score=878, Evalue=0.0,
Organism=Escherichia coli, GI1788573, Length=431, Percent_Identity=38.0510440835267, Blast_Score=274, Evalue=8e-75,
Organism=Escherichia coli, GI2367259, Length=463, Percent_Identity=32.829373650108, Blast_Score=185, Evalue=4e-48,
Organism=Escherichia coli, GI2367379, Length=453, Percent_Identity=22.075055187638, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17542316, Length=451, Percent_Identity=23.9467849223947, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI133901854, Length=444, Percent_Identity=22.972972972973, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI133901856, Length=444, Percent_Identity=22.972972972973, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17561094, Length=398, Percent_Identity=21.8592964824121, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI133930953, Length=444, Percent_Identity=21.8468468468468, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24656861, Length=416, Percent_Identity=26.4423076923077, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24656866, Length=416, Percent_Identity=26.4423076923077, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI45550478, Length=416, Percent_Identity=26.4423076923077, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48265; Mature: 48265

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: PS50850 MFS ; PS00942 GLPT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPFLKAPADAPLMTDKHEIDARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILANG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIMNILFGFSTSLWA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
FAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAASALH
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHCCHHHHHHHHHHHHHH
YGWRAGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQEGAGLTRKE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
ILTKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHH
IGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVFG
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFVVISIAA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHCCCHHHHHHHHHH
GISALLLLPFLNAQTPREA
HHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLPFLKAPADAPLMTDKHEIDARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILANG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIMNILFGFSTSLWA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
FAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAASALH
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHCCHHHHHHHHHHHHHH
YGWRAGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQEGAGLTRKE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
ILTKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHH
IGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVFG
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFVVISIAA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHCCCHHHHHHHHHH
GISALLLLPFLNAQTPREA
HHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1569007; 11677609 [H]