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The map label for this gene is folB

Identifier: 30064406

GI number: 30064406

Start: 3181991

End: 3182359

Strand: Reverse

Name: folB

Synonym: S3304

Alternate gene names: 30064406

Gene position: 3182359-3181991 (Counterclockwise)

Preceding gene: 30064408

Following gene: 30064405

Centisome position: 69.19

GC content: 50.68

Gene sequence:

>369_bases
ATGGATATTGTATTTATAGAGCAACTTTCGGTAATCACCACTATTGGTGTTTACGACTGGGAACAGACCATCGAACAGAA
GTTAGTGTTCGATATCGAAATGGCATGGGATAACCGTAAAGCGGCGAAAAGTGATGATGTGGCGGATTGCCTCAGTTACG
CTGACATTGCAGAAACGGTGGTCAGCCACGTCGAGGGGGCGCGTTTTGCGCTGGTGGAACGCGTGGCTGAAGAGGTGGCG
GAGCTGCTGTTAGCACGCTTCAACTCGCCGTGGGTGCGTATCAAACTCAGCAAGCCAGGCGCAGTGGCGCGGGCGGCGAA
TGTTGGCGTAATCATTGAGCGTGGCAATAATCTGAAAGAAAATAATTAA

Upstream 100 bases:

>100_bases
TGTTCCGTTTTGAAAATTCGTGTTCAACGATGAATCTGTGGATAATACGCACATTTCGCCGGAAGTGGTATCCGGTTAGC
CAAAAAGCAGGCAGGACGTG

Downstream 100 bases:

>100_bases
TTTTACAGCTGTTAAACCAAACGGTTATAACCTGGTCATACTGCAGTAGTTCGGACAAGCGGTACATTTTAATAATTTAG
GGGTTTATTGATGAGCGATA

Product: bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase

Products: NA

Alternate protein names: DHNA

Number of amino acids: Translated: 122; Mature: 122

Protein sequence:

>122_residues
MDIVFIEQLSVITTIGVYDWEQTIEQKLVFDIEMAWDNRKAAKSDDVADCLSYADIAETVVSHVEGARFALVERVAEEVA
ELLLARFNSPWVRIKLSKPGAVARAANVGVIIERGNNLKENN

Sequences:

>Translated_122_residues
MDIVFIEQLSVITTIGVYDWEQTIEQKLVFDIEMAWDNRKAAKSDDVADCLSYADIAETVVSHVEGARFALVERVAEEVA
ELLLARFNSPWVRIKLSKPGAVARAANVGVIIERGNNLKENN
>Mature_122_residues
MDIVFIEQLSVITTIGVYDWEQTIEQKLVFDIEMAWDNRKAAKSDDVADCLSYADIAETVVSHVEGARFALVERVAEEVA
ELLLARFNSPWVRIKLSKPGAVARAANVGVIIERGNNLKENN

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimeriza

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family

Homologues:

Organism=Escherichia coli, GI87082204, Length=122, Percent_Identity=100, Blast_Score=246, Evalue=3e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLB_ECOL6 (P0AC17)

Other databases:

- EMBL:   AE014075
- RefSeq:   NP_755679.1
- ProteinModelPortal:   P0AC17
- SMR:   P0AC17
- EnsemblBacteria:   EBESCT00000044496
- GeneID:   1039956
- GenomeReviews:   AE014075_GR
- KEGG:   ecc:c3808
- GeneTree:   EBGT00050000009852
- HOGENOM:   HBG635896
- OMA:   LITEKPI
- ProtClustDB:   PRK11593
- BRENDA:   4.1.2.25
- InterPro:   IPR006156
- InterPro:   IPR006157
- PANTHER:   PTHR20941:SF3
- SMART:   SM00905
- TIGRFAMs:   TIGR00525
- TIGRFAMs:   TIGR00526

Pfam domain/function: PF02152 FolB

EC number: =4.1.2.25

Molecular weight: Translated: 13620; Mature: 13620

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIVFIEQLSVITTIGVYDWEQTIEQKLVFDIEMAWDNRKAAKSDDVADCLSYADIAETV
CCEEEHHHHHHHHHHCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
VSHVEGARFALVERVAEEVAELLLARFNSPWVRIKLSKPGAVARAANVGVIIERGNNLKE
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHCCCEEEEECCCCCCC
NN
CC
>Mature Secondary Structure
MDIVFIEQLSVITTIGVYDWEQTIEQKLVFDIEMAWDNRKAAKSDDVADCLSYADIAETV
CCEEEHHHHHHHHHHCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
VSHVEGARFALVERVAEEVAELLLARFNSPWVRIKLSKPGAVARAANVGVIIERGNNLKE
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHCCCEEEEECCCCCCC
NN
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157