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The map label for this gene is cbl

Identifier: 30063440

GI number: 30063440

Start: 2052641

End: 2053591

Strand: Reverse

Name: cbl

Synonym: S2165

Alternate gene names: 30063440

Gene position: 2053591-2052641 (Counterclockwise)

Preceding gene: 30063441

Following gene: 30063435

Centisome position: 44.65

GC content: 47.42

Gene sequence:

>951_bases
GTGAATTTCCAACAACTAAAGATAATCCGCGAGGCTGCACGTCAGGATTACAACCTGACAGAGGTTGCGAATATGCTTTT
TACCTCACAGTCAGGCGTTAGCCGTCATATTCGGGAACTGGAGGATGAATTTGGCATCGAAATATTTGTTCGACGAGGTA
AGCGACTGCTGGGGATGACTGAACCGGGCAAAGCATTACTGGTCATTGCAGAACGTATTCTGAATGAAGCCAGTAATGTT
CGTCGGCTTGCAGACCTGTTTACCAACGATACGTCTGGTGTTCTCACTATTGCAACGACGCATACTCAGGCACGTTATAG
CTTGCCAGAGGTCATTAAAGCTTTTCGCGAACTTTTCCCGGAGGTTCGGCTCGAGCTAATCCAGGGTTCGCCACAGGAAA
TTGCGACGTTGTTGCAAAATGGCGAAGCTGATATTGGTATCGCCAGCGAGCGTTTGAGTAATGACCCGCAGCTCGTCGCC
TTCCCATGGTTTTGTTGGCACCATAGTTTGCTTGTTCCACTCGATCATCCCTTAACGCAAATTACACCATTGACGCTGGA
ATCAATAGCGAAGTGGCCGTTAATTACTTACCGACAGGGAATTACGGGGCGCTCACGCACTGATGACGCATTTACCCGCA
AAGGTTTGCCGGCAGATATTGTATTAAGTGCACAGGATTCTGATGTCATTAAAACCTATGTTGCTCTTGGGCTTGGGATC
GGATTAGTTGCCGAACAATCCAGCGGCGAACAAGAGGAAGAGAATTTAATCCGCCTGGATACGCGGCATCTTTTCGATGC
TAATACTGTCTGGTTGGGACTGAAGCGAGGACAACTTCAGCGTAACTATGTTTGGCGCTTTCTGGAACTTTGTAATGCAG
GACTGTCAGTTGAGGATATCAAGCGCCAGGTGATGGAAAACAGTGAAGAGGAAATTGATTATCAGATATAG

Upstream 100 bases:

>100_bases
CGTTATATCGGGATGGAATAAGATGCGGGTTTTTATTATTTGTTATGCCGGGCATTAGACTTTAACAATAACGGGATATC
TGAACTGCCCGGAGTTTACC

Downstream 100 bases:

>100_bases
CAAAAAGCCCGCTATAAAAGCGGGCTTTTCAGAAATTTGGCTCCTCTGACTGGACTCGAACCAGTGACATACGGATTAAC
AGTCCGCCGTTCTACCGACT

Product: transcriptional regulator Cbl

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDEFGIEIFVRRGKRLLGMTEPGKALLVIAERILNEASNV
RRLADLFTNDTSGVLTIATTHTQARYSLPEVIKAFRELFPEVRLELIQGSPQEIATLLQNGEADIGIASERLSNDPQLVA
FPWFCWHHSLLVPLDHPLTQITPLTLESIAKWPLITYRQGITGRSRTDDAFTRKGLPADIVLSAQDSDVIKTYVALGLGI
GLVAEQSSGEQEEENLIRLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDIKRQVMENSEEEIDYQI

Sequences:

>Translated_316_residues
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDEFGIEIFVRRGKRLLGMTEPGKALLVIAERILNEASNV
RRLADLFTNDTSGVLTIATTHTQARYSLPEVIKAFRELFPEVRLELIQGSPQEIATLLQNGEADIGIASERLSNDPQLVA
FPWFCWHHSLLVPLDHPLTQITPLTLESIAKWPLITYRQGITGRSRTDDAFTRKGLPADIVLSAQDSDVIKTYVALGLGI
GLVAEQSSGEQEEENLIRLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDIKRQVMENSEEEIDYQI
>Mature_316_residues
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDEFGIEIFVRRGKRLLGMTEPGKALLVIAERILNEASNV
RRLADLFTNDTSGVLTIATTHTQARYSLPEVIKAFRELFPEVRLELIQGSPQEIATLLQNGEADIGIASERLSNDPQLVA
FPWFCWHHSLLVPLDHPLTQITPLTLESIAKWPLITYRQGITGRSRTDDAFTRKGLPADIVLSAQDSDVIKTYVALGLGI
GLVAEQSSGEQEEENLIRLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDIKRQVMENSEEEIDYQI

Specific function: May be an accessory regulatory protein within the cys regulon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788296, Length=316, Percent_Identity=97.1518987341772, Blast_Score=601, Evalue=1e-173,
Organism=Escherichia coli, GI1787530, Length=313, Percent_Identity=41.2140575079872, Blast_Score=254, Evalue=5e-69,
Organism=Escherichia coli, GI1788481, Length=294, Percent_Identity=27.5510204081633, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI157672245, Length=207, Percent_Identity=28.5024154589372, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1788887, Length=235, Percent_Identity=26.8085106382979, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081904, Length=208, Percent_Identity=29.8076923076923, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790399, Length=243, Percent_Identity=24.2798353909465, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI87082132, Length=134, Percent_Identity=35.8208955223881, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790208, Length=251, Percent_Identity=28.6852589641434, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI2367136, Length=245, Percent_Identity=23.6734693877551, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35842; Mature: 35842

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDEFGIEIFVRRGKRLLGMT
CCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCEEHEECCCCHHCCCC
EPGKALLVIAERILNEASNVRRLADLFTNDTSGVLTIATTHTQARYSLPEVIKAFRELFP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHCCHHHHHHHHHHHHH
EVRLELIQGSPQEIATLLQNGEADIGIASERLSNDPQLVAFPWFCWHHSLLVPLDHPLTQ
HHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEEEHHHHHCCEEEECCCCHHH
ITPLTLESIAKWPLITYRQGITGRSRTDDAFTRKGLPADIVLSAQDSDVIKTYVALGLGI
CCCHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHH
GLVAEQSSGEQEEENLIRLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDI
HEEECCCCCCHHHHHHEEEHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHH
KRQVMENSEEEIDYQI
HHHHHCCCHHHCCCCC
>Mature Secondary Structure
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDEFGIEIFVRRGKRLLGMT
CCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCEEHEECCCCHHCCCC
EPGKALLVIAERILNEASNVRRLADLFTNDTSGVLTIATTHTQARYSLPEVIKAFRELFP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHCCHHHHHHHHHHHHH
EVRLELIQGSPQEIATLLQNGEADIGIASERLSNDPQLVAFPWFCWHHSLLVPLDHPLTQ
HHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEEEHHHHHCCEEEECCCCHHH
ITPLTLESIAKWPLITYRQGITGRSRTDDAFTRKGLPADIVLSAQDSDVIKTYVALGLGI
CCCHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHH
GLVAEQSSGEQEEENLIRLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDI
HEEECCCCCCHHHHHHEEEHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHH
KRQVMENSEEEIDYQI
HHHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8529872; 9097040; 9278503 [H]