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The map label for this gene is pmrB [H]

Identifier: 29144460

GI number: 29144460

Start: 4362407

End: 4363486

Strand: Reverse

Name: pmrB [H]

Synonym: t4198

Alternate gene names: 29144460

Gene position: 4363486-4362407 (Counterclockwise)

Preceding gene: 29144461

Following gene: 29144458

Centisome position: 91.06

GC content: 55.28

Gene sequence:

>1080_bases
GTGAGCCTGATGCGTTTTCAGCGAAGAGCGATGACCCTTCGCCAGCGTTTAACGCTGACAATTGGTCTTATTCTGCTGGT
GTTCCAGCTAATCAGTACCTTCTGGTTATGGCATGAAAGCACTGAGCAAATCCAACTGTTCGAGCAGGCGCTGCGGGATA
ATCGCAACAACGATCGCCATATCATGCACGAAATTCGCGAGGCGGTCGCCAGCCTGATCGTCCCCAGCGTATTTATGGTT
AGCCTGACGCTGCTGGTTTGCTACCAGGCGGTACGGCGTATTACCCGCCCACTCGCCGAACTGCAAAAAGAGCTGGAAGC
GCGGACGGCGGATAATCTGACGCCGATCGCCATTCACAGCTCCACGCTTGAGATTGAGTCCGTCGTCTCGGCGATCAATC
AACTGGTTACGCGTTTGACCACCACGCTCGACAATGAACGCCTTTTTACCGCCGATGTGGCCCATGAGCTACGCACGCCG
CTGTCGGGGGTGCGTTTGCATCTGGAATTATTGTCAAAAACCCACAATGTTGATGTCGCGCCGCTTATCGCCCGTCTTGA
CCAGATGATGGATAGCGTCTCCCAGCTTCTGCAACTGGCGCGCGTGGGCCAGTCATTCTCTTCCGGGAATTATCAGGAAG
TAAAACTGCTGGAAGATGTGATCCTCCCCTCCTACGATGAGCTGAACACCATGCTGGAAACGCGCCAGCAAACTCTGTTG
CTGCCGGAAAGCGCGGCGGACGTGGTGGTGCGCGGTGACGCGACGTTACTGCGTATGCTGCTGCGAAATCTGGTGGAAAA
CGCGCATCGCTATAGCCCTGAAGGAACCCATATCACTATCCACATTAGCGCCGACCCCGACGCTATTATGGCGGTCGAAG
ACGAGGGGCCGGGTATTGATGAAAGCAAATGCGGGAAGCTAAGCGAAGCGTTCGTGCGGATGGACAGCCGTTATGGCGGA
ATTGGCCTGGGGCTGAGTATCGTCAGCCGCATCACCCAGCTACATCAGGGACAGTTTTTCCTGCAAAACCGTACGGAAAG
AACAGGCACCCGTGCCTGGGTGCTGTTGAAAAAGGCATAA

Upstream 100 bases:

>100_bases
GGAAGTGCATATACATAATTTGCGCGACAAAGTCGGCAAGTCGCGCATTCGCACGGTTCGCAGGTTTGGCTACATGCTGG
TTGCCACTGAGGAAAGCTAA

Downstream 100 bases:

>100_bases
CAGGCGTTTAATACGTCGTGACCCACACATAGATAAAACTGCTGACAATCAGCACACTACACAGGGTCGTCAAACTTTTA
TAAATATAGCTTTTCATGAC

Product: sensor protein BasS/PmrB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MSLMRFQRRAMTLRQRLTLTIGLILLVFQLISTFWLWHESTEQIQLFEQALRDNRNNDRHIMHEIREAVASLIVPSVFMV
SLTLLVCYQAVRRITRPLAELQKELEARTADNLTPIAIHSSTLEIESVVSAINQLVTRLTTTLDNERLFTADVAHELRTP
LSGVRLHLELLSKTHNVDVAPLIARLDQMMDSVSQLLQLARVGQSFSSGNYQEVKLLEDVILPSYDELNTMLETRQQTLL
LPESAADVVVRGDATLLRMLLRNLVENAHRYSPEGTHITIHISADPDAIMAVEDEGPGIDESKCGKLSEAFVRMDSRYGG
IGLGLSIVSRITQLHQGQFFLQNRTERTGTRAWVLLKKA

Sequences:

>Translated_359_residues
MSLMRFQRRAMTLRQRLTLTIGLILLVFQLISTFWLWHESTEQIQLFEQALRDNRNNDRHIMHEIREAVASLIVPSVFMV
SLTLLVCYQAVRRITRPLAELQKELEARTADNLTPIAIHSSTLEIESVVSAINQLVTRLTTTLDNERLFTADVAHELRTP
LSGVRLHLELLSKTHNVDVAPLIARLDQMMDSVSQLLQLARVGQSFSSGNYQEVKLLEDVILPSYDELNTMLETRQQTLL
LPESAADVVVRGDATLLRMLLRNLVENAHRYSPEGTHITIHISADPDAIMAVEDEGPGIDESKCGKLSEAFVRMDSRYGG
IGLGLSIVSRITQLHQGQFFLQNRTERTGTRAWVLLKKA
>Mature_358_residues
SLMRFQRRAMTLRQRLTLTIGLILLVFQLISTFWLWHESTEQIQLFEQALRDNRNNDRHIMHEIREAVASLIVPSVFMVS
LTLLVCYQAVRRITRPLAELQKELEARTADNLTPIAIHSSTLEIESVVSAINQLVTRLTTTLDNERLFTADVAHELRTPL
SGVRLHLELLSKTHNVDVAPLIARLDQMMDSVSQLLQLARVGQSFSSGNYQEVKLLEDVILPSYDELNTMLETRQQTLLL
PESAADVVVRGDATLLRMLLRNLVENAHRYSPEGTHITIHISADPDAIMAVEDEGPGIDESKCGKLSEAFVRMDSRYGGI
GLGLSIVSRITQLHQGQFFLQNRTERTGTRAWVLLKKA

Specific function: Member of the two-component regulatory system BasS/BasR. Autophosphorylates and activates BasR by phosphorylation. Plays a role in the adaptation of the organism to the host environment, in particular to neutrophils, and therefore it plays a role in virul

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790551, Length=355, Percent_Identity=85.6338028169014, Blast_Score=629, Evalue=0.0,
Organism=Escherichia coli, GI1789403, Length=276, Percent_Identity=31.1594202898551, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1789808, Length=269, Percent_Identity=28.996282527881, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1786600, Length=227, Percent_Identity=30.8370044052863, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786783, Length=316, Percent_Identity=27.8481012658228, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1790346, Length=236, Percent_Identity=28.3898305084746, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788393, Length=259, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788279, Length=296, Percent_Identity=28.7162162162162, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787894, Length=245, Percent_Identity=28.9795918367347, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87081816, Length=209, Percent_Identity=28.7081339712919, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790861, Length=281, Percent_Identity=24.5551601423488, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1787374, Length=270, Percent_Identity=24.4444444444444, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 40611; Mature: 40479

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLMRFQRRAMTLRQRLTLTIGLILLVFQLISTFWLWHESTEQIQLFEQALRDNRNNDRH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHH
IMHEIREAVASLIVPSVFMVSLTLLVCYQAVRRITRPLAELQKELEARTADNLTPIAIHS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
STLEIESVVSAINQLVTRLTTTLDNERLFTADVAHELRTPLSGVRLHLELLSKTHNVDVA
CHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHH
PLIARLDQMMDSVSQLLQLARVGQSFSSGNYQEVKLLEDVILPSYDELNTMLETRQQTLL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHEE
LPESAADVVVRGDATLLRMLLRNLVENAHRYSPEGTHITIHISADPDAIMAVEDEGPGID
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCCCC
ESKCGKLSEAFVRMDSRYGGIGLGLSIVSRITQLHQGQFFLQNRTERTGTRAWVLLKKA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEEEEEECC
>Mature Secondary Structure 
SLMRFQRRAMTLRQRLTLTIGLILLVFQLISTFWLWHESTEQIQLFEQALRDNRNNDRH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHH
IMHEIREAVASLIVPSVFMVSLTLLVCYQAVRRITRPLAELQKELEARTADNLTPIAIHS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
STLEIESVVSAINQLVTRLTTTLDNERLFTADVAHELRTPLSGVRLHLELLSKTHNVDVA
CHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHH
PLIARLDQMMDSVSQLLQLARVGQSFSSGNYQEVKLLEDVILPSYDELNTMLETRQQTLL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHEE
LPESAADVVVRGDATLLRMLLRNLVENAHRYSPEGTHITIHISADPDAIMAVEDEGPGID
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCCCC
ESKCGKLSEAFVRMDSRYGGIGLGLSIVSRITQLHQGQFFLQNRTERTGTRAWVLLKKA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8391535; 11677609 [H]