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The map label for this gene is trpS [H]

Identifier: 29144293

GI number: 29144293

Start: 4177991

End: 4178995

Strand: Direct

Name: trpS [H]

Synonym: t4024

Alternate gene names: 29144293

Gene position: 4177991-4178995 (Clockwise)

Preceding gene: 29144292

Following gene: 29144300

Centisome position: 87.19

GC content: 51.74

Gene sequence:

>1005_bases
ATGACTAAGCCCATCGTTTTTAGTGGCGCACAGCCCTCAGGTGAATTGACCATTGGCAACTATATGGGGGCATTGCGTCA
GTGGGTAAACATGCAGGATGACTATCATTGCATCTACTGCATCGTAGACCAACATGCTATTACCGTACGTCAGGACGCGC
AGCAGCTACGTAAAGCGACGCTGGATACGCTGGCGCTGTACTTGGCATGTGGTATTGATCCTGAAAAGAGCACTATTTTC
GTTCAGTCCCATGTGCCGGAACATGCGCAGCTTGGCTGGGCGCTGAACTGCTATACCTATTTCGGCGAGCTGAGCCGTAT
GACGCAGTTTAAAGATAAATCTGCGCGCTATGCGGAAAATATTAACGCCGGCCTGTTTGATTACCCGGTGCTGATGGCGG
CAGACATCCTGCTGTACCAAACCAATCTGGTGCCGGTAGGCGAAGATCAGAAGCAGCATCTGGAACTGAGCCGCGATATC
GCCCAGCGTTTCAACGGGCTGTATGGCGATATTTTCAAAGTACCGGAACCGTTTATTCCAAAATCCGGTGCGCGCGTGAT
GTCGTTGCTGGAGCCGACGAAGAAAATGTCCAAATCGGACGATAACCGTAATAACGTAATCGGCCTGTTGGAAGATCCGA
AATCGGTAGTGAAGAAAATCAAACGAGCGGTCACTGACTCCGACGAGCCGCCGGTAGTGCGTTATGATGTGAAAGAGAAA
GCGGGTGTCTCTAACCTGCTGGATATCCTTTCCGCCGTGACCGGTCAGAGCATTCCTGAGCTGGAAAAACAGTTTGAAGG
TAAAATGTATGGCCATTTGAAAGGCGAAGTGGCGGAGGCGGTTTCCGGAATGCTGTCTGAGTTGCAGGAGCGCTATCACC
GTTTCCGCAACGACGAAGCGTTCTTGCAGAAGGTGATGAAAGACGGGGCGGAAAAAGCCAGCGCACGTGCGGCCGAAACG
CTGAAAGCCGTTTACGAAGCCATTGGCTTTGTGGCGAAACCGTAA

Upstream 100 bases:

>100_bases
GAAGTGATCGCCCTTAGCGAGCCGGACGTCATTTATGACAGTTTTAACGATCTTTTGCCCGCACTTGGGCTTCCGCATAG
CGATAACCAGGAAATAAAAA

Downstream 100 bases:

>100_bases
CGGTAATTGCTTGCCCGATGGCGCTAGCTTATCGGGCCTACCAACGAACGTAAGTTGGACAAGGCACCTGTGCCATACTG
TTTATCAGACCTGTAAAAAA

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MTKPIVFSGAQPSGELTIGNYMGALRQWVNMQDDYHCIYCIVDQHAITVRQDAQQLRKATLDTLALYLACGIDPEKSTIF
VQSHVPEHAQLGWALNCYTYFGELSRMTQFKDKSARYAENINAGLFDYPVLMAADILLYQTNLVPVGEDQKQHLELSRDI
AQRFNGLYGDIFKVPEPFIPKSGARVMSLLEPTKKMSKSDDNRNNVIGLLEDPKSVVKKIKRAVTDSDEPPVVRYDVKEK
AGVSNLLDILSAVTGQSIPELEKQFEGKMYGHLKGEVAEAVSGMLSELQERYHRFRNDEAFLQKVMKDGAEKASARAAET
LKAVYEAIGFVAKP

Sequences:

>Translated_334_residues
MTKPIVFSGAQPSGELTIGNYMGALRQWVNMQDDYHCIYCIVDQHAITVRQDAQQLRKATLDTLALYLACGIDPEKSTIF
VQSHVPEHAQLGWALNCYTYFGELSRMTQFKDKSARYAENINAGLFDYPVLMAADILLYQTNLVPVGEDQKQHLELSRDI
AQRFNGLYGDIFKVPEPFIPKSGARVMSLLEPTKKMSKSDDNRNNVIGLLEDPKSVVKKIKRAVTDSDEPPVVRYDVKEK
AGVSNLLDILSAVTGQSIPELEKQFEGKMYGHLKGEVAEAVSGMLSELQERYHRFRNDEAFLQKVMKDGAEKASARAAET
LKAVYEAIGFVAKP
>Mature_333_residues
TKPIVFSGAQPSGELTIGNYMGALRQWVNMQDDYHCIYCIVDQHAITVRQDAQQLRKATLDTLALYLACGIDPEKSTIFV
QSHVPEHAQLGWALNCYTYFGELSRMTQFKDKSARYAENINAGLFDYPVLMAADILLYQTNLVPVGEDQKQHLELSRDIA
QRFNGLYGDIFKVPEPFIPKSGARVMSLLEPTKKMSKSDDNRNNVIGLLEDPKSVVKKIKRAVTDSDEPPVVRYDVKEKA
GVSNLLDILSAVTGQSIPELEKQFEGKMYGHLKGEVAEAVSGMLSELQERYHRFRNDEAFLQKVMKDGAEKASARAAETL
KAVYEAIGFVAKP

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=331, Percent_Identity=42.9003021148036, Blast_Score=269, Evalue=3e-72,
Organism=Homo sapiens, GI41352700, Length=179, Percent_Identity=51.9553072625698, Blast_Score=194, Evalue=1e-49,
Organism=Escherichia coli, GI1789786, Length=334, Percent_Identity=96.7065868263473, Blast_Score=679, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71982800, Length=334, Percent_Identity=36.2275449101796, Blast_Score=207, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI71982793, Length=334, Percent_Identity=36.2275449101796, Blast_Score=206, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6320474, Length=345, Percent_Identity=39.4202898550725, Blast_Score=232, Evalue=5e-62,
Organism=Drosophila melanogaster, GI24666151, Length=334, Percent_Identity=44.0119760479042, Blast_Score=252, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 37401; Mature: 37270

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPIVFSGAQPSGELTIGNYMGALRQWVNMQDDYHCIYCIVDQHAITVRQDAQQLRKAT
CCCCEEEECCCCCCCEEHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
LDTLALYLACGIDPEKSTIFVQSHVPEHAQLGWALNCYTYFGELSRMTQFKDKSARYAEN
HHHHHHHHHHCCCCCCCEEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
INAGLFDYPVLMAADILLYQTNLVPVGEDQKQHLELSRDIAQRFNGLYGDIFKVPEPFIP
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCC
KSGARVMSLLEPTKKMSKSDDNRNNVIGLLEDPKSVVKKIKRAVTDSDEPPVVRYDVKEK
CCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEECCHHH
AGVSNLLDILSAVTGQSIPELEKQFEGKMYGHLKGEVAEAVSGMLSELQERYHRFRNDEA
CCHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
FLQKVMKDGAEKASARAAETLKAVYEAIGFVAKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TKPIVFSGAQPSGELTIGNYMGALRQWVNMQDDYHCIYCIVDQHAITVRQDAQQLRKAT
CCCEEEECCCCCCCEEHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
LDTLALYLACGIDPEKSTIFVQSHVPEHAQLGWALNCYTYFGELSRMTQFKDKSARYAEN
HHHHHHHHHHCCCCCCCEEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
INAGLFDYPVLMAADILLYQTNLVPVGEDQKQHLELSRDIAQRFNGLYGDIFKVPEPFIP
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCC
KSGARVMSLLEPTKKMSKSDDNRNNVIGLLEDPKSVVKKIKRAVTDSDEPPVVRYDVKEK
CCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEECCHHH
AGVSNLLDILSAVTGQSIPELEKQFEGKMYGHLKGEVAEAVSGMLSELQERYHRFRNDEA
CCHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
FLQKVMKDGAEKASARAAETLKAVYEAIGFVAKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]