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The map label for this gene is hemY [H]

Identifier: 29143688

GI number: 29143688

Start: 3463509

End: 3464708

Strand: Direct

Name: hemY [H]

Synonym: t3362

Alternate gene names: 29143688

Gene position: 3463509-3464708 (Clockwise)

Preceding gene: 29143687

Following gene: 29143704

Centisome position: 72.28

GC content: 57.83

Gene sequence:

>1200_bases
ATGATGCTAAAAGTATTATTGCTCTTTGTGTTGTTGCTCGCGGGTATCGTGGTCGGCCCGATGATAGCCGGTCACCAGGG
CTATGTGTTAATCCAGACCGATAACTACAACATTGAAACCAGCGTCACCGGCCTGGCGATCATTCTCATCGTCGCTATGG
TGGTGCTATTCGCCATTGAGTGGTTACTACGCCGTCTGTTTCGTACCGGCGCGCACACCCGCGGTTGGTTTGCCAGCCGT
AAACGCCGTCGCGCCCGCAAGCAGACCGAACAGGCGCTGCTGAAGCTGGCGGAGGGCGACTATCAGCAGGTTGAAAAGCT
GATGTCAAAAAATGCCGACCATGCTGAACAACCGGTGGTAAATTATTTGCTGGCGGCAGAAGCGGCGCAGCAGCGCGGCG
ATGAAGCACGCGCTAATCAGCACCTTGAACGTGCGGCAGAGCTGGCGGGGAACGACACCATCCCGGTCGAGATCACGCGT
GTGCGCTTACAGCTGGCGCGCAATGAAAATCACGCAGCGCGTCACGGCGTGGACAAACTGCTGGAGGTCACGCCGCGTCA
CCCGGAAGTTCTGCGTCTGGCGGAGCAGGCCTATATTCGCACCAGCGCATGGAGTTCTTTACTGGATATCATCCCATCCA
TGGCGAAAGCGCACGTCGGCGATGAAGCGCATCGCGCCATGCTCGAACAACAGGCGTGGATAGGACTCATGGATCAGGCG
CGTGCCGAGCAGGGCAGCGAAGGATTACGCACCTGGTGGAAAAACCAAAGCCGTAAAACCCGCCATCAGGTGGCGCTGCA
GGTCGCGATGGCCGAGCATCTAATCGAGTGTGACGATCATGATATGGCGCAGCAGATTATCATCGACGGTCTGAAACGCC
AGTATGACGATCGGCTGGTGCTGCCCATTCCTCGCCTCAGAACCAATAATCCGGAACAACTGGAGAAAGTGCTGCGCCAG
CAAATCAAGACGGTAGGCGATCGCCCGCTGTTATGGAGCACGCTCGGCCAGTCGCTAATGAAACACGGTGAATGGCAGGA
GGCGACCCTGGCTTTCCGCGCCGCGCTGAAACAACGCCCGGACGCGTATGATTATGCCTGGCTTGCCGATGCGCTTGATC
GACTGCATCAACCGGAAGAGGCCGCCGCCATGCGGCGCGACGGCTTGATGCTGACATTACAGAACAATCCCCCGCAGTAA

Upstream 100 bases:

>100_bases
TGCAAACCCGCGTGCGTAATCTGCTGGCGCAACCGACAGTCTCTACGGCAGCGCCTGCCACGCAGACAGACGCTCCGGCA
GCCGCGCCGCAAGGAGAATA

Downstream 100 bases:

>100_bases
TTCCCTCTTGCCCGGTGGCGCTTCGCTTACCGGGCTTACCGCCTACACAAAATCATTCGGGATGCATAAAAAAACGCCTG
CCCGGTTAAGGGGCAGGCGT

Product: protoheme IX biogenesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MMLKVLLLFVLLLAGIVVGPMIAGHQGYVLIQTDNYNIETSVTGLAIILIVAMVVLFAIEWLLRRLFRTGAHTRGWFASR
KRRRARKQTEQALLKLAEGDYQQVEKLMSKNADHAEQPVVNYLLAAEAAQQRGDEARANQHLERAAELAGNDTIPVEITR
VRLQLARNENHAARHGVDKLLEVTPRHPEVLRLAEQAYIRTSAWSSLLDIIPSMAKAHVGDEAHRAMLEQQAWIGLMDQA
RAEQGSEGLRTWWKNQSRKTRHQVALQVAMAEHLIECDDHDMAQQIIIDGLKRQYDDRLVLPIPRLRTNNPEQLEKVLRQ
QIKTVGDRPLLWSTLGQSLMKHGEWQEATLAFRAALKQRPDAYDYAWLADALDRLHQPEEAAAMRRDGLMLTLQNNPPQ

Sequences:

>Translated_399_residues
MMLKVLLLFVLLLAGIVVGPMIAGHQGYVLIQTDNYNIETSVTGLAIILIVAMVVLFAIEWLLRRLFRTGAHTRGWFASR
KRRRARKQTEQALLKLAEGDYQQVEKLMSKNADHAEQPVVNYLLAAEAAQQRGDEARANQHLERAAELAGNDTIPVEITR
VRLQLARNENHAARHGVDKLLEVTPRHPEVLRLAEQAYIRTSAWSSLLDIIPSMAKAHVGDEAHRAMLEQQAWIGLMDQA
RAEQGSEGLRTWWKNQSRKTRHQVALQVAMAEHLIECDDHDMAQQIIIDGLKRQYDDRLVLPIPRLRTNNPEQLEKVLRQ
QIKTVGDRPLLWSTLGQSLMKHGEWQEATLAFRAALKQRPDAYDYAWLADALDRLHQPEEAAAMRRDGLMLTLQNNPPQ
>Mature_399_residues
MMLKVLLLFVLLLAGIVVGPMIAGHQGYVLIQTDNYNIETSVTGLAIILIVAMVVLFAIEWLLRRLFRTGAHTRGWFASR
KRRRARKQTEQALLKLAEGDYQQVEKLMSKNADHAEQPVVNYLLAAEAAQQRGDEARANQHLERAAELAGNDTIPVEITR
VRLQLARNENHAARHGVDKLLEVTPRHPEVLRLAEQAYIRTSAWSSLLDIIPSMAKAHVGDEAHRAMLEQQAWIGLMDQA
RAEQGSEGLRTWWKNQSRKTRHQVALQVAMAEHLIECDDHDMAQQIIIDGLKRQYDDRLVLPIPRLRTNNPEQLEKVLRQ
QIKTVGDRPLLWSTLGQSLMKHGEWQEATLAFRAALKQRPDAYDYAWLADALDRLHQPEEAAAMRRDGLMLTLQNNPPQ

Specific function: Involved in a late step of protoheme IX synthesis [H]

COG id: COG3071

COG function: function code H; Uncharacterized enzyme of heme biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Escherichia coli, GI1790234, Length=387, Percent_Identity=95.6072351421189, Blast_Score=760, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010817
- InterPro:   IPR005254
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR013105
- InterPro:   IPR019734 [H]

Pfam domain/function: PF07219 HemY_N; PF07719 TPR_2 [H]

EC number: NA

Molecular weight: Translated: 45413; Mature: 45413

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: PS50005 TPR L=RR ; PS50293 TPR_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLKVLLLFVLLLAGIVVGPMIAGHQGYVLIQTDNYNIETSVTGLAIILIVAMVVLFAIE
CHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
WLLRRLFRTGAHTRGWFASRKRRRARKQTEQALLKLAEGDYQQVEKLMSKNADHAEQPVV
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHH
NYLLAAEAAQQRGDEARANQHLERAAELAGNDTIPVEITRVRLQLARNENHAARHGVDKL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
LEVTPRHPEVLRLAEQAYIRTSAWSSLLDIIPSMAKAHVGDEAHRAMLEQQAWIGLMDQA
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
RAEQGSEGLRTWWKNQSRKTRHQVALQVAMAEHLIECDDHDMAQQIIIDGLKRQYDDRLV
HHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEE
LPIPRLRTNNPEQLEKVLRQQIKTVGDRPLLWSTLGQSLMKHGEWQEATLAFRAALKQRP
ECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
DAYDYAWLADALDRLHQPEEAAAMRRDGLMLTLQNNPPQ
CCCHHHHHHHHHHHHCCCHHHHHHHHCCEEEEECCCCCC
>Mature Secondary Structure
MMLKVLLLFVLLLAGIVVGPMIAGHQGYVLIQTDNYNIETSVTGLAIILIVAMVVLFAIE
CHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
WLLRRLFRTGAHTRGWFASRKRRRARKQTEQALLKLAEGDYQQVEKLMSKNADHAEQPVV
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHH
NYLLAAEAAQQRGDEARANQHLERAAELAGNDTIPVEITRVRLQLARNENHAARHGVDKL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHH
LEVTPRHPEVLRLAEQAYIRTSAWSSLLDIIPSMAKAHVGDEAHRAMLEQQAWIGLMDQA
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
RAEQGSEGLRTWWKNQSRKTRHQVALQVAMAEHLIECDDHDMAQQIIIDGLKRQYDDRLV
HHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEE
LPIPRLRTNNPEQLEKVLRQQIKTVGDRPLLWSTLGQSLMKHGEWQEATLAFRAALKQRP
ECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
DAYDYAWLADALDRLHQPEEAAAMRRDGLMLTLQNNPPQ
CCCHHHHHHHHHHHHCCCHHHHHHHHCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]