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The map label for this gene is metC [H]

Identifier: 29143424

GI number: 29143424

Start: 3162172

End: 3163359

Strand: Direct

Name: metC [H]

Synonym: t3081

Alternate gene names: 29143424

Gene position: 3162172-3163359 (Clockwise)

Preceding gene: 29143420

Following gene: 29143425

Centisome position: 65.99

GC content: 53.54

Gene sequence:

>1188_bases
ATGACGGATAAACAGTTGGATACCAAACTGGTAAACGCAGGACGCAGCAAAAAATACACGCTTGGCTCAGTGAATAGTGT
GATTCAACGCGCTTCTTCACTGGTGTTTGACACCGTCGAGGCCAAAAAACACGCTACCCGCAATCGCGCCAACGGCGAAT
TATTTTACGGACGCCGGGGAACGCTGACTCACTTTTCGCTCCAGGAAGCCATGTGTGAACTGGAAGGCGGCGCCGGATGC
GCGCTCTTCCCGTGCGGTGCGGCGGCGGTCGCCAACACCATTCTGGCATTCGTTGAACAGGGCGACCACATCCTGATGAC
CAACACAGCCTATGAACCCAGCCAGGATTTCTGCAGCAAAATTCTCGGCAAACTGGGCGTGACGACAAGCTGGTTCGACC
CGCTCATCGGCGCTGATATCACGCAACATATTCAGCCGAACACGAAAGTCGTATTTCTGGAATCCCCCGGTTCTATTACC
ATGGAAGTACATGATATTCCGACCATTGTTAGTGCGGTCAGACGCGTCGCGCCAGACGCCGTCATCATGATTGATAATAC
CTGGGCGGCTGGCGTTCTGTTCAAAGCTCTGGAATTCGATATTGATATCTCTATCCAGGCGGGCACTAAGTATCTAATTG
GTCATTCTGATGCGATGGTCGGTACTGCCGTTGCAAATGCGCGCTGCTGGGAACAATTGCGGGAAAACGCCTATCTGATG
GGGCAAATGCTCGACGCCGACACGGCTTATATGACCAGCCGCGGTCTGCGCACGCTCGGCGTCCGACTGCGCCAGCATCA
AGAAAGCAGCCTCAAAATCGCCGCGTGGCTGGCGAACCATTCTCAGGTCGCGCGCGTTAATCATCCGGCCCTGCCGGGTA
GCAAAGGTCATGCGTTCTGGAAACGAGACTTTACAGGCAGCAGCGGCCTGTTCTCCTTTGTGCTCAATAAAAAGCTGACC
GAGGCAGAATTATCAGCCTATCTGGATAACTTTTCGCTGTTCAGTATGGCCTACTCCTGGGGAGGCTACGAATCGCTGAT
TATTGCTAATCAGCCGGAACAGATCGCCGCGATTCGTCCCGCAGGCGGCGTAGATTTTACCGGTACGCTGGTTCGAGTGC
ATATTGGTTTAGAGAGTGTTGATGATTTGATCGCTGATTTAGCCGCCGGCTTCGCCAGAATTGTGTAA

Upstream 100 bases:

>100_bases
TTTTGGCAAAATTTTCATCTGTATCACACATCGCCAGGGTGCAGATGGTTATATTCATGCTAGTTTAGACATCCAGACGG
TTAAAATCAGGAAACGCAAC

Downstream 100 bases:

>100_bases
AGTTGCCGTGGATGGACATATATGCAGACAATTTCCGTGGAAAAGTCTGCGTTTGTTGCGTCCGGGATCAAGGCATCCCG
GACGATTCAGGAGTACAATA

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MTDKQLDTKLVNAGRSKKYTLGSVNSVIQRASSLVFDTVEAKKHATRNRANGELFYGRRGTLTHFSLQEAMCELEGGAGC
ALFPCGAAAVANTILAFVEQGDHILMTNTAYEPSQDFCSKILGKLGVTTSWFDPLIGADITQHIQPNTKVVFLESPGSIT
MEVHDIPTIVSAVRRVAPDAVIMIDNTWAAGVLFKALEFDIDISIQAGTKYLIGHSDAMVGTAVANARCWEQLRENAYLM
GQMLDADTAYMTSRGLRTLGVRLRQHQESSLKIAAWLANHSQVARVNHPALPGSKGHAFWKRDFTGSSGLFSFVLNKKLT
EAELSAYLDNFSLFSMAYSWGGYESLIIANQPEQIAAIRPAGGVDFTGTLVRVHIGLESVDDLIADLAAGFARIV

Sequences:

>Translated_395_residues
MTDKQLDTKLVNAGRSKKYTLGSVNSVIQRASSLVFDTVEAKKHATRNRANGELFYGRRGTLTHFSLQEAMCELEGGAGC
ALFPCGAAAVANTILAFVEQGDHILMTNTAYEPSQDFCSKILGKLGVTTSWFDPLIGADITQHIQPNTKVVFLESPGSIT
MEVHDIPTIVSAVRRVAPDAVIMIDNTWAAGVLFKALEFDIDISIQAGTKYLIGHSDAMVGTAVANARCWEQLRENAYLM
GQMLDADTAYMTSRGLRTLGVRLRQHQESSLKIAAWLANHSQVARVNHPALPGSKGHAFWKRDFTGSSGLFSFVLNKKLT
EAELSAYLDNFSLFSMAYSWGGYESLIIANQPEQIAAIRPAGGVDFTGTLVRVHIGLESVDDLIADLAAGFARIV
>Mature_394_residues
TDKQLDTKLVNAGRSKKYTLGSVNSVIQRASSLVFDTVEAKKHATRNRANGELFYGRRGTLTHFSLQEAMCELEGGAGCA
LFPCGAAAVANTILAFVEQGDHILMTNTAYEPSQDFCSKILGKLGVTTSWFDPLIGADITQHIQPNTKVVFLESPGSITM
EVHDIPTIVSAVRRVAPDAVIMIDNTWAAGVLFKALEFDIDISIQAGTKYLIGHSDAMVGTAVANARCWEQLRENAYLMG
QMLDADTAYMTSRGLRTLGVRLRQHQESSLKIAAWLANHSQVARVNHPALPGSKGHAFWKRDFTGSSGLFSFVLNKKLTE
AELSAYLDNFSLFSMAYSWGGYESLIIANQPEQIAAIRPAGGVDFTGTLVRVHIGLESVDDLIADLAAGFARIV

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=292, Percent_Identity=31.1643835616438, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI299473759, Length=232, Percent_Identity=32.3275862068966, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI25453487, Length=292, Percent_Identity=27.7397260273973, Blast_Score=112, Evalue=5e-25,
Organism=Escherichia coli, GI1789383, Length=395, Percent_Identity=86.8354430379747, Blast_Score=739, Evalue=0.0,
Organism=Escherichia coli, GI1790375, Length=397, Percent_Identity=31.2342569269521, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17560056, Length=329, Percent_Identity=31.6109422492401, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17538055, Length=332, Percent_Identity=29.2168674698795, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI71980708, Length=376, Percent_Identity=27.9255319148936, Blast_Score=155, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6321170, Length=335, Percent_Identity=41.1940298507463, Blast_Score=268, Evalue=9e-73,
Organism=Saccharomyces cerevisiae, GI6319307, Length=354, Percent_Identity=31.638418079096, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6321254, Length=263, Percent_Identity=28.1368821292776, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321904, Length=252, Percent_Identity=30.1587301587302, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323333, Length=392, Percent_Identity=25, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19922554, Length=337, Percent_Identity=32.3442136498516, Blast_Score=173, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42905; Mature: 42774

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKQLDTKLVNAGRSKKYTLGSVNSVIQRASSLVFDTVEAKKHATRNRANGELFYGRRG
CCCHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCC
TLTHFSLQEAMCELEGGAGCALFPCGAAAVANTILAFVEQGDHILMTNTAYEPSQDFCSK
CEEEHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHH
ILGKLGVTTSWFDPLIGADITQHIQPNTKVVFLESPGSITMEVHDIPTIVSAVRRVAPDA
HHHHHCCCHHHHHHHHCCCHHHHCCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHCCCE
VIMIDNTWAAGVLFKALEFDIDISIQAGTKYLIGHSDAMVGTAVANARCWEQLRENAYLM
EEEEECCHHHHHHHHHHHCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEEE
GQMLDADTAYMTSRGLRTLGVRLRQHQESSLKIAAWLANHSQVARVNHPALPGSKGHAFW
HHHHCCCHHHHHHCCHHHHHHHHHHCCCCCEEEEEEECCCCCEEECCCCCCCCCCCCCEE
KRDFTGSSGLFSFVLNKKLTEAELSAYLDNFSLFSMAYSWGGYESLIIANQPEQIAAIRP
EECCCCCCHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHCCCCEEEEEEECCCCCEEEECC
AGGVDFTGTLVRVHIGLESVDDLIADLAAGFARIV
CCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDKQLDTKLVNAGRSKKYTLGSVNSVIQRASSLVFDTVEAKKHATRNRANGELFYGRRG
CCHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCC
TLTHFSLQEAMCELEGGAGCALFPCGAAAVANTILAFVEQGDHILMTNTAYEPSQDFCSK
CEEEHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHH
ILGKLGVTTSWFDPLIGADITQHIQPNTKVVFLESPGSITMEVHDIPTIVSAVRRVAPDA
HHHHHCCCHHHHHHHHCCCHHHHCCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHCCCE
VIMIDNTWAAGVLFKALEFDIDISIQAGTKYLIGHSDAMVGTAVANARCWEQLRENAYLM
EEEEECCHHHHHHHHHHHCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEEE
GQMLDADTAYMTSRGLRTLGVRLRQHQESSLKIAAWLANHSQVARVNHPALPGSKGHAFW
HHHHCCCHHHHHHCCHHHHHHHHHHCCCCCEEEEEEECCCCCEEECCCCCCCCCCCCCEE
KRDFTGSSGLFSFVLNKKLTEAELSAYLDNFSLFSMAYSWGGYESLIIANQPEQIAAIRP
EECCCCCCHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHCCCCEEEEEEECCCCCEEEECC
AGGVDFTGTLVRVHIGLESVDDLIADLAAGFARIV
CCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659970; 11677609 [H]