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The map label for this gene is mutH [H]

Identifier: 29143266

GI number: 29143266

Start: 3005521

End: 3006216

Strand: Direct

Name: mutH [H]

Synonym: t2914

Alternate gene names: 29143266

Gene position: 3005521-3006216 (Clockwise)

Preceding gene: 29143252

Following gene: 29143267

Centisome position: 62.72

GC content: 57.9

Gene sequence:

>696_bases
ATGTCCGCTCTTTGTCCGCTACTGACTCCGCCTGCTTCGGAAGCATTGCTGTTAGCCCAGGCGCGGCAGCTTTCCGGCTA
TACGTTAGGCGAGCTGGCGGTGATGGCCGGCATTACCACGCCTAAAGATTTGAAGCGAGACAAAGGCTGGATCGGCGTCT
TGCTGGAGATCTGGCTCGGCGCCAGCGCCGGGAGCAAGCCGGAGCAGGATTTCGCCGCGTTAGGCGTAGAACTGAAAACT
ATCCCGGTGGATAGTCTGGGTCGTCCTCTGGAAACAACCTTTGTTTGCGTGGCGCCGTTAACCGGTAACAGCGGCGTGAC
CTGGGAGACAAGTCACGTACGGCATAAATTGAAGCGCGTGCTATGGGTGCCGGTCGAAGGCGATCGCAGCATACCGTTAG
CCGAACGCCGCGTAGGTTCGCCGCTACTCTGGAGTCCGAGTGAAGAAGAGGACAGGCAGCTACGCCTCGACTGGGAAGAG
CTGATGGACATGATAGTGCTGGGCCAGGTGGAACGCATTACCGCCCGCCATGGCGAAGTCTTGCAACTGCGACCCAAAGC
CGCCAATGCCAGGGCGCTCACCGAGGCTATCGGCGCGCGCGGGGAACCTATTTTGACGCTACCGCGTGGATTTTATCTGA
AAAAAAATTTTACGCAGGCGCTGCTGGCTCGCCATTTTTTATTGCAGAATCCGTAA

Upstream 100 bases:

>100_bases
GCAATAAAAATCAGTCTATTGAATATAAGACACAGAAAAAGATAAACTCTGCCCATACGGTATAAAAACACTGCTCATTT
TTTGACCTAAGGTAATTGTC

Downstream 100 bases:

>100_bases
CGTCCATTACACGCAAATGCGCCTCCGCTATGGCTACGCGTCGGGCCGACGCCGGATAAACGTAAGCGTATTGTCGCCGC
TATTTTACACCGTTCCTGGT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: Methyl-directed mismatch repair protein [H]

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MSALCPLLTPPASEALLLAQARQLSGYTLGELAVMAGITTPKDLKRDKGWIGVLLEIWLGASAGSKPEQDFAALGVELKT
IPVDSLGRPLETTFVCVAPLTGNSGVTWETSHVRHKLKRVLWVPVEGDRSIPLAERRVGSPLLWSPSEEEDRQLRLDWEE
LMDMIVLGQVERITARHGEVLQLRPKAANARALTEAIGARGEPILTLPRGFYLKKNFTQALLARHFLLQNP

Sequences:

>Translated_231_residues
MSALCPLLTPPASEALLLAQARQLSGYTLGELAVMAGITTPKDLKRDKGWIGVLLEIWLGASAGSKPEQDFAALGVELKT
IPVDSLGRPLETTFVCVAPLTGNSGVTWETSHVRHKLKRVLWVPVEGDRSIPLAERRVGSPLLWSPSEEEDRQLRLDWEE
LMDMIVLGQVERITARHGEVLQLRPKAANARALTEAIGARGEPILTLPRGFYLKKNFTQALLARHFLLQNP
>Mature_230_residues
SALCPLLTPPASEALLLAQARQLSGYTLGELAVMAGITTPKDLKRDKGWIGVLLEIWLGASAGSKPEQDFAALGVELKTI
PVDSLGRPLETTFVCVAPLTGNSGVTWETSHVRHKLKRVLWVPVEGDRSIPLAERRVGSPLLWSPSEEEDRQLRLDWEEL
MDMIVLGQVERITARHGEVLQLRPKAANARALTEAIGARGEPILTLPRGFYLKKNFTQALLARHFLLQNP

Specific function: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair [H]

COG id: COG3066

COG function: function code L; DNA mismatch repair protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mutH family [H]

Homologues:

Organism=Escherichia coli, GI1789196, Length=229, Percent_Identity=88.2096069868996, Blast_Score=410, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004230
- InterPro:   IPR011337
- InterPro:   IPR011335 [H]

Pfam domain/function: PF02976 MutH [H]

EC number: NA

Molecular weight: Translated: 25438; Mature: 25307

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALCPLLTPPASEALLLAQARQLSGYTLGELAVMAGITTPKDLKRDKGWIGVLLEIWLG
CCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHC
ASAGSKPEQDFAALGVELKTIPVDSLGRPLETTFVCVAPLTGNSGVTWETSHVRHKLKRV
CCCCCCCCHHHHHHCCEEEEECHHHCCCCCCEEEEEEEEEECCCCCEEEHHHHHHHHHHE
LWVPVEGDRSIPLAERRVGSPLLWSPSEEEDRQLRLDWEELMDMIVLGQVERITARHGEV
EEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCE
LQLRPKAANARALTEAIGARGEPILTLPRGFYLKKNFTQALLARHFLLQNP
EEECCCCCCHHHHHHHHCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SALCPLLTPPASEALLLAQARQLSGYTLGELAVMAGITTPKDLKRDKGWIGVLLEIWLG
CCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHC
ASAGSKPEQDFAALGVELKTIPVDSLGRPLETTFVCVAPLTGNSGVTWETSHVRHKLKRV
CCCCCCCCHHHHHHCCEEEEECHHHCCCCCCEEEEEEEEEECCCCCEEEHHHHHHHHHHE
LWVPVEGDRSIPLAERRVGSPLLWSPSEEEDRQLRLDWEELMDMIVLGQVERITARHGEV
EEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCE
LQLRPKAANARALTEAIGARGEPILTLPRGFYLKKNFTQALLARHFLLQNP
EEECCCCCCHHHHHHHHCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA