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The map label for this gene is sipC

Identifier: 29143145

GI number: 29143145

Start: 2865714

End: 2866943

Strand: Reverse

Name: sipC

Synonym: t2786

Alternate gene names: 29143145

Gene position: 2866943-2865714 (Counterclockwise)

Preceding gene: 29143146

Following gene: 29143144

Centisome position: 59.83

GC content: 47.48

Gene sequence:

>1230_bases
ATGTTAATTAGTAATGTGGGAATAAATCCCGCCGCTTATTTAAATAATCATTCTGTTGAGAATAGTTCACAGACAGCTTC
GCAATCCGTTAGCGCTAAAGATATTCTGAATAGTATTGGTATTAGCAGCAGTAAAGTCAGTGACCTGGGGTTGAGTCCTA
CACTGAGCGCGCCTGCGCCAGGGGTATTAACGCAAACCCCCGGAACGATCACGTCCTTTTTAAAAGCCAGTATTCAAAAT
ACCGACATGAATCAGGATTTGAATGCCCTGGCAAATAATGTCACGACTAAAGCGAATGAGGTTGTGCAAACCCAGTTACG
CGAGCAGCAGGCAGAAGTCGGAAAGTTTTTTGATATTAGCGGAATGTCTTCCAGTGCCGTTGCGCTGTTGGCTGCCGCGA
ATACGTTAATGCTGACGTTGAACCAGGCTGATAGCAAACTGTCTGGTAAGTTGTCATTAGTCAGTTTTGATGCAGCTAAA
ACGACGGCAAGCTCCATGATGCGCGAAGGGATGAATGCGTTGTCCGGTAGTATTTCCCAGAGCGCGCTTCAGTTGGGGAT
CACTGGCGTGGGCGCCAAACTGGAATATAAGGGGCTGCAGAATGAAAGAGGCGCGCTTAAACATAATGCCGCGAAGATCG
ATAAACTGACCACTGAAAGCCACAGTATTAAAAACGTGCTGAACGGGCAGAATAGCGTCAAACTTGGTGCTGAAGGCGTC
GATTCTCTGAAATCGTTAAATATGAAGAAAACCGGTACCGATGCGACGAAAAATCTTAATGATGCGACGCTTAAATCTAA
TGCCGGAACCAGCGCCACGGAAAGTCTGGGTATTAAAAACAGTAATAAACAAATCTCCCCTGAACATCAGGCTATTCTGT
CGAAACGTCTTGAGTCTGTCGAATCCGATATTCGTCTTGAGCAGAATACCATGGATATGACCCGAATCGATGCGCGCAAG
ATGCAGATGACGGGCGATCTGATTATGAAGAACTCAGTCACGGTCGGTGGTATTGCAGGGGCGTCCAGGCAGTACGCCGC
TACTCAGGAACGTTCCGAGCAGCAAATTAGCCAGGTGAATAACCGGGTTGCCAGCACCGCATCGGACGAAGCCCGTGAAA
GTTCACGTAAATCGACCAGCCTGATTCAGGAAATGCTGAAAACAATGGAGAGCATTAACCAGTCGAAAGCATCCGCACTC
GCTGCTATCGCAGGCAATATTCGCGCTTAA

Upstream 100 bases:

>100_bases
AAAAGCCATGTCTTCTGCGGTACAGCAAAATGCGGATGCTTCGCGTTTTATTCTGCGCCAGAGTCGCGCATAAAAACTGC
CAAAATAAAGGGAGAAAAAT

Downstream 100 bases:

>100_bases
TCTGACAGATCAACTATACGCCATCAGGGGGGGATTTAATCGCCCTCCTGATGGCGAACTGGGGATATTATGCTTAATAT
TCAAAATTATTCCGCTTCTC

Product: pathogenicity island 1 effector protein

Products: NA

Alternate protein names: Effector protein sipC

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MLISNVGINPAAYLNNHSVENSSQTASQSVSAKDILNSIGISSSKVSDLGLSPTLSAPAPGVLTQTPGTITSFLKASIQN
TDMNQDLNALANNVTTKANEVVQTQLREQQAEVGKFFDISGMSSSAVALLAAANTLMLTLNQADSKLSGKLSLVSFDAAK
TTASSMMREGMNALSGSISQSALQLGITGVGAKLEYKGLQNERGALKHNAAKIDKLTTESHSIKNVLNGQNSVKLGAEGV
DSLKSLNMKKTGTDATKNLNDATLKSNAGTSATESLGIKNSNKQISPEHQAILSKRLESVESDIRLEQNTMDMTRIDARK
MQMTGDLIMKNSVTVGGIAGASRQYAATQERSEQQISQVNNRVASTASDEARESSRKSTSLIQEMLKTMESINQSKASAL
AAIAGNIRA

Sequences:

>Translated_409_residues
MLISNVGINPAAYLNNHSVENSSQTASQSVSAKDILNSIGISSSKVSDLGLSPTLSAPAPGVLTQTPGTITSFLKASIQN
TDMNQDLNALANNVTTKANEVVQTQLREQQAEVGKFFDISGMSSSAVALLAAANTLMLTLNQADSKLSGKLSLVSFDAAK
TTASSMMREGMNALSGSISQSALQLGITGVGAKLEYKGLQNERGALKHNAAKIDKLTTESHSIKNVLNGQNSVKLGAEGV
DSLKSLNMKKTGTDATKNLNDATLKSNAGTSATESLGIKNSNKQISPEHQAILSKRLESVESDIRLEQNTMDMTRIDARK
MQMTGDLIMKNSVTVGGIAGASRQYAATQERSEQQISQVNNRVASTASDEARESSRKSTSLIQEMLKTMESINQSKASAL
AAIAGNIRA
>Mature_409_residues
MLISNVGINPAAYLNNHSVENSSQTASQSVSAKDILNSIGISSSKVSDLGLSPTLSAPAPGVLTQTPGTITSFLKASIQN
TDMNQDLNALANNVTTKANEVVQTQLREQQAEVGKFFDISGMSSSAVALLAAANTLMLTLNQADSKLSGKLSLVSFDAAK
TTASSMMREGMNALSGSISQSALQLGITGVGAKLEYKGLQNERGALKHNAAKIDKLTTESHSIKNVLNGQNSVKLGAEGV
DSLKSLNMKKTGTDATKNLNDATLKSNAGTSATESLGIKNSNKQISPEHQAILSKRLESVESDIRLEQNTMDMTRIDARK
MQMTGDLIMKNSVTVGGIAGASRQYAATQERSEQQISQVNNRVASTASDEARESSRKSTSLIQEMLKTMESINQSKASAL
AAIAGNIRA

Specific function: Actin-binding protein that interferes with host cell actin cytoskeleton. Nucleates actin polymerization and condensates actin filaments into cables (bundling). SipA potenciates sipC activity and both are required for an efficient bacterial internalization

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Note=Secreted via the type III secretion system 1 (SPI-1 TTSS)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the invasin protein C family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SIPC_SALTI (Q56135)

Other databases:

- EMBL:   X82670
- EMBL:   AE014613
- EMBL:   AL627276
- PIR:   S70215
- RefSeq:   NP_457278.1
- RefSeq:   NP_806487.1
- GeneID:   1068886
- GeneID:   1249313
- GenomeReviews:   AE014613_GR
- GenomeReviews:   AL513382_GR
- KEGG:   stt:t2786
- KEGG:   sty:STY3007
- HOGENOM:   HBG415831
- OMA:   AMESINQ
- ProtClustDB:   PRK15373
- BioCyc:   SENT209261:T2786-MONOMER
- BioCyc:   SENT220341:STY3007-MONOMER
- GO:   GO:0009405
- InterPro:   IPR005427
- PRINTS:   PR01608
- TIGRFAMs:   TIGR02101

Pfam domain/function: PF09599 IpaC_SipC

EC number: NA

Molecular weight: Translated: 43082; Mature: 43082

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLISNVGINPAAYLNNHSVENSSQTASQSVSAKDILNSIGISSSKVSDLGLSPTLSAPAP
CEECCCCCCCHHHHCCCCCCCCHHHHHHCCHHHHHHHHHCCCCCCHHHCCCCCCCCCCCC
GVLTQTPGTITSFLKASIQNTDMNQDLNALANNVTTKANEVVQTQLREQQAEVGKFFDIS
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECC
GMSSSAVALLAAANTLMLTLNQADSKLSGKLSLVSFDAAKTTASSMMREGMNALSGSISQ
CCCHHHHHHHHHHCEEEEEECCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCHHHH
SALQLGITGVGAKLEYKGLQNERGALKHNAAKIDKLTTESHSIKNVLNGQNSVKLGAEGV
HHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEECHHHH
DSLKSLNMKKTGTDATKNLNDATLKSNAGTSATESLGIKNSNKQISPEHQAILSKRLESV
HHHHHCCCCCCCCCHHCCCCCHHCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
ESDIRLEQNTMDMTRIDARKMQMTGDLIMKNSVTVGGIAGASRQYAATQERSEQQISQVN
HHHHEECCCHHHHHHHHHHHHHHHCCEEEECCCEECCCCCCCCHHHHHHHHHHHHHHHHH
NRVASTASDEARESSRKSTSLIQEMLKTMESINQSKASALAAIAGNIRA
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLISNVGINPAAYLNNHSVENSSQTASQSVSAKDILNSIGISSSKVSDLGLSPTLSAPAP
CEECCCCCCCHHHHCCCCCCCCHHHHHHCCHHHHHHHHHCCCCCCHHHCCCCCCCCCCCC
GVLTQTPGTITSFLKASIQNTDMNQDLNALANNVTTKANEVVQTQLREQQAEVGKFFDIS
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECC
GMSSSAVALLAAANTLMLTLNQADSKLSGKLSLVSFDAAKTTASSMMREGMNALSGSISQ
CCCHHHHHHHHHHCEEEEEECCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCHHHH
SALQLGITGVGAKLEYKGLQNERGALKHNAAKIDKLTTESHSIKNVLNGQNSVKLGAEGV
HHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEECHHHH
DSLKSLNMKKTGTDATKNLNDATLKSNAGTSATESLGIKNSNKQISPEHQAILSKRLESV
HHHHHCCCCCCCCCHHCCCCCHHCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
ESDIRLEQNTMDMTRIDARKMQMTGDLIMKNSVTVGGIAGASRQYAATQERSEQQISQVN
HHHHEECCCHHHHHHHHHHHHHHHCCEEEECCCEECCCCCCCCHHHHHHHHHHHHHHHHH
NRVASTASDEARESSRKSTSLIQEMLKTMESINQSKASALAAIAGNIRA
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8801431; 11677608; 12644504