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The map label for this gene is tyrA [H]

Identifier: 29142993

GI number: 29142993

Start: 2701448

End: 2702569

Strand: Reverse

Name: tyrA [H]

Synonym: t2624

Alternate gene names: 29142993

Gene position: 2702569-2701448 (Counterclockwise)

Preceding gene: 29142994

Following gene: 29142992

Centisome position: 56.4

GC content: 55.35

Gene sequence:

>1122_bases
ATGGTTGCTGAATTGACCGCGTTACGCGATCAAATAGATGATGTCGATAAAGCGTTGTTGAATTTACTGGCTAAGCGCCT
GGAACTGGTTGCCAAAGTCGGCGAGGTGAAAAGCCGTTTTGGCCTGCCTATTTACGTGCCGGAGCGTGAGGCCTCTATGC
TGGCTTCACGACGGGCGGAAGCAGAAGCGATCGGTGTCCCGCCCGATCTCATTGAAGATGTCCTGCGCCGGGTAATGCGT
GAATCTTACTCCAGCGAAAATGATAAGGGGTTCAAAACGCTTTGTCCTTCTCTGCGTCCGGTCGTCATTGTGGGCGGCGG
CGGACAGATGGGGCGTCTGTTTGAAAAAATGCTCACGCTGTCGGGCTATCAGGTCCGTATTCTGGAACAACAGGACTGGC
CGCGCGCCAGGGACATTGTCGCCGATGCCGGAATGGTGATCGTCAGCGTGCCGATTCATGTTACTGAACAGGTCATAGCG
CAACTGCCGCCCCTGCCGTCCGACTGTATTCTGGTCGATCTGGCATCGGTGAAAAGCGGTCCGTTACAGGCAATGTTGGC
GGCCCATGATGGCCCCGTGCTGGGCTTGCACCCGATGTTTGGCCCGGACAGCGGGAGCCTGGCGAAGCAGGTGGTGGTCT
GGTGTGATGGGCGTCAACCGGAAGCGTATCAGTGGTTCCTTGAGCAAATCCAGGTGTGGGGCGCGCGGTTGCACCGAATT
AGCGCTGTCGAGCACGATCAGAACATGGCTTTTATCCAGGCGCTGCGCCACTTTGCTACCTTCGCTTATGGGCTGCATCT
GGCGGAAGAGAACGTCCAGCTTGAGCAGCTTCTGGCGCTATCATCGCCGATTTATCGACTGGAGCTGGCGATGGTCGGGC
GTCTGTTCGCCCAGGACCCGCAGCTGTATGCAGACATTATTATGTCGTCGGAGCGCAATCTGGCGCTTATCAAGCGTTAC
TATAAACGTTTTGGCGATGCGATCGGGTTACTGGAACAGGGTGATAAGCAGGCTTTTATCGACAGTTTTCGCAAAGTTGA
ACACTGGTTTGGCGATTATGCCAGACGCTTCCAGAATGAAAGCCGTGTGTTATTACGTCAGGCGAATGACAGCCGACCAT
AA

Upstream 100 bases:

>100_bases
CGATGCTTGTATTAGCTGGGAGATGACCGATGCCCTGTTACGTGAAATTCATAAAGATTTGAGCGGCCAGCTGGCGGTGC
GCGTCGCATAAGAGGTTGTT

Downstream 100 bases:

>100_bases
TGATGACATCTATACTAAAAGCCAGCTTTGCTGGCTTTTTTCGTTTAAGGAACCGTTATGACTACGCCGCACCTTTTATT
TGATTATGTCGGACATTTAC

Product: bifunctional chorismate mutase/prephenate dehydrogenase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydrogenase; PDH [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MVAELTALRDQIDDVDKALLNLLAKRLELVAKVGEVKSRFGLPIYVPEREASMLASRRAEAEAIGVPPDLIEDVLRRVMR
ESYSSENDKGFKTLCPSLRPVVIVGGGGQMGRLFEKMLTLSGYQVRILEQQDWPRARDIVADAGMVIVSVPIHVTEQVIA
QLPPLPSDCILVDLASVKSGPLQAMLAAHDGPVLGLHPMFGPDSGSLAKQVVVWCDGRQPEAYQWFLEQIQVWGARLHRI
SAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDPQLYADIIMSSERNLALIKRY
YKRFGDAIGLLEQGDKQAFIDSFRKVEHWFGDYARRFQNESRVLLRQANDSRP

Sequences:

>Translated_373_residues
MVAELTALRDQIDDVDKALLNLLAKRLELVAKVGEVKSRFGLPIYVPEREASMLASRRAEAEAIGVPPDLIEDVLRRVMR
ESYSSENDKGFKTLCPSLRPVVIVGGGGQMGRLFEKMLTLSGYQVRILEQQDWPRARDIVADAGMVIVSVPIHVTEQVIA
QLPPLPSDCILVDLASVKSGPLQAMLAAHDGPVLGLHPMFGPDSGSLAKQVVVWCDGRQPEAYQWFLEQIQVWGARLHRI
SAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDPQLYADIIMSSERNLALIKRY
YKRFGDAIGLLEQGDKQAFIDSFRKVEHWFGDYARRFQNESRVLLRQANDSRP
>Mature_373_residues
MVAELTALRDQIDDVDKALLNLLAKRLELVAKVGEVKSRFGLPIYVPEREASMLASRRAEAEAIGVPPDLIEDVLRRVMR
ESYSSENDKGFKTLCPSLRPVVIVGGGGQMGRLFEKMLTLSGYQVRILEQQDWPRARDIVADAGMVIVSVPIHVTEQVIA
QLPPLPSDCILVDLASVKSGPLQAMLAAHDGPVLGLHPMFGPDSGSLAKQVVVWCDGRQPEAYQWFLEQIQVWGARLHRI
SAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDPQLYADIIMSSERNLALIKRY
YKRFGDAIGLLEQGDKQAFIDSFRKVEHWFGDYARRFQNESRVLLRQANDSRP

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=372, Percent_Identity=95.4301075268817, Blast_Score=726, Evalue=0.0,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR008244
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR011277
- InterPro:   IPR016040
- InterPro:   IPR003099 [H]

Pfam domain/function: PF01817 CM_2; PF02153 PDH [H]

EC number: =5.4.99.5; =1.3.1.12 [H]

Molecular weight: Translated: 41915; Mature: 41915

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAELTALRDQIDDVDKALLNLLAKRLELVAKVGEVKSRFGLPIYVPEREASMLASRRAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHCC
AEAIGVPPDLIEDVLRRVMRESYSSENDKGFKTLCPSLRPVVIVGGGGQMGRLFEKMLTL
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCEEEECCCCHHHHHHHHHHHC
SGYQVRILEQQDWPRARDIVADAGMVIVSVPIHVTEQVIAQLPPLPSDCILVDLASVKSG
CCCEEEEECCCCCCHHHHHHHHCCEEEEEECHHHHHHHHHHCCCCCCCCEEEEHHHCCCC
PLQAMLAAHDGPVLGLHPMFGPDSGSLAKQVVVWCDGRQPEAYQWFLEQIQVWGARLHRI
CHHHHHHHCCCCEEEECCCCCCCCCHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
SAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDP
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCH
QLYADIIMSSERNLALIKRYYKRFGDAIGLLEQGDKQAFIDSFRKVEHWFGDYARRFQNE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
SRVLLRQANDSRP
HHHHHCCCCCCCC
>Mature Secondary Structure
MVAELTALRDQIDDVDKALLNLLAKRLELVAKVGEVKSRFGLPIYVPEREASMLASRRAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHCC
AEAIGVPPDLIEDVLRRVMRESYSSENDKGFKTLCPSLRPVVIVGGGGQMGRLFEKMLTL
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCEEEECCCCHHHHHHHHHHHC
SGYQVRILEQQDWPRARDIVADAGMVIVSVPIHVTEQVIAQLPPLPSDCILVDLASVKSG
CCCEEEEECCCCCCHHHHHHHHCCEEEEEECHHHHHHHHHHCCCCCCCCEEEEHHHCCCC
PLQAMLAAHDGPVLGLHPMFGPDSGSLAKQVVVWCDGRQPEAYQWFLEQIQVWGARLHRI
CHHHHHHHCCCCEEEECCCCCCCCCHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
SAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDP
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCH
QLYADIIMSSERNLALIKRYYKRFGDAIGLLEQGDKQAFIDSFRKVEHWFGDYARRFQNE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
SRVLLRQANDSRP
HHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6396419; 9205837; 9278503 [H]