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The map label for this gene is lon [H]

Identifier: 29142798

GI number: 29142798

Start: 2481057

End: 2483411

Strand: Reverse

Name: lon [H]

Synonym: t2410

Alternate gene names: 29142798

Gene position: 2483411-2481057 (Counterclockwise)

Preceding gene: 29142799

Following gene: 29142797

Centisome position: 51.82

GC content: 53.89

Gene sequence:

>2355_bases
ATGAATCCTGAGCGTTCTGAACGCATTGAAATCCCCGTATTGCCCTTGCGCGATGTGGTGGTTTATCCGCACATGGTCAT
ACCCTTATTTGTAGGGCGGGAAAAATCTATCCGTTGTCTGGAAGCGGCTATGGACCATGATAAAAAAATCATGCTGGTCG
CCCAGAAGGAAGCATCAACGGATGAGCCGGGTGTAAACGATCTTTTCACCGTCGGGACCGTGGCCTCTATTTTGCAGATG
CTGAAACTGCCTGACGGCACCGTAAAAGTGCTGGTTGAGGGGTTACAGCGCGCGCGTATTTCCGCGCTGTCTGACAACGG
CGAACATTTCTCCGCGAAGGCGGAGTACCTTGATTCGCCAGCCATTGATGAGCGTGAACAAGAAGTGCTGGTGCGTACCG
CTATCAGCCAGTTCGAAGGCTACATCAAGCTGAACAAAAAAATTCCGCCGGAAGTGCTGACGTCACTCAATAGCATTGAC
GACCCTGCACGTCTGGCTGACACCATCGCCGCGCATATGCCGCTGAAACTGGCGGATAAACAGTCCGTACTGGAGATGTC
CGACGTTAACGAACGTCTGGAATATCTGATGGCGATGATGGAATCTGAAATCGATCTGCTGCAGGTTGAGAAACGCATTC
GCAACCGCGTGAAAAAGCAGATGGAGAAATCCCAGCGCGAGTACTATCTGAACGAGCAAATGAAAGCGATTCAGAAAGAA
CTTGGCGAGATGGACGACGCGCCGGACGAAAACGAAGCGCTGAAGCGTAAGATCGACGCGGCGAAAATGCCGAAAGAGGC
GAAAGAGAAAGCGGAAGCGGAACTGCAGAAGCTGAAAATGATGTCTCCGATGTCGGCGGAAGCGACCGTGGTGCGCGGCT
ACATCGACTGGATGGTGCAGGTGCCGTGGAATGCGCGTAGCAAGGTCAAAAAAGACCTGCGTCAGGCGCAGGAAATCCTC
GATACTGACCATTATGGTCTGGAGCGTGTGAAAGACCGCATCCTTGAGTATCTCGCGGTACAAAGCCGTGTAAATAAAAT
CAAGGGGCCGATCCTGTGTCTGGTGGGGCCGCCGGGGGTAGGTAAAACCTCGTTGGGCCAGTCCATCGCTAAAGCCACAG
GGCGTAAATACGTCCGTATGGCGCTGGGCGGCGTGCGTGATGAAGCGGAAATCCGCGGTCATCGCCGGACTTACATTGGC
TCTATGCCGGGTAAACTGATCCAAAAAATGGCCAAAGTGGGGGTTAAAAACCCACTATTCCTGCTCGATGAGATCGACAA
AATGTCCTCGGACATGCGCGGCGATCCGGCTTCCGCACTGCTTGAGGTGCTGGACCCGGAGCAGAACGTGGCGTTCAGCG
ATCATTACCTGGAAGTGGATTACGATCTCAGCGATGTGATGTTCGTCGCCACCTCCAACTCCATGAACATTCCGGCGCCG
CTGCTGGATCGTATGGAAGTGATCCGTCTGTCCGGTTATACCGAAGACGAGAAGCTGAATATTGCTAAACGTCACCTGCT
GCCGAAGCAGATCGAGCGTAACGCGCTGAAGAAAGGCGAACTGACGGTCGACGATAGCGCGATTATCGGTATTATCCGCT
ATTACACGCGTGAAGCGGGCGTTCGTAGTCTGGAGCGTGAAATCTCCAAACTGTGCCGTAAAGCGGTTAAACAACTGTTG
CTCGATAAGTCGTTAAAACATATTGAAATTAACGGCGATAATCTGCACGACTACCTCGGTGTGCAGCGCTTTGATTATGG
CCGCGCGGATAGCGAAAACCGCGTGGGTCAGGTGACGGGGCTGGCGTGGACGGAAGTGGGCGGCGATCTGTTGACCATCG
AAACCGCCTGCGTACCGGGCAAAGGCAAGCTGACCTACACCGGCTCGCTCGGTGAAGTGATGCAGGAATCTATTCAGGCG
GCGCTGACCGTGGTGCGCGCGCGCGCGGAAAAACTGGGTATTAATCCGGACTTTTACGAAAAACGCGATATCCACGTTCA
CGTGCCGGAAGGCGCAACGCCGAAAGACGGTCCAAGCGCCGGTATCGCGATGTGTACCGCGCTGGTTTCCTGCCTGACCG
GTAATCCGGTGCGCGCAGATGTGGCAATGACCGGTGAGATCACGCTGCGTGGTCAGGTGTTGCCGATCGGCGGCCTGAAA
GAAAAACTGTTGGCGGCGCATCGCGGCGGGATTAAAACGGTCTTAATTCCATTCGAAAATAAACGTGATCTGGAGGAAAT
TCCGGACAACGTGATTGCCGATCTGGATATTCATCCTGTGAAGCGCATTGAGGAAGTTCTGACGCTTGCTCTGCAAAACG
AACCGTCTGGAATGCAGGTTGTAACCGCAAAATAG

Upstream 100 bases:

>100_bases
TGGGAAACATCCCCATATACTGACGTACATGTTATAGGTGGTATGGAGCACAGCTATACTATCTGATTACCTGGCGGACA
CTAAACTAAGAGAGAGCTCT

Downstream 100 bases:

>100_bases
TGACCTCGCGCAAATAGCGCTAATAAAAACAGGGCTGGCAGGCTATTTCGGACTTGCCAGCCTTTTTTTGTATAGCTAAT
TTAGATGGTTGATTGGGTCT

Product: DNA-binding ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 784; Mature: 784

Protein sequence:

>784_residues
MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEASTDEPGVNDLFTVGTVASILQM
LKLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLDSPAIDEREQEVLVRTAISQFEGYIKLNKKIPPEVLTSLNSID
DPARLADTIAAHMPLKLADKQSVLEMSDVNERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKE
LGEMDDAPDENEALKRKIDAAKMPKEAKEKAEAELQKLKMMSPMSAEATVVRGYIDWMVQVPWNARSKVKKDLRQAQEIL
DTDHYGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTYIG
SMPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNVAFSDHYLEVDYDLSDVMFVATSNSMNIPAP
LLDRMEVIRLSGYTEDEKLNIAKRHLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAGVRSLEREISKLCRKAVKQLL
LDKSLKHIEINGDNLHDYLGVQRFDYGRADSENRVGQVTGLAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQA
ALTVVRARAEKLGINPDFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLK
EKLLAAHRGGIKTVLIPFENKRDLEEIPDNVIADLDIHPVKRIEEVLTLALQNEPSGMQVVTAK

Sequences:

>Translated_784_residues
MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEASTDEPGVNDLFTVGTVASILQM
LKLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLDSPAIDEREQEVLVRTAISQFEGYIKLNKKIPPEVLTSLNSID
DPARLADTIAAHMPLKLADKQSVLEMSDVNERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKE
LGEMDDAPDENEALKRKIDAAKMPKEAKEKAEAELQKLKMMSPMSAEATVVRGYIDWMVQVPWNARSKVKKDLRQAQEIL
DTDHYGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTYIG
SMPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNVAFSDHYLEVDYDLSDVMFVATSNSMNIPAP
LLDRMEVIRLSGYTEDEKLNIAKRHLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAGVRSLEREISKLCRKAVKQLL
LDKSLKHIEINGDNLHDYLGVQRFDYGRADSENRVGQVTGLAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQA
ALTVVRARAEKLGINPDFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLK
EKLLAAHRGGIKTVLIPFENKRDLEEIPDNVIADLDIHPVKRIEEVLTLALQNEPSGMQVVTAK
>Mature_784_residues
MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEASTDEPGVNDLFTVGTVASILQM
LKLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLDSPAIDEREQEVLVRTAISQFEGYIKLNKKIPPEVLTSLNSID
DPARLADTIAAHMPLKLADKQSVLEMSDVNERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKE
LGEMDDAPDENEALKRKIDAAKMPKEAKEKAEAELQKLKMMSPMSAEATVVRGYIDWMVQVPWNARSKVKKDLRQAQEIL
DTDHYGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTYIG
SMPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNVAFSDHYLEVDYDLSDVMFVATSNSMNIPAP
LLDRMEVIRLSGYTEDEKLNIAKRHLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAGVRSLEREISKLCRKAVKQLL
LDKSLKHIEINGDNLHDYLGVQRFDYGRADSENRVGQVTGLAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQA
ALTVVRARAEKLGINPDFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLK
EKLLAAHRGGIKTVLIPFENKRDLEEIPDNVIADLDIHPVKRIEEVLTLALQNEPSGMQVVTAK

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=627, Percent_Identity=41.6267942583732, Blast_Score=513, Evalue=1e-145,
Organism=Homo sapiens, GI31377667, Length=563, Percent_Identity=46.1811722912966, Blast_Score=513, Evalue=1e-145,
Organism=Escherichia coli, GI1786643, Length=784, Percent_Identity=99.4897959183673, Blast_Score=1590, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=663, Percent_Identity=40.5731523378582, Blast_Score=494, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17556486, Length=794, Percent_Identity=33.5012594458438, Blast_Score=430, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319449, Length=706, Percent_Identity=39.943342776204, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI221513036, Length=628, Percent_Identity=44.7452229299363, Blast_Score=537, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24666867, Length=628, Percent_Identity=44.7452229299363, Blast_Score=537, Evalue=1e-152,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87398; Mature: 87398

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS01046 LON_SER ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEAST
CCCCCCCEEECCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCC
DEPGVNDLFTVGTVASILQMLKLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLDSP
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCC
AIDEREQEVLVRTAISQFEGYIKLNKKIPPEVLTSLNSIDDPARLADTIAAHMPLKLADK
CCCHHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEECCH
QSVLEMSDVNERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGEMDDAPDENEALKRKIDAAKMPKEAKEKAEAELQKLKMMSPMSAEATVVRGYIDWMVQ
HCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEE
VPWNARSKVKKDLRQAQEILDTDHYGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGV
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GKTSLGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLF
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHH
LLDEIDKMSSDMRGDPASALLEVLDPEQNVAFSDHYLEVDYDLSDVMFVATSNSMNIPAP
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEECCCEEEEECCCCCEEEEEECCCCCCCHH
LLDRMEVIRLSGYTEDEKLNIAKRHLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAG
HHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHH
VRSLEREISKLCRKAVKQLLLDKSLKHIEINGDNLHDYLGVQRFDYGRADSENRVGQVTG
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCHHCCCCCCCCCCCCEEEEC
LAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQAALTVVRARAEKLGINPDFYE
EEHHHCCCCEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECEEEEEEEEEECCCHH
EKLLAAHRGGIKTVLIPFENKRDLEEIPDNVIADLDIHPVKRIEEVLTLALQNEPSGMQV
HHHHHHHCCCCEEEEEECCCCCCHHHCCHHHEECCCCCHHHHHHHHHHHHHCCCCCCCEE
VTAK
EECC
>Mature Secondary Structure
MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEAST
CCCCCCCEEECCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCC
DEPGVNDLFTVGTVASILQMLKLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLDSP
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCC
AIDEREQEVLVRTAISQFEGYIKLNKKIPPEVLTSLNSIDDPARLADTIAAHMPLKLADK
CCCHHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEECCH
QSVLEMSDVNERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGEMDDAPDENEALKRKIDAAKMPKEAKEKAEAELQKLKMMSPMSAEATVVRGYIDWMVQ
HCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEE
VPWNARSKVKKDLRQAQEILDTDHYGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGV
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GKTSLGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLF
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHH
LLDEIDKMSSDMRGDPASALLEVLDPEQNVAFSDHYLEVDYDLSDVMFVATSNSMNIPAP
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEECCCEEEEECCCCCEEEEEECCCCCCCHH
LLDRMEVIRLSGYTEDEKLNIAKRHLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAG
HHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHH
VRSLEREISKLCRKAVKQLLLDKSLKHIEINGDNLHDYLGVQRFDYGRADSENRVGQVTG
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCHHCCCCCCCCCCCCEEEEC
LAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQAALTVVRARAEKLGINPDFYE
EEHHHCCCCEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECEEEEEEEEEECCCHH
EKLLAAHRGGIKTVLIPFENKRDLEEIPDNVIADLDIHPVKRIEEVLTLALQNEPSGMQV
HHHHHHHCCCCEEEEEECCCCCCHHHCCHHHEECCCCCHHHHHHHHHHHHHCCCCCCCEE
VTAK
EECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA