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The map label for this gene is fes [H]

Identifier: 29142681

GI number: 29142681

Start: 2351766

End: 2352980

Strand: Reverse

Name: fes [H]

Synonym: t2282

Alternate gene names: 29142681

Gene position: 2352980-2351766 (Counterclockwise)

Preceding gene: 29142686

Following gene: 29142680

Centisome position: 49.1

GC content: 59.75

Gene sequence:

>1215_bases
ATGAAAGAGGCGCTGGCAACGGGAAGTGAGGCCTGGTGGAGGACGAAAACCGGGCCGGAATGGATACGGGAAAAAGACGG
AAATTATCGGGTCACTTTTTGGTGGCGCGACCCGCAGGGAAACGAAACACACTCCCCGATACGGCGTGTCTGGGTCTACA
TCACTGGCGTAACCGATCATCATCAAAACGCGCAGCCTCAGACGATGGCGCGTATTGCCGGAACGGATGTCTGGCGCTGG
AGCACGGCGCTTAGCGCTAACTGGCGCGGCAGCTACTGTTTTATTCCTACCGAGCGAGATGACGTTTTTGCCGCTTTTGC
GCCGGGCGAAACGCCCGATCGGAACGCGCTGCGTGAAGGCTGGCGACAGCTATTACCGCAGGCGATTGCCGACCCGCTTA
ATTCGCAAAGCTGGCGGGGAGGACGTGGTCATGCGGTTTCAGCGCTGGAAATGCCGGATGCGCCCCGTCAGCCGGGATGG
GATCGTCCTGAAACGTCGTACTCACCGCCTTTGATGATGCAGTGGCATAGCGAACGTCTGGGTAACTCCCGCCGCGTATG
GATATTGACGACCGGAGACGAGGCGACGGAGGAAAGACCGTTGGCTATTCTGCTGGACGGTCAATTCTGGGCGGAAAATA
TGCCCGTCTGGCCCGCGCTCGCCTCGCTGACTCATCAACGCCTGCTTCCCGGTGCCGTCTATCTGCTGATTGACGCGATT
GATACTCAACACCGCAACCAGGAGTTGCCCTGCAATGCCGACTTCTGGCTGGCGGTGCAGCAGGAACTGTTGCCGCAAGT
CAGAGCCGTGACGCCTTTTAGCGATGATGCCGGACGAACGGTGGTCGCCGGACAGAGCTTTGGTGGCCTGTCGGCGCTGT
ATGCCGGCCTGAACTGGCCGACGCGTTTTGGCTGTGTACTAAGCCAGTCAGGATCGTTCTGGTGGCCCCATCGCATCACC
CCGCCGGAGGGGGAAGTCATTACCCGGCTGAAAACCGGCGCATTGTGCGCGCGCGGACTGCGTATCGTACTGGAAGCCGG
CGTGCGTGAGCCGATCGTGTTTCAGGCAAATCAGGCGCTTTATGCCCAACTGAATACCTCGCAGCAGTCCATTTTCTGGC
GTCAGGTTGACGGCGGACACGATGCGCTTTGCTGGCGCGGCGGGCTAACGCAAGGGCTGATGCTGCTTTGGCAGCCGCTT
ATCGACACGCTTTAA

Upstream 100 bases:

>100_bases
AGCGCTACAATACGCTATTGCAAATGCAAATAGTTATCAATAATATTATCAATATATTTCACCTTTTATATACAAAATTC
ATAATAAACACAGGGTTATA

Downstream 100 bases:

>100_bases
CCGGGCACATGTCCATGACAGGAGTTGAGTATGGAATTCAGTAATCCCTTCGATAATCCGCAGGGACAGTTTTACATCCT
GCAAAATGCGCAGCGTCAAT

Product: enterobactin/ferric enterobactin esterase

Products: Fe [C]

Alternate protein names: Ferric enterobactin esterase [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MKEALATGSEAWWRTKTGPEWIREKDGNYRVTFWWRDPQGNETHSPIRRVWVYITGVTDHHQNAQPQTMARIAGTDVWRW
STALSANWRGSYCFIPTERDDVFAAFAPGETPDRNALREGWRQLLPQAIADPLNSQSWRGGRGHAVSALEMPDAPRQPGW
DRPETSYSPPLMMQWHSERLGNSRRVWILTTGDEATEERPLAILLDGQFWAENMPVWPALASLTHQRLLPGAVYLLIDAI
DTQHRNQELPCNADFWLAVQQELLPQVRAVTPFSDDAGRTVVAGQSFGGLSALYAGLNWPTRFGCVLSQSGSFWWPHRIT
PPEGEVITRLKTGALCARGLRIVLEAGVREPIVFQANQALYAQLNTSQQSIFWRQVDGGHDALCWRGGLTQGLMLLWQPL
IDTL

Sequences:

>Translated_404_residues
MKEALATGSEAWWRTKTGPEWIREKDGNYRVTFWWRDPQGNETHSPIRRVWVYITGVTDHHQNAQPQTMARIAGTDVWRW
STALSANWRGSYCFIPTERDDVFAAFAPGETPDRNALREGWRQLLPQAIADPLNSQSWRGGRGHAVSALEMPDAPRQPGW
DRPETSYSPPLMMQWHSERLGNSRRVWILTTGDEATEERPLAILLDGQFWAENMPVWPALASLTHQRLLPGAVYLLIDAI
DTQHRNQELPCNADFWLAVQQELLPQVRAVTPFSDDAGRTVVAGQSFGGLSALYAGLNWPTRFGCVLSQSGSFWWPHRIT
PPEGEVITRLKTGALCARGLRIVLEAGVREPIVFQANQALYAQLNTSQQSIFWRQVDGGHDALCWRGGLTQGLMLLWQPL
IDTL
>Mature_404_residues
MKEALATGSEAWWRTKTGPEWIREKDGNYRVTFWWRDPQGNETHSPIRRVWVYITGVTDHHQNAQPQTMARIAGTDVWRW
STALSANWRGSYCFIPTERDDVFAAFAPGETPDRNALREGWRQLLPQAIADPLNSQSWRGGRGHAVSALEMPDAPRQPGW
DRPETSYSPPLMMQWHSERLGNSRRVWILTTGDEATEERPLAILLDGQFWAENMPVWPALASLTHQRLLPGAVYLLIDAI
DTQHRNQELPCNADFWLAVQQELLPQVRAVTPFSDDAGRTVVAGQSFGGLSALYAGLNWPTRFGCVLSQSGSFWWPHRIT
PPEGEVITRLKTGALCARGLRIVLEAGVREPIVFQANQALYAQLNTSQQSIFWRQVDGGHDALCWRGGLTQGLMLLWQPL
IDTL

Specific function: Upon internalization, ferric enterobactin is processed via an exquisitely specific pathway that is dependent on FES activity, making iron available for metabolic use [H]

COG id: COG2382

COG function: function code P; Enterochelin esterase and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fes family [H]

Homologues:

Organism=Escherichia coli, GI1786799, Length=373, Percent_Identity=73.1903485254692, Blast_Score=569, Evalue=1e-163,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021764
- InterPro:   IPR000801
- InterPro:   IPR014756 [H]

Pfam domain/function: PF11806 DUF3327; PF00756 Esterase [H]

EC number: NA

Molecular weight: Translated: 45653; Mature: 45653

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEALATGSEAWWRTKTGPEWIREKDGNYRVTFWWRDPQGNETHSPIRRVWVYITGVTDH
CCCCCCCCCCCEEECCCCHHHHHCCCCCEEEEEEEECCCCCCCHHHHEEEEEEEEECCCC
HQNAQPQTMARIAGTDVWRWSTALSANWRGSYCFIPTERDDVFAAFAPGETPDRNALREG
CCCCCHHHHHHHHCCCEEEEEHEEECCCCCCEEEEECCCCCEEEEECCCCCCCHHHHHHH
WRQLLPQAIADPLNSQSWRGGRGHAVSALEMPDAPRQPGWDRPETSYSPPLMMQWHSERL
HHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECHHHC
GNSRRVWILTTGDEATEERPLAILLDGQFWAENMPVWPALASLTHQRLLPGAVYLLIDAI
CCCCEEEEEECCCCCCCCCCEEEEECCCHHCCCCCHHHHHHHHHHHHHCCCEEEEEEEHH
DTQHRNQELPCNADFWLAVQQELLPQVRAVTPFSDDAGRTVVAGQSFGGLSALYAGLNWP
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHCCCCC
TRFGCVLSQSGSFWWPHRITPPEGEVITRLKTGALCARGLRIVLEAGVREPIVFQANQAL
CCCCEEEECCCCEECCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEE
YAQLNTSQQSIFWRQVDGGHDALCWRGGLTQGLMLLWQPLIDTL
EEEECCCCCEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKEALATGSEAWWRTKTGPEWIREKDGNYRVTFWWRDPQGNETHSPIRRVWVYITGVTDH
CCCCCCCCCCCEEECCCCHHHHHCCCCCEEEEEEEECCCCCCCHHHHEEEEEEEEECCCC
HQNAQPQTMARIAGTDVWRWSTALSANWRGSYCFIPTERDDVFAAFAPGETPDRNALREG
CCCCCHHHHHHHHCCCEEEEEHEEECCCCCCEEEEECCCCCEEEEECCCCCCCHHHHHHH
WRQLLPQAIADPLNSQSWRGGRGHAVSALEMPDAPRQPGWDRPETSYSPPLMMQWHSERL
HHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECHHHC
GNSRRVWILTTGDEATEERPLAILLDGQFWAENMPVWPALASLTHQRLLPGAVYLLIDAI
CCCCEEEEEECCCCCCCCCCEEEEECCCHHCCCCCHHHHHHHHHHHHHCCCEEEEEEEHH
DTQHRNQELPCNADFWLAVQQELLPQVRAVTPFSDDAGRTVVAGQSFGGLSALYAGLNWP
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHCCCCC
TRFGCVLSQSGSFWWPHRITPPEGEVITRLKTGALCARGLRIVLEAGVREPIVFQANQAL
CCCCEEEECCCCEECCCCCCCCCCHHEEHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEE
YAQLNTSQQSIFWRQVDGGHDALCWRGGLTQGLMLLWQPLIDTL
EEEECCCCCEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ferrienterobactin [C]

Specific reaction: ferrienterobactin = Fe [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2974033; 9278503; 8905232 [H]