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The map label for this gene is pbpA [H]

Identifier: 29142628

GI number: 29142628

Start: 2292398

End: 2294299

Strand: Direct

Name: pbpA [H]

Synonym: t2227

Alternate gene names: 29142628

Gene position: 2292398-2294299 (Clockwise)

Preceding gene: 29142627

Following gene: 29142629

Centisome position: 47.84

GC content: 54.05

Gene sequence:

>1902_bases
ATGAAACGACAAAATTCTTTTCGTGACTATACGGCTGAGTCCGCACTGTTTGTGCGTCGGGCGCTGGTCGCCTTTTTGGG
TATTTTGCTGCTGACCGGCGTACTGATCGCCAATTTGTATAATCTGCAAATTCTCCGTTTTACCGATTACCAGACCCGCT
CGAACGAAAACCGTATCAAGCTGGTGCCAATTGCGCCAAGCCGCGGGATAATCTACGACCGCAACGGCATTCCCCTTGCG
CTGAACCGCACTATCTATCAGATTGAAATGATGCCGGAAAAGGTGGATAACGTTCAGCAAACGCTGGATGCACTACGCAG
TGTGGTCGATTTAAACGACGACGATATCGCCGCCTTTAAAAAAGAGCGCGCCCGATCCCATCGCTTTACTTCTATTCCGG
TGAAAACAAACCTGACGGAAGTTCAGGTCGCGCGCTTTGCTGTCAACCAGTACCGTTTTCCGGGCGTCGAAGTCAAAGGC
TATAAACGCCGCTATTATCCATACGGATCGGCGCTGACCCACGTTATCGGCTACGTATCGAAAATCAATGATAAAGACGT
CGAGCGTCTCGACAGAGAAAACAAACTGGCGAACTACGCCGCCACCCATGACATCGGCAAGCTGGGCATTGAGCGCTACT
ATGAAGATATTCTGCATGGGCAAACCGGTTATGAAGAGGTTGAAGTCAACAACCGCGGCCGCGTTATTCGCCAGCTTAAA
GAGGTGCCGCCGCAGGCCGGACACGATATCTACCTGACGCTGGATCTCAAGCTCCAGCAGTATATTGAAACGCTGCTGGC
AGGCAGTCGCGCGGCGGTGATTGTCACCGATCCGCGTACCGGCGGCGTGCTATCGCTGGTCTCCATGCCAAGTTACGACC
CTAACCTTTTCGTGGACGGCATCTCCAGCAAAGATTACTCCGGGCTGCTTAACGACCCGAACACGCCATTAGTGAACCGC
GCGACTCAGGGTGTCTACCCACCCGCTTCTACCGTTAAGCCTTACGTCGCCGTATCGGCGTTAAGCGCTGGCGTCATCAC
CCGTAACACCAGTCTTTTCGACCCTGGCTGGTGGCAGTTGCCGGGGTCTGAGAAACGCTACCGCGACTGGAAAAAATGGG
GCCACGGGCATCTGAATATCACCAAATCCCTTGAAGAGTCGGCAGATACCTTCTTCTATCAGGTGGCCTATGACATGGGG
ATCGATCGCCTGTCAGAATGGATGGGTAAGTTCAGCTATGGTCACTATACCGGAATTGATCTCGCAGAAGAGCGCTCTGG
TAATATGCCGACCCGCGAGTGGAAACAGAAACGCTTTAAAAAACCGTGGTATCAGGGCGATACGATTCCGGTGGGCATCG
GCCAGGGCTACTGGACGGCAACGCCGATTCAGATGAGTAAGGCGCTGATGATCCTTATTAACGACGGTGTAGTTAAAGTC
CCGCATCTGTTAATGAGCACCGCGGAAAACGGTAAACAGGTGCCGTGGGTACAGCCGCATGAGCCACCGGTGGGCGATAT
TCACTCCGGCTACTGGGAAATTGCGAAAGATGGCATGTATGGCGTCGCCAACCGCCCTAACGGCACGGCGCATAAATATT
TTGCCAGCGCGCCCTATAAAATCGCGGCGAAGTCGGGCACCGCGCAGGTCTTTGGCCTGAAGGCCAACGAAACGTACAAT
GCGCATAAAATCGCCGAGCGCCTGCGCGACCATAAATTAATGACCGCCTTTGCGCCGTATAACAATCCCCAGGTCGCCGT
CGCGATCATCCTTGAAAACGGCGGCGCAGGCCCGGCAGTAGGCACGATCATGCGCCAAATCCTTGATCACATCATGCTGG
GCGACAACAACACCCATTTGCCTGCGGAAAACCCGGTGGTTGCAGCGGCGGAGGACCAATAA

Upstream 100 bases:

>100_bases
GGTTCTGGTCGCGGAGAGTTTGTACCGGGCGTGGAGCATCACAACCAACCACCCTTATCACCGTGAGTGATCGTGAAGTC
TTGAGAAGATTAAGCAGCGG

Downstream 100 bases:

>100_bases
TCATGACGGATAATCCGAACAAAAAAACCTTCTGGGATAAAATTCATATCGATCCCACGATGCTACTCATTCTGCTGGCG
TTACTGGTTTATAGCGCGTT

Product: penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MKRQNSFRDYTAESALFVRRALVAFLGILLLTGVLIANLYNLQILRFTDYQTRSNENRIKLVPIAPSRGIIYDRNGIPLA
LNRTIYQIEMMPEKVDNVQQTLDALRSVVDLNDDDIAAFKKERARSHRFTSIPVKTNLTEVQVARFAVNQYRFPGVEVKG
YKRRYYPYGSALTHVIGYVSKINDKDVERLDRENKLANYAATHDIGKLGIERYYEDILHGQTGYEEVEVNNRGRVIRQLK
EVPPQAGHDIYLTLDLKLQQYIETLLAGSRAAVIVTDPRTGGVLSLVSMPSYDPNLFVDGISSKDYSGLLNDPNTPLVNR
ATQGVYPPASTVKPYVAVSALSAGVITRNTSLFDPGWWQLPGSEKRYRDWKKWGHGHLNITKSLEESADTFFYQVAYDMG
IDRLSEWMGKFSYGHYTGIDLAEERSGNMPTREWKQKRFKKPWYQGDTIPVGIGQGYWTATPIQMSKALMILINDGVVKV
PHLLMSTAENGKQVPWVQPHEPPVGDIHSGYWEIAKDGMYGVANRPNGTAHKYFASAPYKIAAKSGTAQVFGLKANETYN
AHKIAERLRDHKLMTAFAPYNNPQVAVAIILENGGAGPAVGTIMRQILDHIMLGDNNTHLPAENPVVAAAEDQ

Sequences:

>Translated_633_residues
MKRQNSFRDYTAESALFVRRALVAFLGILLLTGVLIANLYNLQILRFTDYQTRSNENRIKLVPIAPSRGIIYDRNGIPLA
LNRTIYQIEMMPEKVDNVQQTLDALRSVVDLNDDDIAAFKKERARSHRFTSIPVKTNLTEVQVARFAVNQYRFPGVEVKG
YKRRYYPYGSALTHVIGYVSKINDKDVERLDRENKLANYAATHDIGKLGIERYYEDILHGQTGYEEVEVNNRGRVIRQLK
EVPPQAGHDIYLTLDLKLQQYIETLLAGSRAAVIVTDPRTGGVLSLVSMPSYDPNLFVDGISSKDYSGLLNDPNTPLVNR
ATQGVYPPASTVKPYVAVSALSAGVITRNTSLFDPGWWQLPGSEKRYRDWKKWGHGHLNITKSLEESADTFFYQVAYDMG
IDRLSEWMGKFSYGHYTGIDLAEERSGNMPTREWKQKRFKKPWYQGDTIPVGIGQGYWTATPIQMSKALMILINDGVVKV
PHLLMSTAENGKQVPWVQPHEPPVGDIHSGYWEIAKDGMYGVANRPNGTAHKYFASAPYKIAAKSGTAQVFGLKANETYN
AHKIAERLRDHKLMTAFAPYNNPQVAVAIILENGGAGPAVGTIMRQILDHIMLGDNNTHLPAENPVVAAAEDQ
>Mature_633_residues
MKRQNSFRDYTAESALFVRRALVAFLGILLLTGVLIANLYNLQILRFTDYQTRSNENRIKLVPIAPSRGIIYDRNGIPLA
LNRTIYQIEMMPEKVDNVQQTLDALRSVVDLNDDDIAAFKKERARSHRFTSIPVKTNLTEVQVARFAVNQYRFPGVEVKG
YKRRYYPYGSALTHVIGYVSKINDKDVERLDRENKLANYAATHDIGKLGIERYYEDILHGQTGYEEVEVNNRGRVIRQLK
EVPPQAGHDIYLTLDLKLQQYIETLLAGSRAAVIVTDPRTGGVLSLVSMPSYDPNLFVDGISSKDYSGLLNDPNTPLVNR
ATQGVYPPASTVKPYVAVSALSAGVITRNTSLFDPGWWQLPGSEKRYRDWKKWGHGHLNITKSLEESADTFFYQVAYDMG
IDRLSEWMGKFSYGHYTGIDLAEERSGNMPTREWKQKRFKKPWYQGDTIPVGIGQGYWTATPIQMSKALMILINDGVVKV
PHLLMSTAENGKQVPWVQPHEPPVGDIHSGYWEIAKDGMYGVANRPNGTAHKYFASAPYKIAAKSGTAQVFGLKANETYN
AHKIAERLRDHKLMTAFAPYNNPQVAVAIILENGGAGPAVGTIMRQILDHIMLGDNNTHLPAENPVVAAAEDQ

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=633, Percent_Identity=95.8925750394945, Blast_Score=1264, Evalue=0.0,
Organism=Escherichia coli, GI1786272, Length=637, Percent_Identity=25.2747252747253, Blast_Score=136, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 71065; Mature: 71065

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRQNSFRDYTAESALFVRRALVAFLGILLLTGVLIANLYNLQILRFTDYQTRSNENRIK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCEEE
LVPIAPSRGIIYDRNGIPLALNRTIYQIEMMPEKVDNVQQTLDALRSVVDLNDDDIAAFK
EEEECCCCCEEECCCCCCEEECCEEEEEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
KERARSHRFTSIPVKTNLTEVQVARFAVNQYRFPGVEVKGYKRRYYPYGSALTHVIGYVS
HHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCEEECCEEEECCCHHHHHHHHHHHH
KINDKDVERLDRENKLANYAATHDIGKLGIERYYEDILHGQTGYEEVEVNNRGRVIRQLK
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHH
EVPPQAGHDIYLTLDLKLQQYIETLLAGSRAAVIVTDPRTGGVLSLVSMPSYDPNLFVDG
HCCCCCCCEEEEEEEHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCCCEEEEC
ISSKDYSGLLNDPNTPLVNRATQGVYPPASTVKPYVAVSALSAGVITRNTSLFDPGWWQL
CCCCCCCCCCCCCCCCHHHHCCCCCCCCHHCCCHHHHHHHHHCCEEECCCCCCCCCCEEC
PGSEKRYRDWKKWGHGHLNITKSLEESADTFFYQVAYDMGIDRLSEWMGKFSYGHYTGID
CCCCHHHHHHHHHCCCCEEEHHHHHHHHHHEEEEHHHHHCHHHHHHHHHHCCCCCCCCCC
LAEERSGNMPTREWKQKRFKKPWYQGDTIPVGIGQGYWTATPIQMSKALMILINDGVVKV
CHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCEECCHHHHCCEEEEEEECCCHHH
PHLLMSTAENGKQVPWVQPHEPPVGDIHSGYWEIAKDGMYGVANRPNGTAHKYFASAPYK
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEECCCCCCCCHHHEECCCCEE
IAAKSGTAQVFGLKANETYNAHKIAERLRDHKLMTAFAPYNNPQVAVAIILENGGAGPAV
EEECCCCEEEEEEECCCCCCHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEECCCCCHHH
GTIMRQILDHIMLGDNNTHLPAENPVVAAAEDQ
HHHHHHHHHHHEECCCCCCCCCCCCEEEECCCC
>Mature Secondary Structure
MKRQNSFRDYTAESALFVRRALVAFLGILLLTGVLIANLYNLQILRFTDYQTRSNENRIK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCEEE
LVPIAPSRGIIYDRNGIPLALNRTIYQIEMMPEKVDNVQQTLDALRSVVDLNDDDIAAFK
EEEECCCCCEEECCCCCCEEECCEEEEEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
KERARSHRFTSIPVKTNLTEVQVARFAVNQYRFPGVEVKGYKRRYYPYGSALTHVIGYVS
HHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCEEECCEEEECCCHHHHHHHHHHHH
KINDKDVERLDRENKLANYAATHDIGKLGIERYYEDILHGQTGYEEVEVNNRGRVIRQLK
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHH
EVPPQAGHDIYLTLDLKLQQYIETLLAGSRAAVIVTDPRTGGVLSLVSMPSYDPNLFVDG
HCCCCCCCEEEEEEEHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCCCEEEEC
ISSKDYSGLLNDPNTPLVNRATQGVYPPASTVKPYVAVSALSAGVITRNTSLFDPGWWQL
CCCCCCCCCCCCCCCCHHHHCCCCCCCCHHCCCHHHHHHHHHCCEEECCCCCCCCCCEEC
PGSEKRYRDWKKWGHGHLNITKSLEESADTFFYQVAYDMGIDRLSEWMGKFSYGHYTGID
CCCCHHHHHHHHHCCCCEEEHHHHHHHHHHEEEEHHHHHCHHHHHHHHHHCCCCCCCCCC
LAEERSGNMPTREWKQKRFKKPWYQGDTIPVGIGQGYWTATPIQMSKALMILINDGVVKV
CHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCEECCHHHHCCEEEEEEECCCHHH
PHLLMSTAENGKQVPWVQPHEPPVGDIHSGYWEIAKDGMYGVANRPNGTAHKYFASAPYK
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEECCCCCCCCHHHEECCCCEE
IAAKSGTAQVFGLKANETYNAHKIAERLRDHKLMTAFAPYNNPQVAVAIILENGGAGPAV
EEECCCCEEEEEEECCCCCCHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEECCCCCHHH
GTIMRQILDHIMLGDNNTHLPAENPVVAAAEDQ
HHHHHHHHHHHEECCCCCCCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]