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The map label for this gene is galK [H]

Identifier: 29142528

GI number: 29142528

Start: 2176972

End: 2178120

Strand: Direct

Name: galK [H]

Synonym: t2113

Alternate gene names: 29142528

Gene position: 2176972-2178120 (Clockwise)

Preceding gene: 29142527

Following gene: 29142529

Centisome position: 45.43

GC content: 56.66

Gene sequence:

>1149_bases
ATGAATCTGAAAGAGAAAACGCGCGCGCTGTTTGCTGAAATTTTCGGCTACCCTGCTACCCACACGATTCAGGCGCCAGG
CCGCGTCAATCTGATCGGCGAGCACACTGATTACAATGATGGTTTTGTTCTGCCCTGCGCTATCGATTACCAGACCGTAA
TTAGCTGTGCGCCGCGCGACGATCGTACCGTACGGGTGATTGCCGCCGATTACGACAATCAGGTGGACGAATTTTCACTG
GATGCGCCGATCGTGACCCACGATAGCCAGCAGTGGTCTAACTATGTGCGCGGCGTAGTGAAACACCTGCAACAGCGTAA
CAACGCGTTTGGCGGCGTGGATATGGTCATCAGCGGCAATGTGCCGCAGGGCGCCGGGTTAAGCTCCTCCGCTTCGCTGG
AAGTGGCGGTGGGCACCGTCTTCCAGCAGCTTTATCACCTGCCGCTGGACGGCGCGCAAATTGCGCTCAACGGACAAGAG
GCCGAGAACCAGTTTGTCGGCTGTAACTGCGGCATTATGGATCAGCTCATCTCTGCGCTCGGCAAAAAAGATCATGCGTT
GCTGATTGATTGCCGTACGCTCGGCGCCAAAGCGGTTTCTATGCCGAAAGGCGTCGCCGTGGTGATCATCAACAGTAACT
TTAAGCGCACTCTGGTGGGCAGCGAGTATAATACCCGCCGTGAACAGTGCGAAACCGGCGCCCGTTTCTTCCAGCAGCCG
GCCCTGCGCGATGTCAGCCTTGAGGCGTTCAATGCCGTCGCCAGCGAACTGGACCCGGTAGTCGCAAAACGCGTTCGCCA
TGTATTGAGCGAAAATGCGCGCACCGTTGAAGCGGCAAGCGCGCTGGAGAAAGGTGATTTGCAACGTATGGGCCAACTGA
TGGCGGAGTCCCATGCCTCAATGCGCGATGATTTCGAAATTACCGTCCCGCAGATAGACACGCTGGTAGACATTGTCAAA
GCGACCATCGGCGATCAAGGCGGCGTGCGCATGACCGGCGGCGGCTTTGGCGGCTGTGTTGTCGCGCTGATCCCGGAAGA
TCTGGTTCCCGCTGTGCAGCAGGCCGTTGCGCAACAGTACGAAGCGAAAACCGGAATCAAAGAAACCTTTTATGTATGCA
AACCGTCACAAGGAGCAGGACAGTGCTAA

Upstream 100 bases:

>100_bases
AAATGCTGGCGGAAACCCAGCGTGATTTAACCGCAGAACAAGCGGCTGAACGCCTGCGCGCGGTCAGCGACATCCATTTT
CGCGAATCCGGAGTATAAAA

Downstream 100 bases:

>100_bases
ATGAAACGCCCGCACTGGCCCCCGATGGTCAACCGTACCGCCTGCTAACCCTGCGCAACAGCGCAGGGATGGTGGTAACG
CTGATGGACTGGGGAGCCAC

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MNLKEKTRALFAEIFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRTVRVIAADYDNQVDEFSL
DAPIVTHDSQQWSNYVRGVVKHLQQRNNAFGGVDMVISGNVPQGAGLSSSASLEVAVGTVFQQLYHLPLDGAQIALNGQE
AENQFVGCNCGIMDQLISALGKKDHALLIDCRTLGAKAVSMPKGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQP
ALRDVSLEAFNAVASELDPVVAKRVRHVLSENARTVEAASALEKGDLQRMGQLMAESHASMRDDFEITVPQIDTLVDIVK
ATIGDQGGVRMTGGGFGGCVVALIPEDLVPAVQQAVAQQYEAKTGIKETFYVCKPSQGAGQC

Sequences:

>Translated_382_residues
MNLKEKTRALFAEIFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRTVRVIAADYDNQVDEFSL
DAPIVTHDSQQWSNYVRGVVKHLQQRNNAFGGVDMVISGNVPQGAGLSSSASLEVAVGTVFQQLYHLPLDGAQIALNGQE
AENQFVGCNCGIMDQLISALGKKDHALLIDCRTLGAKAVSMPKGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQP
ALRDVSLEAFNAVASELDPVVAKRVRHVLSENARTVEAASALEKGDLQRMGQLMAESHASMRDDFEITVPQIDTLVDIVK
ATIGDQGGVRMTGGGFGGCVVALIPEDLVPAVQQAVAQQYEAKTGIKETFYVCKPSQGAGQC
>Mature_382_residues
MNLKEKTRALFAEIFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRDDRTVRVIAADYDNQVDEFSL
DAPIVTHDSQQWSNYVRGVVKHLQQRNNAFGGVDMVISGNVPQGAGLSSSASLEVAVGTVFQQLYHLPLDGAQIALNGQE
AENQFVGCNCGIMDQLISALGKKDHALLIDCRTLGAKAVSMPKGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQP
ALRDVSLEAFNAVASELDPVVAKRVRHVLSENARTVEAASALEKGDLQRMGQLMAESHASMRDDFEITVPQIDTLVDIVK
ATIGDQGGVRMTGGGFGGCVVALIPEDLVPAVQQAVAQQYEAKTGIKETFYVCKPSQGAGQC

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=388, Percent_Identity=43.0412371134021, Blast_Score=280, Evalue=1e-75,
Organism=Homo sapiens, GI48527957, Length=439, Percent_Identity=28.9293849658314, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI4503897, Length=439, Percent_Identity=28.9293849658314, Blast_Score=146, Evalue=3e-35,
Organism=Escherichia coli, GI1786972, Length=382, Percent_Identity=90.8376963350785, Blast_Score=737, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71989053, Length=431, Percent_Identity=26.9141531322506, Blast_Score=118, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6319494, Length=240, Percent_Identity=30.8333333333333, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320212, Length=228, Percent_Identity=28.0701754385965, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24661292, Length=408, Percent_Identity=25.9803921568627, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21355577, Length=408, Percent_Identity=25.9803921568627, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24661285, Length=408, Percent_Identity=25.9803921568627, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 41246; Mature: 41246

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKEKTRALFAEIFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRD
CCHHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCCCCCCEEEEEEECHHHHHCCCCCC
DRTVRVIAADYDNQVDEFSLDAPIVTHDSQQWSNYVRGVVKHLQQRNNAFGGVDMVISGN
CCEEEEEEECCCCCCCCEECCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
VPQGAGLSSSASLEVAVGTVFQQLYHLPLDGAQIALNGQEAENQFVGCNCGIMDQLISAL
CCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEECCCCCHHHHHHHHH
GKKDHALLIDCRTLGAKAVSMPKGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQP
CCCCCEEEEEEHHCCCHHHCCCCCEEEEEECCCCCEEECCCCCHHHHHHHHHHHHHHHCC
ALRDVSLEAFNAVASELDPVVAKRVRHVLSENARTVEAASALEKGDLQRMGQLMAESHAS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
MRDDFEITVPQIDTLVDIVKATIGDQGGVRMTGGGFGGCVVALIPEDLVPAVQQAVAQQY
CCCCCEEECCHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEEECCHHHHHHHHHHHHHHH
EAKTGIKETFYVCKPSQGAGQC
HHHCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MNLKEKTRALFAEIFGYPATHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAPRD
CCHHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCCCCCCEEEEEEECHHHHHCCCCCC
DRTVRVIAADYDNQVDEFSLDAPIVTHDSQQWSNYVRGVVKHLQQRNNAFGGVDMVISGN
CCEEEEEEECCCCCCCCEECCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
VPQGAGLSSSASLEVAVGTVFQQLYHLPLDGAQIALNGQEAENQFVGCNCGIMDQLISAL
CCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEECCCCCHHHHHHHHH
GKKDHALLIDCRTLGAKAVSMPKGVAVVIINSNFKRTLVGSEYNTRREQCETGARFFQQP
CCCCCEEEEEEHHCCCHHHCCCCCEEEEEECCCCCEEECCCCCHHHHHHHHHHHHHHHCC
ALRDVSLEAFNAVASELDPVVAKRVRHVLSENARTVEAASALEKGDLQRMGQLMAESHAS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
MRDDFEITVPQIDTLVDIVKATIGDQGGVRMTGGGFGGCVVALIPEDLVPAVQQAVAQQY
CCCCCEEECCHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEEECCHHHHHHHHHHHHHHH
EAKTGIKETFYVCKPSQGAGQC
HHHCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA