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The map label for this gene is galM [H]

Identifier: 29142529

GI number: 29142529

Start: 2178114

End: 2179154

Strand: Direct

Name: galM [H]

Synonym: t2114

Alternate gene names: 29142529

Gene position: 2178114-2179154 (Clockwise)

Preceding gene: 29142528

Following gene: 29142530

Centisome position: 45.45

GC content: 56.68

Gene sequence:

>1041_bases
GTGCTAAATGAAACGCCCGCACTGGCCCCCGATGGTCAACCGTACCGCCTGCTAACCCTGCGCAACAGCGCAGGGATGGT
GGTAACGCTGATGGACTGGGGAGCCACTCTTCTTTCCGCCCGTATTCCGCTGTCTGACGGCAGCGTTCGGGAAGCATTGC
TGGGCTGCGCCAGCCCGGAACACTACCCTGAACAGACGTCATTCCTCGGCGCCTCTATTGGCCGTTACGCGAACCGTATC
GCCAATAGCCGCTATACGTTTGCCGGCGAAACCGTACAGTTAAGCCCAAGCCAGGGCGAGAACCAGCTACACGGCGGACC
GGAAGGCTTTGACAAGCGCCGCTGGCAAATTGTGAACCAAAACGATCGCCAGGTATTATTCGCGCTCACCTCTGATGACG
GCGACCAGGGCTTTCCTGGCCATCTTTGCGCCACGGCGCAATATCGTCTGACCGATGACAATAGAATCTCCATCACCTAC
CGGGCGACGGTCGATAAACCCTGTCCGGTGAATTTGACCAACCACGTCTATTTTAATCTGGACGGCGATCGGACCGACGT
GCGCCAACATAAGCTGCAAATTCTGGCGGATGAGTATCTGCCGGTAGATGAATCCGGTATTCCACGCCAGGGGCTAAAAT
CGGTAGCCAATACCTCGTTTGACTTCCGGATGCCAAAAGTCATTGCCAGCGAGTTTCTCGCCGATGACGATCAGCGCAAG
GTTAAAAGCTACGATCATGCTTTCCTGCTACAGACGCAGGGTGATGGCAAAAAGCCGGCGGCCCGTCTGTGGTCACAGGA
TGGAAAGCTACAAATGATGGTTTACACCACCGCCCCGGCGCTACAGTTTTATTCCGGCAATTATCTGGCGGGTACACCTT
CCCGCGGACCGGAACCTTATGCCGACTGGCAAGGGCTGGCGCTGGAAAGCGAACTGCTGCCGGACAGCCCGAATCATCCT
GAATGGCCGCAGCCTGACTGTATCCTTCGCCCTGGCGAGGAGTACGCCAGCCTGACCGAGTATCAGTTTATTCCGTTCTA
A

Upstream 100 bases:

>100_bases
TGGTTCCCGCTGTGCAGCAGGCCGTTGCGCAACAGTACGAAGCGAAAACCGGAATCAAAGAAACCTTTTATGTATGCAAA
CCGTCACAAGGAGCAGGACA

Downstream 100 bases:

>100_bases
CGATATGCCGCTACATGCCCGATGACGCAAGCTTATCGGGCCTACGCGCCATTGCCCTGCTCAAACCTCCACCACTTAAA
GACAAAATCGCAACTCTGAG

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MLNETPALAPDGQPYRLLTLRNSAGMVVTLMDWGATLLSARIPLSDGSVREALLGCASPEHYPEQTSFLGASIGRYANRI
ANSRYTFAGETVQLSPSQGENQLHGGPEGFDKRRWQIVNQNDRQVLFALTSDDGDQGFPGHLCATAQYRLTDDNRISITY
RATVDKPCPVNLTNHVYFNLDGDRTDVRQHKLQILADEYLPVDESGIPRQGLKSVANTSFDFRMPKVIASEFLADDDQRK
VKSYDHAFLLQTQGDGKKPAARLWSQDGKLQMMVYTTAPALQFYSGNYLAGTPSRGPEPYADWQGLALESELLPDSPNHP
EWPQPDCILRPGEEYASLTEYQFIPF

Sequences:

>Translated_346_residues
MLNETPALAPDGQPYRLLTLRNSAGMVVTLMDWGATLLSARIPLSDGSVREALLGCASPEHYPEQTSFLGASIGRYANRI
ANSRYTFAGETVQLSPSQGENQLHGGPEGFDKRRWQIVNQNDRQVLFALTSDDGDQGFPGHLCATAQYRLTDDNRISITY
RATVDKPCPVNLTNHVYFNLDGDRTDVRQHKLQILADEYLPVDESGIPRQGLKSVANTSFDFRMPKVIASEFLADDDQRK
VKSYDHAFLLQTQGDGKKPAARLWSQDGKLQMMVYTTAPALQFYSGNYLAGTPSRGPEPYADWQGLALESELLPDSPNHP
EWPQPDCILRPGEEYASLTEYQFIPF
>Mature_346_residues
MLNETPALAPDGQPYRLLTLRNSAGMVVTLMDWGATLLSARIPLSDGSVREALLGCASPEHYPEQTSFLGASIGRYANRI
ANSRYTFAGETVQLSPSQGENQLHGGPEGFDKRRWQIVNQNDRQVLFALTSDDGDQGFPGHLCATAQYRLTDDNRISITY
RATVDKPCPVNLTNHVYFNLDGDRTDVRQHKLQILADEYLPVDESGIPRQGLKSVANTSFDFRMPKVIASEFLADDDQRK
VKSYDHAFLLQTQGDGKKPAARLWSQDGKLQMMVYTTAPALQFYSGNYLAGTPSRGPEPYADWQGLALESELLPDSPNHP
EWPQPDCILRPGEEYASLTEYQFIPF

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=320, Percent_Identity=36.875, Blast_Score=192, Evalue=4e-49,
Organism=Escherichia coli, GI1786971, Length=344, Percent_Identity=88.0813953488372, Blast_Score=633, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17557428, Length=329, Percent_Identity=31.0030395136778, Blast_Score=187, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI115533334, Length=329, Percent_Identity=31.0030395136778, Blast_Score=187, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6319493, Length=347, Percent_Identity=25.3602305475504, Blast_Score=116, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6322004, Length=356, Percent_Identity=26.4044943820225, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6324399, Length=353, Percent_Identity=22.6628895184136, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24668278, Length=335, Percent_Identity=33.4328358208955, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI24659048, Length=348, Percent_Identity=33.3333333333333, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24583720, Length=333, Percent_Identity=31.2312312312312, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24641876, Length=354, Percent_Identity=27.9661016949153, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24668282, Length=340, Percent_Identity=29.1176470588235, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 38577; Mature: 38577

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNETPALAPDGQPYRLLTLRNSAGMVVTLMDWGATLLSARIPLSDGSVREALLGCASPE
CCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCHHEEECCCCCCHHHHHHHHCCCCC
HYPEQTSFLGASIGRYANRIANSRYTFAGETVQLSPSQGENQLHGGPEGFDKRRWQIVNQ
CCCCHHHHHHHHHHHHHHHHCCCEEEECCCEEEECCCCCCCCCCCCCCCCCCCEEEEECC
NDRQVLFALTSDDGDQGFPGHLCATAQYRLTDDNRISITYRATVDKPCPVNLTNHVYFNL
CCCEEEEEEECCCCCCCCCCCEEEEEEEEECCCCEEEEEEEEECCCCCCCCCCCEEEEEE
DGDRTDVRQHKLQILADEYLPVDESGIPRQGLKSVANTSFDFRMPKVIASEFLADDDQRK
CCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHH
VKSYDHAFLLQTQGDGKKPAARLWSQDGKLQMMVYTTAPALQFYSGNYLAGTPSRGPEPY
HHCCCCEEEEEECCCCCCHHHHHHCCCCCEEEEEEECCCEEEEECCCEEECCCCCCCCCC
ADWQGLALESELLPDSPNHPEWPQPDCILRPGEEYASLTEYQFIPF
CCCCCEEEEHHCCCCCCCCCCCCCCCCEECCCHHHHHHHCEEECCC
>Mature Secondary Structure
MLNETPALAPDGQPYRLLTLRNSAGMVVTLMDWGATLLSARIPLSDGSVREALLGCASPE
CCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCCHHEEECCCCCCHHHHHHHHCCCCC
HYPEQTSFLGASIGRYANRIANSRYTFAGETVQLSPSQGENQLHGGPEGFDKRRWQIVNQ
CCCCHHHHHHHHHHHHHHHHCCCEEEECCCEEEECCCCCCCCCCCCCCCCCCCEEEEECC
NDRQVLFALTSDDGDQGFPGHLCATAQYRLTDDNRISITYRATVDKPCPVNLTNHVYFNL
CCCEEEEEEECCCCCCCCCCCEEEEEEEEECCCCEEEEEEEEECCCCCCCCCCCEEEEEE
DGDRTDVRQHKLQILADEYLPVDESGIPRQGLKSVANTSFDFRMPKVIASEFLADDDQRK
CCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHH
VKSYDHAFLLQTQGDGKKPAARLWSQDGKLQMMVYTTAPALQFYSGNYLAGTPSRGPEPY
HHCCCCEEEEEECCCCCCHHHHHHCCCCCEEEEEEECCCEEEEECCCEEECCCCCCCCCC
ADWQGLALESELLPDSPNHPEWPQPDCILRPGEEYASLTEYQFIPF
CCCCCEEEEHHCCCCCCCCCCCCCCCCEECCCHHHHHHHCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7966338; 8905232; 9278503 [H]