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The map label for this gene is lpxK [H]

Identifier: 29142372

GI number: 29142372

Start: 1997409

End: 1998386

Strand: Reverse

Name: lpxK [H]

Synonym: t1949

Alternate gene names: 29142372

Gene position: 1998386-1997409 (Counterclockwise)

Preceding gene: 29142373

Following gene: 29142371

Centisome position: 41.7

GC content: 60.43

Gene sequence:

>978_bases
ATGATTGCGCGTATCTGGTCGGGTGAATCCCCGCTATGGCGGTTACTGCTGCCGCTCTCCTGGCTGTATGGCCTGGTGAG
CGGGGCGATTCGTCTGAGCTATAAGCTTGGTTTGAAACGCGCCTGGCGAGCGCCGGTACCGGTGGTTGTGGTAGGGAATC
TTACGGCTGGCGGTAACGGTAAAACACCCGTAGTCATTTGGCTGGTGGAAAAGCTGCAACAGCGTGGCGTGCGCGTGGGG
GTCGTTTCCCGCGGCTACGGCGGGAAAGCTGCCGCTTATCCGCTGCTCCTGACGCCTGAGACGACAACCGCAGAAGCGGG
AGATGAACCGGTATTGATTTATCAGCGGACCGGCGCGCCTGTCGCGGTGGCGCCTGAACGCGCCGCGGCGGTGAAAGCGA
TTCTGGCGGCGCATAATGTGCAGATTATTATCACCGACGATGGGTTGCAGCATTACCGACTAGCGCGAGATATTGAAATT
GTGGTGATTGACGGGGTGCGCCGTTTTGGCAACGGCTGGTGGCTTCCTGCCGGCCCTATGCGCGAACGCGCCAGTCGCCT
GAAAACCGTGGACGCCGCTATCGTGAATGGCGGCGTCGCCCGGGCGGGCGAAATCCCCATGCAGCTAGCGCCTGGACTGG
CGGTGAACTTACGTACGGGAGCGCGTTGCGATGTGGCGCAACTGAGCAATATTGTGGCGATGGCGGGCATCGGTCATCCG
CCGCGCTTTTTCGCCACGCTGGAAGCCTGTGGCGCGCATCCGCAAAAGTGCGTCCCGCTGGCCGATCATCAAACGCTCGC
CCCTGCTGACGTTCAGGCGTTGGTCGGTGAAGGGCAGACCCTGGTAATGACGGAAAAAGACGCGGTGAAATGCCGTGCTT
TCGCCGAAGATAACTGGTGGTTCTTACCGGTTGATGCGCGTTTGTCCGGCGAGCAGCCTGATAAGTTGCTTGAACATATC
ACCTCGCTGGTTCGCTAG

Upstream 100 bases:

>100_bases
TTGTAGTCGAAGACGGTATTATCGTTGAGCGCGGCACTCATAGCGAGCTGCTGGCGCAACACGGCGTTTACGCCCAGCTG
CATAAGATGCAATTTGGCCA

Downstream 100 bases:

>100_bases
CGTACCCCAATGCAGCGGCAGTGATGAATTTATGGAGTCATGAATGTCATTGCCGTACCTTTCTCTTTCCCAGGCCCGTT
GTCTTCACCTTGCTGCGCAG

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MIARIWSGESPLWRLLLPLSWLYGLVSGAIRLSYKLGLKRAWRAPVPVVVVGNLTAGGNGKTPVVIWLVEKLQQRGVRVG
VVSRGYGGKAAAYPLLLTPETTTAEAGDEPVLIYQRTGAPVAVAPERAAAVKAILAAHNVQIIITDDGLQHYRLARDIEI
VVIDGVRRFGNGWWLPAGPMRERASRLKTVDAAIVNGGVARAGEIPMQLAPGLAVNLRTGARCDVAQLSNIVAMAGIGHP
PRFFATLEACGAHPQKCVPLADHQTLAPADVQALVGEGQTLVMTEKDAVKCRAFAEDNWWFLPVDARLSGEQPDKLLEHI
TSLVR

Sequences:

>Translated_325_residues
MIARIWSGESPLWRLLLPLSWLYGLVSGAIRLSYKLGLKRAWRAPVPVVVVGNLTAGGNGKTPVVIWLVEKLQQRGVRVG
VVSRGYGGKAAAYPLLLTPETTTAEAGDEPVLIYQRTGAPVAVAPERAAAVKAILAAHNVQIIITDDGLQHYRLARDIEI
VVIDGVRRFGNGWWLPAGPMRERASRLKTVDAAIVNGGVARAGEIPMQLAPGLAVNLRTGARCDVAQLSNIVAMAGIGHP
PRFFATLEACGAHPQKCVPLADHQTLAPADVQALVGEGQTLVMTEKDAVKCRAFAEDNWWFLPVDARLSGEQPDKLLEHI
TSLVR
>Mature_325_residues
MIARIWSGESPLWRLLLPLSWLYGLVSGAIRLSYKLGLKRAWRAPVPVVVVGNLTAGGNGKTPVVIWLVEKLQQRGVRVG
VVSRGYGGKAAAYPLLLTPETTTAEAGDEPVLIYQRTGAPVAVAPERAAAVKAILAAHNVQIIITDDGLQHYRLARDIEI
VVIDGVRRFGNGWWLPAGPMRERASRLKTVDAAIVNGGVARAGEIPMQLAPGLAVNLRTGARCDVAQLSNIVAMAGIGHP
PRFFATLEACGAHPQKCVPLADHQTLAPADVQALVGEGQTLVMTEKDAVKCRAFAEDNWWFLPVDARLSGEQPDKLLEHI
TSLVR

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=324, Percent_Identity=82.7160493827161, Blast_Score=550, Evalue=1e-158,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 34962; Mature: 34962

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIARIWSGESPLWRLLLPLSWLYGLVSGAIRLSYKLGLKRAWRAPVPVVVVGNLTAGGNG
CEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCHHHCCCCCCEEEEECEECCCCC
KTPVVIWLVEKLQQRGVRVGVVSRGYGGKAAAYPLLLTPETTTAEAGDEPVLIYQRTGAP
CCCEEEEEHHHHHHCCCEEEEEECCCCCCHHCEEEEECCCCCCCCCCCCCEEEEEECCCC
VAVAPERAAAVKAILAAHNVQIIITDDGLQHYRLARDIEIVVIDGVRRFGNGWWLPAGPM
EEECCHHHHHHHHHHHHCCEEEEEECCCHHHHHHHCCEEEEEEECHHHHCCCEECCCCHH
RERASRLKTVDAAIVNGGVARAGEIPMQLAPGLAVNLRTGARCDVAQLSNIVAMAGIGHP
HHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCEEEEECCCCCCCHHHHHCCCEECCCCCC
PRFFATLEACGAHPQKCVPLADHQTLAPADVQALVGEGQTLVMTEKDAVKCRAFAEDNWW
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCEEEEEEECCCEE
FLPVDARLSGEQPDKLLEHITSLVR
EEEECCCCCCCCHHHHHHHHHHHHC
>Mature Secondary Structure
MIARIWSGESPLWRLLLPLSWLYGLVSGAIRLSYKLGLKRAWRAPVPVVVVGNLTAGGNG
CEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCHHHCCCCCCEEEEECEECCCCC
KTPVVIWLVEKLQQRGVRVGVVSRGYGGKAAAYPLLLTPETTTAEAGDEPVLIYQRTGAP
CCCEEEEEHHHHHHCCCEEEEEECCCCCCHHCEEEEECCCCCCCCCCCCCEEEEEECCCC
VAVAPERAAAVKAILAAHNVQIIITDDGLQHYRLARDIEIVVIDGVRRFGNGWWLPAGPM
EEECCHHHHHHHHHHHHCCEEEEEECCCHHHHHHHCCEEEEEEECHHHHCCCEECCCCHH
RERASRLKTVDAAIVNGGVARAGEIPMQLAPGLAVNLRTGARCDVAQLSNIVAMAGIGHP
HHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCEEEEECCCCCCCHHHHHCCCEECCCCCC
PRFFATLEACGAHPQKCVPLADHQTLAPADVQALVGEGQTLVMTEKDAVKCRAFAEDNWW
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCEEEEEEECCCEE
FLPVDARLSGEQPDKLLEHITSLVR
EEEECCCCCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA