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The map label for this gene is trpC

Identifier: 29142073

GI number: 29142073

Start: 1697186

End: 1698544

Strand: Direct

Name: trpC

Synonym: t1637

Alternate gene names: 29142073

Gene position: 1697186-1698544 (Clockwise)

Preceding gene: 29142072

Following gene: 29142074

Centisome position: 35.42

GC content: 55.26

Gene sequence:

>1359_bases
ATGCAAACCGTTTTAGCGAAAATCGTCGCAGACAAGGCGATTTGGGTAGAAGCCCGCAAACAGCAACAGCCGCTGGCCAG
TTTTCAAAATGAGATCCAGCCAAGTACACGCCATTTTTATGATGCGCTCCAGGGCGCGCGTACCGCCTTTATTCTGGAGT
GTAAGAAAGCATCGCCATCAAAAGGCGTGATTCGCGACGATTTCGATCCGGCGCGTATTGCCAGTATTTATCAACATTAC
GCCTCGGCGATCTCGGTGCTCACCGACGAAAAATATTTTCAGGGGAGCTTCGATTTTCTGCCGGTCGTTAGCCAAAGCGC
GCCGCAGCCGATTCTGTGTAAGGATTTTATTATCGATCCCTATCAGATCTACCTTGCCCGTTACTATCAGGCCGATGCCT
GTTTACTGATGCTCTCGGTTCTGGATGACGAACAGTATCGCCAACTCTCCGCCGTCGCGCACAGTCTGAAAATGGGCGTG
CTCACGGAGATCAGTAATGACGAAGAACGGGAGCGCGCGATAGCGTTAGGCGCAAAAGTGGTAGGTATCAACAATCGCGA
TCTGCGCGATCTGTCGATTGATTTGAATCGCACCCGCCAGCTGGCGCCAAAACTGGGCCACGGCGTGACTGTCATCAGCG
AGTCCGGGATTAACACCTATGGTCAGGTACGCGAACTGAGCCACTTCGCCAACGGTTTTTTAATTGGCTCCGCGTTAATG
GCGCATGACGATCTTAACGCCGCCGTCCGTCGCGTGCTGCTTGGCGAAAATAAAGTCTGCGGCCTGACCCGCGCCCAGGA
CGCTAAAGCGGCCTGTGACGCTGGCGCAATATATGGCGGGTTGATTTTTGTGCCCTCATCTCCGCGCGCGGTTAGCGTTG
AGCAGGCGCGAGAAGTGATAAGCGGCGCGCCATTGCAGTATGTCGGCGTTTTCAAGAACGCTGATATCGCCGATGTTTGC
CAGAAAGCCGCCGTCCTGTCGCTTTCTGCCGTACAGCTACATGGCAGCGAAGACCAGGCGTATGTCAACGCGCTGCGCGA
GGCGTTGCCGCGCAATGTGCAAATCTGGAAGGCGCTGAGCGTTAGCAATGCCCTTCCCGCACGCGATTATCACCATGTCG
ATAAATACATTTTCGACAATGGGCAAGGCGGCAGCGGGCAGCGCTTCGACTGGTCACTGCTACAGGGGCAACCGCTGGAT
GATGTGTTACTGGCGGGCGGGCTGGCGGCCGATAACTGCGTCCAGGCGGCGCAAGTCGGCTGTGCCGGTCTCGATTTTAA
TTCAGGTGTGGAGTCACAGCCGGGCATCAAAGATGCTCGTCTTCTGGCCTCGGTTTTTCAGACACTGCGCGCATATTAA

Upstream 100 bases:

>100_bases
TCAGGAAGATCTCAAGGCCAACGCGCAAACCGTGCTTGATGTTCTGCGCAACGGCACCGCATATGACAGAGTCACCGCAC
TGGCGGCAAGAGGGTAAATA

Downstream 100 bases:

>100_bases
GGAAAAAACATGACAACACTTCTCAACCCCTACTTTGGTGAATTCGGCGGCATGTATGTGCCGCAGATCCTGATGCCTGC
GCTGAACCAGCTTGAAGAGG

Product: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: Indole-3-glycerol phosphate synthase; IGPS; N-(5'-phospho-ribosyl)anthranilate isomerase; PRAI

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MQTVLAKIVADKAIWVEARKQQQPLASFQNEIQPSTRHFYDALQGARTAFILECKKASPSKGVIRDDFDPARIASIYQHY
ASAISVLTDEKYFQGSFDFLPVVSQSAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLKMGV
LTEISNDEERERAIALGAKVVGINNRDLRDLSIDLNRTRQLAPKLGHGVTVISESGINTYGQVRELSHFANGFLIGSALM
AHDDLNAAVRRVLLGENKVCGLTRAQDAKAACDAGAIYGGLIFVPSSPRAVSVEQAREVISGAPLQYVGVFKNADIADVC
QKAAVLSLSAVQLHGSEDQAYVNALREALPRNVQIWKALSVSNALPARDYHHVDKYIFDNGQGGSGQRFDWSLLQGQPLD
DVLLAGGLAADNCVQAAQVGCAGLDFNSGVESQPGIKDARLLASVFQTLRAY

Sequences:

>Translated_452_residues
MQTVLAKIVADKAIWVEARKQQQPLASFQNEIQPSTRHFYDALQGARTAFILECKKASPSKGVIRDDFDPARIASIYQHY
ASAISVLTDEKYFQGSFDFLPVVSQSAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLKMGV
LTEISNDEERERAIALGAKVVGINNRDLRDLSIDLNRTRQLAPKLGHGVTVISESGINTYGQVRELSHFANGFLIGSALM
AHDDLNAAVRRVLLGENKVCGLTRAQDAKAACDAGAIYGGLIFVPSSPRAVSVEQAREVISGAPLQYVGVFKNADIADVC
QKAAVLSLSAVQLHGSEDQAYVNALREALPRNVQIWKALSVSNALPARDYHHVDKYIFDNGQGGSGQRFDWSLLQGQPLD
DVLLAGGLAADNCVQAAQVGCAGLDFNSGVESQPGIKDARLLASVFQTLRAY
>Mature_452_residues
MQTVLAKIVADKAIWVEARKQQQPLASFQNEIQPSTRHFYDALQGARTAFILECKKASPSKGVIRDDFDPARIASIYQHY
ASAISVLTDEKYFQGSFDFLPVVSQSAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLKMGV
LTEISNDEERERAIALGAKVVGINNRDLRDLSIDLNRTRQLAPKLGHGVTVISESGINTYGQVRELSHFANGFLIGSALM
AHDDLNAAVRRVLLGENKVCGLTRAQDAKAACDAGAIYGGLIFVPSSPRAVSVEQAREVISGAPLQYVGVFKNADIADVC
QKAAVLSLSAVQLHGSEDQAYVNALREALPRNVQIWKALSVSNALPARDYHHVDKYIFDNGQGGSGQRFDWSLLQGQPLD
DVLLAGGLAADNCVQAAQVGCAGLDFNSGVESQPGIKDARLLASVFQTLRAY

Specific function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=452, Percent_Identity=87.3893805309735, Blast_Score=821, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322638, Length=270, Percent_Identity=34.0740740740741, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320210, Length=217, Percent_Identity=31.3364055299539, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_SALTI (Q8Z7D9)

Other databases:

- EMBL:   AL627269
- EMBL:   AE014613
- RefSeq:   NP_455773.1
- RefSeq:   NP_805415.1
- ProteinModelPortal:   Q8Z7D9
- SMR:   Q8Z7D9
- GeneID:   1071248
- GeneID:   1247726
- GenomeReviews:   AE014613_GR
- GenomeReviews:   AL513382_GR
- KEGG:   stt:t1637
- KEGG:   sty:STY1326
- HOGENOM:   HBG296890
- OMA:   YILECKK
- ProtClustDB:   PRK09427
- BioCyc:   SENT209261:T1637-MONOMER
- BRENDA:   4.1.1.48
- BRENDA:   5.3.1.24
- HAMAP:   MF_00134_B
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48; =5.3.1.24

Molecular weight: Translated: 49230; Mature: 49230

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTVLAKIVADKAIWVEARKQQQPLASFQNEIQPSTRHFYDALQGARTAFILECKKASPS
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEECCCCCC
KGVIRDDFDPARIASIYQHYASAISVLTDEKYFQGSFDFLPVVSQSAPQPILCKDFIIDP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHCCCCCCCEEHHHHCCCH
YQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLKMGVLTEISNDEERERAIALGAKV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCEEE
VGINNRDLRDLSIDLNRTRQLAPKLGHGVTVISESGINTYGQVRELSHFANGFLIGSALM
EECCCCCCCEEEECHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHH
AHDDLNAAVRRVLLGENKVCGLTRAQDAKAACDAGAIYGGLIFVPSSPRAVSVEQAREVI
HHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHCCCCEECCEEEECCCCCEECHHHHHHHH
SGAPLQYVGVFKNADIADVCQKAAVLSLSAVQLHGSEDQAYVNALREALPRNVQIWKALS
CCCCEEEEEEECCCCHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHCCCCEEEHHHHH
VSNALPARDYHHVDKYIFDNGQGGSGQRFDWSLLQGQPLDDVLLAGGLAADNCVQAAQVG
HCCCCCCCHHHHHHHHHEECCCCCCCCCEEEHHCCCCCHHHHHHHCCCCHHHHHHHHHHC
CAGLDFNSGVESQPGIKDARLLASVFQTLRAY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQTVLAKIVADKAIWVEARKQQQPLASFQNEIQPSTRHFYDALQGARTAFILECKKASPS
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEECCCCCC
KGVIRDDFDPARIASIYQHYASAISVLTDEKYFQGSFDFLPVVSQSAPQPILCKDFIIDP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHCCCCCCCEEHHHHCCCH
YQIYLARYYQADACLLMLSVLDDEQYRQLSAVAHSLKMGVLTEISNDEERERAIALGAKV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCEEE
VGINNRDLRDLSIDLNRTRQLAPKLGHGVTVISESGINTYGQVRELSHFANGFLIGSALM
EECCCCCCCEEEECHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHH
AHDDLNAAVRRVLLGENKVCGLTRAQDAKAACDAGAIYGGLIFVPSSPRAVSVEQAREVI
HHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHCCCCEECCEEEECCCCCEECHHHHHHHH
SGAPLQYVGVFKNADIADVCQKAAVLSLSAVQLHGSEDQAYVNALREALPRNVQIWKALS
CCCCEEEEEEECCCCHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHCCCCEEEHHHHH
VSNALPARDYHHVDKYIFDNGQGGSGQRFDWSLLQGQPLDDVLLAGGLAADNCVQAAQVG
HCCCCCCCHHHHHHHHHEECCCCCCCCCEEEHHCCCCCHHHHHHHCCCCHHHHHHHHHHC
CAGLDFNSGVESQPGIKDARLLASVFQTLRAY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504