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The map label for this gene is cho [H]

Identifier: 29141653

GI number: 29141653

Start: 1256994

End: 1257902

Strand: Reverse

Name: cho [H]

Synonym: t1188

Alternate gene names: 29141653

Gene position: 1257902-1256994 (Counterclockwise)

Preceding gene: 29141654

Following gene: 29141647

Centisome position: 26.25

GC content: 54.68

Gene sequence:

>909_bases
ATGAATAACCAGTTAACGGAGATCACTGTGGTACGGCGTCAATCAGCCCCCCGCCTTGAGTTTGAAGCAGCGGCCATTTA
CGAATATCCAGAACATTTACGTCCTTTCCTCAGCGAAGCGCCAGCCTTACCGGGCGTCTATATATTTCATAGCGAAAGCG
ATACGCTGCCGCTTTATATCGGTAAAAGCGTAAATATTCGCAGCCGGGTGCTCTCACATCTGCGAACGCCTGACGAGGCC
GCTATGCTGCGACAGGCGCGGCGGATAAGCTGGATCTGCACCGCTGGGGAAATGGGCGCGTTGCTGCTGGAGGCGCGACT
GATCAAAGAACAACAGCCGCTGTTTAACAAGCGGTTACGTCGTAATCGCCAGCTTTGCTCTCTACAGTTGAGCGAACAAA
AGATTGAGGTCGTTTCCGCCCGCAGCGTCGATTTTTCCCATGAGCCGAACCTGTTTGGACTCTTCGCCAACCGTCGGGCA
GCGCTGCAAAGCTTACAGAACCTCGCCGATGAACAAAAATTGTGTTATGGCCTGCTGGGGCTTGAACCGGTAAGCCGTGG
GCGCGCCTGTTTTCGTTTCGCGCTGAAGCGCTGCGCTGGCGCGTGTTGTGGGCAAGAAACCCCGCAGGCGCATTTTCTTC
GTCTGCAGGCCTCACTGGAACGGTTACGTGTGGTTTGCTGGCCCTGGAAAGGCGCTATCGCGTTAAAAGAGAGCCGCCCA
CAAATGACCCAGTTCCACATTATCAACAACTGGTTATGGCTGGGGGCGGTACCCTCGCTGGATGAGGCCGCCACCCTGGT
GCGCACCCCTGCGGGCTTTGATCAGGATGGCTATAAAATTCTCTGTAAGCCACTAATGTCAGGTCAATATGAGATCATTG
AACTGCACACCGACTGTCGCCAGTCATAA

Upstream 100 bases:

>100_bases
AAAGTAAGCGTACTTCTACTGTTGTGCCGGATATCGCTCGTCTATCCGGCCTCCTCTCTTCCCAGCCTCTTTTTTAATCA
CCCATCCGCTGTTATACTGG

Downstream 100 bases:

>100_bases
AGAAAACCGCCGATCCTGTCCACCTCAACGATTGTGTTGTCGACAAGACCGGCGGTCTTAAATTATGCGGAAAGTTATTC
TGCCGCAGCAGGCATTTTAC

Product: nucleotide excision repair endonuclease

Products: NA

Alternate protein names: Endonuclease cho; UvrC homolog protein [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MNNQLTEITVVRRQSAPRLEFEAAAIYEYPEHLRPFLSEAPALPGVYIFHSESDTLPLYIGKSVNIRSRVLSHLRTPDEA
AMLRQARRISWICTAGEMGALLLEARLIKEQQPLFNKRLRRNRQLCSLQLSEQKIEVVSARSVDFSHEPNLFGLFANRRA
ALQSLQNLADEQKLCYGLLGLEPVSRGRACFRFALKRCAGACCGQETPQAHFLRLQASLERLRVVCWPWKGAIALKESRP
QMTQFHIINNWLWLGAVPSLDEAATLVRTPAGFDQDGYKILCKPLMSGQYEIIELHTDCRQS

Sequences:

>Translated_302_residues
MNNQLTEITVVRRQSAPRLEFEAAAIYEYPEHLRPFLSEAPALPGVYIFHSESDTLPLYIGKSVNIRSRVLSHLRTPDEA
AMLRQARRISWICTAGEMGALLLEARLIKEQQPLFNKRLRRNRQLCSLQLSEQKIEVVSARSVDFSHEPNLFGLFANRRA
ALQSLQNLADEQKLCYGLLGLEPVSRGRACFRFALKRCAGACCGQETPQAHFLRLQASLERLRVVCWPWKGAIALKESRP
QMTQFHIINNWLWLGAVPSLDEAATLVRTPAGFDQDGYKILCKPLMSGQYEIIELHTDCRQS
>Mature_302_residues
MNNQLTEITVVRRQSAPRLEFEAAAIYEYPEHLRPFLSEAPALPGVYIFHSESDTLPLYIGKSVNIRSRVLSHLRTPDEA
AMLRQARRISWICTAGEMGALLLEARLIKEQQPLFNKRLRRNRQLCSLQLSEQKIEVVSARSVDFSHEPNLFGLFANRRA
ALQSLQNLADEQKLCYGLLGLEPVSRGRACFRFALKRCAGACCGQETPQAHFLRLQASLERLRVVCWPWKGAIALKESRP
QMTQFHIINNWLWLGAVPSLDEAATLVRTPAGFDQDGYKILCKPLMSGQYEIIELHTDCRQS

Specific function: Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than uvrC. Not able to incise the 5' site of a lesion. When a lesion remains because uvrC is not able to induce the 3' incision, cho

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrC C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI1788037, Length=286, Percent_Identity=81.1188811188811, Blast_Score=495, Evalue=1e-141,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG [H]

EC number: NA

Molecular weight: Translated: 34346; Mature: 34346

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS50164 UVRC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNQLTEITVVRRQSAPRLEFEAAAIYEYPEHLRPFLSEAPALPGVYIFHSESDTLPLYI
CCCCEEEEEEEECCCCCCCEEHHHHHHHCHHHHHHHHHHCCCCCEEEEEECCCCCEEEEE
GKSVNIRSRVLSHLRTPDEAAMLRQARRISWICTAGEMGALLLEARLIKEQQPLFNKRLR
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHCCHHHHHHHH
RNRQLCSLQLSEQKIEVVSARSVDFSHEPNLFGLFANRRAALQSLQNLADEQKLCYGLLG
HCHHHHEEECCHHHEEEHEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHC
LEPVSRGRACFRFALKRCAGACCGQETPQAHFLRLQASLERLRVVCWPWKGAIALKESRP
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEEEECCCCCEEEECCCC
QMTQFHIINNWLWLGAVPSLDEAATLVRTPAGFDQDGYKILCKPLMSGQYEIIELHTDCR
CHHEEEEECCEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCC
QS
CC
>Mature Secondary Structure
MNNQLTEITVVRRQSAPRLEFEAAAIYEYPEHLRPFLSEAPALPGVYIFHSESDTLPLYI
CCCCEEEEEEEECCCCCCCEEHHHHHHHCHHHHHHHHHHCCCCCEEEEEECCCCCEEEEE
GKSVNIRSRVLSHLRTPDEAAMLRQARRISWICTAGEMGALLLEARLIKEQQPLFNKRLR
CCCCCHHHHHHHHHCCCHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHCCHHHHHHHH
RNRQLCSLQLSEQKIEVVSARSVDFSHEPNLFGLFANRRAALQSLQNLADEQKLCYGLLG
HCHHHHEEECCHHHEEEHEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHC
LEPVSRGRACFRFALKRCAGACCGQETPQAHFLRLQASLERLRVVCWPWKGAIALKESRP
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEEEECCCCCEEEECCCC
QMTQFHIINNWLWLGAVPSLDEAATLVRTPAGFDQDGYKILCKPLMSGQYEIIELHTDCR
CHHEEEEECCEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCC
QS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]