Click here to switch to the map view.

The map label for this gene is cdtB

Identifier: 29141583

GI number: 29141583

Start: 1194935

End: 1195744

Strand: Reverse

Name: cdtB

Synonym: t1111

Alternate gene names: 29141583

Gene position: 1195744-1194935 (Counterclockwise)

Preceding gene: 29141584

Following gene: 29141582

Centisome position: 24.95

GC content: 46.17

Gene sequence:

>810_bases
ATGAAAAAACCTGTTTTTTTCCTTCTGACCATGATCATCTGCAGCTATATTTCTTTTGCCTGCGCTAATATCAGTGACTA
CAAAGTTATGACCTGGAATCTTCAGGGCTCTTCAGCATCTACAGAAAGTAAATGGAATGTCAATGTCAGACAGCTTTTAA
GTGGTACTGCCGGTGTGGATATTCTTATGGTACAGGAGGCCGGTGCTGTTCCCACCTCAGCGGTTCCTACCGGACGACAT
ATTCAGCCTTTTGGAGTGGGTATTCCCATTGATGAATACACCTGGAATCTCGGAACCACCAGCCGTCAGGATATAAGATA
TATCTACCACTCGGCTATTGATGTTGGAGCACGCCGTGTTAATCTGGCAATAGTTTCCAGACAAAGAGCGGATAATGTTT
ATGTCTTGCGTCCGACAACTGTCGCATCTCGCCCCGTCATTGGCATCGGACTGGGTAATGATGTTTTTCTGACAGCGCAC
GCACTGGCTAGTGGAGGTCCGGATGCTGCAGCTATTGTCAGGGTTACCATTAATTTTTTTAGACAACCTCAGATGCGGCA
TTTATCCTGGTTTCTTGCCGGGGATTTTAATCGCAGCCCAGACAGACTTGAAAATGACCTGATGACTGAGCATCTGGAAC
GAGTTGTAGCCGTACTCGCACCTACAGAACCCACGCAAATTGGCGGTGGTATTTTAGATTATGGGGTCATTGTCGATCGA
GCACCTTATTCACAAAGGGTTGAAGCATTACGTAATCCACAACTCGCTTCTGATCATTATCCCGTAGCCTTTTTGGCACG
AAGCTGTTAA

Upstream 100 bases:

>100_bases
AAGTCAGGCATTGCCAGAATAAAATCAACGTCATGAAACAATGGGTTATTAACACATATATCATTCAGATAAAGAAGTAA
TGCTCGGGAGAGTAGATATT

Downstream 100 bases:

>100_bases
TGAGTAAATAGAGTTTACGACATGTACTTTGAGCGTAAGGTGCAGAATATATATTTATTATAAGGTAAAATTATGAGTTG
TTTTACCAGTCCAGCAATTA

Product: toxin-like protein

Products: NA

Alternate protein names: CDT B; Deoxyribonuclease CdtB

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MKKPVFFLLTMIICSYISFACANISDYKVMTWNLQGSSASTESKWNVNVRQLLSGTAGVDILMVQEAGAVPTSAVPTGRH
IQPFGVGIPIDEYTWNLGTTSRQDIRYIYHSAIDVGARRVNLAIVSRQRADNVYVLRPTTVASRPVIGIGLGNDVFLTAH
ALASGGPDAAAIVRVTINFFRQPQMRHLSWFLAGDFNRSPDRLENDLMTEHLERVVAVLAPTEPTQIGGGILDYGVIVDR
APYSQRVEALRNPQLASDHYPVAFLARSC

Sequences:

>Translated_269_residues
MKKPVFFLLTMIICSYISFACANISDYKVMTWNLQGSSASTESKWNVNVRQLLSGTAGVDILMVQEAGAVPTSAVPTGRH
IQPFGVGIPIDEYTWNLGTTSRQDIRYIYHSAIDVGARRVNLAIVSRQRADNVYVLRPTTVASRPVIGIGLGNDVFLTAH
ALASGGPDAAAIVRVTINFFRQPQMRHLSWFLAGDFNRSPDRLENDLMTEHLERVVAVLAPTEPTQIGGGILDYGVIVDR
APYSQRVEALRNPQLASDHYPVAFLARSC
>Mature_269_residues
MKKPVFFLLTMIICSYISFACANISDYKVMTWNLQGSSASTESKWNVNVRQLLSGTAGVDILMVQEAGAVPTSAVPTGRH
IQPFGVGIPIDEYTWNLGTTSRQDIRYIYHSAIDVGARRVNLAIVSRQRADNVYVLRPTTVASRPVIGIGLGNDVFLTAH
ALASGGPDAAAIVRVTINFFRQPQMRHLSWFLAGDFNRSPDRLENDLMTEHLERVVAVLAPTEPTQIGGGILDYGVIVDR
APYSQRVEALRNPQLASDHYPVAFLARSC

Specific function: Produces a CDT (cytolethal distending toxin) activity, which causes DNA damage in intoxicated cells. This damage induces G2/M cell cycle arrest, chromatin fragmentation, cell distention and nucleus enlargement

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Note=Localized to the nucleus of infected cells

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CDTB_SALTI (Q8Z6A7)

Other databases:

- EMBL:   AL627271
- EMBL:   AE014613
- RefSeq:   NP_456275.1
- RefSeq:   NP_804925.1
- ProteinModelPortal:   Q8Z6A7
- GeneID:   1070478
- GeneID:   1248249
- GenomeReviews:   AE014613_GR
- GenomeReviews:   AL513382_GR
- KEGG:   stt:t1111
- KEGG:   sty:STY1886
- HOGENOM:   HBG373988
- OMA:   IRIGNDA
- ProtClustDB:   PRK15251
- BioCyc:   SENT209261:T1111-MONOMER
- BioCyc:   SENT220341:STY1886-MONOMER
- GO:   GO:0009405
- InterPro:   IPR003539
- InterPro:   IPR005135
- PIRSF:   PIRSF018539
- PRINTS:   PR01388

Pfam domain/function: PF03372 Exo_endo_phos; SSF56219 Exo_endo_phos

EC number: NA

Molecular weight: Translated: 29560; Mature: 29560

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS51257 PROKAR_LIPOPROTEIN; PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKPVFFLLTMIICSYISFACANISDYKVMTWNLQGSSASTESKWNVNVRQLLSGTAGVD
CCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHCCCCCEE
ILMVQEAGAVPTSAVPTGRHIQPFGVGIPIDEYTWNLGTTSRQDIRYIYHSAIDVGARRV
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHCEECCCCCCHHHHHHHHHHHHHHCCEEE
NLAIVSRQRADNVYVLRPTTVASRPVIGIGLGNDVFLTAHALASGGPDAAAIVRVTINFF
EEEEEEECCCCCEEEECCCCCCCCCEEEEECCCCEEEEEEHHHCCCCCCEEEEEEEHHHH
RQPQMRHLSWFLAGDFNRSPDRLENDLMTEHLERVVAVLAPTEPTQIGGGILDYGVIVDR
CCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCEEECCEEEEC
APYSQRVEALRNPQLASDHYPVAFLARSC
CCHHHHHHHHCCCCCCCCCCCHHHHCCCC
>Mature Secondary Structure
MKKPVFFLLTMIICSYISFACANISDYKVMTWNLQGSSASTESKWNVNVRQLLSGTAGVD
CCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHCCCCCEE
ILMVQEAGAVPTSAVPTGRHIQPFGVGIPIDEYTWNLGTTSRQDIRYIYHSAIDVGARRV
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHCEECCCCCCHHHHHHHHHHHHHHCCEEE
NLAIVSRQRADNVYVLRPTTVASRPVIGIGLGNDVFLTAHALASGGPDAAAIVRVTINFF
EEEEEEECCCCCEEEECCCCCCCCCEEEEECCCCEEEEEEHHHCCCCCCEEEEEEEHHHH
RQPQMRHLSWFLAGDFNRSPDRLENDLMTEHLERVVAVLAPTEPTQIGGGILDYGVIVDR
CCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCEEECCEEEEC
APYSQRVEALRNPQLASDHYPVAFLARSC
CCHHHHHHHHCCCCCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504