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The map label for this gene is gdhA [H]

Identifier: 29141556

GI number: 29141556

Start: 1164673

End: 1165842

Strand: Reverse

Name: gdhA [H]

Synonym: t1082

Alternate gene names: 29141556

Gene position: 1165842-1164673 (Counterclockwise)

Preceding gene: 29141557

Following gene: 29141554

Centisome position: 24.33

GC content: 57.78

Gene sequence:

>1170_bases
GTGGATACTCTGCGCCACCCAAAACGCGCTCTGATCGTCGATATTCCGGTACAAATGGATGATGGCACTATTCGTCATTT
CGAAGGATATCGCGTGCAGCACAACCTCTCCCGAGGTCCGGGTAAAGGCGGTGTTCGCTACCATCCTGACGTTGATCTCA
ATGAAGTGATGGCCCTGTCAGCATGGATGACCATCAAATGTGCCGCGCTGAATCTGCCGTACGGCGGCGCCAAAGGCGGC
ATCCGCGTCGATCCGTTCTCGCTGTCGGAAGGTGAACTGGAGCGTTTGACCCGCCGCTATACCAGCGAGATCGGCATTAT
CATCGGGCCGCAGAAAGATATTCCTGCGCCGGATGTCGGCACCAACGGTAAAGTGATGGCCTGGATGATGGATACGTATT
CCATGAATCATGGCACGACGGTCACTGGCGTCGTCACCGGTAAGCCTATCCATCTTGGCGGTTCGCTGGGTCGTGAAAAG
GCGACGGGGCGCGGCGTTTTCGTCAGCGGGCTGGAAGCCGCGCGTCGGGCGAATATCGCCGTTGAAGGCGCTCGCGTTGC
GGTTCAGGGTTTTGGTAACGTCGGCAGCGAAGCCGCGCGTCTGTTTGCAGGCGCTGGCGCCCGTGTCGTGGCGATTCAGG
ATCATACCGCGACGCTGTTTAACGCCACCGGTATTGACATGAAGGCGCTCACGGCATGGCAGACAGAACACAAACAGATA
GCCGGTTTCCCGGGCGCGGAAACTATCGCCAGCGATGCGTTCTGGCGTCTGGAGATGGATATTCTGATCCCGGCGGCGCT
TGAAGGCCAGATAACTCGTCAGCGCGCGGAAGCCCTGACGTGTAAGCTGGTGCTGGAAGGGGCTAACGGCCCGACCTATC
CGGATGCTGATGATGTTCTGGCCAGCCGTGGTATCCTTGTGGTGCCTGACGTGGTCTGTAACGCAGGCGGCGTAACCGTC
AGCTACTTCGAATGGGTACAAGATATGGCCAGCTTCTTCTGGAGCGAAGAAGAGATCAACGCGCGCATGGACAAAATCAT
GACCGACGCGATCGTCCATGTCTGGGAGAAAGCGGCTGAGAAATCCTGTTCTCTGCGCACCGCAGCCTATATTGTCGCCT
GTGAGCGCATTCTGCTGGCCCGTAAAGATCGCGGTATCTATCCAGGTTAA

Upstream 100 bases:

>100_bases
TAAGTTATCTTACGCTTCAGATAGCAGCACATCTGCCTGGAATACCTACCTGCAACAAATCGAGCGTGTGGCCCCTTATC
TGGGCGAGTTATCCCCCTAG

Downstream 100 bases:

>100_bases
GGCGACAAATCATTGCGCTAAAATCCACGTCCCGGCGTGGATTTTTTGTCTGTATACCCCGTTTTCCACGCGCGCGCCGA
TAAATTCTGTCTCAATAAAA

Product: glutamate dehydrogenase

Products: NA

Alternate protein names: GDH [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MDTLRHPKRALIVDIPVQMDDGTIRHFEGYRVQHNLSRGPGKGGVRYHPDVDLNEVMALSAWMTIKCAALNLPYGGAKGG
IRVDPFSLSEGELERLTRRYTSEIGIIIGPQKDIPAPDVGTNGKVMAWMMDTYSMNHGTTVTGVVTGKPIHLGGSLGREK
ATGRGVFVSGLEAARRANIAVEGARVAVQGFGNVGSEAARLFAGAGARVVAIQDHTATLFNATGIDMKALTAWQTEHKQI
AGFPGAETIASDAFWRLEMDILIPAALEGQITRQRAEALTCKLVLEGANGPTYPDADDVLASRGILVVPDVVCNAGGVTV
SYFEWVQDMASFFWSEEEINARMDKIMTDAIVHVWEKAAEKSCSLRTAAYIVACERILLARKDRGIYPG

Sequences:

>Translated_389_residues
MDTLRHPKRALIVDIPVQMDDGTIRHFEGYRVQHNLSRGPGKGGVRYHPDVDLNEVMALSAWMTIKCAALNLPYGGAKGG
IRVDPFSLSEGELERLTRRYTSEIGIIIGPQKDIPAPDVGTNGKVMAWMMDTYSMNHGTTVTGVVTGKPIHLGGSLGREK
ATGRGVFVSGLEAARRANIAVEGARVAVQGFGNVGSEAARLFAGAGARVVAIQDHTATLFNATGIDMKALTAWQTEHKQI
AGFPGAETIASDAFWRLEMDILIPAALEGQITRQRAEALTCKLVLEGANGPTYPDADDVLASRGILVVPDVVCNAGGVTV
SYFEWVQDMASFFWSEEEINARMDKIMTDAIVHVWEKAAEKSCSLRTAAYIVACERILLARKDRGIYPG
>Mature_389_residues
MDTLRHPKRALIVDIPVQMDDGTIRHFEGYRVQHNLSRGPGKGGVRYHPDVDLNEVMALSAWMTIKCAALNLPYGGAKGG
IRVDPFSLSEGELERLTRRYTSEIGIIIGPQKDIPAPDVGTNGKVMAWMMDTYSMNHGTTVTGVVTGKPIHLGGSLGREK
ATGRGVFVSGLEAARRANIAVEGARVAVQGFGNVGSEAARLFAGAGARVVAIQDHTATLFNATGIDMKALTAWQTEHKQI
AGFPGAETIASDAFWRLEMDILIPAALEGQITRQRAEALTCKLVLEGANGPTYPDADDVLASRGILVVPDVVCNAGGVTV
SYFEWVQDMASFFWSEEEINARMDKIMTDAIVHVWEKAAEKSCSLRTAAYIVACERILLARKDRGIYPG

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=333, Percent_Identity=42.9429429429429, Blast_Score=275, Evalue=6e-74,
Organism=Homo sapiens, GI4885281, Length=338, Percent_Identity=42.0118343195266, Blast_Score=271, Evalue=1e-72,
Organism=Escherichia coli, GI1788059, Length=362, Percent_Identity=33.1491712707182, Blast_Score=173, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17544676, Length=381, Percent_Identity=38.8451443569554, Blast_Score=261, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6319256, Length=390, Percent_Identity=28.974358974359, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6324951, Length=375, Percent_Identity=29.0666666666667, Blast_Score=140, Evalue=4e-34,
Organism=Drosophila melanogaster, GI45549226, Length=331, Percent_Identity=44.1087613293051, Blast_Score=275, Evalue=4e-74,
Organism=Drosophila melanogaster, GI45553475, Length=331, Percent_Identity=44.1087613293051, Blast_Score=274, Evalue=6e-74,
Organism=Drosophila melanogaster, GI24649283, Length=330, Percent_Identity=44.5454545454545, Blast_Score=272, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24649460, Length=281, Percent_Identity=44.4839857651246, Blast_Score=231, Evalue=4e-61,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.3 [H]

Molecular weight: Translated: 42039; Mature: 42039

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00074 GLFV_DEHYDROGENASE ; PS00137 SUBTILASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTLRHPKRALIVDIPVQMDDGTIRHFEGYRVQHNLSRGPGKGGVRYHPDVDLNEVMALS
CCCCCCCCEEEEEEEEEEECCCCEEEECCEEEEECCCCCCCCCCCEECCCCCHHHHHHHH
AWMTIKCAALNLPYGGAKGGIRVDPFSLSEGELERLTRRYTSEIGIIIGPQKDIPAPDVG
HCEEEEEEEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCC
TNGKVMAWMMDTYSMNHGTTVTGVVTGKPIHLGGSLGREKATGRGVFVSGLEAARRANIA
CCCCEEEEEEEEEECCCCCEEEEEEECCEEEECCCCCCCCCCCCCEEEECHHHHHHCCEE
VEGARVAVQGFGNVGSEAARLFAGAGARVVAIQDHTATLFNATGIDMKALTAWQTEHKQI
EECCEEEEEECCCCCHHHHHHHHCCCEEEEEEECCCEEEEECCCCCHHHHHHHHHCCHHH
AGFPGAETIASDAFWRLEMDILIPAALEGQITRQRAEALTCKLVLEGANGPTYPDADDVL
CCCCCHHHHHCCCEEEEEEEEEECCHHCCHHHHHHHHHEEEEEEEECCCCCCCCCHHHHH
ASRGILVVPDVVCNAGGVTVSYFEWVQDMASFFWSEEEINARMDKIMTDAIVHVWEKAAE
HHCCEEEECHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
KSCSLRTAAYIVACERILLARKDRGIYPG
HCCCHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDTLRHPKRALIVDIPVQMDDGTIRHFEGYRVQHNLSRGPGKGGVRYHPDVDLNEVMALS
CCCCCCCCEEEEEEEEEEECCCCEEEECCEEEEECCCCCCCCCCCEECCCCCHHHHHHHH
AWMTIKCAALNLPYGGAKGGIRVDPFSLSEGELERLTRRYTSEIGIIIGPQKDIPAPDVG
HCEEEEEEEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCC
TNGKVMAWMMDTYSMNHGTTVTGVVTGKPIHLGGSLGREKATGRGVFVSGLEAARRANIA
CCCCEEEEEEEEEECCCCCEEEEEEECCEEEECCCCCCCCCCCCCEEEECHHHHHHCCEE
VEGARVAVQGFGNVGSEAARLFAGAGARVVAIQDHTATLFNATGIDMKALTAWQTEHKQI
EECCEEEEEECCCCCHHHHHHHHCCCEEEEEEECCCEEEEECCCCCHHHHHHHHHCCHHH
AGFPGAETIASDAFWRLEMDILIPAALEGQITRQRAEALTCKLVLEGANGPTYPDADDVL
CCCCCHHHHHCCCEEEEEEEEEECCHHCCHHHHHHHHHEEEEEEEECCCCCCCCCHHHHH
ASRGILVVPDVVCNAGGVTVSYFEWVQDMASFFWSEEEINARMDKIMTDAIVHVWEKAAE
HHCCEEEECHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
KSCSLRTAAYIVACERILLARKDRGIYPG
HCCCHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9680336; 10360571; 9135121; 9654452; 10366510 [H]