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The map label for this gene is edd [H]

Identifier: 29141473

GI number: 29141473

Start: 1081409

End: 1083220

Strand: Direct

Name: edd [H]

Synonym: t0992

Alternate gene names: 29141473

Gene position: 1081409-1083220 (Clockwise)

Preceding gene: 29141472

Following gene: 29141474

Centisome position: 22.57

GC content: 55.85

Gene sequence:

>1812_bases
ATGAATCCTAATTTGTTACGCGTAACACAGCGCATTGTCGAACGCTCGCAGCAGACCCGAAAAGCCTATCTTGCCCGCAT
TGAGCAGGCGAAAACCGCCACGGTCCACCGATCTCAACTGGCCTGCGGCAACCTGGCGCATGGCTTCGCCGCCTGTCAGC
CAGAGGACAAAGCCTCGCTGAAAAGTATGTTGCGCAATAATATCGCCATCATTACCTCCTACAATGACATGCTCTCTGCG
CATCAACCGTATGAACATTATCCGCAGATTATTCGTCAGGCCCTGCATTCCGTGAATGCGGTAGGTCAGGTCGCAGGCGG
CGTACCGGCAATGTGCGATGGCGTTACGCAAGGGCAGGATGGCATGGAGTTGTCATTACTCAGCCGCGAAGTGATAGCGA
TGTCGGCAGCAGTAGGCCTTTCTCACAATATGTTTGACGGCGCGTTATTCCTCGGCGTATGCGACAAAATTGTTCCGGGG
CTGGCGATGGCCGCGCTCTCTTTTGGTCATTTACCCGCGATTTTTGTTCCGTCAGGCCCGATGGCGAGCGGCCTGCCGAA
TAAAGAAAAAGTCCGTATTCGTCAGCTATATGCGGAAGGAAAAGTAGACAGAATGGCGCTGCTGGAGTCGGAAGCCGCCT
CTTACCATGCGCCGGGCACCTGTACATTTTACGGCACTGCCAACACCAACCAGATGGTGGTGGAGTTTATGGGAATGCAG
TTGCCGGGTTCCTCGTTTGTGCATCCGGATGCGCCGCTGCGCGAGGCATTGACTGCCGCTGCCGCACGTCAGGTAACACG
TCTTACCGGCAACGGCAATACGTGGATGCCGCTCGGTAAAATGATCGACGAAAAAGTCGTGGTGAACGGCATTGTCGCGC
TGCTGGCTACCGGCGGTTCCACCAACCACACCATGCATCTGGTTGCAATGGCGCGCGCGGCGGGCATTCTGATCAACTGG
GATGACTTCTCGGATTTGTCGGAAGTGGTTCCGTTGATGGCGCGTCTGTACCCGAACGGTCCGGCGGACATTAACCACTT
CCAGGCGGCGGGCGGCGTACCGGTATTGATGCGTGAGCTGCTCAATGCCGGATTGCTGCACGAAGACGTTAATACTGTCG
CAGGCTTCGGCCTGAAACGCTATACGCTGGAGCCCTGGCTCAACAACGGCGAGCTGGACTGGCGTGAAGGCGCGGAAAGG
TCACTGGATAACGATGTCATTGCCTCTTTTGATAAGCCGTTCTCTCCTCACGGCGGTACTAAGGTGCTAAGCGGTAATCT
GGGGCGCGCAGTAATGAAGACGTCTGCGGTACCGGTTGAAAACCAGATCATTGAAGCGCCTGCCATGGTATTTGAAAGTC
AGCATGATGTGCTGCCTGCGTTTGACGCGGGCCTGCTTGACCGGGATTGTGTCGTTGTCGTGCGTCATCAGGGACCAAAA
GCGAATGGAATGCCAGAATTACATAAACTCATGCCGCCACTTGGTGTATTATTGGACCGCCGTTTCAAAATCGCGTTAGT
TACTGATGGACGACTTTCAGGCGCTTCGGGTAAAGTGCCTTCAGCTATCCACGTAACGCCGGAAGCCTACGATGGCGGCT
TACTGGCAAAAGTGCGCGATGGCGACATCATTCGCGTGAATGGGCAGACAGGTGAGTTAACTCTGCTGGTCGACGAGGCG
GAACTTGCCGCTCGTCAGCCTCATATTCCGGACCTGAGCGCGTCGCGCGTCGGAACGGGGCGTGAGTTGTTTGGCGCGCT
GCGCGAAAAGCTGTCGGGTGCGGAGCAGGGCGCAACCTGTATCACTTTTTAA

Upstream 100 bases:

>100_bases
TGCCCCATTATCCCCGGACATCATGTATTTCACTGTCTTTCCACATTGATGAAACGCATGGTAAACCCGGTAGCCGGACA
GATAAATTTCAGGAGCCTCT

Downstream 100 bases:

>100_bases
GATGACACACTAGTAATCAGGCGAGAGAAGAATTCCGATGAAAAACTGGAAAACAAGTGCAGAAGCAATCCTGACCACCG
GCCCGGTTGTCCCGGTCATT

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MNPNLLRVTQRIVERSQQTRKAYLARIEQAKTATVHRSQLACGNLAHGFAACQPEDKASLKSMLRNNIAIITSYNDMLSA
HQPYEHYPQIIRQALHSVNAVGQVAGGVPAMCDGVTQGQDGMELSLLSREVIAMSAAVGLSHNMFDGALFLGVCDKIVPG
LAMAALSFGHLPAIFVPSGPMASGLPNKEKVRIRQLYAEGKVDRMALLESEAASYHAPGTCTFYGTANTNQMVVEFMGMQ
LPGSSFVHPDAPLREALTAAAARQVTRLTGNGNTWMPLGKMIDEKVVVNGIVALLATGGSTNHTMHLVAMARAAGILINW
DDFSDLSEVVPLMARLYPNGPADINHFQAAGGVPVLMRELLNAGLLHEDVNTVAGFGLKRYTLEPWLNNGELDWREGAER
SLDNDVIASFDKPFSPHGGTKVLSGNLGRAVMKTSAVPVENQIIEAPAMVFESQHDVLPAFDAGLLDRDCVVVVRHQGPK
ANGMPELHKLMPPLGVLLDRRFKIALVTDGRLSGASGKVPSAIHVTPEAYDGGLLAKVRDGDIIRVNGQTGELTLLVDEA
ELAARQPHIPDLSASRVGTGRELFGALREKLSGAEQGATCITF

Sequences:

>Translated_603_residues
MNPNLLRVTQRIVERSQQTRKAYLARIEQAKTATVHRSQLACGNLAHGFAACQPEDKASLKSMLRNNIAIITSYNDMLSA
HQPYEHYPQIIRQALHSVNAVGQVAGGVPAMCDGVTQGQDGMELSLLSREVIAMSAAVGLSHNMFDGALFLGVCDKIVPG
LAMAALSFGHLPAIFVPSGPMASGLPNKEKVRIRQLYAEGKVDRMALLESEAASYHAPGTCTFYGTANTNQMVVEFMGMQ
LPGSSFVHPDAPLREALTAAAARQVTRLTGNGNTWMPLGKMIDEKVVVNGIVALLATGGSTNHTMHLVAMARAAGILINW
DDFSDLSEVVPLMARLYPNGPADINHFQAAGGVPVLMRELLNAGLLHEDVNTVAGFGLKRYTLEPWLNNGELDWREGAER
SLDNDVIASFDKPFSPHGGTKVLSGNLGRAVMKTSAVPVENQIIEAPAMVFESQHDVLPAFDAGLLDRDCVVVVRHQGPK
ANGMPELHKLMPPLGVLLDRRFKIALVTDGRLSGASGKVPSAIHVTPEAYDGGLLAKVRDGDIIRVNGQTGELTLLVDEA
ELAARQPHIPDLSASRVGTGRELFGALREKLSGAEQGATCITF
>Mature_603_residues
MNPNLLRVTQRIVERSQQTRKAYLARIEQAKTATVHRSQLACGNLAHGFAACQPEDKASLKSMLRNNIAIITSYNDMLSA
HQPYEHYPQIIRQALHSVNAVGQVAGGVPAMCDGVTQGQDGMELSLLSREVIAMSAAVGLSHNMFDGALFLGVCDKIVPG
LAMAALSFGHLPAIFVPSGPMASGLPNKEKVRIRQLYAEGKVDRMALLESEAASYHAPGTCTFYGTANTNQMVVEFMGMQ
LPGSSFVHPDAPLREALTAAAARQVTRLTGNGNTWMPLGKMIDEKVVVNGIVALLATGGSTNHTMHLVAMARAAGILINW
DDFSDLSEVVPLMARLYPNGPADINHFQAAGGVPVLMRELLNAGLLHEDVNTVAGFGLKRYTLEPWLNNGELDWREGAER
SLDNDVIASFDKPFSPHGGTKVLSGNLGRAVMKTSAVPVENQIIEAPAMVFESQHDVLPAFDAGLLDRDCVVVVRHQGPK
ANGMPELHKLMPPLGVLLDRRFKIALVTDGRLSGASGKVPSAIHVTPEAYDGGLLAKVRDGDIIRVNGQTGELTLLVDEA
ELAARQPHIPDLSASRVGTGRELFGALREKLSGAEQGATCITF

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=603, Percent_Identity=94.0298507462687, Blast_Score=1181, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=540, Percent_Identity=30, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI2367371, Length=486, Percent_Identity=30.6584362139918, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1786464, Length=551, Percent_Identity=28.3121597096189, Blast_Score=136, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322476, Length=481, Percent_Identity=30.7692307692308, Blast_Score=176, Evalue=7e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 64639; Mature: 64639

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPNLLRVTQRIVERSQQTRKAYLARIEQAKTATVHRSQLACGNLAHGFAACQPEDKASL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHCCCCCHHHHH
KSMLRNNIAIITSYNDMLSAHQPYEHYPQIIRQALHSVNAVGQVAGGVPAMCDGVTQGQD
HHHHHCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCC
GMELSLLSREVIAMSAAVGLSHNMFDGALFLGVCDKIVPGLAMAALSFGHLPAIFVPSGP
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
MASGLPNKEKVRIRQLYAEGKVDRMALLESEAASYHAPGTCTFYGTANTNQMVVEFMGMQ
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHCCC
LPGSSFVHPDAPLREALTAAAARQVTRLTGNGNTWMPLGKMIDEKVVVNGIVALLATGGS
CCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
TNHTMHLVAMARAAGILINWDDFSDLSEVVPLMARLYPNGPADINHFQAAGGVPVLMREL
CCCHHHHEEHHHHCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHH
LNAGLLHEDVNTVAGFGLKRYTLEPWLNNGELDWREGAERSLDNDVIASFDKPFSPHGGT
HHCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHCHHHCCCCHHHHHCCCCCCCCCCC
KVLSGNLGRAVMKTSAVPVENQIIEAPAMVFESQHDVLPAFDAGLLDRDCVVVVRHQGPK
EEECCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCC
ANGMPELHKLMPPLGVLLDRRFKIALVTDGRLSGASGKVPSAIHVTPEAYDGGLLAKVRD
CCCCHHHHHHCCCHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCEEEEECC
GDIIRVNGQTGELTLLVDEAELAARQPHIPDLSASRVGTGRELFGALREKLSGAEQGATC
CCEEEEECCCCEEEEEEECHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEE
ITF
ECC
>Mature Secondary Structure
MNPNLLRVTQRIVERSQQTRKAYLARIEQAKTATVHRSQLACGNLAHGFAACQPEDKASL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHCCCCCHHHHH
KSMLRNNIAIITSYNDMLSAHQPYEHYPQIIRQALHSVNAVGQVAGGVPAMCDGVTQGQD
HHHHHCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCC
GMELSLLSREVIAMSAAVGLSHNMFDGALFLGVCDKIVPGLAMAALSFGHLPAIFVPSGP
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
MASGLPNKEKVRIRQLYAEGKVDRMALLESEAASYHAPGTCTFYGTANTNQMVVEFMGMQ
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHCCC
LPGSSFVHPDAPLREALTAAAARQVTRLTGNGNTWMPLGKMIDEKVVVNGIVALLATGGS
CCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
TNHTMHLVAMARAAGILINWDDFSDLSEVVPLMARLYPNGPADINHFQAAGGVPVLMREL
CCCHHHHEEHHHHCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHH
LNAGLLHEDVNTVAGFGLKRYTLEPWLNNGELDWREGAERSLDNDVIASFDKPFSPHGGT
HHCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHCHHHCCCCHHHHHCCCCCCCCCCC
KVLSGNLGRAVMKTSAVPVENQIIEAPAMVFESQHDVLPAFDAGLLDRDCVVVVRHQGPK
EEECCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCC
ANGMPELHKLMPPLGVLLDRRFKIALVTDGRLSGASGKVPSAIHVTPEAYDGGLLAKVRD
CCCCHHHHHHCCCHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCEEEEECC
GDIIRVNGQTGELTLLVDEAELAARQPHIPDLSASRVGTGRELFGALREKLSGAEQGATC
CCEEEEECCCCEEEEEEECHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEE
ITF
ECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]