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The map label for this gene is zwf [H]

Identifier: 29141472

GI number: 29141472

Start: 1079699

End: 1081174

Strand: Direct

Name: zwf [H]

Synonym: t0991

Alternate gene names: 29141472

Gene position: 1079699-1081174 (Clockwise)

Preceding gene: 29141469

Following gene: 29141473

Centisome position: 22.53

GC content: 53.46

Gene sequence:

>1476_bases
ATGGCGGTAACGCAAACAGCCCAGGCATGTGACCTGGTCATTTTCGGCGCGAAAGGCGACCTGGCGCGCCGGAAACTGCT
GCCTTCCCTGTATCAGCTTGAGAAAGCCGGCCAGATCCATCCGGATACCCGGATCATTGGGGTGGGGCGCGCGGACTGGG
ATAAAGAAGCTTATACCCACGTTGTGCGTGAGGCGCTGGAAACCTTCATGAAGGAAAAAATTGATGAAGGCTTGTGGGAT
ACGCTGAGCGGCCGTCTGGATTTTTGTAATCTTGACGTTAACGATACGCCTGCGTTCAGTCGCCTGGGCGATATGCTGGA
TCAAAAAAACCGCACCACCATTAACTATTTTGCGATGCCGCCCAGCACGTTTGGCGCTATTTGCAAAGGGTTAGGGGAGG
CTAAACTCAACGCCAAACCGGCGCGTGTCGTGATGGAGAAACCGTTGGGTACTTCGCTGGCGACCTCGCGTGAGATTAAC
GATCGGGTCGGCGAATACTTTGAAGAGTGCCAAGTATATCGTATCGACCACTATCTGGGCAAAGAAACGGTTCTCAACCT
GCTGGCGCTGCGTTTTGCCAACTCGTTATTCGTTAATAACTGGGATAACCGCACTATCGATCACGTTGAGATTACCGTAG
CGGAAGAGGTGGGGATTGAAGGGCGCTGGGGATATTTTGACCAGGCCGGTCAGATGCGCGATATGATCCAGAACCACTTG
CTGCAAATTCTCTGCATGATTGCCATGTCACCGCCGTCTGACCTGAGCGCCGACAGTATTCGCGATGAAAAAGTAAAAGT
GTTGAAATCGTTGCGCCGTATTGATCGCTCCAACGTGCGTGAAAAAACGGTTCGTGGTCAATACACCGCGGGCTTTGCGC
AGGGTCAAAAGGTGCCGGGCTATCTGGAAGAAGAGGGCGCGAATAAAAGCAGCAACACCGAAACTTTCGTCGCGATCCGC
GTCGACATCGATAACTGGCGTTGGGCGGGCGTGCCATTCTATCTGCGCACCGGCAAGCGTCTGCCAACTAAGTGCTCTGA
AGTCGTGGTTTATTTCAAGACGCCTGAACTGAATCTCTTTAAAGAGTCCTGGCAAGACCTGCCGCAGAACAAATTGACGA
TTCGCCTGCAGCCGGATGAAGGCGTAGATATTCAGGTACTTAACAAAGTACCGAGGCTGGATCATAAGCATAATCTGCAA
ATCACGAAGCTTGATCTGAGCTACTCCGAGACCTTTAATCAGACGCACCTGGCGGATGCATATGAGCGCCTGCTGCTGGA
AACGATGCGTGGCATTCAGGCGCTGTTTGTCCGCCGTGACGAAGTGGAAGAAGCCTGGAAGTGGGTGGACTCCATTACCG
AAGCATGGGCGATGGACAACGACGCGCCGAAGCCGTATCAGGCGGGCACCTGGGGACCGGTAGCGTCCGTGGCGATGATT
ACCCGTGACGGTCGTTCGTGGAATGAGTTTGAGTAA

Upstream 100 bases:

>100_bases
TTACGGTTTCCGTAATCTCGTAAAAGCAGTACAGTGCTGTGTAATAAAATTACAACGATATCCTGGCTAAAGTACCAGGA
GATTAACTGAGGAGAATGAC

Downstream 100 bases:

>100_bases
ATTTGCCACTCACTCTTAGGTGGTATTTTACCGGTAACATGATCTAACACAGATTGTAGAATCATTTTTGCACTTTTAAG
CCTCGTGTGGATTCACCTGC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MAVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQIHPDTRIIGVGRADWDKEAYTHVVREALETFMKEKIDEGLWD
TLSGRLDFCNLDVNDTPAFSRLGDMLDQKNRTTINYFAMPPSTFGAICKGLGEAKLNAKPARVVMEKPLGTSLATSREIN
DRVGEYFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDNRTIDHVEITVAEEVGIEGRWGYFDQAGQMRDMIQNHL
LQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGQKVPGYLEEEGANKSSNTETFVAIR
VDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKESWQDLPQNKLTIRLQPDEGVDIQVLNKVPRLDHKHNLQ
ITKLDLSYSETFNQTHLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAMDNDAPKPYQAGTWGPVASVAMI
TRDGRSWNEFE

Sequences:

>Translated_491_residues
MAVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQIHPDTRIIGVGRADWDKEAYTHVVREALETFMKEKIDEGLWD
TLSGRLDFCNLDVNDTPAFSRLGDMLDQKNRTTINYFAMPPSTFGAICKGLGEAKLNAKPARVVMEKPLGTSLATSREIN
DRVGEYFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDNRTIDHVEITVAEEVGIEGRWGYFDQAGQMRDMIQNHL
LQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGQKVPGYLEEEGANKSSNTETFVAIR
VDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKESWQDLPQNKLTIRLQPDEGVDIQVLNKVPRLDHKHNLQ
ITKLDLSYSETFNQTHLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAMDNDAPKPYQAGTWGPVASVAMI
TRDGRSWNEFE
>Mature_490_residues
AVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQIHPDTRIIGVGRADWDKEAYTHVVREALETFMKEKIDEGLWDT
LSGRLDFCNLDVNDTPAFSRLGDMLDQKNRTTINYFAMPPSTFGAICKGLGEAKLNAKPARVVMEKPLGTSLATSREIND
RVGEYFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDNRTIDHVEITVAEEVGIEGRWGYFDQAGQMRDMIQNHLL
QILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGQKVPGYLEEEGANKSSNTETFVAIRV
DIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKESWQDLPQNKLTIRLQPDEGVDIQVLNKVPRLDHKHNLQI
TKLDLSYSETFNQTHLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAMDNDAPKPYQAGTWGPVASVAMIT
RDGRSWNEFE

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=485, Percent_Identity=35.8762886597938, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI108773793, Length=485, Percent_Identity=35.8762886597938, Blast_Score=303, Evalue=2e-82,
Organism=Homo sapiens, GI52145310, Length=496, Percent_Identity=27.0161290322581, Blast_Score=154, Evalue=2e-37,
Organism=Escherichia coli, GI1788158, Length=491, Percent_Identity=97.1486761710794, Blast_Score=993, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17538218, Length=485, Percent_Identity=35.8762886597938, Blast_Score=300, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6324088, Length=478, Percent_Identity=33.8912133891213, Blast_Score=273, Evalue=4e-74,
Organism=Drosophila melanogaster, GI24643350, Length=478, Percent_Identity=36.1924686192469, Blast_Score=279, Evalue=3e-75,
Organism=Drosophila melanogaster, GI24643352, Length=478, Percent_Identity=36.1924686192469, Blast_Score=279, Evalue=3e-75,
Organism=Drosophila melanogaster, GI221513548, Length=488, Percent_Identity=28.2786885245902, Blast_Score=179, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56021; Mature: 55890

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQIHPDTRIIGVGRADWDKEAYTH
CCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHH
VVREALETFMKEKIDEGLWDTLSGRLDFCNLDVNDTPAFSRLGDMLDQKNRTTINYFAMP
HHHHHHHHHHHHHHHCCHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECC
PSTFGAICKGLGEAKLNAKPARVVMEKPLGTSLATSREINDRVGEYFEECQVYRIDHYLG
CHHHHHHHHCCCCCCCCCCCHHHEEECCCCCCHHHHHHHHHHHHHHHHHCEEEEHHHHHC
KETVLNLLALRFANSLFVNNWDNRTIDHVEITVAEEVGIEGRWGYFDQAGQMRDMIQNHL
HHHHHHHHHHHHHHHHEEECCCCCEECEEEEEEHHHCCCCCCCCCHHCCHHHHHHHHHHH
LQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGQKVPG
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCC
YLEEEGANKSSNTETFVAIRVDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLF
CHHHCCCCCCCCCEEEEEEEEEECCCEECCCCEEEECCCCCCCCCCCEEEEEECCCCHHH
KESWQDLPQNKLTIRLQPDEGVDIQVLNKVPRLDHKHNLQITKLDLSYSETFNQTHLADA
HHHHHHCCCCCEEEEECCCCCCCHHHHHHCCCCCCCCCCEEEEEECCHHHHCCHHHHHHH
YERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAMDNDAPKPYQAGTWGPVASVAMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEE
TRDGRSWNEFE
EECCCCCCCCC
>Mature Secondary Structure 
AVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQIHPDTRIIGVGRADWDKEAYTH
CCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHH
VVREALETFMKEKIDEGLWDTLSGRLDFCNLDVNDTPAFSRLGDMLDQKNRTTINYFAMP
HHHHHHHHHHHHHHHCCHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECC
PSTFGAICKGLGEAKLNAKPARVVMEKPLGTSLATSREINDRVGEYFEECQVYRIDHYLG
CHHHHHHHHCCCCCCCCCCCHHHEEECCCCCCHHHHHHHHHHHHHHHHHCEEEEHHHHHC
KETVLNLLALRFANSLFVNNWDNRTIDHVEITVAEEVGIEGRWGYFDQAGQMRDMIQNHL
HHHHHHHHHHHHHHHHEEECCCCCEECEEEEEEHHHCCCCCCCCCHHCCHHHHHHHHHHH
LQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGQKVPG
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCC
YLEEEGANKSSNTETFVAIRVDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLF
CHHHCCCCCCCCCEEEEEEEEEECCCEECCCCEEEECCCCCCCCCCCEEEEEECCCCHHH
KESWQDLPQNKLTIRLQPDEGVDIQVLNKVPRLDHKHNLQITKLDLSYSETFNQTHLADA
HHHHHHCCCCCEEEEECCCCCCCHHHHHHCCCCCCCCCCEEEEEECCHHHHCCHHHHHHH
YERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAMDNDAPKPYQAGTWGPVASVAMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEE
TRDGRSWNEFE
EECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]