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The map label for this gene is wzb

Identifier: 29141257

GI number: 29141257

Start: 844467

End: 844916

Strand: Direct

Name: wzb

Synonym: t0755

Alternate gene names: 29141257

Gene position: 844467-844916 (Clockwise)

Preceding gene: 29141256

Following gene: 29141258

Centisome position: 17.62

GC content: 57.11

Gene sequence:

>450_bases
ATGTTTAACAAAATCTTAGTGGTCTGTGTGGGGAATGTTTGCCGTTCCCCGACGGCGGAACGTTTGCTAAAGCGCTTTCA
TCCTTCGCTGACGGTTGCGTCTGCCGGATTAGGCGCGCTGGTCGGCAAAGGAGCCGATCCTGCGGCGGCGAGCGTGGCGA
GCGCCCACGATCTGTCTTTGGAAAATCACTGCGCAAGGCAAATTTCCGCGCGCCTGTGCCGGGAATATGACCTGATTCTG
ACGATGGAGAAACGCCACATCGCCGCCCTGTGCGACATTGCGCCGGAAATGCGCAGCAAGGTAATGCTGTTTGGTCACTG
GGACAGCGAGCGTGAAATACCAGACCCGTATCGCAAAAGCCGCGATGCGTTTGAGGCGGTGTACACATTACTGGAAAGGT
CTGCCCGCCAGTGGGCGCAGGCACTGAATGCAGAGCAGGGAAAACCATGA

Upstream 100 bases:

>100_bases
TTGCTCGCTGGAACCGTCTGATCAATCAGTTGCTGCCGACCATTAGCGGTGTCCGTTATATGACGGATACGGCCAGCGAC
ATTCATTCCTGGTAATCGTT

Downstream 100 bases:

>100_bases
CAGAAAAAGTAAAACAATCTGCGGCGGTTACGGGTAGCGATGAAATCGATATCGGGCGTCTGGTCGGAACGGTGATTGAA
GCGCGTTGGTGGGTGTTGGG

Product: tyrosine phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MFNKILVVCVGNVCRSPTAERLLKRFHPSLTVASAGLGALVGKGADPAAASVASAHDLSLENHCARQISARLCREYDLIL
TMEKRHIAALCDIAPEMRSKVMLFGHWDSEREIPDPYRKSRDAFEAVYTLLERSARQWAQALNAEQGKP

Sequences:

>Translated_149_residues
MFNKILVVCVGNVCRSPTAERLLKRFHPSLTVASAGLGALVGKGADPAAASVASAHDLSLENHCARQISARLCREYDLIL
TMEKRHIAALCDIAPEMRSKVMLFGHWDSEREIPDPYRKSRDAFEAVYTLLERSARQWAQALNAEQGKP
>Mature_149_residues
MFNKILVVCVGNVCRSPTAERLLKRFHPSLTVASAGLGALVGKGADPAAASVASAHDLSLENHCARQISARLCREYDLIL
TMEKRHIAALCDIAPEMRSKVMLFGHWDSEREIPDPYRKSRDAFEAVYTLLERSARQWAQALNAEQGKP

Specific function: Dephosphorylates wzc. Required for the extracellular polysaccharide colanic acid synthesis. Probably involved in the export of colanic acid from the cell to medium

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family

Homologues:

Organism=Escherichia coli, GI1788375, Length=146, Percent_Identity=82.8767123287671, Blast_Score=257, Evalue=2e-70,
Organism=Escherichia coli, GI87081812, Length=142, Percent_Identity=56.3380281690141, Blast_Score=162, Evalue=7e-42,
Organism=Drosophila melanogaster, GI78706766, Length=139, Percent_Identity=33.0935251798561, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI78706768, Length=139, Percent_Identity=33.0935251798561, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI78706764, Length=127, Percent_Identity=33.8582677165354, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): WZB_SALTI (Q8Z5G5)

Other databases:

- EMBL:   AL627273
- EMBL:   AE014613
- RefSeq:   NP_456663.1
- RefSeq:   NP_804599.1
- ProteinModelPortal:   Q8Z5G5
- SMR:   Q8Z5G5
- GeneID:   1070002
- GeneID:   1248662
- GenomeReviews:   AE014613_GR
- GenomeReviews:   AL513382_GR
- KEGG:   stt:t0755
- KEGG:   sty:STY2330
- HOGENOM:   HBG730979
- OMA:   ENSRQIL
- ProtClustDB:   PRK10126
- BioCyc:   SENT209261:T0755-MONOMER
- BioCyc:   SENT220341:STY2330-MONOMER
- BRENDA:   3.1.3.48
- InterPro:   IPR000106
- InterPro:   IPR017867
- PANTHER:   PTHR11717
- PRINTS:   PR00719
- SMART:   SM00226

Pfam domain/function: PF01451 LMWPc; SSF52788 Tyr_Pase_low_mol_wt

EC number: =3.1.3.48

Molecular weight: Translated: 16504; Mature: 16504

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: NA

Important sites: ACT_SITE 9-9 ACT_SITE 14-14 ACT_SITE 115-115

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNKILVVCVGNVCRSPTAERLLKRFHPSLTVASAGLGALVGKGADPAAASVASAHDLSL
CCCCEEHEECCHHHCCCHHHHHHHHHCCCCCHHHCCHHHHHCCCCCCHHHHHHHHHHCCH
ENHCARQISARLCREYDLILTMEKRHIAALCDIAPEMRSKVMLFGHWDSEREIPDPYRKS
HHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHCHHHHCCEEEEECCCCCCCCCCHHHHH
RDAFEAVYTLLERSARQWAQALNAEQGKP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFNKILVVCVGNVCRSPTAERLLKRFHPSLTVASAGLGALVGKGADPAAASVASAHDLSL
CCCCEEHEECCHHHCCCHHHHHHHHHCCCCCHHHCCHHHHHCCCCCCHHHHHHHHHHCCH
ENHCARQISARLCREYDLILTMEKRHIAALCDIAPEMRSKVMLFGHWDSEREIPDPYRKS
HHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHCHHHHCCEEEEECCCCCCCCCCHHHHH
RDAFEAVYTLLERSARQWAQALNAEQGKP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504