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The map label for this gene is wzc

Identifier: 29141258

GI number: 29141258

Start: 844913

End: 847072

Strand: Direct

Name: wzc

Synonym: t0756

Alternate gene names: 29141258

Gene position: 844913-847072 (Clockwise)

Preceding gene: 29141257

Following gene: 29141259

Centisome position: 17.63

GC content: 53.89

Gene sequence:

>2160_bases
ATGACAGAAAAAGTAAAACAATCTGCGGCGGTTACGGGTAGCGATGAAATCGATATCGGGCGTCTGGTCGGAACGGTGAT
TGAAGCGCGTTGGTGGGTGTTGGGGACGACGGCCATATTTGCGCTGTGCGCGGTAATTTATACGTTCTTCGCCACGCCCA
TCTATAGCGCCGATGCGCTGGTGCAGATTGAACAAAACGCCGGTAATTCGCTGGTACAGGATATCAACAGCGCATTAGCG
AATAAGCCGCCGGCTTCCGATGCGGAAATTCAGCTCATTCGATCGCGCCTGGTGCTGGGGAAGACCGTTGACGATCTGGA
TCTGGATATTGCCGTCACCAAAAACACCTTTCCGCTGTTCGGCGCCGGGTGGGAGCGGCTGATGGGACGTCACAATGAAA
TGGTGAAAGTCACGACATTCACCCGACCAGAGACGATGAGCGGACAGATCTTCACCCTCAAAGTGCTGGGCGACAAACGT
TATCAGTTGGTCAGCGACGGCGGATTTAGCGCGCAGGGCGTTGTGGGCCAGCCACTCAATAAAGACGGCGTGACGATGCG
GGTAGAGGCGATTGACGCCCGTCCTGATACGGAATTTACGGTGAGTAAATTCTCAACGCTTGGCATGATTAATAACCTGC
AAAATAACCTCACCGTAACGGAAACCGGCAAAGATACCGGCGTTCTGAACCTGACGTTCACGGGAGAGGATCGCGACCAG
ATCCGCGACATTCTCAACAGTATTACCCGTAACTATCTGCAACAGGATATTGCGTGGAAATCTGAAGAGGCGGGGAAGAG
CCTGGCGTTTCTGGCAAAACAACTGCCGGAAGTCCGCAGCCGTCTGGATGTGGCGGAAAACAAGCTAAACGCTTTCCGCC
AGGATAAAGACTCGGTGGATTTACCGCTGGAGGCGAAGGCGGTGCTCGATTCGATGGTTAATATCGACGCCCAGTTGAAT
GAGTTGACGTTTAAAGAAGCGGAAATTTCCAAGCTCTTTACCAAAGCGCATCCGGCTTACCGCACCCTGCTGGAAAAACG
TAAAGGGCTGGAAGATAAAAAAGCCAAACTGAACGGGCGGGTGACGGCGATGCCGAAAACCCAGCAGGAGATTGTGCGTT
TGACCCGCGATGTGGAGTCCGGCCAGCAGGTTTATATGCAACTGCTTAATAAACAGCAGGAGCTGAAAATCACCGAAGCC
AGCACCGTTGGCAACGTGCGCATCGTTGACCCGGCGATTACCCAGCCGGGCGTGCTAAAGCCGAAAAAGGCGTTGATTAT
TCTCGGCAGCATTATTCTGGGATTAATGTTATCGATTGTCGGCGTGCTGCTGCGCTCGCTGTTTAATCGCGGTATCGAAA
GCCCGCAGGCGCTGGAGGAGCACGGGATCAGCGTCTATGCCAGTATTCCGCTGTCGGAATGGCAAAAAGCGCGCGATAGC
GTCAAAACCATTAAAGGGATTAAGCGTTACAAGCAGAGCCAACTGCTGGCGGTGGGCAATCCGACCGATCTGGCGATTGA
GGCGATTCGCAGCCTGCGCACCAGCCTCCATTTCGCCATGATGCAGGCGCAAAATAATGTACTCATGCTCACAGGCGTCA
GCTCCTCTATCGGTAAAACCTTTGTTTGCGCCAACCTGGCGGCCGTCATCAGCCAGACGCATAAACGGGTATTACTGATC
GACTGCGATATGCGCAAGGGCTACACCCATGAACTGCTCGGCACCAATAACGTGGACGGCTTATCTGACATTCTGGCGGG
CAAAGGCGAGATAGCCTCCTGCGCGAAACCCACGGCGATCGCTAATTTTGATCTTATTCCGCGCGGTCAGGTACCGCCTA
ATCCATCGGAATTGCTGATGAGCGAGCGCTTCGGCGAGCTGATCGCCTGGGCAAGCAGCCGCTACGACCTGGTATTAATC
GACACGCCGCCGATTCTGGCCGTGACGGACGCCGCGATTGTGGGTCGTCACGTTGGGACGACGCTGATGGTGGCGCGTTA
TGCCGTCAACACCTTGAAAGAAGTGGAAACCAGTCTGAGCCGTTTTGACCAGAATGGCATTCAGGTCAAAGGCGTCATTC
TCAACTCCATTTTCCGCCGGGCGACGGGCTACCAGGATTATGGCTATTACGAGTATGAATACCAGTCAGATTCCAAATAA

Upstream 100 bases:

>100_bases
CGTATCGCAAAAGCCGCGATGCGTTTGAGGCGGTGTACACATTACTGGAAAGGTCTGCCCGCCAGTGGGCGCAGGCACTG
AATGCAGAGCAGGGAAAACC

Downstream 100 bases:

>100_bases
AAAATAAGGCGTGCCGGATGGCGCGGCCTGTGACTGTAGGCCGGACAAGCGTAGCGCCATGCGGCAAAACTATCTGGGGA
ATAAGCATGACAACAGACAA

Product: tyrosine kinase

Products: ADP; protein tyrosine phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 719; Mature: 718

Protein sequence:

>719_residues
MTEKVKQSAAVTGSDEIDIGRLVGTVIEARWWVLGTTAIFALCAVIYTFFATPIYSADALVQIEQNAGNSLVQDINSALA
NKPPASDAEIQLIRSRLVLGKTVDDLDLDIAVTKNTFPLFGAGWERLMGRHNEMVKVTTFTRPETMSGQIFTLKVLGDKR
YQLVSDGGFSAQGVVGQPLNKDGVTMRVEAIDARPDTEFTVSKFSTLGMINNLQNNLTVTETGKDTGVLNLTFTGEDRDQ
IRDILNSITRNYLQQDIAWKSEEAGKSLAFLAKQLPEVRSRLDVAENKLNAFRQDKDSVDLPLEAKAVLDSMVNIDAQLN
ELTFKEAEISKLFTKAHPAYRTLLEKRKGLEDKKAKLNGRVTAMPKTQQEIVRLTRDVESGQQVYMQLLNKQQELKITEA
STVGNVRIVDPAITQPGVLKPKKALIILGSIILGLMLSIVGVLLRSLFNRGIESPQALEEHGISVYASIPLSEWQKARDS
VKTIKGIKRYKQSQLLAVGNPTDLAIEAIRSLRTSLHFAMMQAQNNVLMLTGVSSSIGKTFVCANLAAVISQTHKRVLLI
DCDMRKGYTHELLGTNNVDGLSDILAGKGEIASCAKPTAIANFDLIPRGQVPPNPSELLMSERFGELIAWASSRYDLVLI
DTPPILAVTDAAIVGRHVGTTLMVARYAVNTLKEVETSLSRFDQNGIQVKGVILNSIFRRATGYQDYGYYEYEYQSDSK

Sequences:

>Translated_719_residues
MTEKVKQSAAVTGSDEIDIGRLVGTVIEARWWVLGTTAIFALCAVIYTFFATPIYSADALVQIEQNAGNSLVQDINSALA
NKPPASDAEIQLIRSRLVLGKTVDDLDLDIAVTKNTFPLFGAGWERLMGRHNEMVKVTTFTRPETMSGQIFTLKVLGDKR
YQLVSDGGFSAQGVVGQPLNKDGVTMRVEAIDARPDTEFTVSKFSTLGMINNLQNNLTVTETGKDTGVLNLTFTGEDRDQ
IRDILNSITRNYLQQDIAWKSEEAGKSLAFLAKQLPEVRSRLDVAENKLNAFRQDKDSVDLPLEAKAVLDSMVNIDAQLN
ELTFKEAEISKLFTKAHPAYRTLLEKRKGLEDKKAKLNGRVTAMPKTQQEIVRLTRDVESGQQVYMQLLNKQQELKITEA
STVGNVRIVDPAITQPGVLKPKKALIILGSIILGLMLSIVGVLLRSLFNRGIESPQALEEHGISVYASIPLSEWQKARDS
VKTIKGIKRYKQSQLLAVGNPTDLAIEAIRSLRTSLHFAMMQAQNNVLMLTGVSSSIGKTFVCANLAAVISQTHKRVLLI
DCDMRKGYTHELLGTNNVDGLSDILAGKGEIASCAKPTAIANFDLIPRGQVPPNPSELLMSERFGELIAWASSRYDLVLI
DTPPILAVTDAAIVGRHVGTTLMVARYAVNTLKEVETSLSRFDQNGIQVKGVILNSIFRRATGYQDYGYYEYEYQSDSK
>Mature_718_residues
TEKVKQSAAVTGSDEIDIGRLVGTVIEARWWVLGTTAIFALCAVIYTFFATPIYSADALVQIEQNAGNSLVQDINSALAN
KPPASDAEIQLIRSRLVLGKTVDDLDLDIAVTKNTFPLFGAGWERLMGRHNEMVKVTTFTRPETMSGQIFTLKVLGDKRY
QLVSDGGFSAQGVVGQPLNKDGVTMRVEAIDARPDTEFTVSKFSTLGMINNLQNNLTVTETGKDTGVLNLTFTGEDRDQI
RDILNSITRNYLQQDIAWKSEEAGKSLAFLAKQLPEVRSRLDVAENKLNAFRQDKDSVDLPLEAKAVLDSMVNIDAQLNE
LTFKEAEISKLFTKAHPAYRTLLEKRKGLEDKKAKLNGRVTAMPKTQQEIVRLTRDVESGQQVYMQLLNKQQELKITEAS
TVGNVRIVDPAITQPGVLKPKKALIILGSIILGLMLSIVGVLLRSLFNRGIESPQALEEHGISVYASIPLSEWQKARDSV
KTIKGIKRYKQSQLLAVGNPTDLAIEAIRSLRTSLHFAMMQAQNNVLMLTGVSSSIGKTFVCANLAAVISQTHKRVLLID
CDMRKGYTHELLGTNNVDGLSDILAGKGEIASCAKPTAIANFDLIPRGQVPPNPSELLMSERFGELIAWASSRYDLVLID
TPPILAVTDAAIVGRHVGTTLMVARYAVNTLKEVETSLSRFDQNGIQVKGVILNSIFRRATGYQDYGYYEYEYQSDSK

Specific function: Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium

COG id: COG3206

COG function: function code M; Uncharacterized protein involved in exopolysaccharide biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the etk/wzc family

Homologues:

Organism=Escherichia coli, GI87082032, Length=720, Percent_Identity=87.5, Blast_Score=1299, Evalue=0.0,
Organism=Escherichia coli, GI1787216, Length=708, Percent_Identity=50.7062146892655, Blast_Score=728, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): WZC_SALTI (Q8Z5G6)

Other databases:

- EMBL:   AL627273
- EMBL:   AE014613
- RefSeq:   NP_456662.1
- RefSeq:   NP_804600.1
- ProteinModelPortal:   Q8Z5G6
- SMR:   Q8Z5G6
- GeneID:   1070003
- GeneID:   1248661
- GenomeReviews:   AE014613_GR
- GenomeReviews:   AL513382_GR
- KEGG:   stt:t0756
- KEGG:   sty:STY2329
- HOGENOM:   HBG309770
- OMA:   IRMTEKV
- ProtClustDB:   PRK11519
- BioCyc:   SENT209261:T0756-MONOMER
- BioCyc:   SENT220341:STY2329-MONOMER
- BRENDA:   2.7.10.1
- BRENDA:   2.7.10.2
- InterPro:   IPR002586
- InterPro:   IPR005702
- InterPro:   IPR003856
- TIGRFAMs:   TIGR01007

Pfam domain/function: PF01656 CbiA; PF02706 Wzz

EC number: 2.7.1.112 [C]

Molecular weight: Translated: 79188; Mature: 79057

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xda4d16c)-; HASH(0xd1f60d8)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKVKQSAAVTGSDEIDIGRLVGTVIEARWWVLGTTAIFALCAVIYTFFATPIYSADAL
CCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
VQIEQNAGNSLVQDINSALANKPPASDAEIQLIRSRLVLGKTVDDLDLDIAVTKNTFPLF
EEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCC
GAGWERLMGRHNEMVKVTTFTRPETMSGQIFTLKVLGDKRYQLVSDGGFSAQGVVGQPLN
CCCHHHHCCCCCCEEEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCCC
KDGVTMRVEAIDARPDTEFTVSKFSTLGMINNLQNNLTVTETGKDTGVLNLTFTGEDRDQ
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCHHH
IRDILNSITRNYLQQDIAWKSEEAGKSLAFLAKQLPEVRSRLDVAENKLNAFRQDKDSVD
HHHHHHHHHHHHHHHHHCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LPLEAKAVLDSMVNIDAQLNELTFKEAEISKLFTKAHPAYRTLLEKRKGLEDKKAKLNGR
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHCCCE
VTAMPKTQQEIVRLTRDVESGQQVYMQLLNKQQELKITEASTVGNVRIVDPAITQPGVLK
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEECCCCCCEEEECCCCCCCCCCC
PKKALIILGSIILGLMLSIVGVLLRSLFNRGIESPQALEEHGISVYASIPLSEWQKARDS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEECCHHHHHHHHHH
VKTIKGIKRYKQSQLLAVGNPTDLAIEAIRSLRTSLHFAMMQAQNNVLMLTGVSSSIGKT
HHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHCHH
FVCANLAAVISQTHKRVLLIDCDMRKGYTHELLGTNNVDGLSDILAGKGEIASCAKPTAI
HHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHCCCCCCCCHHHHHCCCCCCCCCCCCCEE
ANFDLIPRGQVPPNPSELLMSERFGELIAWASSRYDLVLIDTPPILAVTDAAIVGRHVGT
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEECHHHHHHHHHHH
TLMVARYAVNTLKEVETSLSRFDQNGIQVKGVILNSIFRRATGYQDYGYYEYEYQSDSK
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCEEEEEECCCCH
>Mature Secondary Structure 
TEKVKQSAAVTGSDEIDIGRLVGTVIEARWWVLGTTAIFALCAVIYTFFATPIYSADAL
CCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
VQIEQNAGNSLVQDINSALANKPPASDAEIQLIRSRLVLGKTVDDLDLDIAVTKNTFPLF
EEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCC
GAGWERLMGRHNEMVKVTTFTRPETMSGQIFTLKVLGDKRYQLVSDGGFSAQGVVGQPLN
CCCHHHHCCCCCCEEEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCCC
KDGVTMRVEAIDARPDTEFTVSKFSTLGMINNLQNNLTVTETGKDTGVLNLTFTGEDRDQ
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCHHH
IRDILNSITRNYLQQDIAWKSEEAGKSLAFLAKQLPEVRSRLDVAENKLNAFRQDKDSVD
HHHHHHHHHHHHHHHHHCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LPLEAKAVLDSMVNIDAQLNELTFKEAEISKLFTKAHPAYRTLLEKRKGLEDKKAKLNGR
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHCCCE
VTAMPKTQQEIVRLTRDVESGQQVYMQLLNKQQELKITEASTVGNVRIVDPAITQPGVLK
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEECCCCCCEEEECCCCCCCCCCC
PKKALIILGSIILGLMLSIVGVLLRSLFNRGIESPQALEEHGISVYASIPLSEWQKARDS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEECCHHHHHHHHHH
VKTIKGIKRYKQSQLLAVGNPTDLAIEAIRSLRTSLHFAMMQAQNNVLMLTGVSSSIGKT
HHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHCHH
FVCANLAAVISQTHKRVLLIDCDMRKGYTHELLGTNNVDGLSDILAGKGEIASCAKPTAI
HHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHCCCCCCCCHHHHHCCCCCCCCCCCCCEE
ANFDLIPRGQVPPNPSELLMSERFGELIAWASSRYDLVLIDTPPILAVTDAAIVGRHVGT
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEECHHHHHHHHHHH
TLMVARYAVNTLKEVETSLSRFDQNGIQVKGVILNSIFRRATGYQDYGYYEYEYQSDSK
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCEEEEEECCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; a protein tyrosine [C]

Specific reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504