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The map label for this gene is rnz

Identifier: 29141065

GI number: 29141065

Start: 626544

End: 627461

Strand: Reverse

Name: rnz

Synonym: t0550

Alternate gene names: 29141065

Gene position: 627461-626544 (Counterclockwise)

Preceding gene: 29141075

Following gene: 29141064

Centisome position: 13.09

GC content: 55.88

Gene sequence:

>918_bases
ATGGAATTAATTTTTTTAGGTACGTCCGCAGGCGTTCCCACACGCTCACGCAATGTAACGGCAATTTTATTACATCTGCA
ACATCCAACGCAGCCGGGAGTATGGCTTTTTGATTGCGGCGAAGGGACACAGCATCAAATGCTTAATACCGCGTTTCATC
CCGGTAAGCTTGAGCGCATTTTTATCAGCCATCTTCACGGCGATCATCTGTTTGGCCTGCCGGGTCTGCTATGCAGCCGG
TCGATGGCGGGGAATCCCCATCCGCTAACCGTATACGGGCCTCAAGGCGTGCGTGAGTTTATTGCAACCACACTGCGCCT
TAGCGGTTCATGGACCGATTTTCCGTTGCAAATTGAAGAAATTAGCGCTGGCGATATTCTTGACGACGGTCTGCGTAAAG
TGACCGCATTCAGGCTGGAGCATCCACTGGAGTGCTACGGATATCGCGTTGTTGAACATGACAAGCCTGGCGCGCTGAAT
GCCAGGGCGTTAAAAGCCGCAGGCGTTACGCCCGGCCCGCTGTTTCAGGCGTTGAAGGCAGGAAAAACCGTCACGCTTGC
CGATGGAAGGCAGATCAATGGCGCCGACTACCTTGCTCCCGCCGTGGCCGGGAAATCAGTGGCGATTTTCGGCGATACCG
CGCCCTGCGAGGCCGCCCTCGCACTGGCGCAGGGTGTGGATGTGATGGTTCATGAAACCACGCTGGATGCGTCAATGGAG
GAGAAAGCCAACGCTCGCGGACACAGCTCCACCCGTCAAACCGCGACGCTGGCGCGGGAGGCTGCCGTTGGTCGGCTGAT
CATGACCCACATTAGCTCACGCTATGACGATAAAGGCTGTCAGCGCTTACTGGCGGAATGCCGCGCTATTTTCCCGGCGA
CGGAGCTGGCTTACGATTTTTCTGTTTTCCCGGTTTAG

Upstream 100 bases:

>100_bases
CAGTAAGTTCGCTATGGTGGAGATCCTGCCAGTCAATCATGATGCGCTCCTGTGTTGTGGTAATCTTGGGTTAAACGATA
ACCAAACGCGTATGGACAAG

Downstream 100 bases:

>100_bases
CGCTCCATTTTTTGTCCTCATTGCCGATAACACTAAAAAAGGCAGGCTTTCATAATGAGGTTAGGATGGACAATTTTCAG
AAAGATATTGATGACAGGGC

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MELIFLGTSAGVPTRSRNVTAILLHLQHPTQPGVWLFDCGEGTQHQMLNTAFHPGKLERIFISHLHGDHLFGLPGLLCSR
SMAGNPHPLTVYGPQGVREFIATTLRLSGSWTDFPLQIEEISAGDILDDGLRKVTAFRLEHPLECYGYRVVEHDKPGALN
ARALKAAGVTPGPLFQALKAGKTVTLADGRQINGADYLAPAVAGKSVAIFGDTAPCEAALALAQGVDVMVHETTLDASME
EKANARGHSSTRQTATLAREAAVGRLIMTHISSRYDDKGCQRLLAECRAIFPATELAYDFSVFPV

Sequences:

>Translated_305_residues
MELIFLGTSAGVPTRSRNVTAILLHLQHPTQPGVWLFDCGEGTQHQMLNTAFHPGKLERIFISHLHGDHLFGLPGLLCSR
SMAGNPHPLTVYGPQGVREFIATTLRLSGSWTDFPLQIEEISAGDILDDGLRKVTAFRLEHPLECYGYRVVEHDKPGALN
ARALKAAGVTPGPLFQALKAGKTVTLADGRQINGADYLAPAVAGKSVAIFGDTAPCEAALALAQGVDVMVHETTLDASME
EKANARGHSSTRQTATLAREAAVGRLIMTHISSRYDDKGCQRLLAECRAIFPATELAYDFSVFPV
>Mature_305_residues
MELIFLGTSAGVPTRSRNVTAILLHLQHPTQPGVWLFDCGEGTQHQMLNTAFHPGKLERIFISHLHGDHLFGLPGLLCSR
SMAGNPHPLTVYGPQGVREFIATTLRLSGSWTDFPLQIEEISAGDILDDGLRKVTAFRLEHPLECYGYRVVEHDKPGALN
ARALKAAGVTPGPLFQALKAGKTVTLADGRQINGADYLAPAVAGKSVAIFGDTAPCEAALALAQGVDVMVHETTLDASME
EKANARGHSSTRQTATLAREAAVGRLIMTHISSRYDDKGCQRLLAECRAIFPATELAYDFSVFPV

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=361, Percent_Identity=33.5180055401662, Blast_Score=202, Evalue=2e-52,
Organism=Homo sapiens, GI260166619, Length=110, Percent_Identity=39.0909090909091, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI145553959, Length=110, Percent_Identity=39.0909090909091, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI260166622, Length=110, Percent_Identity=39.0909090909091, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI87082078, Length=305, Percent_Identity=80.9836065573771, Blast_Score=524, Evalue=1e-150,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_SALA4 (B5EZJ2)

Other databases:

- EMBL:   CP001138
- RefSeq:   YP_002147269.1
- ProteinModelPortal:   B5EZJ2
- SMR:   B5EZJ2
- PRIDE:   B5EZJ2
- GeneID:   6794588
- GenomeReviews:   CP001138_GR
- KEGG:   sea:SeAg_B2449
- HOGENOM:   HBG648406
- OMA:   HSTSTMA
- ProtClustDB:   PRK00055
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- InterPro:   IPR013469
- SMART:   SM00849
- TIGRFAMs:   TIGR02651
- TIGRFAMs:   TIGR02649

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 32877; Mature: 32877

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELIFLGTSAGVPTRSRNVTAILLHLQHPTQPGVWLFDCGEGTQHQMLNTAFHPGKLERI
CEEEEEECCCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHCCCCCCHHHH
FISHLHGDHLFGLPGLLCSRSMAGNPHPLTVYGPQGVREFIATTLRLSGSWTDFPLQIEE
HHHHHCCCCCCCCCHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCEEEEE
ISAGDILDDGLRKVTAFRLEHPLECYGYRVVEHDKPGALNARALKAAGVTPGPLFQALKA
CCCCCHHHHHHHHHHHHHHCCCHHHHCEEEEECCCCCCCCHHHHEECCCCCHHHHHHHHC
GKTVTLADGRQINGADYLAPAVAGKSVAIFGDTAPCEAALALAQGVDVMVHETTLDASME
CCEEEEECCCEECCCHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCEEEEEEEECCCHHH
EKANARGHSSTRQTATLAREAAVGRLIMTHISSRYDDKGCQRLLAECRAIFPATELAYDF
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHEEEE
SVFPV
EECCC
>Mature Secondary Structure
MELIFLGTSAGVPTRSRNVTAILLHLQHPTQPGVWLFDCGEGTQHQMLNTAFHPGKLERI
CEEEEEECCCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHCCCCCCHHHH
FISHLHGDHLFGLPGLLCSRSMAGNPHPLTVYGPQGVREFIATTLRLSGSWTDFPLQIEE
HHHHHCCCCCCCCCHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCEEEEE
ISAGDILDDGLRKVTAFRLEHPLECYGYRVVEHDKPGALNARALKAAGVTPGPLFQALKA
CCCCCHHHHHHHHHHHHHHCCCHHHHCEEEEECCCCCCCCHHHHEECCCCCHHHHHHHHC
GKTVTLADGRQINGADYLAPAVAGKSVAIFGDTAPCEAALALAQGVDVMVHETTLDASME
CCEEEEECCCEECCCHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCEEEEEEEECCCHHH
EKANARGHSSTRQTATLAREAAVGRLIMTHISSRYDDKGCQRLLAECRAIFPATELAYDF
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHEEEE
SVFPV
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA