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The map label for this gene is tktB [H]

Identifier: 29140912

GI number: 29140912

Start: 459006

End: 461006

Strand: Reverse

Name: tktB [H]

Synonym: t0385

Alternate gene names: 29140912

Gene position: 461006-459006 (Counterclockwise)

Preceding gene: 29140913

Following gene: 29140908

Centisome position: 9.62

GC content: 56.17

Gene sequence:

>2001_bases
ATGTCCCGTAAAGACCTTGCCAATGCGATTCGTGCGCTGAGCATGGATGCCGTTCAAAAAGCCAATTCCGGGCACCCCGG
CGCGCCGATGGGGATGGCGGATATCGCTGAAGTGCTATGGAACGATTTTCTTAAACATAACCCCACCGATCCGACCTGGT
ATGACCGTGATCGTTTTATCCTTTCCAACAGTCACGCCTCCATGCTGCTCTATAGTCTGCTGCATTTAACCGGGTATGAC
CTGCCGCTGGAGGAGCTAAAAAACTTCCGTCAACTGCACTCTAAAACGCCTGGTCACCCGGAGATTGGCTATACGCCTGG
CGTTGAAACCACCACCGGGCCGCTGGGCCAGGGGCTGGCGAATGCCGTCGGGCTGGCGATTGCCGAGCGTACGTTAGGCG
CACAGTTCAACCGGCCGGACCATGAGATTGTCGACCACTACACCTATGTCTTTATGGGCGACGGCTGTCTGATGGAGGGG
ATCTCGCATGAGGTGTGTTCGCTGGCTGGTACGCTGGGACTGGGCAAACTGATCGGCTTTTACGATCACAACGGCATCTC
CATTGATGGCGAAACCGAAGGCTGGTTTACCGACGATACAGCCAAACGTTTTGAAGCCTACCACTGGCATGTCGTGCATG
ACATTGACGGGCACGCTCCGGAGGCGGTGAAAAAAGCCATTCTGGAAGCCCAGAGCGTAAAAGATAAACCTTCGCTAATT
ATCTGTCGGACGGTGATAGGTTTTGGCTCGCCGAATAAAGCCGGGAAGGAGGAGTCGCACGGCGCGGCGCTGGGCGAAGA
AGAGGTGGCGCTGACCCGCCAGAAGCTGGGATGGCATCATCCGGCGTTTGAGATCCCAAAAGAGATTTACCGCGCGTGGG
ATGGCCGTGAAAAAGGCGAGAAAGCGCAGCAGCAGTGGCAGGAAAAGTTTGCTGCTTATGAGAAGGCTTATCCTGAGCTG
GCCGCGGAGTTTACCCGCCGGATGAGCGGCGGATTGCCGGAGGCATGGGAATCCGCCACGCAAAAATTTATTAACGACTT
GCAGGCTAATCCGGCCAAAATCGCCACCCGTAAAGCATCGCAAAATACGCTCAATGCCTATGGTCCCCTGTTGCCGGAAC
TGTTGGGCGGATCGGCGGATCTGGCGCCGAGCAACCTGACTATCTGGAAAGGTTTGACCTCGTTGAAAGAGGATCCGGCA
GGTAATTACATCCACTATGGCGTGCGCGAATTCGGCATGACCGCCATTGCCAACGGCATCGCCCACCACGGCGGCTTTGT
ACCGTATACCGCCACGTTTCTGATGTTTGTCGAATATGCGCGTAACGCGGCGCGTATGGCGGCCTTAATGAAAGCCCGGC
AGATTATGGTCTATACCCACGACTCCATCGGTTTGGGCGAAGATGGCCCGACGCACCAGGCCATGGAACAACTGGCGAGC
CTGCGCTTAACGCCTAACTTCAGCACCTGGCGTCCCTGCGATCAGGTTGAGGCGGCAGTCGGTTGGAAGCTGGCCATTGA
ACGTCAGCACGGGCCGACGGCGTTGATTCTCTCGCGGCAGAATCTGGCGCAGGTGGAACGCACGCCGGAACAGGTGAAAG
CGATTGCCCGCGGCGGTTATATTCTGAAAGATAGCGGCGGCAAGCCGGATATCATTCTGATCGCTACCGGATCGGAAATG
GAAATTACCCTCCAGGCGGCGGAAAAATTGACTGGCGAGGGGCATAACGTTCGGGTGGTGTCGTTGCCTTCAACGGATAT
TTTCGATGCGCAGGACGAGGCATATCGCGAATCAGTGCTACCGGCGCACGTAACCGCCCGCGTCGCGGTGGAGGCCGGTA
TAGCCGACTACTGGTATAAATATGTTGGCCTAAAAGGCGCAATTATCGGCATGACGGGATACGGTGAATCCGCCCCGGCT
GACAAACTGTTCCCGTATTTTGGCTTTACCGTGGAAAATATTGTGGAAAAAGCCCGCCGGGTGCTGAACATCAAAGGCTA
A

Upstream 100 bases:

>100_bases
GTAGAGAAGCTGTCGGAAGGTATCCGCCTTTTCGCCGTTGACCAGCGCAAACTGGAAGACCTGCTTGCCGCCAAACTATA
AACCTTGCATGGAGTGATTT

Downstream 100 bases:

>100_bases
GGCGGGCGTTAGCAACACAGACTTTGCACAGTCTGCAGACCTGTTCTGTAGGCTGTGCAAAATTACTTCGTAGACTCAGG
CGCATCTGACTGCCCGATGA

Product: transketolase

Products: NA

Alternate protein names: TK 2 [H]

Number of amino acids: Translated: 666; Mature: 665

Protein sequence:

>666_residues
MSRKDLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPTDPTWYDRDRFILSNSHASMLLYSLLHLTGYD
LPLEELKNFRQLHSKTPGHPEIGYTPGVETTTGPLGQGLANAVGLAIAERTLGAQFNRPDHEIVDHYTYVFMGDGCLMEG
ISHEVCSLAGTLGLGKLIGFYDHNGISIDGETEGWFTDDTAKRFEAYHWHVVHDIDGHAPEAVKKAILEAQSVKDKPSLI
ICRTVIGFGSPNKAGKEESHGAALGEEEVALTRQKLGWHHPAFEIPKEIYRAWDGREKGEKAQQQWQEKFAAYEKAYPEL
AAEFTRRMSGGLPEAWESATQKFINDLQANPAKIATRKASQNTLNAYGPLLPELLGGSADLAPSNLTIWKGLTSLKEDPA
GNYIHYGVREFGMTAIANGIAHHGGFVPYTATFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAMEQLAS
LRLTPNFSTWRPCDQVEAAVGWKLAIERQHGPTALILSRQNLAQVERTPEQVKAIARGGYILKDSGGKPDIILIATGSEM
EITLQAAEKLTGEGHNVRVVSLPSTDIFDAQDEAYRESVLPAHVTARVAVEAGIADYWYKYVGLKGAIIGMTGYGESAPA
DKLFPYFGFTVENIVEKARRVLNIKG

Sequences:

>Translated_666_residues
MSRKDLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPTDPTWYDRDRFILSNSHASMLLYSLLHLTGYD
LPLEELKNFRQLHSKTPGHPEIGYTPGVETTTGPLGQGLANAVGLAIAERTLGAQFNRPDHEIVDHYTYVFMGDGCLMEG
ISHEVCSLAGTLGLGKLIGFYDHNGISIDGETEGWFTDDTAKRFEAYHWHVVHDIDGHAPEAVKKAILEAQSVKDKPSLI
ICRTVIGFGSPNKAGKEESHGAALGEEEVALTRQKLGWHHPAFEIPKEIYRAWDGREKGEKAQQQWQEKFAAYEKAYPEL
AAEFTRRMSGGLPEAWESATQKFINDLQANPAKIATRKASQNTLNAYGPLLPELLGGSADLAPSNLTIWKGLTSLKEDPA
GNYIHYGVREFGMTAIANGIAHHGGFVPYTATFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAMEQLAS
LRLTPNFSTWRPCDQVEAAVGWKLAIERQHGPTALILSRQNLAQVERTPEQVKAIARGGYILKDSGGKPDIILIATGSEM
EITLQAAEKLTGEGHNVRVVSLPSTDIFDAQDEAYRESVLPAHVTARVAVEAGIADYWYKYVGLKGAIIGMTGYGESAPA
DKLFPYFGFTVENIVEKARRVLNIKG
>Mature_665_residues
SRKDLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPTDPTWYDRDRFILSNSHASMLLYSLLHLTGYDL
PLEELKNFRQLHSKTPGHPEIGYTPGVETTTGPLGQGLANAVGLAIAERTLGAQFNRPDHEIVDHYTYVFMGDGCLMEGI
SHEVCSLAGTLGLGKLIGFYDHNGISIDGETEGWFTDDTAKRFEAYHWHVVHDIDGHAPEAVKKAILEAQSVKDKPSLII
CRTVIGFGSPNKAGKEESHGAALGEEEVALTRQKLGWHHPAFEIPKEIYRAWDGREKGEKAQQQWQEKFAAYEKAYPELA
AEFTRRMSGGLPEAWESATQKFINDLQANPAKIATRKASQNTLNAYGPLLPELLGGSADLAPSNLTIWKGLTSLKEDPAG
NYIHYGVREFGMTAIANGIAHHGGFVPYTATFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAMEQLASL
RLTPNFSTWRPCDQVEAAVGWKLAIERQHGPTALILSRQNLAQVERTPEQVKAIARGGYILKDSGGKPDIILIATGSEME
ITLQAAEKLTGEGHNVRVVSLPSTDIFDAQDEAYRESVLPAHVTARVAVEAGIADYWYKYVGLKGAIIGMTGYGESAPAD
KLFPYFGFTVENIVEKARRVLNIKG

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=579, Percent_Identity=29.1882556131261, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI4507521, Length=579, Percent_Identity=29.1882556131261, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI133778974, Length=678, Percent_Identity=26.5486725663717, Blast_Score=159, Evalue=1e-38,
Organism=Escherichia coli, GI1788808, Length=666, Percent_Identity=92.3423423423423, Blast_Score=1291, Evalue=0.0,
Organism=Escherichia coli, GI48994911, Length=661, Percent_Identity=75.3403933434191, Blast_Score=1073, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=666, Percent_Identity=25.2252252252252, Blast_Score=152, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6325331, Length=666, Percent_Identity=47.7477477477478, Blast_Score=588, Evalue=1e-168,
Organism=Saccharomyces cerevisiae, GI6319593, Length=669, Percent_Identity=45.1420029895366, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI45551847, Length=592, Percent_Identity=28.0405405405405, Blast_Score=166, Evalue=7e-41,
Organism=Drosophila melanogaster, GI45550715, Length=592, Percent_Identity=28.0405405405405, Blast_Score=166, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24666278, Length=587, Percent_Identity=25.5536626916525, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24645119, Length=552, Percent_Identity=27.7173913043478, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 73105; Mature: 72973

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKDLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPTDPTWYDRDRFI
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
LSNSHASMLLYSLLHLTGYDLPLEELKNFRQLHSKTPGHPEIGYTPGVETTTGPLGQGLA
EECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHH
NAVGLAIAERTLGAQFNRPDHEIVDHYTYVFMGDGCLMEGISHEVCSLAGTLGLGKLIGF
HHHHHHHHHHHHCCCCCCCCHHHHHCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHE
YDHNGISIDGETEGWFTDDTAKRFEAYHWHVVHDIDGHAPEAVKKAILEAQSVKDKPSLI
ECCCCEEECCCCCCCCCCHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEE
ICRTVIGFGSPNKAGKEESHGAALGEEEVALTRQKLGWHHPAFEIPKEIYRAWDGREKGE
EEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHH
KAQQQWQEKFAAYEKAYPELAAEFTRRMSGGLPEAWESATQKFINDLQANPAKIATRKAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCC
QNTLNAYGPLLPELLGGSADLAPSNLTIWKGLTSLKEDPAGNYIHYGVREFGMTAIANGI
CCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHH
AHHGGFVPYTATFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAMEQLAS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHH
LRLTPNFSTWRPCDQVEAAVGWKLAIERQHGPTALILSRQNLAQVERTPEQVKAIARGGY
EECCCCCCCCCCHHHHHHHCCEEEEEECCCCCEEEEEECHHHHHHHCCHHHHHHHHHCCE
ILKDSGGKPDIILIATGSEMEITLQAAEKLTGEGHNVRVVSLPSTDIFDAQDEAYRESVL
EEECCCCCCCEEEEEECCCEEEEHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHCC
PAHVTARVAVEAGIADYWYKYVGLKGAIIGMTGYGESAPADKLFPYFGFTVENIVEKARR
CHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHCCHHHCCCHHHHHHHHHH
VLNIKG
HHCCCC
>Mature Secondary Structure 
SRKDLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPTDPTWYDRDRFI
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
LSNSHASMLLYSLLHLTGYDLPLEELKNFRQLHSKTPGHPEIGYTPGVETTTGPLGQGLA
EECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHH
NAVGLAIAERTLGAQFNRPDHEIVDHYTYVFMGDGCLMEGISHEVCSLAGTLGLGKLIGF
HHHHHHHHHHHHCCCCCCCCHHHHHCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHE
YDHNGISIDGETEGWFTDDTAKRFEAYHWHVVHDIDGHAPEAVKKAILEAQSVKDKPSLI
ECCCCEEECCCCCCCCCCHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEE
ICRTVIGFGSPNKAGKEESHGAALGEEEVALTRQKLGWHHPAFEIPKEIYRAWDGREKGE
EEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHH
KAQQQWQEKFAAYEKAYPELAAEFTRRMSGGLPEAWESATQKFINDLQANPAKIATRKAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCC
QNTLNAYGPLLPELLGGSADLAPSNLTIWKGLTSLKEDPAGNYIHYGVREFGMTAIANGI
CCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHH
AHHGGFVPYTATFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAMEQLAS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHH
LRLTPNFSTWRPCDQVEAAVGWKLAIERQHGPTALILSRQNLAQVERTPEQVKAIARGGY
EECCCCCCCCCCHHHHHHHCCEEEEEECCCCCEEEEEECHHHHHHHCCHHHHHHHHHCCE
ILKDSGGKPDIILIATGSEMEITLQAAEKLTGEGHNVRVVSLPSTDIFDAQDEAYRESVL
EEECCCCCCCEEEEEECCCEEEEHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHCC
PAHVTARVAVEAGIADYWYKYVGLKGAIIGMTGYGESAPADKLFPYFGFTVENIVEKARR
CHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHCCHHHCCCHHHHHHHHHH
VLNIKG
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8396116; 9205837; 9278503 [H]