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The map label for this gene is guaB [H]

Identifier: 29140875

GI number: 29140875

Start: 414059

End: 415531

Strand: Direct

Name: guaB [H]

Synonym: t0346

Alternate gene names: 29140875

Gene position: 414059-415531 (Clockwise)

Preceding gene: 29140873

Following gene: 29140876

Centisome position: 8.64

GC content: 57.5

Gene sequence:

>1473_bases
TTGCCCATGCTACGTATCGCTAAAGAAGCCCTGACGTTTGACGACGTCCTCCTTGTTCCCGCTCACTCCACCGTTTTGCC
GAATACTGCTGATCTCAGCACGCAGTTGACGAAAACTATTCGTCTGAATATTCCTATGCTTTCTGCGGCGATGGACACCG
TGACGGAAGCGCGCCTGGCAATTGCCCTGGCCCAGGAAGGCGGCATCGGTTTTATCCACAAAAACATGTCTATTGAGCGC
CAGGCGGAAGAAGTTCGCCGCGTGAAGAAACACGAGTCCGGCGTAGTGACCGACCCGCAGACCGTCCTGCCAACCACCAC
GTTGCATGAAGTGAAAGCCCTGACCGAGCGTAACGGTTTTGCGGGCTATCCGGTGGTGACTGAAGATAACGAGCTGGTGG
GTATCATCACCGGTCGTGACGTGCGTTTTGTGACTGACCTGAACCAGCCGGTGAGTGTTTACATGACGCCGAAAGAGCGT
CTGGTGACCGTTCGTGAAGGCGAAGCCCGTGAAGTCGTGCTGGCAAAAATGCACGAAAAACGCGTAGAAAAAGCGCTGGT
CGTTGATGATAACTTCCATCTGCTTGGCATGATTACCGTAAAAGATTTCCAGAAAGCGGAACGTAAACCAAACTCCTGTA
AAGATGAGCAGGGCCGTTTACGTGTCGGCGCGGCGGTCGGCGCAGGCGCGGGCAACGAAGAGCGCGTTGACGCGCTGGTG
GCGGCAGGCGTTGACGTCCTGCTGATCGACTCTTCTCACGGTCACTCTGAAGGCGTGTTGCAACGTATCCGTGAAACCCG
TGCTAAATATCCTGACCTGCAAATCATCGGCGGCAACGTCGCGACGGGCGCAGGCGCTCGCGCACTGGCGGAAGCCGGTT
GCAGCGCGGTGAAAGTCGGTATCGGCCCGGGTTCCATCTGTACCACTCGTATCGTGACTGGCGTGGGCGTTCCGCAGATT
ACCGCTGTTTCTGACGCAGTTGAAGCGCTGGAAGGCACCGGGATTCCGGTTATCGCTGACGGCGGTATCCGTTTCTCCGG
CGACATCGCCAAAGCCATCGCCGCAGGCGCGAGCGCTGTCATGGTCGGTTCTATGCTGGCGGGTACCGAAGAATCCCCGG
GCGAAATCGAACTCTACCAGGGCCGTTCTTACAAATCTTACCGCGGCATGGGCTCGCTGGGCGCGATGTCCAAAGGTTCC
TCTGACCGTTACTTCCAGAGCGACAACGCCGCCGACAAACTGGTGCCGGAAGGTATCGAAGGCCGCGTAGCCTATAAAGG
TCGCCTGAAAGAGATCATTCACCAGCAGATGGGCGGCCTGCGCTCCTGTATGGGGCTGACCGGTTGTGCTACCATCGACG
AACTGCGTACTAAAGCGGAGTTTGTGCGTATCAGCGGTGCGGGTATCCAGGAAAGCCACGTTCACGACGTGACCATCACC
AAAGAGTCCCCGAACTACCGTCTGGGCTCCTGA

Upstream 100 bases:

>100_bases
CACGGGGGATCGCAAGCACTATTTGCAAAAAAATGTAGATGCAACCGATTACGTTCTGTATAATGCCGCGGCAATATTTA
TTAACCTCCCAGGTGAGATA

Downstream 100 bases:

>100_bases
TTTTCTTCGCCCGACCTTCGCGTCGGGCGATTTATTTAATCTGTTTCACTTGCCTCGGAATAAGCGTCAATGACGGAAAA
CATTCATAAGCATCGCATCC

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MPMLRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLAIALAQEGGIGFIHKNMSIER
QAEEVRRVKKHESGVVTDPQTVLPTTTLHEVKALTERNGFAGYPVVTEDNELVGIITGRDVRFVTDLNQPVSVYMTPKER
LVTVREGEAREVVLAKMHEKRVEKALVVDDNFHLLGMITVKDFQKAERKPNSCKDEQGRLRVGAAVGAGAGNEERVDALV
AAGVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATGAGARALAEAGCSAVKVGIGPGSICTTRIVTGVGVPQI
TAVSDAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASAVMVGSMLAGTEESPGEIELYQGRSYKSYRGMGSLGAMSKGS
SDRYFQSDNAADKLVPEGIEGRVAYKGRLKEIIHQQMGGLRSCMGLTGCATIDELRTKAEFVRISGAGIQESHVHDVTIT
KESPNYRLGS

Sequences:

>Translated_490_residues
MPMLRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLAIALAQEGGIGFIHKNMSIER
QAEEVRRVKKHESGVVTDPQTVLPTTTLHEVKALTERNGFAGYPVVTEDNELVGIITGRDVRFVTDLNQPVSVYMTPKER
LVTVREGEAREVVLAKMHEKRVEKALVVDDNFHLLGMITVKDFQKAERKPNSCKDEQGRLRVGAAVGAGAGNEERVDALV
AAGVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATGAGARALAEAGCSAVKVGIGPGSICTTRIVTGVGVPQI
TAVSDAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASAVMVGSMLAGTEESPGEIELYQGRSYKSYRGMGSLGAMSKGS
SDRYFQSDNAADKLVPEGIEGRVAYKGRLKEIIHQQMGGLRSCMGLTGCATIDELRTKAEFVRISGAGIQESHVHDVTIT
KESPNYRLGS
>Mature_489_residues
PMLRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLAIALAQEGGIGFIHKNMSIERQ
AEEVRRVKKHESGVVTDPQTVLPTTTLHEVKALTERNGFAGYPVVTEDNELVGIITGRDVRFVTDLNQPVSVYMTPKERL
VTVREGEAREVVLAKMHEKRVEKALVVDDNFHLLGMITVKDFQKAERKPNSCKDEQGRLRVGAAVGAGAGNEERVDALVA
AGVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATGAGARALAEAGCSAVKVGIGPGSICTTRIVTGVGVPQIT
AVSDAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASAVMVGSMLAGTEESPGEIELYQGRSYKSYRGMGSLGAMSKGSS
DRYFQSDNAADKLVPEGIEGRVAYKGRLKEIIHQQMGGLRSCMGLTGCATIDELRTKAEFVRISGAGIQESHVHDVTITK
ESPNYRLGS

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=466, Percent_Identity=40.7725321888412, Blast_Score=321, Evalue=9e-88,
Organism=Homo sapiens, GI66933016, Length=460, Percent_Identity=41.0869565217391, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI34328928, Length=466, Percent_Identity=40.7725321888412, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI156616279, Length=466, Percent_Identity=40.5579399141631, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI34328930, Length=466, Percent_Identity=40.7725321888412, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI217035152, Length=455, Percent_Identity=41.0989010989011, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI217035148, Length=466, Percent_Identity=39.9141630901288, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI217035150, Length=466, Percent_Identity=37.3390557939914, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI156104880, Length=247, Percent_Identity=36.8421052631579, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=36.8421052631579, Blast_Score=159, Evalue=8e-39,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=36.8421052631579, Blast_Score=159, Evalue=8e-39,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=36.8421052631579, Blast_Score=159, Evalue=8e-39,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=36.8421052631579, Blast_Score=158, Evalue=9e-39,
Organism=Escherichia coli, GI1788855, Length=488, Percent_Identity=98.155737704918, Blast_Score=969, Evalue=0.0,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=37.10407239819, Blast_Score=144, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71994385, Length=478, Percent_Identity=36.6108786610879, Blast_Score=271, Evalue=6e-73,
Organism=Caenorhabditis elegans, GI71994389, Length=423, Percent_Identity=39.0070921985816, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17560440, Length=219, Percent_Identity=37.4429223744292, Blast_Score=150, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323585, Length=466, Percent_Identity=40.5579399141631, Blast_Score=320, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6322012, Length=487, Percent_Identity=39.4250513347023, Blast_Score=320, Evalue=3e-88,
Organism=Saccharomyces cerevisiae, GI6323464, Length=449, Percent_Identity=42.0935412026726, Blast_Score=314, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=39.4736842105263, Blast_Score=239, Evalue=6e-64,
Organism=Saccharomyces cerevisiae, GI6319353, Length=118, Percent_Identity=40.6779661016949, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24641071, Length=486, Percent_Identity=40.9465020576132, Blast_Score=321, Evalue=6e-88,
Organism=Drosophila melanogaster, GI24641073, Length=486, Percent_Identity=40.9465020576132, Blast_Score=321, Evalue=6e-88,
Organism=Drosophila melanogaster, GI28571163, Length=444, Percent_Identity=41.4414414414414, Blast_Score=288, Evalue=8e-78,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52177; Mature: 52046

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMLRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLA
CCHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHEEEEEEECCCHHHHHHHHHHHHHEE
IALAQEGGIGFIHKNMSIERQAEEVRRVKKHESGVVTDPQTVLPTTTLHEVKALTERNGF
EEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHCCCCHHHHHHHHHHCCCC
AGYPVVTEDNELVGIITGRDVRFVTDLNQPVSVYMTPKERLVTVREGEAREVVLAKMHEK
CCCCEEECCCCEEEEEECCCEEEEECCCCCEEEEECCHHHEEEEECCCCHHHHHHHHHHH
RVEKALVVDDNFHLLGMITVKDFQKAERKPNSCKDEQGRLRVGAAVGAGAGNEERVDALV
HHHEEEEECCCCEEEEEEEEHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHH
AAGVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATGAGARALAEAGCSAVKVG
HCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHCCCCEEEEE
IGPGSICTTRIVTGVGVPQITAVSDAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASAV
CCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCEEECCHHHHHHHCCCHHH
MVGSMLAGTEESPGEIELYQGRSYKSYRGMGSLGAMSKGSSDRYFQSDNAADKLVPEGIE
HHHHHHCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCC
GRVAYKGRLKEIIHQQMGGLRSCMGLTGCATIDELRTKAEFVRISGAGIQESHVHDVTIT
CEEEEHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHEEEEECCCCCCCCEEEEEEE
KESPNYRLGS
ECCCCCCCCC
>Mature Secondary Structure 
PMLRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLA
CHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHEEEEEEECCCHHHHHHHHHHHHHEE
IALAQEGGIGFIHKNMSIERQAEEVRRVKKHESGVVTDPQTVLPTTTLHEVKALTERNGF
EEEECCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHCCCCHHHHHHHHHHCCCC
AGYPVVTEDNELVGIITGRDVRFVTDLNQPVSVYMTPKERLVTVREGEAREVVLAKMHEK
CCCCEEECCCCEEEEEECCCEEEEECCCCCEEEEECCHHHEEEEECCCCHHHHHHHHHHH
RVEKALVVDDNFHLLGMITVKDFQKAERKPNSCKDEQGRLRVGAAVGAGAGNEERVDALV
HHHEEEEECCCCEEEEEEEEHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHH
AAGVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATGAGARALAEAGCSAVKVG
HCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHCCCCEEEEE
IGPGSICTTRIVTGVGVPQITAVSDAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASAV
CCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCEEECCHHHHHHHCCCHHH
MVGSMLAGTEESPGEIELYQGRSYKSYRGMGSLGAMSKGSSDRYFQSDNAADKLVPEGIE
HHHHHHCCCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCC
GRVAYKGRLKEIIHQQMGGLRSCMGLTGCATIDELRTKAEFVRISGAGIQESHVHDVTIT
CEEEEHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHEEEEECCCCCCCCEEEEEEE
KESPNYRLGS
ECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]