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The map label for this gene is lpxD [H]

Identifier: 29140766

GI number: 29140766

Start: 262278

End: 263303

Strand: Direct

Name: lpxD [H]

Synonym: t0227

Alternate gene names: 29140766

Gene position: 262278-263303 (Clockwise)

Preceding gene: 29140765

Following gene: 29140767

Centisome position: 5.47

GC content: 51.95

Gene sequence:

>1026_bases
ATGCCTTCAATTCGACTGGCTGACTTAGCAGAACAGTTGGATGCAGAATTACACGGTGATGGCGATATCGTCATCACCGG
CGTTGCGTCCATGCAATCTGCAACAACAGGCCACATTACGTTTATGGTAAATCCTAAGTACCGTGAACACTTAGGTTTAT
GCCAGGCTTCTGCGGTTGTCATGACGCAGGACGATCTTCCTTTTGCCAAGAGCGCGGCGCTGGTAGTTAAAAATCCCTAC
CTGACCTACGCGCGCATGGCGCAAATTTTAGATACTACGCCGCAACCCGCGCAGAATATCGCGCCAAGCGCCGTGATTGA
TGCGACGGCAACGCTGGGTAGCAATGTTTCAGTCGGCGCGAATGCGGTGATTGAATCTGGCGTACAACTGGGCGATAACG
TGGTTATCGGCGCAGGCTGTTTCGTCGGAAAAAATAGCAAAATCGGGGCGGGTTCACGCTTGTGGGCGAACGTAACGATT
TACCACGACATTCAGATCGGTGAGAATTGCCTGATCCAGTCCAGTACGGTGATCGGCGCGGACGGTTTTGGCTACGCTAA
CGATCGTGGCAACTGGGTGAAGATCCCACAACTGGGCCGGGTCATTATTGGCGATCGTGTCGAGATCGGCGCTTGTACCA
CCATTGACCGTGGCGCGTTGGATGATACTGTTATTGGCAATGGCGTGATTATTGATAATCAGTGCCAGATTGCACATAAC
GTCGTGATTGGCGACAATACGGCAGTTGCCGGTGGCGTCATTATGGCGGGTAGCCTGAAGATTGGCCGTTACTGCATGAT
TGGCGGCGCCAGCGTGATCAATGGGCATATGGAAATATGCGACAAAGTCACGGTAACTGGCATGGGTATGGTGATGCGTC
CCATCACGGAACCGGGCGTCTACTCCTCAGGCATTCCGCTGCAACCCAACAAAGTATGGCGTAAAACTGCTGCACTGGTG
ATGAACATTGATGATATGAGCAAGCGTCTCAAAGCGATTGAGCGCAAGGTTAATCAACAAGACTAA

Upstream 100 bases:

>100_bases
CCAGAGTATCGATCTGGTGGTAGACGCAAACACCGTTGCTTACAACAGCAGCGATGTGAAAGACATCACCGCTGACGTAC
TGAAACAGGTTAAATAAGTA

Downstream 100 bases:

>100_bases
CGTTCCGCCTTGTAGTTGCCATTCTTTTCCGGCCTGTCACATTCATACGATTGCGGCAGGCCGTGTTATTATTGCCTTTT
TGTATATTTGGACAGGAAGA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MPSIRLADLAEQLDAELHGDGDIVITGVASMQSATTGHITFMVNPKYREHLGLCQASAVVMTQDDLPFAKSAALVVKNPY
LTYARMAQILDTTPQPAQNIAPSAVIDATATLGSNVSVGANAVIESGVQLGDNVVIGAGCFVGKNSKIGAGSRLWANVTI
YHDIQIGENCLIQSSTVIGADGFGYANDRGNWVKIPQLGRVIIGDRVEIGACTTIDRGALDDTVIGNGVIIDNQCQIAHN
VVIGDNTAVAGGVIMAGSLKIGRYCMIGGASVINGHMEICDKVTVTGMGMVMRPITEPGVYSSGIPLQPNKVWRKTAALV
MNIDDMSKRLKAIERKVNQQD

Sequences:

>Translated_341_residues
MPSIRLADLAEQLDAELHGDGDIVITGVASMQSATTGHITFMVNPKYREHLGLCQASAVVMTQDDLPFAKSAALVVKNPY
LTYARMAQILDTTPQPAQNIAPSAVIDATATLGSNVSVGANAVIESGVQLGDNVVIGAGCFVGKNSKIGAGSRLWANVTI
YHDIQIGENCLIQSSTVIGADGFGYANDRGNWVKIPQLGRVIIGDRVEIGACTTIDRGALDDTVIGNGVIIDNQCQIAHN
VVIGDNTAVAGGVIMAGSLKIGRYCMIGGASVINGHMEICDKVTVTGMGMVMRPITEPGVYSSGIPLQPNKVWRKTAALV
MNIDDMSKRLKAIERKVNQQD
>Mature_340_residues
PSIRLADLAEQLDAELHGDGDIVITGVASMQSATTGHITFMVNPKYREHLGLCQASAVVMTQDDLPFAKSAALVVKNPYL
TYARMAQILDTTPQPAQNIAPSAVIDATATLGSNVSVGANAVIESGVQLGDNVVIGAGCFVGKNSKIGAGSRLWANVTIY
HDIQIGENCLIQSSTVIGADGFGYANDRGNWVKIPQLGRVIIGDRVEIGACTTIDRGALDDTVIGNGVIIDNQCQIAHNV
VIGDNTAVAGGVIMAGSLKIGRYCMIGGASVINGHMEICDKVTVTGMGMVMRPITEPGVYSSGIPLQPNKVWRKTAALVM
NIDDMSKRLKAIERKVNQQD

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=341, Percent_Identity=95.6011730205279, Blast_Score=674, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 35931; Mature: 35800

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSIRLADLAEQLDAELHGDGDIVITGVASMQSATTGHITFMVNPKYREHLGLCQASAVV
CCCCHHHHHHHHHCHHCCCCCCEEEEEECCCCCCCCEEEEEEECCCHHHHHCCCCCCEEE
MTQDDLPFAKSAALVVKNPYLTYARMAQILDTTPQPAQNIAPSAVIDATATLGSNVSVGA
EEECCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHCCCCCEEEHHHHCCCCCCCCH
NAVIESGVQLGDNVVIGAGCFVGKNSKIGAGSRLWANVTIYHDIQIGENCLIQSSTVIGA
HHHHHCCHHCCCCEEEECEEEECCCCCCCCCCEEEEEEEEEEEEEECCCEEEECCEEEEC
DGFGYANDRGNWVKIPQLGRVIIGDRVEIGACTTIDRGALDDTVIGNGVIIDNQCQIAHN
CCCCCCCCCCCEEECCCCCEEEECCEEEECEECCCCCCCCCCEEECCCEEECCCCEEEEE
VVIGDNTAVAGGVIMAGSLKIGRYCMIGGASVINGHMEICDKVTVTGMGMVMRPITEPGV
EEECCCCEEECCEEEECCEEECCEEEECCHHHCCCHHHHHCEEEEECCCEEEECCCCCCC
YSSGIPLQPNKVWRKTAALVMNIDDMSKRLKAIERKVNQQD
CCCCCCCCCHHHHHHEEHEEEEHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PSIRLADLAEQLDAELHGDGDIVITGVASMQSATTGHITFMVNPKYREHLGLCQASAVV
CCCHHHHHHHHHCHHCCCCCCEEEEEECCCCCCCCEEEEEEECCCHHHHHCCCCCCEEE
MTQDDLPFAKSAALVVKNPYLTYARMAQILDTTPQPAQNIAPSAVIDATATLGSNVSVGA
EEECCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHCCCCCEEEHHHHCCCCCCCCH
NAVIESGVQLGDNVVIGAGCFVGKNSKIGAGSRLWANVTIYHDIQIGENCLIQSSTVIGA
HHHHHCCHHCCCCEEEECEEEECCCCCCCCCCEEEEEEEEEEEEEECCCEEEECCEEEEC
DGFGYANDRGNWVKIPQLGRVIIGDRVEIGACTTIDRGALDDTVIGNGVIIDNQCQIAHN
CCCCCCCCCCCEEECCCCCEEEECCEEEECEECCCCCCCCCCEEECCCEEECCCCEEEEE
VVIGDNTAVAGGVIMAGSLKIGRYCMIGGASVINGHMEICDKVTVTGMGMVMRPITEPGV
EEECCCCEEECCEEEECCEEECCEEEECCHHHCCCHHHHHCEEEEECCCEEEECCCCCCC
YSSGIPLQPNKVWRKTAALVMNIDDMSKRLKAIERKVNQQD
CCCCCCCCCHHHHHHEEHEEEEHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]