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The map label for this gene is fhuB [H]

Identifier: 29140742

GI number: 29140742

Start: 232062

End: 234119

Strand: Direct

Name: fhuB [H]

Synonym: t0202

Alternate gene names: 29140742

Gene position: 232062-234119 (Clockwise)

Preceding gene: 29140741

Following gene: 29140744

Centisome position: 4.84

GC content: 60.84

Gene sequence:

>2058_bases
GTGAGCAGAAAACGTGAAATACCGGATGGCGGTGCGAAAAACGCCTTAACCGACCTACGGTTCGGGCGCTTTGTAGGCCG
GATAAGGCGAAGCCGCCATCCGGCGTTGCTGTTATTGGCGCTGTTGGTTGCCGCCTGCTGGCTGACATGGGTTAACTTCT
CCGTTGCGCTACCGCGCAGTCAGTGGCAACAGGCTATCTGGTCACCAGATATCGACATCATTGAGCAGATGATTTTTCAT
TACAGCCAGCTGCCAAGACTGGCGATTTCGCTGCTGGTGGGCGCGGGGCTTGGGCTGGTAGGCGTCCTGTTCCAGCAAGT
ATTACGTAACCCGCTGGCGGAACCGACCACGCTGGGCGTGGCGACCGGCGCGCAATTGGGGATCACGGTGACTACGCTTT
GGGCGATTCCCGGCGCGCTGACCACGCAGTTTGCCGCCCTGACGGGAGCCTGCATCGTCGGCGCGCTGGTGTTCGGCGTG
GCGTGGGGCAAACGTCTGTCGCCAGTGACCCTGATCCTCGCCGGGCTGGTGGTCAGCCTCTATTGTGGCGCAATCAACCA
GTTACTGGTGATTTTCCACCACGATCAGTTGCAAAGCATGTTTTTATGGAGCACTGGAACGCTAACGCAAACCGACTGGA
GCGGCGTGCAGCGTCTGTGGCCGCAGTTGCTGGGCGGCGTGATGCTCACGTTATTGTTGTTACGTCCGATGACGCTGATG
GGGCTGGATGACGGCGTTGCGCGTAATCTGGGGCTGGCGCTGTCGTTAGCGCGTCTGGCGGCGTTGTCGCTGGCGATTGT
GTTGAGCGCGCTGCTGGTCAACGCGGTGGGCATTATCGGTTTTATCGGCCTGTTTGCGCCGCTGCTGGCGAAAATGCTTG
GCGCAAGACGTCTGCTGGCGCGCCTGATGCTGGCGCCGCTCATTGGGGCGCTTATTTTATGGCTATCCGATCAGATTATC
CTTTGGCTAACCCGCGTATGGATGGAAGTCTCCACCGGGTCAGTGACGGCGTTAATCGGCGCGCCGCTGCTCCTATGGCT
GCTGCCGCGGCTTAAAAGCATGAGCGCGCCGGATATGAACGCCAGCGATCGTGTGGCGGCGGAGCGTCGACATGTCCTCA
CTTTTGCCGTTGCCGGTGGCGCGCTCCTGCTGCTGGCAACATGGGTCGCGCTCTCTTTTGGTCGCGACGCGCACGGCTGG
ACGTGGGCGAGCGGAACGCTGCTTGAAGAACTGATGCCGTGGCGCTGGCCGCGGATACTGGCGGCGTTAATGGCGGGCGT
CATGCTGGCGGTGGCGGGCTGCATTATTCAGCGTCTGACCGGTAACCCAATGGCCAGCCCGGAAGTGCTGGGGATCAGTT
CCGGAGCCGCGTTTGGCGTGGTGTTGATGCTGTTTTTGGTGCCGGGGAATGCTTTCGGTTGGCTACTGCCTGCCGGAAGC
CTGGGCGCGGCGGCGACACTGCTGATTATTATGATAGCCGCCGGGCGCGGCGGTTTCTCGCCGCAACGGATGTTGCTGGC
GGGGATGGCGCTCAGCACCGCGTTTACCATGCTGCTAATGATGCTCCAGGCGAGCGGCGATCCGCGGATGGCGGATGTGT
TGACCTGGATCTCAGGATCTACCTATAACGCCACTGGCGGGCAGGTTACGCGAACCGCGATCGTGATGGTGATTTTGCTG
GCCGTTGTGCCGTTGTGTCGCCGCTGGTTAACGATTTTGCCACTGGGCGGCGATGCCGCGCGCGCGGTGGGCATAGCGCT
TACGCCGTCGCGTATCGCGCTGCTGGCGTTGGCGGCTTGTTTGACGGCAACCGCGACGATGACCATTGGGCCGCTGAGTT
TCGTTGGATTGATGGCGCCGCATATTGCGCGGATGCTCGGTTTTCGCCGGACGATGCCGCATATGGTCATCTCAGCGCTG
GCAGGGGGCGTTTTATTGGTCTTTGCCGACTGGTGCGGCAGGATGGCGCTATTTCCGTATCAGATCCCGGCGGGACTGCT
TTCAAGCTTTATTGGCGCGCCGTACTTTATCTATTTGCTACGTAAACAGAGCCGCTGA

Upstream 100 bases:

>100_bases
CCGGGCGTTTTCACCGGGTGCCCGCCGTTTGGTTCTATGGCGCGACCCTCTCCACGATGCATTTTGTCCGCATCCTGAAT
AACGTGTTGGGAGGCAAAGC

Downstream 100 bases:

>100_bases
GTTTGCCGGATGGCGGCATAAATGCCTTATCCGGCCTGCGGTGTAGAATGTAGGCCGGGTAAGCGTAAGCGTCACCCGGC
AATTCATCCTTTACAATTTC

Product: iron-hydroxamate transporter permease

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Ferrichrome uptake protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 685; Mature: 684

Protein sequence:

>685_residues
MSRKREIPDGGAKNALTDLRFGRFVGRIRRSRHPALLLLALLVAACWLTWVNFSVALPRSQWQQAIWSPDIDIIEQMIFH
YSQLPRLAISLLVGAGLGLVGVLFQQVLRNPLAEPTTLGVATGAQLGITVTTLWAIPGALTTQFAALTGACIVGALVFGV
AWGKRLSPVTLILAGLVVSLYCGAINQLLVIFHHDQLQSMFLWSTGTLTQTDWSGVQRLWPQLLGGVMLTLLLLRPMTLM
GLDDGVARNLGLALSLARLAALSLAIVLSALLVNAVGIIGFIGLFAPLLAKMLGARRLLARLMLAPLIGALILWLSDQII
LWLTRVWMEVSTGSVTALIGAPLLLWLLPRLKSMSAPDMNASDRVAAERRHVLTFAVAGGALLLLATWVALSFGRDAHGW
TWASGTLLEELMPWRWPRILAALMAGVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGS
LGAAATLLIIMIAAGRGGFSPQRMLLAGMALSTAFTMLLMMLQASGDPRMADVLTWISGSTYNATGGQVTRTAIVMVILL
AVVPLCRRWLTILPLGGDAARAVGIALTPSRIALLALAACLTATATMTIGPLSFVGLMAPHIARMLGFRRTMPHMVISAL
AGGVLLVFADWCGRMALFPYQIPAGLLSSFIGAPYFIYLLRKQSR

Sequences:

>Translated_685_residues
MSRKREIPDGGAKNALTDLRFGRFVGRIRRSRHPALLLLALLVAACWLTWVNFSVALPRSQWQQAIWSPDIDIIEQMIFH
YSQLPRLAISLLVGAGLGLVGVLFQQVLRNPLAEPTTLGVATGAQLGITVTTLWAIPGALTTQFAALTGACIVGALVFGV
AWGKRLSPVTLILAGLVVSLYCGAINQLLVIFHHDQLQSMFLWSTGTLTQTDWSGVQRLWPQLLGGVMLTLLLLRPMTLM
GLDDGVARNLGLALSLARLAALSLAIVLSALLVNAVGIIGFIGLFAPLLAKMLGARRLLARLMLAPLIGALILWLSDQII
LWLTRVWMEVSTGSVTALIGAPLLLWLLPRLKSMSAPDMNASDRVAAERRHVLTFAVAGGALLLLATWVALSFGRDAHGW
TWASGTLLEELMPWRWPRILAALMAGVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGS
LGAAATLLIIMIAAGRGGFSPQRMLLAGMALSTAFTMLLMMLQASGDPRMADVLTWISGSTYNATGGQVTRTAIVMVILL
AVVPLCRRWLTILPLGGDAARAVGIALTPSRIALLALAACLTATATMTIGPLSFVGLMAPHIARMLGFRRTMPHMVISAL
AGGVLLVFADWCGRMALFPYQIPAGLLSSFIGAPYFIYLLRKQSR
>Mature_684_residues
SRKREIPDGGAKNALTDLRFGRFVGRIRRSRHPALLLLALLVAACWLTWVNFSVALPRSQWQQAIWSPDIDIIEQMIFHY
SQLPRLAISLLVGAGLGLVGVLFQQVLRNPLAEPTTLGVATGAQLGITVTTLWAIPGALTTQFAALTGACIVGALVFGVA
WGKRLSPVTLILAGLVVSLYCGAINQLLVIFHHDQLQSMFLWSTGTLTQTDWSGVQRLWPQLLGGVMLTLLLLRPMTLMG
LDDGVARNLGLALSLARLAALSLAIVLSALLVNAVGIIGFIGLFAPLLAKMLGARRLLARLMLAPLIGALILWLSDQIIL
WLTRVWMEVSTGSVTALIGAPLLLWLLPRLKSMSAPDMNASDRVAAERRHVLTFAVAGGALLLLATWVALSFGRDAHGWT
WASGTLLEELMPWRWPRILAALMAGVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGSL
GAAATLLIIMIAAGRGGFSPQRMLLAGMALSTAFTMLLMMLQASGDPRMADVLTWISGSTYNATGGQVTRTAIVMVILLA
VVPLCRRWLTILPLGGDAARAVGIALTPSRIALLALAACLTATATMTIGPLSFVGLMAPHIARMLGFRRTMPHMVISALA
GGVLLVFADWCGRMALFPYQIPAGLLSSFIGAPYFIYLLRKQSR

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=644, Percent_Identity=90.527950310559, Blast_Score=1031, Evalue=0.0,
Organism=Escherichia coli, GI1790740, Length=321, Percent_Identity=34.5794392523364, Blast_Score=120, Evalue=4e-28,
Organism=Escherichia coli, GI1790741, Length=281, Percent_Identity=35.2313167259786, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI1786804, Length=278, Percent_Identity=31.6546762589928, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1786805, Length=278, Percent_Identity=35.2517985611511, Blast_Score=96, Evalue=9e-21,
Organism=Escherichia coli, GI1788004, Length=284, Percent_Identity=33.0985915492958, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522
- InterPro:   IPR006311 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 73150; Mature: 73019

Theoretical pI: Translated: 11.63; Mature: 11.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKREIPDGGAKNALTDLRFGRFVGRIRRSRHPALLLLALLVAACWLTWVNFSVALPRS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEECCHH
QWQQAIWSPDIDIIEQMIFHYSQLPRLAISLLVGAGLGLVGVLFQQVLRNPLAEPTTLGV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCE
ATGAQLGITVTTLWAIPGALTTQFAALTGACIVGALVFGVAWGKRLSPVTLILAGLVVSL
ECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
YCGAINQLLVIFHHDQLQSMFLWSTGTLTQTDWSGVQRLWPQLLGGVMLTLLLLRPMTLM
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHH
GLDDGVARNLGLALSLARLAALSLAIVLSALLVNAVGIIGFIGLFAPLLAKMLGARRLLA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLMLAPLIGALILWLSDQIILWLTRVWMEVSTGSVTALIGAPLLLWLLPRLKSMSAPDMN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
ASDRVAAERRHVLTFAVAGGALLLLATWVALSFGRDAHGWTWASGTLLEELMPWRWPRIL
CCHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCHHHHH
AALMAGVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCHHCCCCC
LGAAATLLIIMIAAGRGGFSPQRMLLAGMALSTAFTMLLMMLQASGDPRMADVLTWISGS
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
TYNATGGQVTRTAIVMVILLAVVPLCRRWLTILPLGGDAARAVGIALTPSRIALLALAAC
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHEEEEECHHHHHHHHHHHH
LTATATMTIGPLSFVGLMAPHIARMLGFRRTMPHMVISALAGGVLLVFADWCGRMALFPY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
QIPAGLLSSFIGAPYFIYLLRKQSR
HCCHHHHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure 
SRKREIPDGGAKNALTDLRFGRFVGRIRRSRHPALLLLALLVAACWLTWVNFSVALPRS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEECCHH
QWQQAIWSPDIDIIEQMIFHYSQLPRLAISLLVGAGLGLVGVLFQQVLRNPLAEPTTLGV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCE
ATGAQLGITVTTLWAIPGALTTQFAALTGACIVGALVFGVAWGKRLSPVTLILAGLVVSL
ECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
YCGAINQLLVIFHHDQLQSMFLWSTGTLTQTDWSGVQRLWPQLLGGVMLTLLLLRPMTLM
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHH
GLDDGVARNLGLALSLARLAALSLAIVLSALLVNAVGIIGFIGLFAPLLAKMLGARRLLA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLMLAPLIGALILWLSDQIILWLTRVWMEVSTGSVTALIGAPLLLWLLPRLKSMSAPDMN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
ASDRVAAERRHVLTFAVAGGALLLLATWVALSFGRDAHGWTWASGTLLEELMPWRWPRIL
CCHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCHHHHH
AALMAGVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCHHCCCCC
LGAAATLLIIMIAAGRGGFSPQRMLLAGMALSTAFTMLLMMLQASGDPRMADVLTWISGS
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
TYNATGGQVTRTAIVMVILLAVVPLCRRWLTILPLGGDAARAVGIALTPSRIALLALAAC
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHEEEEECHHHHHHHHHHHH
LTATATMTIGPLSFVGLMAPHIARMLGFRRTMPHMVISALAGGVLLVFADWCGRMALFPY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
QIPAGLLSSFIGAPYFIYLLRKQSR
HCCHHHHHHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 10103258 [H]