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The map label for this gene is fhuD [H]

Identifier: 29140741

GI number: 29140741

Start: 231175

End: 232065

Strand: Direct

Name: fhuD [H]

Synonym: t0201

Alternate gene names: 29140741

Gene position: 231175-232065 (Clockwise)

Preceding gene: 29140740

Following gene: 29140742

Centisome position: 4.82

GC content: 59.03

Gene sequence:

>891_bases
ATGCGTGAGTTATATCCTCTTACTCGCCGCCGTTTATTAACGGCGATGGCGCTCTCGCCGCTGCTGTGGCAAATGAATAC
GGCGCAGGCTGCCGCTATCGATCCCCGCCGGATTGTGGCGCTGGAGTGGCTGCCGGTTGAGCTGCTGCTGGCGCTCGGTA
TTACGCCTTATGGTGTGGCGGACGTGCCAAATTATAAGCTGTGGGTTAGCGAACCGCCGTTGCCGGATTCGGTGATTGAT
GTGGGTCTTCGCACTGAACCCAATCTCGAACTGCTGACGGAGATGAAGCCGTCGTTTATGGTGTGGTCGGCAGGTTACGG
ACCCTCGCCGGAGAAACTGGCGCGGATCGCGCCGGGGCGCGGGTTCGATTTTAGCGACGGCAAAAAGCCGCTGGCGGTGG
CCCGACGCTCGCTGGTTGAACTGGCGCAGACGCTGAATCTGGAAGCTGCGGCAGAAAAACATCTGGCGCAATACGATCGC
TTCATCGCCAGCCAGAAGCCACGTTTTATCCGCCGCGGGGGACGTCCGTTACTGATGACGACGCTTATCGATCCGCGGCA
TATGCTGGTGCTCGGCCCGAATTGCCTGTTCCAGGAGGTGCTGGACGAGTATGGCATCGTCAATGCCTGGCAGGGTGAAA
CCAACTTTTGGGGCAGTACGGCGGTCAGCATCGATCGGCTGGCGATGTATAAAGAAGCGGATGTGATCTGCTTCGATCAC
GGGAATAGCACCGATATGAACGCGCTGATGGCAACGCCGCTGTGGCAGGCCATGTCGTTTGTCCGCGCCGGGCGTTTTCA
CCGGGTGCCCGCCGTTTGGTTCTATGGCGCGACCCTCTCCACGATGCATTTTGTCCGCATCCTGAATAACGTGTTGGGAG
GCAAAGCGTGA

Upstream 100 bases:

>100_bases
CGGAACTGATGCGCAGTGACACGCTGGAACAGATTTACGGTATCCCGATGGGTATCCTTCCGCATCCGGCGGGCGCCGCG
CCTGTGAGTTTTGTGTATTA

Downstream 100 bases:

>100_bases
GCAGAAAACGTGAAATACCGGATGGCGGTGCGAAAAACGCCTTAACCGACCTACGGTTCGGGCGCTTTGTAGGCCGGATA
AGGCGAAGCCGCCATCCGGC

Product: iron-hydroxamate transporter substrate-binding protein

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein D; Ferrichrome-binding periplasmic protein; Iron(III)-hydroxamate-binding protein fhuD [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MRELYPLTRRRLLTAMALSPLLWQMNTAQAAAIDPRRIVALEWLPVELLLALGITPYGVADVPNYKLWVSEPPLPDSVID
VGLRTEPNLELLTEMKPSFMVWSAGYGPSPEKLARIAPGRGFDFSDGKKPLAVARRSLVELAQTLNLEAAAEKHLAQYDR
FIASQKPRFIRRGGRPLLMTTLIDPRHMLVLGPNCLFQEVLDEYGIVNAWQGETNFWGSTAVSIDRLAMYKEADVICFDH
GNSTDMNALMATPLWQAMSFVRAGRFHRVPAVWFYGATLSTMHFVRILNNVLGGKA

Sequences:

>Translated_296_residues
MRELYPLTRRRLLTAMALSPLLWQMNTAQAAAIDPRRIVALEWLPVELLLALGITPYGVADVPNYKLWVSEPPLPDSVID
VGLRTEPNLELLTEMKPSFMVWSAGYGPSPEKLARIAPGRGFDFSDGKKPLAVARRSLVELAQTLNLEAAAEKHLAQYDR
FIASQKPRFIRRGGRPLLMTTLIDPRHMLVLGPNCLFQEVLDEYGIVNAWQGETNFWGSTAVSIDRLAMYKEADVICFDH
GNSTDMNALMATPLWQAMSFVRAGRFHRVPAVWFYGATLSTMHFVRILNNVLGGKA
>Mature_296_residues
MRELYPLTRRRLLTAMALSPLLWQMNTAQAAAIDPRRIVALEWLPVELLLALGITPYGVADVPNYKLWVSEPPLPDSVID
VGLRTEPNLELLTEMKPSFMVWSAGYGPSPEKLARIAPGRGFDFSDGKKPLAVARRSLVELAQTLNLEAAAEKHLAQYDR
FIASQKPRFIRRGGRPLLMTTLIDPRHMLVLGPNCLFQEVLDEYGIVNAWQGETNFWGSTAVSIDRLAMYKEADVICFDH
GNSTDMNALMATPLWQAMSFVRAGRFHRVPAVWFYGATLSTMHFVRILNNVLGGKA

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrich

COG id: COG0614

COG function: function code P; ABC-type Fe3+-hydroxamate transport system, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Fe/B12 periplasmic-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786346, Length=290, Percent_Identity=84.1379310344828, Blast_Score=514, Evalue=1e-147,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008091
- InterPro:   IPR002491 [H]

Pfam domain/function: PF01497 Peripla_BP_2 [H]

EC number: NA

Molecular weight: Translated: 33165; Mature: 33165

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS50983 FE_B12_PBP ; PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRELYPLTRRRLLTAMALSPLLWQMNTAQAAAIDPRRIVALEWLPVELLLALGITPYGVA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEEECHHHHHHHHHCCCCCCCC
DVPNYKLWVSEPPLPDSVIDVGLRTEPNLELLTEMKPSFMVWSAGYGPSPEKLARIAPGR
CCCCCEEEECCCCCCHHHHHCCCCCCCCHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCC
GFDFSDGKKPLAVARRSLVELAQTLNLEAAAEKHLAQYDRFIASQKPRFIRRGGRPLLMT
CCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEE
TLIDPRHMLVLGPNCLFQEVLDEYGIVNAWQGETNFWGSTAVSIDRLAMYKEADVICFDH
EECCCCEEEEECCHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEC
GNSTDMNALMATPLWQAMSFVRAGRFHRVPAVWFYGATLSTMHFVRILNNVLGGKA
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRELYPLTRRRLLTAMALSPLLWQMNTAQAAAIDPRRIVALEWLPVELLLALGITPYGVA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEEECHHHHHHHHHCCCCCCCC
DVPNYKLWVSEPPLPDSVIDVGLRTEPNLELLTEMKPSFMVWSAGYGPSPEKLARIAPGR
CCCCCEEEECCCCCCHHHHHCCCCCCCCHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCC
GFDFSDGKKPLAVARRSLVELAQTLNLEAAAEKHLAQYDRFIASQKPRFIRRGGRPLLMT
CCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEE
TLIDPRHMLVLGPNCLFQEVLDEYGIVNAWQGETNFWGSTAVSIDRLAMYKEADVICFDH
EECCCCEEEEECCHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEC
GNSTDMNALMATPLWQAMSFVRAGRFHRVPAVWFYGATLSTMHFVRILNNVLGGKA
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3301821; 2823072; 8202364; 9278503; 7651325; 10742172 [H]