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The map label for this gene is pdxA

Identifier: 29140709

GI number: 29140709

Start: 194590

End: 195573

Strand: Direct

Name: pdxA

Synonym: t0168

Alternate gene names: 29140709

Gene position: 194590-195573 (Clockwise)

Preceding gene: 29140708

Following gene: 29140710

Centisome position: 4.06

GC content: 55.18

Gene sequence:

>984_bases
GTGGAGACTAAAACCGTTGCCATTACCATGGGCGATCCAGCGGGCATTGGGCCGGAAATTATTGTTAAAGCGCTAAGTGA
AGACGGTCTCAACGGCGCGCCGCTGGTGGTGATTGGATGCCTCGCAACCTTGAAATGTTTACAGGCGAAGGGCATCACGC
CGAACGTCGAGTTACGGGCCATTGAACGGGTCGCCGAAGCGCGTTTTGCGCCCGGCATCATTCATGTGATTGATGAGCCG
CTGGCGCAGCCGGAGGCGCTGGAGGCCGGGAAAGTTCAGGCGCAGGCGGGGGATTTAGCGTATCGCTGCGTGAAGCGCGC
CACCGAGTTAGCGTTACGGGGCGACGTACAGGCTATCGCTACCGCGCCGCTGAATAAAGAGGCGCTGCACCTGGCGGGGC
ACAACTATCCGGGCCATACCGAGCTGCTCGCGACTCTGACCCATAGCCGCGATTACGCGATGGTACTTTACACCGATAAA
CTAAAAGTGATTCACGTTTCAACGCATATCGCGCTGCGTAAATTCCTTGATACGTTAAGTACCACGCGTGTCGAAACGGT
GATTGGTATTGCTGATACTTTCCTCAAGCGTGTGGGTTACGTTAAACCGCGTATCGCCGTGGCAGGCGTGAATCCTCATG
CGGGCGAGAATGGTCTGTTTGGCGATGAAGAGACGCGTATCCTGACGCCAGCCATTACCGATGCCCGCGCAAAAGGTATG
GACGTTTATGGGCCGTGCCCGCCGGATACTGTATTTCTCCAGGCTTATGAGGGACAGTATGATATGGTGGTGGCGATGTA
TCATGACCAGGGGCATATCCCGTTGAAATTGCTTGGCTTTTATGATGGCGTGAATATCACCGCAGGGCTGCCGTTTATCC
GGACCTCTGCCGATCATGGCACCGCATTTGATATCGCCTGGACGGGAAAAGCAAAATCTGAGAGCATGGCCGTATCGATC
AAACTGGCAATGCAACTGGCATAA

Upstream 100 bases:

>100_bases
AACAGCGAAATTGACGATCTGCCGGTCATTACCAAAGCGGGCGGATTCGGTTCAGACAGTACGTTGTGTGACGCGCTTTA
TTATATTGAGGAGATGTATT

Downstream 100 bases:

>100_bases
TTCCCTGTTATGAAAGGACAACACCGTCTGGATCTCATTGTGGCGTATCTGAAAAACCATACGCTGGTTACGGTAGAACA
GCTGGTTGAGGCGGTTGACG

Product: 4-hydroxythreonine-4-phosphate dehydrogenase 2

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase 2

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
METKTVAITMGDPAGIGPEIIVKALSEDGLNGAPLVVIGCLATLKCLQAKGITPNVELRAIERVAEARFAPGIIHVIDEP
LAQPEALEAGKVQAQAGDLAYRCVKRATELALRGDVQAIATAPLNKEALHLAGHNYPGHTELLATLTHSRDYAMVLYTDK
LKVIHVSTHIALRKFLDTLSTTRVETVIGIADTFLKRVGYVKPRIAVAGVNPHAGENGLFGDEETRILTPAITDARAKGM
DVYGPCPPDTVFLQAYEGQYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSADHGTAFDIAWTGKAKSESMAVSI
KLAMQLA

Sequences:

>Translated_327_residues
METKTVAITMGDPAGIGPEIIVKALSEDGLNGAPLVVIGCLATLKCLQAKGITPNVELRAIERVAEARFAPGIIHVIDEP
LAQPEALEAGKVQAQAGDLAYRCVKRATELALRGDVQAIATAPLNKEALHLAGHNYPGHTELLATLTHSRDYAMVLYTDK
LKVIHVSTHIALRKFLDTLSTTRVETVIGIADTFLKRVGYVKPRIAVAGVNPHAGENGLFGDEETRILTPAITDARAKGM
DVYGPCPPDTVFLQAYEGQYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSADHGTAFDIAWTGKAKSESMAVSI
KLAMQLA
>Mature_327_residues
METKTVAITMGDPAGIGPEIIVKALSEDGLNGAPLVVIGCLATLKCLQAKGITPNVELRAIERVAEARFAPGIIHVIDEP
LAQPEALEAGKVQAQAGDLAYRCVKRATELALRGDVQAIATAPLNKEALHLAGHNYPGHTELLATLTHSRDYAMVLYTDK
LKVIHVSTHIALRKFLDTLSTTRVETVIGIADTFLKRVGYVKPRIAVAGVNPHAGENGLFGDEETRILTPAITDARAKGM
DVYGPCPPDTVFLQAYEGQYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSADHGTAFDIAWTGKAKSESMAVSI
KLAMQLA

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family

Homologues:

Organism=Escherichia coli, GI1786237, Length=329, Percent_Identity=36.7781155015198, Blast_Score=197, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXA2_SALTI (P58716)

Other databases:

- EMBL:   AL627265
- EMBL:   AE014613
- RefSeq:   NP_454776.1
- RefSeq:   NP_804051.1
- ProteinModelPortal:   P58716
- SMR:   P58716
- GeneID:   1067754
- GeneID:   1246679
- GenomeReviews:   AE014613_GR
- GenomeReviews:   AL513382_GR
- KEGG:   stt:t0168
- KEGG:   sty:STY0185
- HOGENOM:   HBG451136
- OMA:   MEFLAPA
- ProtClustDB:   PRK03371
- BioCyc:   SENT209261:T0168-MONOMER
- BioCyc:   SENT220341:STY0185-MONOMER
- BRENDA:   1.1.1.262
- GO:   GO:0005737
- HAMAP:   MF_00536
- InterPro:   IPR005255
- TIGRFAMs:   TIGR00557

Pfam domain/function: PF04166 PdxA

EC number: =1.1.1.262

Molecular weight: Translated: 35042; Mature: 35042

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: BINDING 139-139 BINDING 140-140 BINDING 276-276 BINDING 285-285 BINDING 294-294

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METKTVAITMGDPAGIGPEIIVKALSEDGLNGAPLVVIGCLATLKCLQAKGITPNVELRA
CCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHH
IERVAEARFAPGIIHVIDEPLAQPEALEAGKVQAQAGDLAYRCVKRATELALRGDVQAIA
HHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCEEEE
TAPLNKEALHLAGHNYPGHTELLATLTHSRDYAMVLYTDKLKVIHVSTHIALRKFLDTLS
ECCCCCCEEEECCCCCCCHHHHHHHHHCCCCEEEEEEECCEEEEEEHHHHHHHHHHHHHH
TTRVETVIGIADTFLKRVGYVKPRIAVAGVNPHAGENGLFGDEETRILTPAITDARAKGM
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCHHHCCC
DVYGPCPPDTVFLQAYEGQYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSADHG
CCCCCCCCCEEEEEEECCCEEEEEEEEECCCCCCEEEEEEECCCEEEECCCEEEECCCCC
TAFDIAWTGKAKSESMAVSIKLAMQLA
CEEEEEECCCCCCCCEEEEEEEEEEEC
>Mature Secondary Structure
METKTVAITMGDPAGIGPEIIVKALSEDGLNGAPLVVIGCLATLKCLQAKGITPNVELRA
CCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHH
IERVAEARFAPGIIHVIDEPLAQPEALEAGKVQAQAGDLAYRCVKRATELALRGDVQAIA
HHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCEEEE
TAPLNKEALHLAGHNYPGHTELLATLTHSRDYAMVLYTDKLKVIHVSTHIALRKFLDTLS
ECCCCCCEEEECCCCCCCHHHHHHHHHCCCCEEEEEEECCEEEEEEHHHHHHHHHHHHHH
TTRVETVIGIADTFLKRVGYVKPRIAVAGVNPHAGENGLFGDEETRILTPAITDARAKGM
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCHHHCCC
DVYGPCPPDTVFLQAYEGQYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSADHG
CCCCCCCCCEEEEEEECCCEEEEEEEEECCCCCCEEEEEEECCCEEEECCCEEEECCCCC
TAFDIAWTGKAKSESMAVSIKLAMQLA
CEEEEEECCCCCCCCEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504