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The map label for this gene is glcR [H]

Identifier: 28378573

GI number: 28378573

Start: 1746521

End: 1747273

Strand: Direct

Name: glcR [H]

Synonym: lp_1926

Alternate gene names: 28378573

Gene position: 1746521-1747273 (Clockwise)

Preceding gene: 28378570

Following gene: 28378574

Centisome position: 52.79

GC content: 45.29

Gene sequence:

>753_bases
ATGAACCAAAAAACACGCTTAACATTGATTCTTGATGAATTAAAAACCCACCCATCACTGAGTTTAAAAGACATTATGCA
ATTAACGGGGACTTCACGCGACACTGCCCGGCGCGATATTGTCAAACTCGCAGCTCATAATTTGGCTGAACGAAACTACG
GCGGCATTAGTCGGCCAAATACGTTTAATAAGCTGGATCAGTACCTGGACCGGGATGATGACTTACTGCAAACTAAACGA
GCCCTGGCCCACACTGCCAGTTCGTATTTACTAAATGATGCGTTATTATTTCTAGATATCTCAACCACCGTTGCCTGTCT
ACCACAATATCTCCAGTCCAAGCACCCCGGCATGATCGTTACGAATTCCCTTGACATTGCTGACCAGGCATTACGACATA
GCAATTTTCAAACGCGTATCCTGGGTGGCACATTAGATGCACAACAACGGTGTGTTCAAGGCGCTGACAGCATTCTAGCA
CTACACAAATTTCGATTTACGACCACGGTCTTGAGTTGCGCTGGGTTGACCGCAGACGGCGTTTATTACGCTTACGAATC
TGATATCGCTTTAAAGGAAACGTTACGCGCCCAAAGCGACCGGCTAGTGCTGTTGTTTGACCACACCAAGGTGAACGTCA
GCCACAACTTCAACTTGCTAGCTCTCAGTGATTTTGATTACTTTGTGACTGATCAGCCACTACCGGATAACCTAGCTACT
AAAATTGCACCTGATAAACTTATTTACCTTTAG

Upstream 100 bases:

>100_bases
TAATTCAACCGTTTTCATTAATTGACGTCATTGGCTTTCTATTTAAGTTAAAATAAGTTAGTATGTGTTTAACACTTAAA
AAAACTTAAGGTGATCAATT

Downstream 100 bases:

>100_bases
AGGAGGATCATTAACATGCCATCTTCACTATTAACTACTCAACGAGCAATGTTAGCCTTGATTCAAAGCGGATTAGCCTA
CACGACTGACCCGTTCGACA

Product: transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MNQKTRLTLILDELKTHPSLSLKDIMQLTGTSRDTARRDIVKLAAHNLAERNYGGISRPNTFNKLDQYLDRDDDLLQTKR
ALAHTASSYLLNDALLFLDISTTVACLPQYLQSKHPGMIVTNSLDIADQALRHSNFQTRILGGTLDAQQRCVQGADSILA
LHKFRFTTTVLSCAGLTADGVYYAYESDIALKETLRAQSDRLVLLFDHTKVNVSHNFNLLALSDFDYFVTDQPLPDNLAT
KIAPDKLIYL

Sequences:

>Translated_250_residues
MNQKTRLTLILDELKTHPSLSLKDIMQLTGTSRDTARRDIVKLAAHNLAERNYGGISRPNTFNKLDQYLDRDDDLLQTKR
ALAHTASSYLLNDALLFLDISTTVACLPQYLQSKHPGMIVTNSLDIADQALRHSNFQTRILGGTLDAQQRCVQGADSILA
LHKFRFTTTVLSCAGLTADGVYYAYESDIALKETLRAQSDRLVLLFDHTKVNVSHNFNLLALSDFDYFVTDQPLPDNLAT
KIAPDKLIYL
>Mature_250_residues
MNQKTRLTLILDELKTHPSLSLKDIMQLTGTSRDTARRDIVKLAAHNLAERNYGGISRPNTFNKLDQYLDRDDDLLQTKR
ALAHTASSYLLNDALLFLDISTTVACLPQYLQSKHPGMIVTNSLDIADQALRHSNFQTRILGGTLDAQQRCVQGADSILA
LHKFRFTTTVLSCAGLTADGVYYAYESDIALKETLRAQSDRLVLLFDHTKVNVSHNFNLLALSDFDYFVTDQPLPDNLAT
KIAPDKLIYL

Specific function: Plays a role in carbon catabolite repression (CCR). Specifically required for transcriptional repression of the levanase operon by glucose but not by other sugars [H]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789829, Length=236, Percent_Identity=25.8474576271186, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI87082344, Length=224, Percent_Identity=25, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI226510968, Length=232, Percent_Identity=24.5689655172414, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1788069, Length=235, Percent_Identity=24.2553191489362, Blast_Score=71, Evalue=7e-14,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28013; Mature: 28013

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQKTRLTLILDELKTHPSLSLKDIMQLTGTSRDTARRDIVKLAAHNLAERNYGGISRPN
CCCCEEEEEEEEHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
TFNKLDQYLDRDDDLLQTKRALAHTASSYLLNDALLFLDISTTVACLPQYLQSKHPGMIV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHCCCCCEEE
TNSLDIADQALRHSNFQTRILGGTLDAQQRCVQGADSILALHKFRFTTTVLSCAGLTADG
ECCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VYYAYESDIALKETLRAQSDRLVLLFDHTKVNVSHNFNLLALSDFDYFVTDQPLPDNLAT
EEEEEECCHHHHHHHHCCCCCEEEEEECEEEEECCCCEEEEEECCCEEECCCCCCCCHHH
KIAPDKLIYL
HCCCCCEEEC
>Mature Secondary Structure
MNQKTRLTLILDELKTHPSLSLKDIMQLTGTSRDTARRDIVKLAAHNLAERNYGGISRPN
CCCCEEEEEEEEHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
TFNKLDQYLDRDDDLLQTKRALAHTASSYLLNDALLFLDISTTVACLPQYLQSKHPGMIV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHCCCCCEEE
TNSLDIADQALRHSNFQTRILGGTLDAQQRCVQGADSILALHKFRFTTTVLSCAGLTADG
ECCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VYYAYESDIALKETLRAQSDRLVLLFDHTKVNVSHNFNLLALSDFDYFVTDQPLPDNLAT
EEEEEECCHHHHHHHHCCCCCEEEEEECEEEEECCCCEEEEEECCCEEECCCCCCCCHHH
KIAPDKLIYL
HCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]