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The map label for this gene is pyrR2

Identifier: 28378456

GI number: 28378456

Start: 1614005

End: 1614529

Strand: Direct

Name: pyrR2

Synonym: lp_1782

Alternate gene names: 28378456

Gene position: 1614005-1614529 (Clockwise)

Preceding gene: 28378455

Following gene: 28378457

Centisome position: 48.79

GC content: 48.57

Gene sequence:

>525_bases
ATGCAAAAAGAAGTTGTTGATTCAATGGCGATGAAACGGGCATTGACCCGGATCACCTATGAAATTATCGAACAGAACAA
AGGCATTAAAAATGTCGTCTTAGTGGGCGTTAAAACCCGCGGCGTCTATATTGCGCAGCGGATTGCAGCCCAATTACAAC
AGCTTGAAGGTACTGCGATTCCAGTTGGCGAGTTAGACATCACGGCATTTCGTGATGATCAGCCGCTGGATCAAGCACGG
CTTTCAACGGACTATCAGTTAACGTTTTCGGTGGCGGATAAGCGGGTCATTTTAGTCGATGATGTTCTATTTACCGGCCG
AACAATTCGCGCGGCTTTAGACGCATTAATGGGTGGCGGTCGGCCCCAGAGCATTGCCTTGGCGGTACTAGTCGATCGTG
GTCACCGCGAATTGCCGATTCGCGCTGATTTTATTGGTCGCAACATTCCCACCGCGCGTCAAGAACGCATCAAAGTGACG
GTCAATGAAATCGACGGTCACGATGGTATTGAAATTATTAACTAG

Upstream 100 bases:

>100_bases
ACAATAACTTTTCGTCGACGGCCGTGACACCTTGTCCGGCCGTCTTTCTTTGTCGTACGGGTTGCTCAAAAAAGCGATAA
CCACAAATTGGGAGGCAATT

Downstream 100 bases:

>100_bases
TACGACAAAGTCAAACAGATGAGAAGGGATCGCAATGGCAGACCGCTATTTGATTCTTGAAGATGGCAGCGCCTATTTAG
GTGAAGGCTTTGGCTCGCCA

Product: bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase

Products: NA

Alternate protein names: Pyrimidine operon regulatory protein 2; Uracil phosphoribosyltransferase 2; UPRTase 2

Number of amino acids: Translated: 174; Mature: 174

Protein sequence:

>174_residues
MQKEVVDSMAMKRALTRITYEIIEQNKGIKNVVLVGVKTRGVYIAQRIAAQLQQLEGTAIPVGELDITAFRDDQPLDQAR
LSTDYQLTFSVADKRVILVDDVLFTGRTIRAALDALMGGGRPQSIALAVLVDRGHRELPIRADFIGRNIPTARQERIKVT
VNEIDGHDGIEIIN

Sequences:

>Translated_174_residues
MQKEVVDSMAMKRALTRITYEIIEQNKGIKNVVLVGVKTRGVYIAQRIAAQLQQLEGTAIPVGELDITAFRDDQPLDQAR
LSTDYQLTFSVADKRVILVDDVLFTGRTIRAALDALMGGGRPQSIALAVLVDRGHRELPIRADFIGRNIPTARQERIKVT
VNEIDGHDGIEIIN
>Mature_174_residues
MQKEVVDSMAMKRALTRITYEIIEQNKGIKNVVLVGVKTRGVYIAQRIAAQLQQLEGTAIPVGELDITAFRDDQPLDQAR
LSTDYQLTFSVADKRVILVDDVLFTGRTIRAALDALMGGGRPQSIALAVLVDRGHRELPIRADFIGRNIPTARQERIKVT
VNEIDGHDGIEIIN

Specific function: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant

COG id: COG2065

COG function: function code F; Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRR2_LACPL (P59389)

Other databases:

- EMBL:   AL935257
- RefSeq:   NP_785348.1
- ProteinModelPortal:   P59389
- SMR:   P59389
- GeneID:   1063520
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_1782
- HOGENOM:   HBG641958
- OMA:   IAHEVLE
- ProtClustDB:   PRK05205
- BioCyc:   LPLA220668:LP_1782-MONOMER
- BRENDA:   2.4.2.9
- HAMAP:   MF_01219
- InterPro:   IPR000836
- InterPro:   IPR023050

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 19304; Mature: 19304

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 133-133

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKEVVDSMAMKRALTRITYEIIEQNKGIKNVVLVGVKTRGVYIAQRIAAQLQQLEGTAI
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCC
PVGELDITAFRDDQPLDQARLSTDYQLTFSVADKRVILVDDVLFTGRTIRAALDALMGGG
CCCCEEEEEECCCCCHHHHHCCCCEEEEEEECCCEEEEEECHHHCCHHHHHHHHHHHCCC
RPQSIALAVLVDRGHRELPIRADFIGRNIPTARQERIKVTVNEIDGHDGIEIIN
CCHHEEEEEEEECCCCCCCEEHHHCCCCCCCCCCCEEEEEEEECCCCCCEEECC
>Mature Secondary Structure
MQKEVVDSMAMKRALTRITYEIIEQNKGIKNVVLVGVKTRGVYIAQRIAAQLQQLEGTAI
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCC
PVGELDITAFRDDQPLDQARLSTDYQLTFSVADKRVILVDDVLFTGRTIRAALDALMGGG
CCCCEEEEEECCCCCHHHHHCCCCEEEEEEECCCEEEEEECHHHCCHHHHHHHHHHHCCC
RPQSIALAVLVDRGHRELPIRADFIGRNIPTARQERIKVTVNEIDGHDGIEIIN
CCHHEEEEEEEECCCCCCCEEHHHCCCCCCCCCCCEEEEEEEECCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566