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The map label for this gene is fhs

Identifier: 28378453

GI number: 28378453

Start: 1610466

End: 1612121

Strand: Direct

Name: fhs

Synonym: lp_1779

Alternate gene names: 28378453

Gene position: 1610466-1612121 (Clockwise)

Preceding gene: 28378452

Following gene: 28378454

Centisome position: 48.68

GC content: 49.52

Gene sequence:

>1656_bases
ATGAAGGATATTGAAATTGCACAGCAAGTGACACCAGAACCGATTACGGCGATTGCGGCTAAAGCGGGCTTGACGGTTGA
CCAGATCGACCAATATGGGAGCACGAAGGCTAAACTCAAATTACCGTTACCGGTTAAGAAAACTCAACGCAACCTTATTT
TAGTAACGTCGATTAACCCGACGCCTGCTGGTGAGGGAAAGTCAACCGTGACTATTGGGTTAGGTGACGCGTTGACTAAG
ATTGGTAAGTCAACGATGATTGCATTGCGGGAACCTTCATTAGGACCAGTTATGGGGATGAAGGGTGGCGCCACTGGTGG
CGGGTACTCACAAGTGATTCCAATGGAAGATATCAATTTGCACTTCACCGGCGACATGCATGCCCTGACGGCTGCGAACA
ACACGCTCGCGGCCTTAATTGACAACCATATTCAACAAGGTAACCAGTTGGGTATCGATCAGCGTCGAATTCAATGGAAG
CGCGCGTTGGATATTAATGATCGGGCGCTCCGGCATACGGTGATTGGCCTTGGTGGTGCAACGTCGGGTGTACCTCGTGA
AGATGGGTTTGACATTACCGTCGCGAGTGAACTGATGGCCATTCTCTGTCTTTCAGAAAATATTGCGGACTTGAAACAAC
GTGTTAATCGAATTGTAATTGGCTACACACATGACCGTCAACCAGTGACAGTTGCTGATTTGAACGTCGGTGGCGCGATC
ACGTTACTTTTGAAAGACGCGTTACGTCCAAATTTAGTTCAAACCCTGGCGCATACCCCAGCACTCGTTCATGGTGGTCC
GTTCGCCAATATCGCGCATGGTTGTAACAGTGTACTTGCCACGCAAGCTGGATTGAATCTAGCCGACTATACGGTAACCG
AGGCGGGCTTCGGTGCTGATTTGGGTGGTCAGAAATTCATGGATATTAACGTGCCAGCGGTCGGACAAGCGCCCAATGCC
GTGGTAATCGTGGCGACGATTCGGGCTTTAAAGTTACATGGTGGCGTGGCTTTGCAAGATTTGGCAACCGAAAATGTAGC
GGCCTTGAAAGCCGGTGCGGCTAATTTAGGACATCATATCCATGCCATGCAACGTTATGGGGTGCCAGTCGTGGTGGCCA
TCAACGAATTTACGGCCGATACTGACGCCGAAATCCATGCCGTCAAAGACTATTGTGCCGATCTTGGAGTCGATGCAGTC
TTGGCTGATGTCTGGGGTCGTGGGGGTGACGGGGCAACCGACTTAGCTGCCGCAGTGGTTGATTTATGTGCTCAGCCAAG
TCATTTTCAACCGTTATCACCAGCGGATGCGGATCTTAAGACGAAAATCAACGATATTGTCACTAAGACGTATGGTGGAG
CCAATGTCGAATATTCAGCGAAAGCTCAGCGCCAATTGAGAACGTTTGCTAAGCAAGGGTGGGATCATTTGCCAGTCTGC
ATGGCGAAGACGCAATATTCATTGAGCGATGATCCCAAACGTCTCGGAGCACCAACCGGATTTACAATTAATGTTCGTGA
ATTTGTGCCGAAGTTAGGTGCGGGTTTCATTGTCGCTTTGACCGGGAATGTGTTGACGATGCCAGGACTGCCAAAACATC
CGGCCGCACTCGATATGGACATTAGTGATGATGGAAAAATCTCAGGTTTGTTCTAA

Upstream 100 bases:

>100_bases
TCGATAGATACGAATAAAAACAATCAATATACAAATAATGTTCATAATTTCAGGAAGATTGTTATAATGGAGTAAGTAAA
AACAGAAGGGCGGAGAATTG

Downstream 100 bases:

>100_bases
AGCTTGACCGATAAGTCGATGCCAGTGGGGGTCGGCTTTTTATTTGCGTTGTTTTTGGAAGACTGCGACAGCGAATCAAT
CACACACGTTTAATTTGTGA

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MKDIEIAQQVTPEPITAIAAKAGLTVDQIDQYGSTKAKLKLPLPVKKTQRNLILVTSINPTPAGEGKSTVTIGLGDALTK
IGKSTMIALREPSLGPVMGMKGGATGGGYSQVIPMEDINLHFTGDMHALTAANNTLAALIDNHIQQGNQLGIDQRRIQWK
RALDINDRALRHTVIGLGGATSGVPREDGFDITVASELMAILCLSENIADLKQRVNRIVIGYTHDRQPVTVADLNVGGAI
TLLLKDALRPNLVQTLAHTPALVHGGPFANIAHGCNSVLATQAGLNLADYTVTEAGFGADLGGQKFMDINVPAVGQAPNA
VVIVATIRALKLHGGVALQDLATENVAALKAGAANLGHHIHAMQRYGVPVVVAINEFTADTDAEIHAVKDYCADLGVDAV
LADVWGRGGDGATDLAAAVVDLCAQPSHFQPLSPADADLKTKINDIVTKTYGGANVEYSAKAQRQLRTFAKQGWDHLPVC
MAKTQYSLSDDPKRLGAPTGFTINVREFVPKLGAGFIVALTGNVLTMPGLPKHPAALDMDISDDGKISGLF

Sequences:

>Translated_551_residues
MKDIEIAQQVTPEPITAIAAKAGLTVDQIDQYGSTKAKLKLPLPVKKTQRNLILVTSINPTPAGEGKSTVTIGLGDALTK
IGKSTMIALREPSLGPVMGMKGGATGGGYSQVIPMEDINLHFTGDMHALTAANNTLAALIDNHIQQGNQLGIDQRRIQWK
RALDINDRALRHTVIGLGGATSGVPREDGFDITVASELMAILCLSENIADLKQRVNRIVIGYTHDRQPVTVADLNVGGAI
TLLLKDALRPNLVQTLAHTPALVHGGPFANIAHGCNSVLATQAGLNLADYTVTEAGFGADLGGQKFMDINVPAVGQAPNA
VVIVATIRALKLHGGVALQDLATENVAALKAGAANLGHHIHAMQRYGVPVVVAINEFTADTDAEIHAVKDYCADLGVDAV
LADVWGRGGDGATDLAAAVVDLCAQPSHFQPLSPADADLKTKINDIVTKTYGGANVEYSAKAQRQLRTFAKQGWDHLPVC
MAKTQYSLSDDPKRLGAPTGFTINVREFVPKLGAGFIVALTGNVLTMPGLPKHPAALDMDISDDGKISGLF
>Mature_551_residues
MKDIEIAQQVTPEPITAIAAKAGLTVDQIDQYGSTKAKLKLPLPVKKTQRNLILVTSINPTPAGEGKSTVTIGLGDALTK
IGKSTMIALREPSLGPVMGMKGGATGGGYSQVIPMEDINLHFTGDMHALTAANNTLAALIDNHIQQGNQLGIDQRRIQWK
RALDINDRALRHTVIGLGGATSGVPREDGFDITVASELMAILCLSENIADLKQRVNRIVIGYTHDRQPVTVADLNVGGAI
TLLLKDALRPNLVQTLAHTPALVHGGPFANIAHGCNSVLATQAGLNLADYTVTEAGFGADLGGQKFMDINVPAVGQAPNA
VVIVATIRALKLHGGVALQDLATENVAALKAGAANLGHHIHAMQRYGVPVVVAINEFTADTDAEIHAVKDYCADLGVDAV
LADVWGRGGDGATDLAAAVVDLCAQPSHFQPLSPADADLKTKINDIVTKTYGGANVEYSAKAQRQLRTFAKQGWDHLPVC
MAKTQYSLSDDPKRLGAPTGFTINVREFVPKLGAGFIVALTGNVLTMPGLPKHPAALDMDISDDGKISGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI36796743, Length=617, Percent_Identity=43.5980551053485, Blast_Score=434, Evalue=1e-121,
Organism=Homo sapiens, GI222136639, Length=617, Percent_Identity=40.3565640194489, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI310124614, Length=85, Percent_Identity=36.4705882352941, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17568737, Length=621, Percent_Identity=42.3510466988728, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17568739, Length=621, Percent_Identity=42.3510466988728, Blast_Score=421, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6319558, Length=629, Percent_Identity=40.6995230524642, Blast_Score=439, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6321643, Length=625, Percent_Identity=42.56, Blast_Score=433, Evalue=1e-122,
Organism=Drosophila melanogaster, GI62472483, Length=617, Percent_Identity=40.8427876823339, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI45551871, Length=617, Percent_Identity=40.8427876823339, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24645718, Length=617, Percent_Identity=40.8427876823339, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI17137370, Length=617, Percent_Identity=40.8427876823339, Blast_Score=426, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_LACPL (Q88W76)

Other databases:

- EMBL:   AL935257
- RefSeq:   NP_785345.1
- ProteinModelPortal:   Q88W76
- SMR:   Q88W76
- GeneID:   1064084
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_1779
- NMPDR:   fig|220668.1.peg.1479
- HOGENOM:   HBG677721
- OMA:   EIMAVLC
- ProtClustDB:   PRK13505
- BioCyc:   LPLA220668:LP_1779-MONOMER
- BRENDA:   6.3.4.3
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 57937; Mature: 57937

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDIEIAQQVTPEPITAIAAKAGLTVDQIDQYGSTKAKLKLPLPVKKTQRNLILVTSINP
CCCHHHHHHCCCCHHHHHHHHCCCCHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEECCC
TPAGEGKSTVTIGLGDALTKIGKSTMIALREPSLGPVMGMKGGATGGGYSQVIPMEDINL
CCCCCCCCEEEEECCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCEE
HFTGDMHALTAANNTLAALIDNHIQQGNQLGIDQRRIQWKRALDINDRALRHTVIGLGGA
EECCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHEEEEECCCC
TSGVPREDGFDITVASELMAILCLSENIADLKQRVNRIVIGYTHDRQPVTVADLNVGGAI
CCCCCCCCCCCEEHHHHHHHHHHHHCCHHHHHHHHCEEEEEEECCCCCEEEEECCCCCEE
TLLLKDALRPNLVQTLAHTPALVHGGPFANIAHGCNSVLATQAGLNLADYTVTEAGFGAD
EEEEHHHCCHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCCCHHEEEECCCCCCC
LGGQKFMDINVPAVGQAPNAVVIVATIRALKLHGGVALQDLATENVAALKAGAANLGHHI
CCCCEEEEECCCCCCCCCCCEEEEEEEEEHHHCCCEEEHHHHCCCHHHHHCCCHHHHHHH
HAMQRYGVPVVVAINEFTADTDAEIHAVKDYCADLGVDAVLADVWGRGGDGATDLAAAVV
HHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHH
DLCAQPSHFQPLSPADADLKTKINDIVTKTYGGANVEYSAKAQRQLRTFAKQGWDHLPVC
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHCCCCCCCEE
MAKTQYSLSDDPKRLGAPTGFTINVREFVPKLGAGFIVALTGNVLTMPGLPKHPAALDMD
EECCCCCCCCCHHHHCCCCCCEEEHHHHHHHCCCCEEEEEECCEEECCCCCCCCCEEEEC
ISDDGKISGLF
CCCCCCEECCC
>Mature Secondary Structure
MKDIEIAQQVTPEPITAIAAKAGLTVDQIDQYGSTKAKLKLPLPVKKTQRNLILVTSINP
CCCHHHHHHCCCCHHHHHHHHCCCCHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEECCC
TPAGEGKSTVTIGLGDALTKIGKSTMIALREPSLGPVMGMKGGATGGGYSQVIPMEDINL
CCCCCCCCEEEEECCHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCEE
HFTGDMHALTAANNTLAALIDNHIQQGNQLGIDQRRIQWKRALDINDRALRHTVIGLGGA
EECCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHEEEEECCCC
TSGVPREDGFDITVASELMAILCLSENIADLKQRVNRIVIGYTHDRQPVTVADLNVGGAI
CCCCCCCCCCCEEHHHHHHHHHHHHCCHHHHHHHHCEEEEEEECCCCCEEEEECCCCCEE
TLLLKDALRPNLVQTLAHTPALVHGGPFANIAHGCNSVLATQAGLNLADYTVTEAGFGAD
EEEEHHHCCHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCCCHHEEEECCCCCCC
LGGQKFMDINVPAVGQAPNAVVIVATIRALKLHGGVALQDLATENVAALKAGAANLGHHI
CCCCEEEEECCCCCCCCCCCEEEEEEEEEHHHCCCEEEHHHHCCCHHHHHCCCHHHHHHH
HAMQRYGVPVVVAINEFTADTDAEIHAVKDYCADLGVDAVLADVWGRGGDGATDLAAAVV
HHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHH
DLCAQPSHFQPLSPADADLKTKINDIVTKTYGGANVEYSAKAQRQLRTFAKQGWDHLPVC
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHCCCCCCCEE
MAKTQYSLSDDPKRLGAPTGFTINVREFVPKLGAGFIVALTGNVLTMPGLPKHPAALDMD
EECCCCCCCCCHHHHCCCCCCEEEHHHHHHHCCCCEEEEEECCEEECCCCCCCCCEEEEC
ISDDGKISGLF
CCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566