Click here to switch to the map view.

The map label for this gene is glmS1

Identifier: 28377671

GI number: 28377671

Start: 761633

End: 763450

Strand: Direct

Name: glmS1

Synonym: lp_0822

Alternate gene names: 28377671

Gene position: 761633-763450 (Clockwise)

Preceding gene: 28377670

Following gene: 28377672

Centisome position: 23.02

GC content: 44.44

Gene sequence:

>1818_bases
ATGTGTGGAATTGTTGGTGTAACGGGTAAAGATAGTGCAGTATCAATCTTACTGAACGGATTGGAAAAGTTGGAATACCG
GGGCTATGATTCAGCTGGTATCTATGTCAATGATCAAGATGGTCATGACTATTTAGTTAAGGAAAAGGGTCGGATCGATG
ACTTACGTAAAGAAGTAGGCGAAGCTGTTCATGGTTCGACCGGGATTGGGCATACTCGCTGGGCGACTCACGGTGAACCG
AGTGTTGCCAATGCGCATCCTCAAGTTTCTGCGGATGGCCGCTTCTACTTAGTTCACAATGGCGTGATCGAAAACTTTGA
AGACTTAAAACAGACTTATTTAAGTGACGTGACTTTTAAGTCTCAAACAGATACAGAAGTCATTGTTCAATTAGTCGATC
GGTTTGTCACCAAGGAAGGCTTGAGTACGTTGGCCGCTTTCCGTAAGACGTTAGGGCTACTCGGCCATTCTTCATATGGG
TTCTTACTGATGGATAAGGAAGATCCTGACACCTTATACGTCGCAAAGAATAAGAGTCCATTATTAATTGGGGTCGGCGA
AGGCTTCAACGTGGTCTGCTCAGATAGTTTAGCGATGTTAGACCAAACGAAAGATTTCTTGGAATTACATGATGGCGAAA
TCGTGGTCGTTAAACCTGATGAAATTAAAATCACGAACCAGGCCGGCGAACCAGTTGAACGGAAACCATTCCATGTCGAC
ATTGACGCAGCTCAAGCTGACAAGGGAACTTATCCATTCTACATGTTAAAAGAAATCGATGAACAACCGAATGTGATGCG
GAAGCTATCCCAAGTTTATCTTAATGATGCGGGTGATCCAATCATCAATGATGACTTGTTAACAGCTCTTAAAGCAGCCG
ATCGACTATACATTGTGGCTGCTGGGACTAGTTATCATGCTGGTCTGGTTGGTGCAAAGTTATTTGAATCGTTGGCTAAC
GTGCCAACTGAAGTGCACGTTTCTTCAGAATTTGCATACAACCAACCATTATTATCAGCACATCCATTCTTCATCTTCTT
GACCCAGTCTGGTGAAACTGCTGATAGTCGTGAAGTGTTATTGAATGTGAACGATCAACATTTCCCAAGCTTGACCATCA
CGAACGTGCCAAACTCAACGCTATCGCGCGAAGCAACGTACACGTTGTTATTGCATGCCGGACCAGAAATTGCGGTTGCT
TCAACCAAAGCCTATACCGCACAGATTGCCTTACAAGCCATCTTGGCTAAGGCGTTAGGTGTGGCCGTTGACCAACCAGC
TGCAACAGCTTTCGACGTAAAACAGCAGTTGGCGTTAGTCGCTAATGGGATGCAAAGCTTAGTTGATGAAAAGGCTACTT
TTGAAAAGATTGCTAAGAGTGCCTTATTGAATACGCCAAACGCCTTTTATATTGGTCGGGGACTGGATTACGCCGTCTCA
TTAGAAACGGCCTTGAAACTCAAGGAAATCTCTTACGTTCAAGCTGAAGGTTTCGCATCTGGTGAATTAAAGCACGGTAC
GATTGCTTTGATTGAAAAGGATACCCCAGTGATTGGGATTATTACGCAAAAGAATACCGCTGGGTTGACCCGCTCCAACT
TACAAGAAGTTGCTGCACGGGGAGCTAAGACAGTTACTATCGTCACCGATAGTTTAGCTAAAGATGGTGACACGGTTATC
TTGCCAACGGTTGATGAACGATTAACGGCTTTGCTTAGTGTTGTTCCTGGTCAGTTATTGGCCTACTATACGAGCTTAAA
CAAGGGCTTAGATGTGGACAAACCACGGAACCTTGCCAAGAGTGTGACCGTTGAATAA

Upstream 100 bases:

>100_bases
GCACTCTACAGGTCAATTACAAAAACCGACTGTGAGGTTGGTGACAGATATATTGACCACGCAGCTAGAAACAATTCAAA
CAGTAAAGGAAGATTAATTT

Downstream 100 bases:

>100_bases
TTTAAAGTAAGTGTGTGGGCACCAAGAAACGTCACCGTTCGATTACGGTGGCGTTTTTTGATTGCCCACAAAGCTTTTGC
ATAATTTTTAACTACTAATA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MCGIVGVTGKDSAVSILLNGLEKLEYRGYDSAGIYVNDQDGHDYLVKEKGRIDDLRKEVGEAVHGSTGIGHTRWATHGEP
SVANAHPQVSADGRFYLVHNGVIENFEDLKQTYLSDVTFKSQTDTEVIVQLVDRFVTKEGLSTLAAFRKTLGLLGHSSYG
FLLMDKEDPDTLYVAKNKSPLLIGVGEGFNVVCSDSLAMLDQTKDFLELHDGEIVVVKPDEIKITNQAGEPVERKPFHVD
IDAAQADKGTYPFYMLKEIDEQPNVMRKLSQVYLNDAGDPIINDDLLTALKAADRLYIVAAGTSYHAGLVGAKLFESLAN
VPTEVHVSSEFAYNQPLLSAHPFFIFLTQSGETADSREVLLNVNDQHFPSLTITNVPNSTLSREATYTLLLHAGPEIAVA
STKAYTAQIALQAILAKALGVAVDQPAATAFDVKQQLALVANGMQSLVDEKATFEKIAKSALLNTPNAFYIGRGLDYAVS
LETALKLKEISYVQAEGFASGELKHGTIALIEKDTPVIGIITQKNTAGLTRSNLQEVAARGAKTVTIVTDSLAKDGDTVI
LPTVDERLTALLSVVPGQLLAYYTSLNKGLDVDKPRNLAKSVTVE

Sequences:

>Translated_605_residues
MCGIVGVTGKDSAVSILLNGLEKLEYRGYDSAGIYVNDQDGHDYLVKEKGRIDDLRKEVGEAVHGSTGIGHTRWATHGEP
SVANAHPQVSADGRFYLVHNGVIENFEDLKQTYLSDVTFKSQTDTEVIVQLVDRFVTKEGLSTLAAFRKTLGLLGHSSYG
FLLMDKEDPDTLYVAKNKSPLLIGVGEGFNVVCSDSLAMLDQTKDFLELHDGEIVVVKPDEIKITNQAGEPVERKPFHVD
IDAAQADKGTYPFYMLKEIDEQPNVMRKLSQVYLNDAGDPIINDDLLTALKAADRLYIVAAGTSYHAGLVGAKLFESLAN
VPTEVHVSSEFAYNQPLLSAHPFFIFLTQSGETADSREVLLNVNDQHFPSLTITNVPNSTLSREATYTLLLHAGPEIAVA
STKAYTAQIALQAILAKALGVAVDQPAATAFDVKQQLALVANGMQSLVDEKATFEKIAKSALLNTPNAFYIGRGLDYAVS
LETALKLKEISYVQAEGFASGELKHGTIALIEKDTPVIGIITQKNTAGLTRSNLQEVAARGAKTVTIVTDSLAKDGDTVI
LPTVDERLTALLSVVPGQLLAYYTSLNKGLDVDKPRNLAKSVTVE
>Mature_605_residues
MCGIVGVTGKDSAVSILLNGLEKLEYRGYDSAGIYVNDQDGHDYLVKEKGRIDDLRKEVGEAVHGSTGIGHTRWATHGEP
SVANAHPQVSADGRFYLVHNGVIENFEDLKQTYLSDVTFKSQTDTEVIVQLVDRFVTKEGLSTLAAFRKTLGLLGHSSYG
FLLMDKEDPDTLYVAKNKSPLLIGVGEGFNVVCSDSLAMLDQTKDFLELHDGEIVVVKPDEIKITNQAGEPVERKPFHVD
IDAAQADKGTYPFYMLKEIDEQPNVMRKLSQVYLNDAGDPIINDDLLTALKAADRLYIVAAGTSYHAGLVGAKLFESLAN
VPTEVHVSSEFAYNQPLLSAHPFFIFLTQSGETADSREVLLNVNDQHFPSLTITNVPNSTLSREATYTLLLHAGPEIAVA
STKAYTAQIALQAILAKALGVAVDQPAATAFDVKQQLALVANGMQSLVDEKATFEKIAKSALLNTPNAFYIGRGLDYAVS
LETALKLKEISYVQAEGFASGELKHGTIALIEKDTPVIGIITQKNTAGLTRSNLQEVAARGAKTVTIVTDSLAKDGDTVI
LPTVDERLTALLSVVPGQLLAYYTSLNKGLDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI205277386, Length=696, Percent_Identity=33.4770114942529, Blast_Score=305, Evalue=6e-83,
Organism=Homo sapiens, GI4826742, Length=690, Percent_Identity=32.1739130434783, Blast_Score=300, Evalue=3e-81,
Organism=Escherichia coli, GI1790167, Length=619, Percent_Identity=41.1954765751212, Blast_Score=428, Evalue=1e-121,
Organism=Escherichia coli, GI1788651, Length=139, Percent_Identity=31.6546762589928, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17539970, Length=432, Percent_Identity=31.712962962963, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17532899, Length=430, Percent_Identity=31.1627906976744, Blast_Score=202, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17532897, Length=430, Percent_Identity=31.1627906976744, Blast_Score=202, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6322745, Length=430, Percent_Identity=32.5581395348837, Blast_Score=219, Evalue=7e-58,
Organism=Saccharomyces cerevisiae, GI6323731, Length=377, Percent_Identity=26.2599469496021, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6323730, Length=231, Percent_Identity=35.0649350649351, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI21357745, Length=689, Percent_Identity=30.188679245283, Blast_Score=300, Evalue=3e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_LACPL (Q88YE7)

Other databases:

- EMBL:   AL935254
- RefSeq:   NP_784563.1
- ProteinModelPortal:   Q88YE7
- SMR:   Q88YE7
- GeneID:   1063937
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_0822
- NMPDR:   fig|220668.1.peg.697
- HOGENOM:   HBG645312
- OMA:   ARTATIC
- ProtClustDB:   PRK00331
- BioCyc:   LPLA220668:LP_0822-MONOMER
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 65468; Mature: 65468

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 600-600

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGVTGKDSAVSILLNGLEKLEYRGYDSAGIYVNDQDGHDYLVKEKGRIDDLRKEVG
CCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEECCCCHHHHHHHHH
EAVHGSTGIGHTRWATHGEPSVANAHPQVSADGRFYLVHNGVIENFEDLKQTYLSDVTFK
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCEEC
SQTDTEVIVQLVDRFVTKEGLSTLAAFRKTLGLLGHSSYGFLLMDKEDPDTLYVAKNKSP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCC
LLIGVGEGFNVVCSDSLAMLDQTKDFLELHDGEIVVVKPDEIKITNQAGEPVERKPFHVD
EEEECCCCCEEEECCCHHHHHCCHHHHHCCCCEEEEECCCCEEEECCCCCCCCCCCEEEE
IDAAQADKGTYPFYMLKEIDEQPNVMRKLSQVYLNDAGDPIINDDLLTALKAADRLYIVA
EECCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCEEEEEE
AGTSYHAGLVGAKLFESLANVPTEVHVSSEFAYNQPLLSAHPFFIFLTQSGETADSREVL
ECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEE
LNVNDQHFPSLTITNVPNSTLSREATYTLLLHAGPEIAVASTKAYTAQIALQAILAKALG
EECCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHC
VAVDQPAATAFDVKQQLALVANGMQSLVDEKATFEKIAKSALLNTPNAFYIGRGLDYAVS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEE
LETALKLKEISYVQAEGFASGELKHGTIALIEKDTPVIGIITQKNTAGLTRSNLQEVAAR
HHHHHHHHHHHEEECCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHC
GAKTVTIVTDSLAKDGDTVILPTVDERLTALLSVVPGQLLAYYTSLNKGLDVDKPRNLAK
CCCEEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
SVTVE
HCCCC
>Mature Secondary Structure
MCGIVGVTGKDSAVSILLNGLEKLEYRGYDSAGIYVNDQDGHDYLVKEKGRIDDLRKEVG
CCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEECCCCHHHHHHHHH
EAVHGSTGIGHTRWATHGEPSVANAHPQVSADGRFYLVHNGVIENFEDLKQTYLSDVTFK
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCEEC
SQTDTEVIVQLVDRFVTKEGLSTLAAFRKTLGLLGHSSYGFLLMDKEDPDTLYVAKNKSP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCC
LLIGVGEGFNVVCSDSLAMLDQTKDFLELHDGEIVVVKPDEIKITNQAGEPVERKPFHVD
EEEECCCCCEEEECCCHHHHHCCHHHHHCCCCEEEEECCCCEEEECCCCCCCCCCCEEEE
IDAAQADKGTYPFYMLKEIDEQPNVMRKLSQVYLNDAGDPIINDDLLTALKAADRLYIVA
EECCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCEEEEEE
AGTSYHAGLVGAKLFESLANVPTEVHVSSEFAYNQPLLSAHPFFIFLTQSGETADSREVL
ECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEE
LNVNDQHFPSLTITNVPNSTLSREATYTLLLHAGPEIAVASTKAYTAQIALQAILAKALG
EECCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHC
VAVDQPAATAFDVKQQLALVANGMQSLVDEKATFEKIAKSALLNTPNAFYIGRGLDYAVS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEE
LETALKLKEISYVQAEGFASGELKHGTIALIEKDTPVIGIITQKNTAGLTRSNLQEVAAR
HHHHHHHHHHHEEECCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHC
GAKTVTIVTDSLAKDGDTVILPTVDERLTALLSVVPGQLLAYYTSLNKGLDVDKPRNLAK
CCCEEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
SVTVE
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566