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The map label for this gene is nhaK [H]

Identifier: 28377665

GI number: 28377665

Start: 754186

End: 756315

Strand: Direct

Name: nhaK [H]

Synonym: lp_0815

Alternate gene names: 28377665

Gene position: 754186-756315 (Clockwise)

Preceding gene: 28377664

Following gene: 28377666

Centisome position: 22.8

GC content: 47.79

Gene sequence:

>2130_bases
ATGCCGATTATCGAATTAGTGATTTTACTGGCATGTTTAGTGCTGCTGTCGAATGTATTGAGCCACTATCTAGTCGCAAT
CCCGGTCAGTTTAATTCAAGTCGGGCTGGGTCTAGGAGTGGCTTTATTATTAAATGTACAGGTAAAATTGCAAACGGATT
GGTTTATGCTCGTCTTTATTGCGCCCATGCTGTACAACGATGGCAGAGAATTTCCAAAACAGGAATTATGGGAACTACGC
GGGGCAATTTTTGCGAATGCAATCGTCCTCGTCTTTATTACCACCATTCTCGGTGGCTTTTTGATTCACGTATTGATCCC
AACGATTCCGCTCGCTGTTGGAATCGCGTTGGCGGCCATTTTATCGCCAACTGATCCGATTGCCGTGCAGTCGATCTCGG
AAGGGGTCAAGTTACCTAAAGAAATTTTGCACTTGGTCAGTGGCGAAAGCCTGATTAATGATGCGAGTGGGTTAATTGGG
TTCAAATATGCGTTAGCAGCAGCGGTTACCGGTACGTTTGTACTCGGTGAAGCTGTTGGGGATTTCTTCTATATTAGTCT
GGTCGGTTTGGCCGTTGGGCTGGCGCTGATCACGATCATTCAACTCATTCGGGATGTGTTACGACGAGAGGGTATCAACG
ATATCGTGTTCAACGTGGTGTTACAGATTCTCACGCCGTTTGCAATTTATTTCATTGCTGAAGAATGGTTCCACGCGTCC
GGTGTTGTCGCCGTTGTTGCGGCCGGGGTATTATCGCACTTGCAAAATTCACATGAAAGTGAAGATGCGCCGGAATTACG
ATTAGTGACGGAACGGGTCTGGAACGTGGTTGTTTACTTATTGAATGGGATCGTCTTCCTGATTCTTGGTATTGAATTGC
CGGCAGCAACGCAAGCAACCATTAAAGGCGCGCATACAAATACGTTTCATGCGGTCTTTGACGTTTTAATCGTCTGGGGG
ATTTTGTTACTGATTCGGGTTGCTTGGACATACGCTTACATGTTGTTCAACTGGTTACGACATCACAAGAAGGCCAAACC
TAGTCTCAGAATTGCAGCATTGTCCGGTTTATCAGGTGTGCGGGGGGCCATTACGATGGCTGGGGTCTTCACGATTCCAA
CCGTGGTGGCCTCAGGCAAAGCCTTTCCGGAACGTGCGCTCGTACTGTTCATTGCGGCTGGAGTCATCATTGTAAGTTTA
GTTGCTGCGGCGGCTATTTTGCCATTGATGGCGGCCAAATCACTCCCCTTTGTTACTCGGGGATCCAGTCCGGATGAAGA
CGACGCGGTCTTGGCAGAGGGAACGGATGACGGTGATGATAGCAGTGGGCAATTGCCACAGTTAACATACAAGCAAGCCC
GCATTTATATCTTACAGTTAGCGATTCAAAATATTGAAGAACATCGGCGGCCAGCTAACCAACGTGCGGCCTATGATTTG
ATCCTGGACCAGCAGTTTCAGATTCGGCGTCTAGAAGTGGCGTCGCAGACTGCGGATGAGTTGGCGCCGATGCTGACAGA
TGAATTGGAACTTCGCTTAGTGGCACTGAATGGTGAACGGGCAGCAGTTAGAGAAATGATTGCCAATAAACAAACTAGTA
AGTTAGCTGGACAGGTCTACTTGCGGCGTGTCGATCGGCGCGAACAACGTTTCTTACAGGCGACACATCGACAGGGGCTT
CCGACACTGCGCTCATTACGGTTGTTGTTGACGCGTGCAATGCAAGGGATTCGACTATGGTTAGCACCTGGCGATAGCGA
AGAATTACGAGTGGCGTTGTTGGATATTCAGCGTGAAGCTTCTAAAGCTGCTATTAAAGCGTTGTCGCAGTATCTCAAAC
AGGCCAACGTTGATGAGCAACAGTTTGATCGCCAGGCTCTGTATCACTTGATCGTTCATTACCGGAATCGCATCGAGAAT
GCGAAAAATGATCACACGTTATCACGTGATGATTATGAACAACAGCTGCATGGACTACGCATCAAGAGTCTTGGTGCCGA
ACGTGCGGGTGTACAGCATTTGTTAGAGAGTGGACAAATTAGTTTACGCACCGCGGCAAAGTTACGGCAGTTCATTAATT
ACTCGGAGAACTTATTGATGCTCAATGATATTGAGGCCGATGAAGATTAG

Upstream 100 bases:

>100_bases
TGAACGGTTTGGCGTCCATCTTCAGACGGAAGTCCGAATCATTGGTGAAGACGTCGTTCAAGGTTAGTTATGTCAATTTA
ACAAAGGGGGCAACCACTAG

Downstream 100 bases:

>100_bases
TTAACTTTTTAGATTGTAAATCAGTAGTTCTAGGTTATAATGATGTTAGAGTAGTATTGACGGTGAATGGTTAGGTTTGC
AAATTAATCATTACTTAAGC

Product: Na(+)/H(+) antiporter (putative)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 709; Mature: 708

Protein sequence:

>709_residues
MPIIELVILLACLVLLSNVLSHYLVAIPVSLIQVGLGLGVALLLNVQVKLQTDWFMLVFIAPMLYNDGREFPKQELWELR
GAIFANAIVLVFITTILGGFLIHVLIPTIPLAVGIALAAILSPTDPIAVQSISEGVKLPKEILHLVSGESLINDASGLIG
FKYALAAAVTGTFVLGEAVGDFFYISLVGLAVGLALITIIQLIRDVLRREGINDIVFNVVLQILTPFAIYFIAEEWFHAS
GVVAVVAAGVLSHLQNSHESEDAPELRLVTERVWNVVVYLLNGIVFLILGIELPAATQATIKGAHTNTFHAVFDVLIVWG
ILLLIRVAWTYAYMLFNWLRHHKKAKPSLRIAALSGLSGVRGAITMAGVFTIPTVVASGKAFPERALVLFIAAGVIIVSL
VAAAAILPLMAAKSLPFVTRGSSPDEDDAVLAEGTDDGDDSSGQLPQLTYKQARIYILQLAIQNIEEHRRPANQRAAYDL
ILDQQFQIRRLEVASQTADELAPMLTDELELRLVALNGERAAVREMIANKQTSKLAGQVYLRRVDRREQRFLQATHRQGL
PTLRSLRLLLTRAMQGIRLWLAPGDSEELRVALLDIQREASKAAIKALSQYLKQANVDEQQFDRQALYHLIVHYRNRIEN
AKNDHTLSRDDYEQQLHGLRIKSLGAERAGVQHLLESGQISLRTAAKLRQFINYSENLLMLNDIEADED

Sequences:

>Translated_709_residues
MPIIELVILLACLVLLSNVLSHYLVAIPVSLIQVGLGLGVALLLNVQVKLQTDWFMLVFIAPMLYNDGREFPKQELWELR
GAIFANAIVLVFITTILGGFLIHVLIPTIPLAVGIALAAILSPTDPIAVQSISEGVKLPKEILHLVSGESLINDASGLIG
FKYALAAAVTGTFVLGEAVGDFFYISLVGLAVGLALITIIQLIRDVLRREGINDIVFNVVLQILTPFAIYFIAEEWFHAS
GVVAVVAAGVLSHLQNSHESEDAPELRLVTERVWNVVVYLLNGIVFLILGIELPAATQATIKGAHTNTFHAVFDVLIVWG
ILLLIRVAWTYAYMLFNWLRHHKKAKPSLRIAALSGLSGVRGAITMAGVFTIPTVVASGKAFPERALVLFIAAGVIIVSL
VAAAAILPLMAAKSLPFVTRGSSPDEDDAVLAEGTDDGDDSSGQLPQLTYKQARIYILQLAIQNIEEHRRPANQRAAYDL
ILDQQFQIRRLEVASQTADELAPMLTDELELRLVALNGERAAVREMIANKQTSKLAGQVYLRRVDRREQRFLQATHRQGL
PTLRSLRLLLTRAMQGIRLWLAPGDSEELRVALLDIQREASKAAIKALSQYLKQANVDEQQFDRQALYHLIVHYRNRIEN
AKNDHTLSRDDYEQQLHGLRIKSLGAERAGVQHLLESGQISLRTAAKLRQFINYSENLLMLNDIEADED
>Mature_708_residues
PIIELVILLACLVLLSNVLSHYLVAIPVSLIQVGLGLGVALLLNVQVKLQTDWFMLVFIAPMLYNDGREFPKQELWELRG
AIFANAIVLVFITTILGGFLIHVLIPTIPLAVGIALAAILSPTDPIAVQSISEGVKLPKEILHLVSGESLINDASGLIGF
KYALAAAVTGTFVLGEAVGDFFYISLVGLAVGLALITIIQLIRDVLRREGINDIVFNVVLQILTPFAIYFIAEEWFHASG
VVAVVAAGVLSHLQNSHESEDAPELRLVTERVWNVVVYLLNGIVFLILGIELPAATQATIKGAHTNTFHAVFDVLIVWGI
LLLIRVAWTYAYMLFNWLRHHKKAKPSLRIAALSGLSGVRGAITMAGVFTIPTVVASGKAFPERALVLFIAAGVIIVSLV
AAAAILPLMAAKSLPFVTRGSSPDEDDAVLAEGTDDGDDSSGQLPQLTYKQARIYILQLAIQNIEEHRRPANQRAAYDLI
LDQQFQIRRLEVASQTADELAPMLTDELELRLVALNGERAAVREMIANKQTSKLAGQVYLRRVDRREQRFLQATHRQGLP
TLRSLRLLLTRAMQGIRLWLAPGDSEELRVALLDIQREASKAAIKALSQYLKQANVDEQQFDRQALYHLIVHYRNRIENA
KNDHTLSRDDYEQQLHGLRIKSLGAERAGVQHLLESGQISLRTAAKLRQFINYSENLLMLNDIEADED

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=425, Percent_Identity=24.4705882352941, Blast_Score=83, Evalue=8e-16,
Organism=Escherichia coli, GI1790501, Length=573, Percent_Identity=30.3664921465969, Blast_Score=212, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI71980847, Length=351, Percent_Identity=23.9316239316239, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281364513, Length=343, Percent_Identity=23.9067055393586, Blast_Score=76, Evalue=9e-14,
Organism=Drosophila melanogaster, GI221473212, Length=343, Percent_Identity=23.9067055393586, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221473215, Length=343, Percent_Identity=23.9067055393586, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221473222, Length=343, Percent_Identity=23.9067055393586, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281360447, Length=388, Percent_Identity=23.9690721649485, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 78202; Mature: 78071

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIIELVILLACLVLLSNVLSHYLVAIPVSLIQVGLGLGVALLLNVQVKLQTDWFMLVFI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHH
APMLYNDGREFPKQELWELRGAIFANAIVLVFITTILGGFLIHVLIPTIPLAVGIALAAI
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSPTDPIAVQSISEGVKLPKEILHLVSGESLINDASGLIGFKYALAAAVTGTFVLGEAVG
HCCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFFYISLVGLAVGLALITIIQLIRDVLRREGINDIVFNVVLQILTPFAIYFIAEEWFHAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVVAVVAAGVLSHLQNSHESEDAPELRLVTERVWNVVVYLLNGIVFLILGIELPAATQAT
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
IKGAHTNTFHAVFDVLIVWGILLLIRVAWTYAYMLFNWLRHHKKAKPSLRIAALSGLSGV
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
RGAITMAGVFTIPTVVASGKAFPERALVLFIAAGVIIVSLVAAAAILPLMAAKSLPFVTR
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEC
GSSPDEDDAVLAEGTDDGDDSSGQLPQLTYKQARIYILQLAIQNIEEHRRPANQRAAYDL
CCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ILDQQFQIRRLEVASQTADELAPMLTDELELRLVALNGERAAVREMIANKQTSKLAGQVY
HHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCHHHHHHHHHH
LRRVDRREQRFLQATHRQGLPTLRSLRLLLTRAMQGIRLWLAPGDSEELRVALLDIQREA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHH
SKAAIKALSQYLKQANVDEQQFDRQALYHLIVHYRNRIENAKNDHTLSRDDYEQQLHGLR
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCH
IKSLGAERAGVQHLLESGQISLRTAAKLRQFINYSENLLMLNDIEADED
HHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCC
>Mature Secondary Structure 
PIIELVILLACLVLLSNVLSHYLVAIPVSLIQVGLGLGVALLLNVQVKLQTDWFMLVFI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHH
APMLYNDGREFPKQELWELRGAIFANAIVLVFITTILGGFLIHVLIPTIPLAVGIALAAI
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSPTDPIAVQSISEGVKLPKEILHLVSGESLINDASGLIGFKYALAAAVTGTFVLGEAVG
HCCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFFYISLVGLAVGLALITIIQLIRDVLRREGINDIVFNVVLQILTPFAIYFIAEEWFHAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVVAVVAAGVLSHLQNSHESEDAPELRLVTERVWNVVVYLLNGIVFLILGIELPAATQAT
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
IKGAHTNTFHAVFDVLIVWGILLLIRVAWTYAYMLFNWLRHHKKAKPSLRIAALSGLSGV
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
RGAITMAGVFTIPTVVASGKAFPERALVLFIAAGVIIVSLVAAAAILPLMAAKSLPFVTR
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEC
GSSPDEDDAVLAEGTDDGDDSSGQLPQLTYKQARIYILQLAIQNIEEHRRPANQRAAYDL
CCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ILDQQFQIRRLEVASQTADELAPMLTDELELRLVALNGERAAVREMIANKQTSKLAGQVY
HHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCHHHHHHHHHH
LRRVDRREQRFLQATHRQGLPTLRSLRLLLTRAMQGIRLWLAPGDSEELRVALLDIQREA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHH
SKAAIKALSQYLKQANVDEQQFDRQALYHLIVHYRNRIENAKNDHTLSRDDYEQQLHGLR
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCH
IKSLGAERAGVQHLLESGQISLRTAAKLRQFINYSENLLMLNDIEADED
HHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]