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The map label for this gene is murB

Identifier: 28377664

GI number: 28377664

Start: 753244

End: 754152

Strand: Direct

Name: murB

Synonym: lp_0814

Alternate gene names: 28377664

Gene position: 753244-754152 (Clockwise)

Preceding gene: 28377663

Following gene: 28377665

Centisome position: 22.77

GC content: 46.2

Gene sequence:

>909_bases
ATGACCAAAGATGTCTTGGCCACTTTTCCAGCCATCGAAATTAAAAAAAATGAATCACTAAGTCATTATACGAATACTAA
AACAGGCGGTCCCGCCGATTACGTTCGCTTTCCAAAGTCAATCAGCGAGACGAAAGCTCTGATTACGTTTGCCAATGAGC
AAAATTTACCACTAACCGTGATTGGTAATGCCAGTAATTTGATTGTCAAAGATGGTGGTATCCGTGGATTAACGATCATT
CTCACCCGCATGAAGCAAATTCATGCGAGTGGCACCAAAGTTGTTGCTGAAGCTGGTGCCGCAATTATTGCGACGACTAA
GGTTGCTTGTGGCGCTAGCTTGACTGGTCTCGAATTCGCAGCTGGGATTCCCGGTAGTGTCGGGGGTGCGATTTTCATGA
ATGCTGGTGCGTACGGCGGCGAAATGAGTGAAGTTGTTGAAACGGTGACGGTTTTGACGCCAGCGGGTCAGCTTAAAACC
CTGGATCATGACGAATTAGATTTTGGCTATCGGCACAGTACGATCCAGGACTATGATGATATTGTCGTATCGGTGACGTT
TGGTCTCAAGCCAGGTAATCAGACCAAGATTCAAGCGCGGATGGACGAATTGAATACGTTGCGAGCAGCCAAACAACCGT
TGGAATGGCCATCATGCGGGAGTGTTTTTAAGCGACCAACTGGGTATTTTACTGGTAAACTGATTCATGATGCTGGCTTA
CAGGGCCATCGAATCGGTGGTGCTGAAGTTTCTAAGAAACACGCGGGTTTTATTATCAATGTCGATCACGCTACAGCGAC
CGATTATATGGATATGATTCACTACGTCCAGAAAGTTGTATTTGAACGGTTTGGCGTCCATCTTCAGACGGAAGTCCGAA
TCATTGGTGAAGACGTCGTTCAAGGTTAG

Upstream 100 bases:

>100_bases
TGCGGTGCTTGATACGTCGGCCTAAATTAAAAACGCTATGCGGTTAAAGTGATTATTAACGTAAGTGAATTAAATCGAAA
CACGAAAGGAACTTTTCACC

Downstream 100 bases:

>100_bases
TTATGTCAATTTAACAAAGGGGGCAACCACTAGATGCCGATTATCGAATTAGTGATTTTACTGGCATGTTTAGTGCTGCT
GTCGAATGTATTGAGCCACT

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MTKDVLATFPAIEIKKNESLSHYTNTKTGGPADYVRFPKSISETKALITFANEQNLPLTVIGNASNLIVKDGGIRGLTII
LTRMKQIHASGTKVVAEAGAAIIATTKVACGASLTGLEFAAGIPGSVGGAIFMNAGAYGGEMSEVVETVTVLTPAGQLKT
LDHDELDFGYRHSTIQDYDDIVVSVTFGLKPGNQTKIQARMDELNTLRAAKQPLEWPSCGSVFKRPTGYFTGKLIHDAGL
QGHRIGGAEVSKKHAGFIINVDHATATDYMDMIHYVQKVVFERFGVHLQTEVRIIGEDVVQG

Sequences:

>Translated_302_residues
MTKDVLATFPAIEIKKNESLSHYTNTKTGGPADYVRFPKSISETKALITFANEQNLPLTVIGNASNLIVKDGGIRGLTII
LTRMKQIHASGTKVVAEAGAAIIATTKVACGASLTGLEFAAGIPGSVGGAIFMNAGAYGGEMSEVVETVTVLTPAGQLKT
LDHDELDFGYRHSTIQDYDDIVVSVTFGLKPGNQTKIQARMDELNTLRAAKQPLEWPSCGSVFKRPTGYFTGKLIHDAGL
QGHRIGGAEVSKKHAGFIINVDHATATDYMDMIHYVQKVVFERFGVHLQTEVRIIGEDVVQG
>Mature_301_residues
TKDVLATFPAIEIKKNESLSHYTNTKTGGPADYVRFPKSISETKALITFANEQNLPLTVIGNASNLIVKDGGIRGLTIIL
TRMKQIHASGTKVVAEAGAAIIATTKVACGASLTGLEFAAGIPGSVGGAIFMNAGAYGGEMSEVVETVTVLTPAGQLKTL
DHDELDFGYRHSTIQDYDDIVVSVTFGLKPGNQTKIQARMDELNTLRAAKQPLEWPSCGSVFKRPTGYFTGKLIHDAGLQ
GHRIGGAEVSKKHAGFIINVDHATATDYMDMIHYVQKVVFERFGVHLQTEVRIIGEDVVQG

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_LACPL (Q88YF4)

Other databases:

- EMBL:   AL935254
- RefSeq:   NP_784556.1
- ProteinModelPortal:   Q88YF4
- SMR:   Q88YF4
- GeneID:   1063918
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_0814
- NMPDR:   fig|220668.1.peg.690
- HOGENOM:   HBG686573
- OMA:   SKKHAGF
- ProtClustDB:   PRK13905
- BioCyc:   LPLA220668:LP_0814-MONOMER
- BRENDA:   1.1.1.158
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 32418; Mature: 32287

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 171-171 ACT_SITE 221-221 ACT_SITE 291-291

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKDVLATFPAIEIKKNESLSHYTNTKTGGPADYVRFPKSISETKALITFANEQNLPLTV
CCCCHHHHCCEEEEECCCCCCCCCCCCCCCCHHHHHCCCHHHCCEEEEEEECCCCCCEEE
IGNASNLIVKDGGIRGLTIILTRMKQIHASGTKVVAEAGAAIIATTKVACGASLTGLEFA
EECCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEHHCCCEEEEEEEHHCCCCCCCCHHH
AGIPGSVGGAIFMNAGAYGGEMSEVVETVTVLTPAGQLKTLDHDELDFGYRHSTIQDYDD
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCC
IVVSVTFGLKPGNQTKIQARMDELNTLRAAKQPLEWPSCGSVFKRPTGYFTGKLIHDAGL
EEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCEEEEEEECCCC
QGHRIGGAEVSKKHAGFIINVDHATATDYMDMIHYVQKVVFERFGVHLQTEVRIIGEDVV
CCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECHHHC
QG
CC
>Mature Secondary Structure 
TKDVLATFPAIEIKKNESLSHYTNTKTGGPADYVRFPKSISETKALITFANEQNLPLTV
CCCHHHHCCEEEEECCCCCCCCCCCCCCCCHHHHHCCCHHHCCEEEEEEECCCCCCEEE
IGNASNLIVKDGGIRGLTIILTRMKQIHASGTKVVAEAGAAIIATTKVACGASLTGLEFA
EECCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEHHCCCEEEEEEEHHCCCCCCCCHHH
AGIPGSVGGAIFMNAGAYGGEMSEVVETVTVLTPAGQLKTLDHDELDFGYRHSTIQDYDD
CCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCC
IVVSVTFGLKPGNQTKIQARMDELNTLRAAKQPLEWPSCGSVFKRPTGYFTGKLIHDAGL
EEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCEEEEEEECCCC
QGHRIGGAEVSKKHAGFIINVDHATATDYMDMIHYVQKVVFERFGVHLQTEVRIIGEDVV
CCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECHHHC
QG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566