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The map label for this gene is rnr1 [H]

Identifier: 28377650

GI number: 28377650

Start: 733254

End: 735689

Strand: Direct

Name: rnr1 [H]

Synonym: lp_0797

Alternate gene names: 28377650

Gene position: 733254-735689 (Clockwise)

Preceding gene: 28377649

Following gene: 28377651

Centisome position: 22.16

GC content: 45.2

Gene sequence:

>2436_bases
ATGTCAGAAGCAAACTTACAAGAACAAATCCTGACTTTTTTGCAAGCTCATCCCGATCGCACGTATAGTGTTGAACAACT
AACGGATGAATTGCATTTTACAGGCGCAACGGCGTTTACTTTTCTAGTAAAGGAACTTGCGAATATGGAACGTAAAAAAT
TAGTTAGTACCGATGATCATGATCATTTCAAGCTGGTCCAGGAAACGAAGACTGTTGAAGGTTCATTTCATGGTAATGAC
AAGGGCTTTGGTTTCGTTCGTTACGATCCCGATTTGCCTGATATTTACATTAATCCGGACAACACGCAGTTTGCCATTAC
CGGTGACGATGTTGCGGTTGAAATCATTCGACCAGCCCGTCCCGGTTCCGACCGCGGCCCTGAAGGTAAAATTGTCAGCA
TCGTTAAACGGAACTATACCCAGATTGTCGGTGCGTATACACCAAGTACGGATGAAGACGGGATTATTGGTTCTGTGGAA
ATTAAGGATAAGAAATTATCCAAATATCAGTTATTAATCACTGATCAGGGCTTACACCCCACTGAGGGGGAAGTCATCAT
TGCTGAAGTGGCTGCTTATCCTGACGCTCAGCATCCAACGCGGATGATTGGGATTGCCAAGCAGGTCATTGGGAGTGTTG
ATGATCCTGGGATGGACGTCTTACAAGTGGTCTACCAACACGACGTCCCATCAGTGTTTCCAGAAGAAGTGACGGATGAA
GCCAACCGGATTCCGGATTACGTGACTGATGAAGAAAAAGTTGGTCGGGTCGACATTACGGACCAGCCATTAGTAACGAT
TGATGGCGCCGAATCTAAAGACTTGGATGACGCGGTTGTTGCTTGGCGCTTGCCAAATGGGAACTTCCATCTAGGCGTTC
ACATTGCGGATGTTAGCCATTATGTCACCGAGAACTCTGAGTTAGACCGGGAAGCATTCAAACGTGGGACGTCAGTTTAC
TTAACTGACCGTGTGATTCCAATGTTGCCACGGCGGCTATCAAACGGGATTTGTTCCTTAAATCCTGATGTTGAACGATT
AGCCATGAGTTGTGAGATGGAGATTGATCAAACGGGGGAAATCGTTAACCATAAGATTTTCCAAAGTGTGATTCGGTCAC
ACGCCCGGATGACTTATGACGCTGTTAATCAGATTCTCGAAGCCCATGACCCCAAGACGCGTGAAAAGTACGCGGACTTG
GTCGACATGTTTGATACGATGGGCGACTTACACCGTATCTTGTACAAGCATCGGCGGCATCGTGGTGCGATCGATTTTGA
TGATAACGAAGCTAAAATTATCGTTGACGAAGCCGGTCATCCAATTGACATTCAATTACGGGTACGTGGCTTAGCTGAAC
GAATGATCGAAAGTTTCATGTTGGCAGCCAACGAAACGGTTGCAAAAAACTATAGTCAACTTAAGGTACCGTTTATCTAC
CGGGTACATGAAACGCCTGATAGTGACCGGATGCTTAGTTTCTTTGAATTCGTCACTAACTTTGGTGTCAGTGTCAAGGG
GAGTTCTAAGGATGTTAAGCCGAAGATGCTTCAAGACGTTTTGAAGAAGGTTGCTGGTAAGCCCGAAGAAGCCATGGTCT
CAGTCATGATGCTGCGGAGCATGAAGCAGGCCCGATACGCTGACCAGTCGCTTGGTCACTTTGGGTTGGCGGCACCGTAT
TATACTCACTTTACGTCACCAATTCGGCGGTATCCAGATATGATGGTTCATCGTTTGATTCGCCATTATGCTGAAAACGG
CACTGGTGAAGAAGCCCGGGCACGTTATCGGGATAACCTACCAAATATTGCGGAAACGACTTCTGATCATGAACGGCGGG
GGATTGATACTGAACGCGACGTTGATTCGATGAAGAAGGCTGAATATATGGCTGATCACGTTGGTGAGACGTTTGAAGCC
GTTGTTGATTCCGTTATGAAATTCGGTCTGTTTGTTGAACTAGAAAATACCGTTGAAGGCTTAGTTCATATCAGTACTAT
GGACGACGACTACTACGAATACGTTGAAAAACAATTAGCGTTGGTTGGTCGTAAGACGAAACGGACATTTAGAATCGGCC
AGCCCGTCAAAGTTCAACTAATGCGGGTCGATAAGGATCAACGAGAAGTCGACTTTAAGTTATTGAATCCTGAAGAAGCG
CCAAAGACTGATTTATTGCCAAAGCGGGAACATCATGATAACTATCGTGGTAATAACCGGCGTGGTGGCAATAACGGTAA
CTACCGGCGAAATGGGAACAATAATAACCGGAATAATGACCATCGTGGTGGCAACAACAATAACCATCGTAATGGCAATA
GCAATGGTCGCCGGAACAATAATAATCATAATAGCAACAATAATAATCATAATAGCAACAATAATAATCATAGTACTAAC
AACAATCGGCGGTCATCAACTGATCGTCGGCGTTAA

Upstream 100 bases:

>100_bases
ATGCTGATGCTGGACACGTGATTACCGTCAACAGTGCGCATCACCAATTGGAACAAGATGTTTTAACATATTTAAAAACT
ATTTATAAATGAGGTAAATA

Downstream 100 bases:

>100_bases
TTTTTAAGTAAGGGGATGTGCGGCAATGGCCAAACAACACGGTAAGCACCCAGATACCGCCCTCGCTCAAAATCGGAAAG
CACGCCATGACTACGCTGTT

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R 1; VacB protein homolog 1 [H]

Number of amino acids: Translated: 811; Mature: 810

Protein sequence:

>811_residues
MSEANLQEQILTFLQAHPDRTYSVEQLTDELHFTGATAFTFLVKELANMERKKLVSTDDHDHFKLVQETKTVEGSFHGND
KGFGFVRYDPDLPDIYINPDNTQFAITGDDVAVEIIRPARPGSDRGPEGKIVSIVKRNYTQIVGAYTPSTDEDGIIGSVE
IKDKKLSKYQLLITDQGLHPTEGEVIIAEVAAYPDAQHPTRMIGIAKQVIGSVDDPGMDVLQVVYQHDVPSVFPEEVTDE
ANRIPDYVTDEEKVGRVDITDQPLVTIDGAESKDLDDAVVAWRLPNGNFHLGVHIADVSHYVTENSELDREAFKRGTSVY
LTDRVIPMLPRRLSNGICSLNPDVERLAMSCEMEIDQTGEIVNHKIFQSVIRSHARMTYDAVNQILEAHDPKTREKYADL
VDMFDTMGDLHRILYKHRRHRGAIDFDDNEAKIIVDEAGHPIDIQLRVRGLAERMIESFMLAANETVAKNYSQLKVPFIY
RVHETPDSDRMLSFFEFVTNFGVSVKGSSKDVKPKMLQDVLKKVAGKPEEAMVSVMMLRSMKQARYADQSLGHFGLAAPY
YTHFTSPIRRYPDMMVHRLIRHYAENGTGEEARARYRDNLPNIAETTSDHERRGIDTERDVDSMKKAEYMADHVGETFEA
VVDSVMKFGLFVELENTVEGLVHISTMDDDYYEYVEKQLALVGRKTKRTFRIGQPVKVQLMRVDKDQREVDFKLLNPEEA
PKTDLLPKREHHDNYRGNNRRGGNNGNYRRNGNNNNRNNDHRGGNNNNHRNGNSNGRRNNNNHNSNNNNHNSNNNNHSTN
NNRRSSTDRRR

Sequences:

>Translated_811_residues
MSEANLQEQILTFLQAHPDRTYSVEQLTDELHFTGATAFTFLVKELANMERKKLVSTDDHDHFKLVQETKTVEGSFHGND
KGFGFVRYDPDLPDIYINPDNTQFAITGDDVAVEIIRPARPGSDRGPEGKIVSIVKRNYTQIVGAYTPSTDEDGIIGSVE
IKDKKLSKYQLLITDQGLHPTEGEVIIAEVAAYPDAQHPTRMIGIAKQVIGSVDDPGMDVLQVVYQHDVPSVFPEEVTDE
ANRIPDYVTDEEKVGRVDITDQPLVTIDGAESKDLDDAVVAWRLPNGNFHLGVHIADVSHYVTENSELDREAFKRGTSVY
LTDRVIPMLPRRLSNGICSLNPDVERLAMSCEMEIDQTGEIVNHKIFQSVIRSHARMTYDAVNQILEAHDPKTREKYADL
VDMFDTMGDLHRILYKHRRHRGAIDFDDNEAKIIVDEAGHPIDIQLRVRGLAERMIESFMLAANETVAKNYSQLKVPFIY
RVHETPDSDRMLSFFEFVTNFGVSVKGSSKDVKPKMLQDVLKKVAGKPEEAMVSVMMLRSMKQARYADQSLGHFGLAAPY
YTHFTSPIRRYPDMMVHRLIRHYAENGTGEEARARYRDNLPNIAETTSDHERRGIDTERDVDSMKKAEYMADHVGETFEA
VVDSVMKFGLFVELENTVEGLVHISTMDDDYYEYVEKQLALVGRKTKRTFRIGQPVKVQLMRVDKDQREVDFKLLNPEEA
PKTDLLPKREHHDNYRGNNRRGGNNGNYRRNGNNNNRNNDHRGGNNNNHRNGNSNGRRNNNNHNSNNNNHNSNNNNHSTN
NNRRSSTDRRR
>Mature_810_residues
SEANLQEQILTFLQAHPDRTYSVEQLTDELHFTGATAFTFLVKELANMERKKLVSTDDHDHFKLVQETKTVEGSFHGNDK
GFGFVRYDPDLPDIYINPDNTQFAITGDDVAVEIIRPARPGSDRGPEGKIVSIVKRNYTQIVGAYTPSTDEDGIIGSVEI
KDKKLSKYQLLITDQGLHPTEGEVIIAEVAAYPDAQHPTRMIGIAKQVIGSVDDPGMDVLQVVYQHDVPSVFPEEVTDEA
NRIPDYVTDEEKVGRVDITDQPLVTIDGAESKDLDDAVVAWRLPNGNFHLGVHIADVSHYVTENSELDREAFKRGTSVYL
TDRVIPMLPRRLSNGICSLNPDVERLAMSCEMEIDQTGEIVNHKIFQSVIRSHARMTYDAVNQILEAHDPKTREKYADLV
DMFDTMGDLHRILYKHRRHRGAIDFDDNEAKIIVDEAGHPIDIQLRVRGLAERMIESFMLAANETVAKNYSQLKVPFIYR
VHETPDSDRMLSFFEFVTNFGVSVKGSSKDVKPKMLQDVLKKVAGKPEEAMVSVMMLRSMKQARYADQSLGHFGLAAPYY
THFTSPIRRYPDMMVHRLIRHYAENGTGEEARARYRDNLPNIAETTSDHERRGIDTERDVDSMKKAEYMADHVGETFEAV
VDSVMKFGLFVELENTVEGLVHISTMDDDYYEYVEKQLALVGRKTKRTFRIGQPVKVQLMRVDKDQREVDFKLLNPEEAP
KTDLLPKREHHDNYRGNNRRGGNNGNYRRNGNNNNRNNDHRGGNNNNHRNGNSNGRRNNNNHNSNNNNHNSNNNNHSTNN
NRRSSTDRRR

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=473, Percent_Identity=31.2896405919662, Blast_Score=218, Evalue=2e-56,
Organism=Homo sapiens, GI190014625, Length=473, Percent_Identity=31.2896405919662, Blast_Score=217, Evalue=3e-56,
Organism=Homo sapiens, GI134288890, Length=433, Percent_Identity=31.6397228637413, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI19115966, Length=502, Percent_Identity=29.0836653386454, Blast_Score=153, Evalue=8e-37,
Organism=Homo sapiens, GI219521928, Length=502, Percent_Identity=29.0836653386454, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI156105695, Length=574, Percent_Identity=22.6480836236934, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI156105693, Length=204, Percent_Identity=27.9411764705882, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI87082383, Length=712, Percent_Identity=35.9550561797753, Blast_Score=448, Evalue=1e-127,
Organism=Escherichia coli, GI1787542, Length=609, Percent_Identity=28.4072249589491, Blast_Score=153, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI212645896, Length=468, Percent_Identity=30.7692307692308, Blast_Score=186, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17553506, Length=396, Percent_Identity=31.8181818181818, Blast_Score=162, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6324552, Length=488, Percent_Identity=31.1475409836066, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6320499, Length=431, Percent_Identity=23.8979118329466, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6323943, Length=359, Percent_Identity=22.5626740947075, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24649634, Length=484, Percent_Identity=33.2644628099174, Blast_Score=235, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24654592, Length=444, Percent_Identity=27.2522522522523, Blast_Score=163, Evalue=5e-40,
Organism=Drosophila melanogaster, GI19922976, Length=442, Percent_Identity=27.3755656108597, Blast_Score=163, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24654597, Length=442, Percent_Identity=27.3755656108597, Blast_Score=163, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 92362; Mature: 92231

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEANLQEQILTFLQAHPDRTYSVEQLTDELHFTGATAFTFLVKELANMERKKLVSTDDH
CCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCC
DHFKLVQETKTVEGSFHGNDKGFGFVRYDPDLPDIYINPDNTQFAITGDDVAVEIIRPAR
HHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEECCCCCEEEEECCCEEEEEEECCC
PGSDRGPEGKIVSIVKRNYTQIVGAYTPSTDEDGIIGSVEIKDKKLSKYQLLITDQGLHP
CCCCCCCCCCEEHHHHHCHHHEEEEECCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCC
TEGEVIIAEVAAYPDAQHPTRMIGIAKQVIGSVDDPGMDVLQVVYQHDVPSVFPEEVTDE
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHH
ANRIPDYVTDEEKVGRVDITDQPLVTIDGAESKDLDDAVVAWRLPNGNFHLGVHIADVSH
HHCCCCCCCCHHHCCEEECCCCCEEEECCCCCCCCCCEEEEEECCCCCEEEEEEEECHHH
YVTENSELDREAFKRGTSVYLTDRVIPMLPRRLSNGICSLNPDVERLAMSCEMEIDQTGE
HHCCCCCCCHHHHHCCCEEEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHH
IVNHKIFQSVIRSHARMTYDAVNQILEAHDPKTREKYADLVDMFDTMGDLHRILYKHRRH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGAIDFDDNEAKIIVDEAGHPIDIQLRVRGLAERMIESFMLAANETVAKNYSQLKVPFIY
CCCCCCCCCCCEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHCCHHHHHCHHHEECCEEE
RVHETPDSDRMLSFFEFVTNFGVSVKGSSKDVKPKMLQDVLKKVAGKPEEAMVSVMMLRS
EEECCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
MKQARYADQSLGHFGLAAPYYTHFTSPIRRYPDMMVHRLIRHYAENGTGEEARARYRDNL
HHHHHHHHHHCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
PNIAETTSDHERRGIDTERDVDSMKKAEYMADHVGETFEAVVDSVMKFGLFVELENTVEG
CCHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCHHCC
LVHISTMDDDYYEYVEKQLALVGRKTKRTFRIGQPVKVQLMRVDKDQREVDFKLLNPEEA
EEEEEECCHHHHHHHHHHHHHHHHHHHCEEECCCCCEEEEEECCCCCCCCCEEEECCCCC
PKTDLLPKREHHDNYRGNNRRGGNNGNYRRNGNNNNRNNDHRGGNNNNHRNGNSNGRRNN
CCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NNHNSNNNNHNSNNNNHSTNNNRRSSTDRRR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SEANLQEQILTFLQAHPDRTYSVEQLTDELHFTGATAFTFLVKELANMERKKLVSTDDH
CCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCC
DHFKLVQETKTVEGSFHGNDKGFGFVRYDPDLPDIYINPDNTQFAITGDDVAVEIIRPAR
HHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEECCCCCEEEEECCCEEEEEEECCC
PGSDRGPEGKIVSIVKRNYTQIVGAYTPSTDEDGIIGSVEIKDKKLSKYQLLITDQGLHP
CCCCCCCCCCEEHHHHHCHHHEEEEECCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCC
TEGEVIIAEVAAYPDAQHPTRMIGIAKQVIGSVDDPGMDVLQVVYQHDVPSVFPEEVTDE
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHH
ANRIPDYVTDEEKVGRVDITDQPLVTIDGAESKDLDDAVVAWRLPNGNFHLGVHIADVSH
HHCCCCCCCCHHHCCEEECCCCCEEEECCCCCCCCCCEEEEEECCCCCEEEEEEEECHHH
YVTENSELDREAFKRGTSVYLTDRVIPMLPRRLSNGICSLNPDVERLAMSCEMEIDQTGE
HHCCCCCCCHHHHHCCCEEEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHH
IVNHKIFQSVIRSHARMTYDAVNQILEAHDPKTREKYADLVDMFDTMGDLHRILYKHRRH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGAIDFDDNEAKIIVDEAGHPIDIQLRVRGLAERMIESFMLAANETVAKNYSQLKVPFIY
CCCCCCCCCCCEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHCCHHHHHCHHHEECCEEE
RVHETPDSDRMLSFFEFVTNFGVSVKGSSKDVKPKMLQDVLKKVAGKPEEAMVSVMMLRS
EEECCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
MKQARYADQSLGHFGLAAPYYTHFTSPIRRYPDMMVHRLIRHYAENGTGEEARARYRDNL
HHHHHHHHHHCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
PNIAETTSDHERRGIDTERDVDSMKKAEYMADHVGETFEAVVDSVMKFGLFVELENTVEG
CCHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCHHCC
LVHISTMDDDYYEYVEKQLALVGRKTKRTFRIGQPVKVQLMRVDKDQREVDFKLLNPEEA
EEEEEECCHHHHHHHHHHHHHHHHHHHCEEECCCCCEEEEEECCCCCCCCCEEEECCCCC
PKTDLLPKREHHDNYRGNNRRGGNNGNYRRNGNNNNRNNDHRGGNNNNHRNGNSNGRRNN
CCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NNHNSNNNNHNSNNNNHSTNNNRRSSTDRRR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]