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The map label for this gene is uvrB

Identifier: 28377628

GI number: 28377628

Start: 705174

End: 707177

Strand: Direct

Name: uvrB

Synonym: lp_0772

Alternate gene names: 28377628

Gene position: 705174-707177 (Clockwise)

Preceding gene: 28377627

Following gene: 28377629

Centisome position: 21.32

GC content: 46.86

Gene sequence:

>2004_bases
TTGATTGATCGGGTAGATAATAATCATTTTGACTTAGTTTCAGATTACCAACCAACGGGCGATCAACCCCAAGCGATCCA
GCAATTAACCGCTGGCATTGAATCGGGAGAAAAAGAGCAGATCTTGTTGGGGGCGACCGGGACCGGGAAGACCTTTACAA
TTTCGAACGTGATTGCAAAGGTGAATAAGCCAACGTTAATCTTGTCACATAACAAGACGTTAGCGGGTCAATTATACGGG
GAGTTTAAGAAGTTTTTCCCGAACAATGCCGTTGAATATTTTGTGAGTTATTACGATTATTATCAGCCGGAAGCGTACGT
GCCTTCGAGTGATACCTATATCGAAAAGGACTCGGCAATCAACGATGAAATCGATAAGTTACGGCACTCTGCGACCAGCT
CATTATTGGAACGCAACGATGTGATCGTCGTGGCATCGGTCTCCAGTATTTTCGGTTTAGGTGATCCTCACGAGTACCAA
GATCACGTAGTCTCACTGCGAGTCGGCATGGAGATCGACCGCAATGATCTGTTGCGTAAACTTGTTGATATTCAATTTGA
TCGTAACGATATTGATTTCCAGCGGGGGCGTTTTCGGGTCCATGGTGATGTCGTAGAAATCTTTCCGGCTTCACGGGATG
ACCACGCATTGCGCGTTGAATTCTTTGGCGATGAGATTGATCGAATCCGTGAGATTGACGCCTTAACCGGTGAAATTGTA
GCTGATCGTGAACATGTTGCGATCTTCCCAGCGACCCACTTTATGACGAATGATGCGATTATGGAACACGCCATCAAGGG
CATTGAAGATGAGTTGGATGGCCGCCTGAAAGAATTGACAGCCGATGGCAAATTGTTAGAGGCGCAACGACTCAAGCAGC
GGACGACCTATGATGTCGAAATGCTCAAAGAAATGGGCTACACTAGTGGTATCGAGAACTATTCACGTTTTATGGATGGC
CGTAAACCTGGCGAACCACCGTATACGTTACTGGACTTCTTCCCGAAGGACTTTTTGCTCGTGGTCGATGAGTCACACGT
GACGATGCCCCAAGTTCGGGGAATGTATAATGGGGACCGAGCACGTAAACAAATGCTAGTCGATTATGGCTTCCGTTTGC
CAAGTGCGTTGGACAACCGGCCATTGAAACTTGAAGAAGTTGAACAGCATATTAATCAAGTGGTTTATATGTCCGCAACG
CCGGGCCCTTACGAAATGGATCGGACCAAGCATGTCGTCCAGCAAATTATTCGACCAACTGGTTTATTGGATCCTACGAT
TGAGGTTCGACCGATTATGGGTCAGATCGATGACTTAGTGGGTGAAATCAATAAGCGCATTGAGGTCAACGAACGGGTCT
TTATCACCACGTTAACTAAGAAGATGGCGGAAGATTTGACCGACTACTTTAAGGATTTAGGCATCAAGGTACGGTACTTG
CACAGTGATATTAAGACGTTGGAACGAACGCAGATCATCCGCGACCTGCGTCTGGGCAAGTTCGATGTGTTGGTCGGGAT
CAACTTGTTGCGGGAAGGAATTGACGTTCCCGAAGTTTCACTAGTTGCGATTTTGGATGCGGATAAGGAAGGTTTCCTTC
GTAACGAGCGTTCGTTGATCCAAACGATTGGTCGGGCGGCTCGTAATGAGCACGGTTCAGTGATTATGTACGCTGACACC
ACGACTGATTCGATGCAGGCCGCGATGGATGAGACTGCACGTCGTCGTGCCGTACAGATGAAGTACAATGAAGATCATCA
CATCACGCCACATACGATTAAGAAGGCCATTCCAGAGCTAATTGCTTCGACGAAGACCACTGAAGACGCGGGCAAGAAGG
ATGACTTCTTAGAAACTGACTTTGATGATATGACCCGTGAACAACAATTAGATATGATTAGTAAGTTGGAAGAACAGATG
AAGACCGCCGCTAAGAAGCTCGACTTTGAACAAGCCGCAACGCTGCGTGATACGGTCATGGAATTGAAAGCACAAATTAG
CTAG

Upstream 100 bases:

>100_bases
ATAGGGAAGCGCGGGCTTGCCTATTTTTTATGGTGCGACAGTAAGATTTAGTTATCAATAGATGATATGAACGGGTGACC
GTTTAAAAGGAGGACTACGT

Downstream 100 bases:

>100_bases
CAGGTTGCTGGCTTGAGATTGAGGAGGCCTTTTTTTGGCAAATGATAAGATTGTCATTCACGGTGCGCGAGCCCATAATT
TAAAAGATATCGACGTTACC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 667; Mature: 667

Protein sequence:

>667_residues
MIDRVDNNHFDLVSDYQPTGDQPQAIQQLTAGIESGEKEQILLGATGTGKTFTISNVIAKVNKPTLILSHNKTLAGQLYG
EFKKFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSAINDEIDKLRHSATSSLLERNDVIVVASVSSIFGLGDPHEYQ
DHVVSLRVGMEIDRNDLLRKLVDIQFDRNDIDFQRGRFRVHGDVVEIFPASRDDHALRVEFFGDEIDRIREIDALTGEIV
ADREHVAIFPATHFMTNDAIMEHAIKGIEDELDGRLKELTADGKLLEAQRLKQRTTYDVEMLKEMGYTSGIENYSRFMDG
RKPGEPPYTLLDFFPKDFLLVVDESHVTMPQVRGMYNGDRARKQMLVDYGFRLPSALDNRPLKLEEVEQHINQVVYMSAT
PGPYEMDRTKHVVQQIIRPTGLLDPTIEVRPIMGQIDDLVGEINKRIEVNERVFITTLTKKMAEDLTDYFKDLGIKVRYL
HSDIKTLERTQIIRDLRLGKFDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNERSLIQTIGRAARNEHGSVIMYADT
TTDSMQAAMDETARRRAVQMKYNEDHHITPHTIKKAIPELIASTKTTEDAGKKDDFLETDFDDMTREQQLDMISKLEEQM
KTAAKKLDFEQAATLRDTVMELKAQIS

Sequences:

>Translated_667_residues
MIDRVDNNHFDLVSDYQPTGDQPQAIQQLTAGIESGEKEQILLGATGTGKTFTISNVIAKVNKPTLILSHNKTLAGQLYG
EFKKFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSAINDEIDKLRHSATSSLLERNDVIVVASVSSIFGLGDPHEYQ
DHVVSLRVGMEIDRNDLLRKLVDIQFDRNDIDFQRGRFRVHGDVVEIFPASRDDHALRVEFFGDEIDRIREIDALTGEIV
ADREHVAIFPATHFMTNDAIMEHAIKGIEDELDGRLKELTADGKLLEAQRLKQRTTYDVEMLKEMGYTSGIENYSRFMDG
RKPGEPPYTLLDFFPKDFLLVVDESHVTMPQVRGMYNGDRARKQMLVDYGFRLPSALDNRPLKLEEVEQHINQVVYMSAT
PGPYEMDRTKHVVQQIIRPTGLLDPTIEVRPIMGQIDDLVGEINKRIEVNERVFITTLTKKMAEDLTDYFKDLGIKVRYL
HSDIKTLERTQIIRDLRLGKFDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNERSLIQTIGRAARNEHGSVIMYADT
TTDSMQAAMDETARRRAVQMKYNEDHHITPHTIKKAIPELIASTKTTEDAGKKDDFLETDFDDMTREQQLDMISKLEEQM
KTAAKKLDFEQAATLRDTVMELKAQIS
>Mature_667_residues
MIDRVDNNHFDLVSDYQPTGDQPQAIQQLTAGIESGEKEQILLGATGTGKTFTISNVIAKVNKPTLILSHNKTLAGQLYG
EFKKFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSAINDEIDKLRHSATSSLLERNDVIVVASVSSIFGLGDPHEYQ
DHVVSLRVGMEIDRNDLLRKLVDIQFDRNDIDFQRGRFRVHGDVVEIFPASRDDHALRVEFFGDEIDRIREIDALTGEIV
ADREHVAIFPATHFMTNDAIMEHAIKGIEDELDGRLKELTADGKLLEAQRLKQRTTYDVEMLKEMGYTSGIENYSRFMDG
RKPGEPPYTLLDFFPKDFLLVVDESHVTMPQVRGMYNGDRARKQMLVDYGFRLPSALDNRPLKLEEVEQHINQVVYMSAT
PGPYEMDRTKHVVQQIIRPTGLLDPTIEVRPIMGQIDDLVGEINKRIEVNERVFITTLTKKMAEDLTDYFKDLGIKVRYL
HSDIKTLERTQIIRDLRLGKFDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNERSLIQTIGRAARNEHGSVIMYADT
TTDSMQAAMDETARRRAVQMKYNEDHHITPHTIKKAIPELIASTKTTEDAGKKDDFLETDFDDMTREQQLDMISKLEEQM
KTAAKKLDFEQAATLRDTVMELKAQIS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=663, Percent_Identity=59.1251885369532, Blast_Score=769, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_LACPL (Q88YI8)

Other databases:

- EMBL:   AL935254
- RefSeq:   NP_784520.1
- ProteinModelPortal:   Q88YI8
- SMR:   Q88YI8
- GeneID:   1063751
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_0772
- NMPDR:   fig|220668.1.peg.654
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- BioCyc:   LPLA220668:LP_0772-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 76126; Mature: 76126

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDRVDNNHFDLVSDYQPTGDQPQAIQQLTAGIESGEKEQILLGATGTGKTFTISNVIAK
CCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEHHHHHHH
VNKPTLILSHNKTLAGQLYGEFKKFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSAI
CCCCEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEECCCCCCEECCCCCC
NDEIDKLRHSATSSLLERNDVIVVASVSSIFGLGDPHEYQDHVVSLRVGMEIDRNDLLRK
HHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCCHHHHHEEEEEECCEECHHHHHHH
LVDIQFDRNDIDFQRGRFRVHGDVVEIFPASRDDHALRVEFFGDEIDRIREIDALTGEIV
HHHCEECCCCCCCCCCEEEEECCEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHE
ADREHVAIFPATHFMTNDAIMEHAIKGIEDELDGRLKELTADGKLLEAQRLKQRTTYDVE
ECCCCEEEEEHHHHHHHHHHHHHHHHCCHHHHCHHHHHHCCCCCHHHHHHHHHHCHHHHH
MLKEMGYTSGIENYSRFMDGRKPGEPPYTLLDFFPKDFLLVVDESHVTMPQVRGMYNGDR
HHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCEEEEECCCCCCHHHHCCCCCCHH
ARKQMLVDYGFRLPSALDNRPLKLEEVEQHINQVVYMSATPGPYEMDRTKHVVQQIIRPT
HHHHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHCCC
GLLDPTIEVRPIMGQIDDLVGEINKRIEVNERVFITTLTKKMAEDLTDYFKDLGIKVRYL
CCCCCCCEEEHHHHHHHHHHHHHHCCEECCCEEEEHHHHHHHHHHHHHHHHHCCCEEEEH
HSDIKTLERTQIIRDLRLGKFDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNERSLI
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHH
QTIGRAARNEHGSVIMYADTTTDSMQAAMDETARRRAVQMKYNEDHHITPHTIKKAIPEL
HHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHH
IASTKTTEDAGKKDDFLETDFDDMTREQQLDMISKLEEQMKTAAKKLDFEQAATLRDTVM
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ELKAQIS
HHHHHCC
>Mature Secondary Structure
MIDRVDNNHFDLVSDYQPTGDQPQAIQQLTAGIESGEKEQILLGATGTGKTFTISNVIAK
CCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEHHHHHHH
VNKPTLILSHNKTLAGQLYGEFKKFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSAI
CCCCEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEECCCCCCEECCCCCC
NDEIDKLRHSATSSLLERNDVIVVASVSSIFGLGDPHEYQDHVVSLRVGMEIDRNDLLRK
HHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCCHHHHHEEEEEECCEECHHHHHHH
LVDIQFDRNDIDFQRGRFRVHGDVVEIFPASRDDHALRVEFFGDEIDRIREIDALTGEIV
HHHCEECCCCCCCCCCEEEEECCEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHE
ADREHVAIFPATHFMTNDAIMEHAIKGIEDELDGRLKELTADGKLLEAQRLKQRTTYDVE
ECCCCEEEEEHHHHHHHHHHHHHHHHCCHHHHCHHHHHHCCCCCHHHHHHHHHHCHHHHH
MLKEMGYTSGIENYSRFMDGRKPGEPPYTLLDFFPKDFLLVVDESHVTMPQVRGMYNGDR
HHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCEEEEECCCCCCHHHHCCCCCCHH
ARKQMLVDYGFRLPSALDNRPLKLEEVEQHINQVVYMSATPGPYEMDRTKHVVQQIIRPT
HHHHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHCCC
GLLDPTIEVRPIMGQIDDLVGEINKRIEVNERVFITTLTKKMAEDLTDYFKDLGIKVRYL
CCCCCCCEEEHHHHHHHHHHHHHHCCEECCCEEEEHHHHHHHHHHHHHHHHHCCCEEEEH
HSDIKTLERTQIIRDLRLGKFDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNERSLI
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHH
QTIGRAARNEHGSVIMYADTTTDSMQAAMDETARRRAVQMKYNEDHHITPHTIKKAIPEL
HHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHH
IASTKTTEDAGKKDDFLETDFDDMTREQQLDMISKLEEQMKTAAKKLDFEQAATLRDTVM
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ELKAQIS
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566