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The map label for this gene is trmH [H]

Identifier: 28377488

GI number: 28377488

Start: 583127

End: 583894

Strand: Direct

Name: trmH [H]

Synonym: lp_0612

Alternate gene names: 28377488

Gene position: 583127-583894 (Clockwise)

Preceding gene: 28377487

Following gene: 28377489

Centisome position: 17.63

GC content: 47.66

Gene sequence:

>768_bases
GTGTCAAATAACGAACAAGACCAAACAGCAGCTGACTTTGTAATCGGGCGGCACCCCGCCATGGCAGCAATCAAGAGTGA
TCAACAGATCAACAAAGTCTTTATTCAAAGCGGTCTACAGGCCGATGTACTGAATGACATTGCCAAGATTGCGAAGAAAC
GTAATTTGATCGTACAGTACGTGCCGAAACAAAAGTTAGACCGTTTAACCGACAACGCCAACCATCAGGGGGTAGCTGTG
GGGGTGGCTGCTTTTGAATATGCCACCATTGATGATTTATTTGCTGTTGCTAAGGCTAAGAATGAAGCGCCATTTTTCTT
GATCTTGGATAATATCGAAGATCCCCATAACTTAGGTTCGATTATGCGGACGGCCGATGCAGCTGGCGCCCATGGCATCA
TTATTCCGAAACGGCGCGCCGTGGGGTTAACCAGTACGGTTGCCAAGACGTCAACGGGGGCTATCGAACACGTGAAAGTT
GCGCGGGTGACGAACTTGGTTCAAACGGTTAAACAATTGCAAGAAGCCGGTCTGTGGATCTTTGGGACTGATATGAACGG
GACGGACTACCGACAGTGGGATGCTTCCGGTGCCGTTGGTTTGATTATTGGTAATGAAGGTAAGGGAATTTCACCATTAC
TTAAGAAGAGTGTGGACGAAATGTTGACCATTCCAATGATTGGTCATGTTCAAAGTTTGAATGCCAGTGTGGCGGCCAGC
CTTCTGATTTATCAAGGCTACACGTCCCGGCATCCACTGGGAAAATAA

Upstream 100 bases:

>100_bases
GAAGCCGTTTTTGGGTATTTACAATTGACTCAGCAGGCGGACCGAATTGCAGAACTGGCACAGTGGTGTATTAAACAAGT
TGATGAAGGGAGGGTTTCCA

Downstream 100 bases:

>100_bases
GATGAAACAACAATTATTGATTGTCGATGCTTACAATATGATTGGCAACTGGCCAGAACTCAATCATTTAAAACAAACGG
ACCGGTTGCCGCAAGCTCGT

Product: tRNA/rRNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MSNNEQDQTAADFVIGRHPAMAAIKSDQQINKVFIQSGLQADVLNDIAKIAKKRNLIVQYVPKQKLDRLTDNANHQGVAV
GVAAFEYATIDDLFAVAKAKNEAPFFLILDNIEDPHNLGSIMRTADAAGAHGIIIPKRRAVGLTSTVAKTSTGAIEHVKV
ARVTNLVQTVKQLQEAGLWIFGTDMNGTDYRQWDASGAVGLIIGNEGKGISPLLKKSVDEMLTIPMIGHVQSLNASVAAS
LLIYQGYTSRHPLGK

Sequences:

>Translated_255_residues
MSNNEQDQTAADFVIGRHPAMAAIKSDQQINKVFIQSGLQADVLNDIAKIAKKRNLIVQYVPKQKLDRLTDNANHQGVAV
GVAAFEYATIDDLFAVAKAKNEAPFFLILDNIEDPHNLGSIMRTADAAGAHGIIIPKRRAVGLTSTVAKTSTGAIEHVKV
ARVTNLVQTVKQLQEAGLWIFGTDMNGTDYRQWDASGAVGLIIGNEGKGISPLLKKSVDEMLTIPMIGHVQSLNASVAAS
LLIYQGYTSRHPLGK
>Mature_254_residues
SNNEQDQTAADFVIGRHPAMAAIKSDQQINKVFIQSGLQADVLNDIAKIAKKRNLIVQYVPKQKLDRLTDNANHQGVAVG
VAAFEYATIDDLFAVAKAKNEAPFFLILDNIEDPHNLGSIMRTADAAGAHGIIIPKRRAVGLTSTVAKTSTGAIEHVKVA
RVTNLVQTVKQLQEAGLWIFGTDMNGTDYRQWDASGAVGLIIGNEGKGISPLLKKSVDEMLTIPMIGHVQSLNASVAASL
LIYQGYTSRHPLGK

Specific function: Unknown

COG id: COG0566

COG function: function code J; rRNA methylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNA methyltransferase TrmH family [H]

Homologues:

Organism=Homo sapiens, GI40068479, Length=261, Percent_Identity=26.0536398467433, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1790623, Length=246, Percent_Identity=35.7723577235772, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1790083, Length=172, Percent_Identity=30.8139534883721, Blast_Score=84, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17555908, Length=256, Percent_Identity=25, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324775, Length=165, Percent_Identity=35.1515151515151, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004441
- InterPro:   IPR001537
- InterPro:   IPR013123 [H]

Pfam domain/function: PF00588 SpoU_methylase; PF08032 SpoU_sub_bind [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 27480; Mature: 27349

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNNEQDQTAADFVIGRHPAMAAIKSDQQINKVFIQSGLQADVLNDIAKIAKKRNLIVQY
CCCCCCHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEE
VPKQKLDRLTDNANHQGVAVGVAAFEYATIDDLFAVAKAKNEAPFFLILDNIEDPHNLGS
CCHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHH
IMRTADAAGAHGIIIPKRRAVGLTSTVAKTSTGAIEHVKVARVTNLVQTVKQLQEAGLWI
HHHHHHCCCCCCEEECCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
FGTDMNGTDYRQWDASGAVGLIIGNEGKGISPLLKKSVDEMLTIPMIGHVQSLNASVAAS
EECCCCCCCCCEECCCCCEEEEECCCCCCCCHHHHHHHHHHEECCHHHHHHHCCHHHHHH
LLIYQGYTSRHPLGK
HHHCCCCCCCCCCCC
>Mature Secondary Structure 
SNNEQDQTAADFVIGRHPAMAAIKSDQQINKVFIQSGLQADVLNDIAKIAKKRNLIVQY
CCCCCHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEE
VPKQKLDRLTDNANHQGVAVGVAAFEYATIDDLFAVAKAKNEAPFFLILDNIEDPHNLGS
CCHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHH
IMRTADAAGAHGIIIPKRRAVGLTSTVAKTSTGAIEHVKVARVTNLVQTVKQLQEAGLWI
HHHHHHCCCCCCEEECCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
FGTDMNGTDYRQWDASGAVGLIIGNEGKGISPLLKKSVDEMLTIPMIGHVQSLNASVAAS
EECCCCCCCCCEECCCCCEEEEECCCCCCCCHHHHHHHHHHEECCHHHHHHHCCHHHHHH
LLIYQGYTSRHPLGK
HHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 7510287; 3145906 [H]