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The map label for this gene is hom2 [H]

Identifier: 28377453

GI number: 28377453

Start: 529456

End: 530742

Strand: Direct

Name: hom2 [H]

Synonym: lp_0571

Alternate gene names: 28377453

Gene position: 529456-530742 (Clockwise)

Preceding gene: 28377452

Following gene: 28377454

Centisome position: 16.0

GC content: 46.08

Gene sequence:

>1287_bases
ATGGAAACGATTAAAATTGGTGTGGTCGGACTAGGCACAGTCGGGACCGGCGTTGTAAAAATGCTTCAAGCGCATCAGGA
AAAGATTTCAGAAATTACCGGTCGTAAGTTGGAACTAGCCTGCGTAGTTGTCCACAACTTGAAAAAGCACGAACAAGTTG
ATTTGGGGGACGTTCAGATGACCGACCAAATCGCGACCCTGCTTGATGATCCGTCCATTCAAATTATGGTCGAAGTGATG
GGTTCAATTCATCCGGCGAAGGAATATATTACGCAAGCCTTGCAAGCTGGCAAACACGTGGTGACGGCCAATAAGGACTT
GATTGCGCAATATGGCCGGGAGTTGGTTCAGATTGCTCGTGAAAATCATCGCGACTTATTCTATGAAGCTAGTGTTGCTG
GTGGGATTCCAATTTTACGGACGATTGATAATAGTTTCGCCGCTGACCGGATTCAACGGGTCATGGGAATCGTCAACGGG
ACCACTAATTACATCATGACGCAGATGCTGACTAAGCATTGGTCGTATGATCAAGCCTTGAGCTCAGCACAAGACTTGGG
GTTTGCCGAAAGTGATCCCACTAATGATGTCGAAGGCCTTGATGCGGCGTTCAAGATGATTATTTTAACGCAGTTTGCCT
TTGGGATGAGTCTTTCCCTCGACCACGTTCAAGTTCAGGGAATTACGAAAATCAGCCCAGAGGATATTGCGGAAGCTCAT
CAGCTTGGGTATACGATTAAATTACTCGGGATTGCGGAAGAAATTGACGATCGCATTGCGGTATCAGTCGGGCCTGTGCT
CGTTTCTGATCAACATCCACTTGCCACGGTACAAAATGAGAATAATGCTGTAATGGTAACGGGAACGGCTGTGGGGAACA
CGATGTTTTACGGTCCCGGCGCTGGAGAACTCCCGACCGCCAACAGTGTGCTGAGTGATATTACAACGGTTGCGAAAAAT
ATTGCGTTGAATACGACTGGTAACACGTTTAACTCTTATCGCCAGGAGACAGTCTTAGCAACGCCTGAAGATGTTGTGTA
TCCTCACTTTATTGCCTTGAAGATGCGTGATGTGCCGGGGATGATGATGAAATTGACGGCGATTATGACCCGCGCAGAAG
TTTCATTTAGTCGAATCATTCAAAATCAATTAGGTGACGGCAACGCTCGTGTTGTGATCATTACCCATGCCATGAATGAT
CAACAGTTAGCAGATATCACTCGTGAAATCGGTGAACAAGAGAATATGCAACTATTAGCGAGTTATAAAGTTTTAAAGAA
TGCGTAG

Upstream 100 bases:

>100_bases
GTGGTCGTTGTCAGGGGCCAATTAAATTAGTCTGAAAAGGTTTGCTAAAGTGGTACGCTTCCGATAGAATTAGCTTAACT
GTTGATATGGAGGGATTAAG

Downstream 100 bases:

>100_bases
GTGAGGACATGTTAACGATTTCGGTTCCGGCGACTTCCGCTAATCTTGGTCCCGGTTTTGATTCAATCGGTCTGGCGCTG
GACATGCAACTAACGCTACA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
METIKIGVVGLGTVGTGVVKMLQAHQEKISEITGRKLELACVVVHNLKKHEQVDLGDVQMTDQIATLLDDPSIQIMVEVM
GSIHPAKEYITQALQAGKHVVTANKDLIAQYGRELVQIARENHRDLFYEASVAGGIPILRTIDNSFAADRIQRVMGIVNG
TTNYIMTQMLTKHWSYDQALSSAQDLGFAESDPTNDVEGLDAAFKMIILTQFAFGMSLSLDHVQVQGITKISPEDIAEAH
QLGYTIKLLGIAEEIDDRIAVSVGPVLVSDQHPLATVQNENNAVMVTGTAVGNTMFYGPGAGELPTANSVLSDITTVAKN
IALNTTGNTFNSYRQETVLATPEDVVYPHFIALKMRDVPGMMMKLTAIMTRAEVSFSRIIQNQLGDGNARVVIITHAMND
QQLADITREIGEQENMQLLASYKVLKNA

Sequences:

>Translated_428_residues
METIKIGVVGLGTVGTGVVKMLQAHQEKISEITGRKLELACVVVHNLKKHEQVDLGDVQMTDQIATLLDDPSIQIMVEVM
GSIHPAKEYITQALQAGKHVVTANKDLIAQYGRELVQIARENHRDLFYEASVAGGIPILRTIDNSFAADRIQRVMGIVNG
TTNYIMTQMLTKHWSYDQALSSAQDLGFAESDPTNDVEGLDAAFKMIILTQFAFGMSLSLDHVQVQGITKISPEDIAEAH
QLGYTIKLLGIAEEIDDRIAVSVGPVLVSDQHPLATVQNENNAVMVTGTAVGNTMFYGPGAGELPTANSVLSDITTVAKN
IALNTTGNTFNSYRQETVLATPEDVVYPHFIALKMRDVPGMMMKLTAIMTRAEVSFSRIIQNQLGDGNARVVIITHAMND
QQLADITREIGEQENMQLLASYKVLKNA
>Mature_428_residues
METIKIGVVGLGTVGTGVVKMLQAHQEKISEITGRKLELACVVVHNLKKHEQVDLGDVQMTDQIATLLDDPSIQIMVEVM
GSIHPAKEYITQALQAGKHVVTANKDLIAQYGRELVQIARENHRDLFYEASVAGGIPILRTIDNSFAADRIQRVMGIVNG
TTNYIMTQMLTKHWSYDQALSSAQDLGFAESDPTNDVEGLDAAFKMIILTQFAFGMSLSLDHVQVQGITKISPEDIAEAH
QLGYTIKLLGIAEEIDDRIAVSVGPVLVSDQHPLATVQNENNAVMVTGTAVGNTMFYGPGAGELPTANSVLSDITTVAKN
IALNTTGNTFNSYRQETVLATPEDVVYPHFIALKMRDVPGMMMKLTAIMTRAEVSFSRIIQNQLGDGNARVVIITHAMND
QQLADITREIGEQENMQLLASYKVLKNA

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=273, Percent_Identity=26.007326007326, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790376, Length=357, Percent_Identity=24.3697478991597, Blast_Score=75, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46673; Mature: 46673

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METIKIGVVGLGTVGTGVVKMLQAHQEKISEITGRKLELACVVVHNLKKHEQVDLGDVQM
CCEEEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHCCCCCCCCHH
TDQIATLLDDPSIQIMVEVMGSIHPAKEYITQALQAGKHVVTANKDLIAQYGRELVQIAR
HHHHHHHHCCCCCEEHHHHHHCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHH
ENHRDLFYEASVAGGIPILRTIDNSFAADRIQRVMGIVNGTTNYIMTQMLTKHWSYDQAL
HCCCCEEEEEHHCCCCCCHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHH
SSAQDLGFAESDPTNDVEGLDAAFKMIILTQFAFGMSLSLDHVQVQGITKISPEDIAEAH
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEECEEEECCCCCCCHHHHHHHH
QLGYTIKLLGIAEEIDDRIAVSVGPVLVSDQHPLATVQNENNAVMVTGTAVGNTMFYGPG
HCCCEEEEEEEHHHHCCCEEEEECCEEECCCCCCEEEECCCCEEEEEEEEECCEEEECCC
AGELPTANSVLSDITTVAKNIALNTTGNTFNSYRQETVLATPEDVVYPHFIALKMRDVPG
CCCCCCHHHHHHHHHHHHHHCEEECCCCCHHHHHHHEEEECCCCCCCCEEEEEEECCCCH
MMMKLTAIMTRAEVSFSRIIQNQLGDGNARVVIITHAMNDQQLADITREIGEQENMQLLA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCHHHHH
SYKVLKNA
HHHHHHCC
>Mature Secondary Structure
METIKIGVVGLGTVGTGVVKMLQAHQEKISEITGRKLELACVVVHNLKKHEQVDLGDVQM
CCEEEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHCCCCCCCCHH
TDQIATLLDDPSIQIMVEVMGSIHPAKEYITQALQAGKHVVTANKDLIAQYGRELVQIAR
HHHHHHHHCCCCCEEHHHHHHCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHH
ENHRDLFYEASVAGGIPILRTIDNSFAADRIQRVMGIVNGTTNYIMTQMLTKHWSYDQAL
HCCCCEEEEEHHCCCCCCHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHH
SSAQDLGFAESDPTNDVEGLDAAFKMIILTQFAFGMSLSLDHVQVQGITKISPEDIAEAH
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEECEEEECCCCCCCHHHHHHHH
QLGYTIKLLGIAEEIDDRIAVSVGPVLVSDQHPLATVQNENNAVMVTGTAVGNTMFYGPG
HCCCEEEEEEEHHHHCCCEEEEECCEEECCCCCCEEEECCCCEEEEEEEEECCEEEECCC
AGELPTANSVLSDITTVAKNIALNTTGNTFNSYRQETVLATPEDVVYPHFIALKMRDVPG
CCCCCCHHHHHHHHHHHHHHCEEECCCCCHHHHHHHEEEECCCCCCCCEEEEEEECCCCH
MMMKLTAIMTRAEVSFSRIIQNQLGDGNARVVIITHAMNDQQLADITREIGEQENMQLLA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCHHHHH
SYKVLKNA
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3139660; 9384377; 3098560 [H]