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The map label for this gene is glyA [H]

Identifier: 28199621

GI number: 28199621

Start: 2036311

End: 2037585

Strand: Reverse

Name: glyA [H]

Synonym: PD1750

Alternate gene names: 28199621

Gene position: 2037585-2036311 (Counterclockwise)

Preceding gene: 28199624

Following gene: 28199620

Centisome position: 80.86

GC content: 53.25

Gene sequence:

>1275_bases
GTGTTTTTTTCCGGAGTTGCCATGTTCCCGCGTGATGCTCGTCTTGATATGTACGATCCCGAGTTGGCTAAGGCCATCGC
TGCTGAAGTGAGGCGTCAGGAGGATCACGTTGAGTTGATTGCCAGTGAAAATTATTGCAGTACGTTGGTGATGCAGGTGC
AGGGGAGTCAACTGACTAATAAGTATGCTGAAGGGTATTCTGGAAAGCGTTACTACGGTGGTTGTGAGTATGTCGATATC
GCTGAGCAATTGGCGATTGAGCGTGCCAAAAAACTGTTTGGTGCCGATTATGCCAATGTGCAGCCCCATAGCGGTTCACA
AGCCAATCAAGCGGTGTACTTTGCCTTGTTGCAGCCAGGCGATACGATCCTCGGGATGAGCTTGGCGCATGGCGGTCACT
TGACTCACGGCGCCAATGTTAATGTGTCTGGCAAGTTGTTCAATGCGGTTCAGTACGGAGTGAATGCTCAAGGGTTGATT
GATTACGAGGCTGTTGAATCGCTTGCGTTAGAGCATCGGCCGAAGATGGTTGTGGCGGGCTTTTCGGCGTATTCGCAGAA
AATTGATTGGGCGCGCTTCCGTGCCATTGCTGATCAGGTGGGCGCTTACTTGCTTGTTGATATGGCACATGTGGCTGGCT
TGGTGGCGGCTGGTGTCTATCCGAGTCCGCTGCCGCATGCGCATGTTGTGACTTCGACGACGCATAAGACACTGCGCGGC
CCACGTGGCGGCATTATTGTTGCGCAGGCTCCGCAGGAGGCGTTGGTTAAGAAGTTGCAGTCGATAGTGTTTCCTGGGAT
CCAGGGTGGTCCATTGATGCATGTGATCGCGGCCAAAGCGGTTGCTTTTAAGGAGGCGTTGGAGCCTGCGTTTAAGGTGT
ATCAGCAGCAGGTGGTGAAGAATGCGAAGGCGATGGCTGGGACCCTCATGTTACGCGGCTATAAGATTGTCTCTGGTGGT
ACAGAAAATCATTTGATGTTGGTTGACATGATCGGTAGGGATGTCTCTGGGAAGGACGCTGAGGGCGCATTGGGTCAGGT
TCATATCACTGTCAATAAGAATGCGGTACCGGATGATCCGCGCTCTCCGTTCGTAACCTCCGGGTTACGCTTGGGGACTC
CAGCAGTCACGACACGGGGTTACCAGGAGCAGGATTGTGTGGACTTAGCGCACTGGATTGCTGATGTGCTTGACGCGCCT
GCAGATGTGACGGTCATTGCCGCAGTCCGTGAGAAGGTTGCGGCGCAGTGCAAGAAGTATCCTGTGTATCGCTGA

Upstream 100 bases:

>100_bases
AGGGGAAGGGGCAGAGTGAAACGTGTAGGCTGATGAATTTGCTCAGTCCAGTGTGGTGCGTTTTATAATTTTTGGTGTCC
AGATGCTGATTGCATCCCCT

Downstream 100 bases:

>100_bases
GTGTCTGGGGTTGGAATGTTACGGTGCTTGGAACGCAGTGACGTTTCTTGGATATTCTTGCTGTGCTTCAGTGAAGGATA
TTTGGGTGATGATGCGTTTT

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MFFSGVAMFPRDARLDMYDPELAKAIAAEVRRQEDHVELIASENYCSTLVMQVQGSQLTNKYAEGYSGKRYYGGCEYVDI
AEQLAIERAKKLFGADYANVQPHSGSQANQAVYFALLQPGDTILGMSLAHGGHLTHGANVNVSGKLFNAVQYGVNAQGLI
DYEAVESLALEHRPKMVVAGFSAYSQKIDWARFRAIADQVGAYLLVDMAHVAGLVAAGVYPSPLPHAHVVTSTTHKTLRG
PRGGIIVAQAPQEALVKKLQSIVFPGIQGGPLMHVIAAKAVAFKEALEPAFKVYQQQVVKNAKAMAGTLMLRGYKIVSGG
TENHLMLVDMIGRDVSGKDAEGALGQVHITVNKNAVPDDPRSPFVTSGLRLGTPAVTTRGYQEQDCVDLAHWIADVLDAP
ADVTVIAAVREKVAAQCKKYPVYR

Sequences:

>Translated_424_residues
MFFSGVAMFPRDARLDMYDPELAKAIAAEVRRQEDHVELIASENYCSTLVMQVQGSQLTNKYAEGYSGKRYYGGCEYVDI
AEQLAIERAKKLFGADYANVQPHSGSQANQAVYFALLQPGDTILGMSLAHGGHLTHGANVNVSGKLFNAVQYGVNAQGLI
DYEAVESLALEHRPKMVVAGFSAYSQKIDWARFRAIADQVGAYLLVDMAHVAGLVAAGVYPSPLPHAHVVTSTTHKTLRG
PRGGIIVAQAPQEALVKKLQSIVFPGIQGGPLMHVIAAKAVAFKEALEPAFKVYQQQVVKNAKAMAGTLMLRGYKIVSGG
TENHLMLVDMIGRDVSGKDAEGALGQVHITVNKNAVPDDPRSPFVTSGLRLGTPAVTTRGYQEQDCVDLAHWIADVLDAP
ADVTVIAAVREKVAAQCKKYPVYR
>Mature_424_residues
MFFSGVAMFPRDARLDMYDPELAKAIAAEVRRQEDHVELIASENYCSTLVMQVQGSQLTNKYAEGYSGKRYYGGCEYVDI
AEQLAIERAKKLFGADYANVQPHSGSQANQAVYFALLQPGDTILGMSLAHGGHLTHGANVNVSGKLFNAVQYGVNAQGLI
DYEAVESLALEHRPKMVVAGFSAYSQKIDWARFRAIADQVGAYLLVDMAHVAGLVAAGVYPSPLPHAHVVTSTTHKTLRG
PRGGIIVAQAPQEALVKKLQSIVFPGIQGGPLMHVIAAKAVAFKEALEPAFKVYQQQVVKNAKAMAGTLMLRGYKIVSGG
TENHLMLVDMIGRDVSGKDAEGALGQVHITVNKNAVPDDPRSPFVTSGLRLGTPAVTTRGYQEQDCVDLAHWIADVLDAP
ADVTVIAAVREKVAAQCKKYPVYR

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=389, Percent_Identity=49.3573264781491, Blast_Score=352, Evalue=4e-97,
Organism=Homo sapiens, GI261862352, Length=397, Percent_Identity=48.6146095717884, Blast_Score=351, Evalue=7e-97,
Organism=Homo sapiens, GI261862350, Length=397, Percent_Identity=48.6146095717884, Blast_Score=351, Evalue=7e-97,
Organism=Homo sapiens, GI261862348, Length=397, Percent_Identity=48.6146095717884, Blast_Score=351, Evalue=7e-97,
Organism=Homo sapiens, GI261862346, Length=388, Percent_Identity=48.1958762886598, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI22547186, Length=419, Percent_Identity=46.3007159904535, Blast_Score=323, Evalue=1e-88,
Organism=Homo sapiens, GI22547189, Length=407, Percent_Identity=44.7174447174447, Blast_Score=294, Evalue=1e-79,
Organism=Escherichia coli, GI1788902, Length=416, Percent_Identity=67.5480769230769, Blast_Score=573, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI25144732, Length=396, Percent_Identity=46.4646464646465, Blast_Score=340, Evalue=9e-94,
Organism=Caenorhabditis elegans, GI25144729, Length=396, Percent_Identity=46.4646464646465, Blast_Score=339, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6319739, Length=398, Percent_Identity=46.9849246231156, Blast_Score=350, Evalue=3e-97,
Organism=Saccharomyces cerevisiae, GI6323087, Length=397, Percent_Identity=44.5843828715365, Blast_Score=328, Evalue=1e-90,
Organism=Drosophila melanogaster, GI24640005, Length=411, Percent_Identity=47.9318734793187, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI221329721, Length=411, Percent_Identity=47.9318734793187, Blast_Score=362, Evalue=1e-100,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45735; Mature: 45735

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFSGVAMFPRDARLDMYDPELAKAIAAEVRRQEDHVELIASENYCSTLVMQVQGSQLTN
CCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHEEHEEECCCHHHH
KYAEGYSGKRYYGGCEYVDIAEQLAIERAKKLFGADYANVQPHSGSQANQAVYFALLQPG
HHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCC
DTILGMSLAHGGHLTHGANVNVSGKLFNAVQYGVNAQGLIDYEAVESLALEHRPKMVVAG
CCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEECHHHHHHHHHHCCCCEEEEE
FSAYSQKIDWARFRAIADQVGAYLLVDMAHVAGLVAAGVYPSPLPHAHVVTSTTHKTLRG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHCC
PRGGIIVAQAPQEALVKKLQSIVFPGIQGGPLMHVIAAKAVAFKEALEPAFKVYQQQVVK
CCCCEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAKAMAGTLMLRGYKIVSGGTENHLMLVDMIGRDVSGKDAEGALGQVHITVNKNAVPDDP
HHHHHHHHHHHCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCC
RSPFVTSGLRLGTPAVTTRGYQEQDCVDLAHWIADVLDAPADVTVIAAVREKVAAQCKKY
CCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHC
PVYR
CCCC
>Mature Secondary Structure
MFFSGVAMFPRDARLDMYDPELAKAIAAEVRRQEDHVELIASENYCSTLVMQVQGSQLTN
CCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHEEHEEECCCHHHH
KYAEGYSGKRYYGGCEYVDIAEQLAIERAKKLFGADYANVQPHSGSQANQAVYFALLQPG
HHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCC
DTILGMSLAHGGHLTHGANVNVSGKLFNAVQYGVNAQGLIDYEAVESLALEHRPKMVVAG
CCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEECHHHHHHHHHHCCCCEEEEE
FSAYSQKIDWARFRAIADQVGAYLLVDMAHVAGLVAAGVYPSPLPHAHVVTSTTHKTLRG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHCC
PRGGIIVAQAPQEALVKKLQSIVFPGIQGGPLMHVIAAKAVAFKEALEPAFKVYQQQVVK
CCCCEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAKAMAGTLMLRGYKIVSGGTENHLMLVDMIGRDVSGKDAEGALGQVHITVNKNAVPDDP
HHHHHHHHHHHCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCC
RSPFVTSGLRLGTPAVTTRGYQEQDCVDLAHWIADVLDAPADVTVIAAVREKVAAQCKKY
CCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHC
PVYR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA