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The map label for this gene is hemY [H]

Identifier: 62185449

GI number: 62185449

Start: 981729

End: 982997

Strand: Direct

Name: hemY [H]

Synonym: CAB846

Alternate gene names: 62185449

Gene position: 981729-982997 (Clockwise)

Preceding gene: 62185448

Following gene: 62185451

Centisome position: 85.79

GC content: 42.24

Gene sequence:

>1269_bases
ATGAAAAAAGCCATTATCATAGGCGCAGGAATTTCAGGGTTATCCACAGCGTGGTGGTTACATAGGAAATTCCCCAATAG
CGAACTTATAATTATAGATAAGGCAGATCGACCTGGCGGGCTTATCTACTCAGATTACCAAAAGAATTTTTCCTTAGATC
TCGGGCCTAAAAGTTTTCTAGTCCGTGGTGAGGGACACTATACCCTGGAATTAATTCGTGATTTACAGCTGGAAGAGGCT
CTCATTGTTAGTGATAAAACCGCGAAAAAACGTTTTATACGTTACAAAGGGAAAACACGAAAAGTCTCCCCATGGACATT
AATCAAAGAAGGTTTGCCTTTCGCAATCATCAAAGATCTCTTTGCCTCCCGATATACAAAAGACAGCTCTGTATATGATT
TCCTAAGTCGCCATAGCACAGTACATCTGATTCACAATATATTGAATCCTGTTGTTACCGCAGTTCGGGCAGGACATAGT
CATCTACTTTCTGCGCATATGGCCTTTCCTTCCCTTTCTCAACGCGAAGCAAAAACAGGATCCATTTTACGCAGCTACTT
AAAAGAACCTTCGAAGAAAAAAACACCTGGAGCTCCTTATCTGGTTTCTCTACGTCCCAATCTAGGCATCCTCATTGATA
CTTTAGTAAAAAAACTGCCCGTTACGTGGAAGCTTTCTTCTCCTGTTACAAAGATAGAGTGTTTCCCATCCAAGGTTGTG
GTATCCACTACACAAGAAACATTCTCAGGAGATCTAGCCATATATACGGGGGCCACGTCTCTACTTCCTTCTCTTATTGA
TATCCCAGGAATGCAACAGCTTGCGAATAAAACACTTCATTGGGATCTTTCGTGTGCAACATTGGGGTGGAGTAGGGATA
TACCCACCATCCCTAAGGGTTATGGTATGCTGTTCTCTGACGAACCCCCGTTATTAGGTATTGTCTATAACTCGCGAGTC
TTTCCTAACCAGATGCCTGGGAAAACAGTTCTATCATTACTATTAGAAAACCGTTGGCATCAAGAAGAAGCTTACGCTTT
TTCCTTAGCGGCGATTTCTGAGTATTTAGGGATTTCTACACAACCGGATGTATTTTCATTATTTTCCCCAGAAGACGGTC
TACCTCAACACGGCGTAGGGTTTGTAGAAATGAAAAACCGGATACTCCCCGCTATTCCTCATAATCTAAAAATTGTCGGG
CAGAACTTCTCTGGTCCAGGATTAAACAGATGTGTAGCCTCAGCCTATCAAACTGTTGCTGCTATCTAA

Upstream 100 bases:

>100_bases
TAACACCATTAGGAGAGCTGTTTGTACGTGTAATTGCTACAACGTTTGATGCCTATTTCTTAAAAACTGTGTCTTCACAT
CCTAGGTTTTCAAGATCCAT

Downstream 100 bases:

>100_bases
GGGGAGGAAACGCTCACAAAGAGAAAGTGTTGTGGTGATCATCTCTCTGAAATATTCTCTTCTTGAAGACGTTTCGAGTA
GTCTTTTTTCCACATGATCT

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MKKAIIIGAGISGLSTAWWLHRKFPNSELIIIDKADRPGGLIYSDYQKNFSLDLGPKSFLVRGEGHYTLELIRDLQLEEA
LIVSDKTAKKRFIRYKGKTRKVSPWTLIKEGLPFAIIKDLFASRYTKDSSVYDFLSRHSTVHLIHNILNPVVTAVRAGHS
HLLSAHMAFPSLSQREAKTGSILRSYLKEPSKKKTPGAPYLVSLRPNLGILIDTLVKKLPVTWKLSSPVTKIECFPSKVV
VSTTQETFSGDLAIYTGATSLLPSLIDIPGMQQLANKTLHWDLSCATLGWSRDIPTIPKGYGMLFSDEPPLLGIVYNSRV
FPNQMPGKTVLSLLLENRWHQEEAYAFSLAAISEYLGISTQPDVFSLFSPEDGLPQHGVGFVEMKNRILPAIPHNLKIVG
QNFSGPGLNRCVASAYQTVAAI

Sequences:

>Translated_422_residues
MKKAIIIGAGISGLSTAWWLHRKFPNSELIIIDKADRPGGLIYSDYQKNFSLDLGPKSFLVRGEGHYTLELIRDLQLEEA
LIVSDKTAKKRFIRYKGKTRKVSPWTLIKEGLPFAIIKDLFASRYTKDSSVYDFLSRHSTVHLIHNILNPVVTAVRAGHS
HLLSAHMAFPSLSQREAKTGSILRSYLKEPSKKKTPGAPYLVSLRPNLGILIDTLVKKLPVTWKLSSPVTKIECFPSKVV
VSTTQETFSGDLAIYTGATSLLPSLIDIPGMQQLANKTLHWDLSCATLGWSRDIPTIPKGYGMLFSDEPPLLGIVYNSRV
FPNQMPGKTVLSLLLENRWHQEEAYAFSLAAISEYLGISTQPDVFSLFSPEDGLPQHGVGFVEMKNRILPAIPHNLKIVG
QNFSGPGLNRCVASAYQTVAAI
>Mature_422_residues
MKKAIIIGAGISGLSTAWWLHRKFPNSELIIIDKADRPGGLIYSDYQKNFSLDLGPKSFLVRGEGHYTLELIRDLQLEEA
LIVSDKTAKKRFIRYKGKTRKVSPWTLIKEGLPFAIIKDLFASRYTKDSSVYDFLSRHSTVHLIHNILNPVVTAVRAGHS
HLLSAHMAFPSLSQREAKTGSILRSYLKEPSKKKTPGAPYLVSLRPNLGILIDTLVKKLPVTWKLSSPVTKIECFPSKVV
VSTTQETFSGDLAIYTGATSLLPSLIDIPGMQQLANKTLHWDLSCATLGWSRDIPTIPKGYGMLFSDEPPLLGIVYNSRV
FPNQMPGKTVLSLLLENRWHQEEAYAFSLAAISEYLGISTQPDVFSLFSPEDGLPQHGVGFVEMKNRILPAIPHNLKIVG
QNFSGPGLNRCVASAYQTVAAI

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. May have an essential extracellular function during development, possibly as a pheromone [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=469, Percent_Identity=24.9466950959488, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI4506001, Length=469, Percent_Identity=24.9466950959488, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24649745, Length=474, Percent_Identity=25.3164556962025, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 46767; Mature: 46767

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKAIIIGAGISGLSTAWWLHRKFPNSELIIIDKADRPGGLIYSDYQKNFSLDLGPKSFL
CCCEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEECCCCCEEEECCCCEEE
VRGEGHYTLELIRDLQLEEALIVSDKTAKKRFIRYKGKTRKVSPWTLIKEGLPFAIIKDL
EECCCCEEEHHHHHHHHHHEEEECCCHHHHHHHHCCCCCCCCCCHHHHHCCCCHHHHHHH
FASRYTKDSSVYDFLSRHSTVHLIHNILNPVVTAVRAGHSHLLSAHMAFPSLSQREAKTG
HHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHH
SILRSYLKEPSKKKTPGAPYLVSLRPNLGILIDTLVKKLPVTWKLSSPVTKIECFPSKVV
HHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCEEEECCCCEEEEECCCEEE
VSTTQETFSGDLAIYTGATSLLPSLIDIPGMQQLANKTLHWDLSCATLGWSRDIPTIPKG
EEECHHHHCCCEEEEECHHHHHHHHHCCCCHHHHHCCCEEEEEEEEEECCCCCCCCCCCC
YGMLFSDEPPLLGIVYNSRVFPNQMPGKTVLSLLLENRWHQEEAYAFSLAAISEYLGIST
CCEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
QPDVFSLFSPEDGLPQHGVGFVEMKNRILPAIPHNLKIVGQNFSGPGLNRCVASAYQTVA
CCCEEEECCCCCCCCCCCCCHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
AI
CC
>Mature Secondary Structure
MKKAIIIGAGISGLSTAWWLHRKFPNSELIIIDKADRPGGLIYSDYQKNFSLDLGPKSFL
CCCEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEECCCCCEEEECCCCEEE
VRGEGHYTLELIRDLQLEEALIVSDKTAKKRFIRYKGKTRKVSPWTLIKEGLPFAIIKDL
EECCCCEEEHHHHHHHHHHEEEECCCHHHHHHHHCCCCCCCCCCHHHHHCCCCHHHHHHH
FASRYTKDSSVYDFLSRHSTVHLIHNILNPVVTAVRAGHSHLLSAHMAFPSLSQREAKTG
HHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHH
SILRSYLKEPSKKKTPGAPYLVSLRPNLGILIDTLVKKLPVTWKLSSPVTKIECFPSKVV
HHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCEEEECCCCEEEEECCCEEE
VSTTQETFSGDLAIYTGATSLLPSLIDIPGMQQLANKTLHWDLSCATLGWSRDIPTIPKG
EEECHHHHCCCEEEEECHHHHHHHHHCCCCHHHHHCCCEEEEEEEEEECCCCCCCCCCCC
YGMLFSDEPPLLGIVYNSRVFPNQMPGKTVLSLLLENRWHQEEAYAFSLAAISEYLGIST
CCEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
QPDVFSLFSPEDGLPQHGVGFVEMKNRILPAIPHNLKIVGQNFSGPGLNRCVASAYQTVA
CCCEEEECCCCCCCCCCCCCHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
AI
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1372277; 8621504 [H]