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The map label for this gene is hemN [H]

Identifier: 62185448

GI number: 62185448

Start: 980356

End: 981732

Strand: Direct

Name: hemN [H]

Synonym: CAB845

Alternate gene names: 62185448

Gene position: 980356-981732 (Clockwise)

Preceding gene: 62185447

Following gene: 62185449

Centisome position: 85.67

GC content: 39.07

Gene sequence:

>1377_bases
ATGTTTAACGTCAATTTCAACTTCTTAGAAGGTCTTCATCAACCTGCACCGAGATACACAAGCTACCCAACAGCTCTTGA
ATGGGAGGAATCTGACGCGAATCCTGCCTACCTTGCTTTTGAGTATCTTCAAAAAGATAACAGCCCTTTATCCCTGTACT
TTCATATTCCCTTTTGCCAGTCTATGTGTCTGTACTGTGGATGTTCTGTAGTCATCAACCGTCGCGAAGATGTTGTAGAA
AACTATATAGCTACGCTGATCAAGGAAATGGAGTATGTGCATACGCTCTTAGGAGGAAGACGGAAAACTTCACGGATCCA
TTTCGGAGGAGGAACTCCAAGCAGGTTATCCAGAAAACTCTTTGAAACACTGTTTTCCCATATTCATCGTTTATTTGATC
TTTCCGAAGCTGAAGAAATTGCTATTGAATTTGATCCGCGTTCTTTAAGGAACGATGATACAAAAGCAGAATTTATCCAG
TCTCTAGGGTTTAATCGTGTGAGCTTAGGCGTCCAAGATACCCAAGCTGCTGTTCAAGAAGCTGTACGGCGTCGGCAAAG
TTACGAAGAGTCACTGTATGCTTATGAAAAATTCCGTGAGTTAGGTTTTGAAAGCATAAATATAGATCTCATTTACGGTC
TTCCAAAACAAACGAAGGTAACATTTACGCAAACGATTGCGGATATTTTACACATGCGTCCTGACCGCTTAGCGTTATTT
TCATTTGCTTCTGTTCCCTGGATAAAACCCCATCAGAAAGCTATGAAAGAAAGTGACATGCCCTCTATGGAGGAAAAATT
CGCCATATATTCTTATGCTCGGCATACGTTAACAAAAGCTGGTTACCAAGCTATTGGATTAGATCATTTTTCTCTACCTG
AAGACCCATTAAGCATCGCCTTTAAAAACAAAACTTTGATTCGAAATTTCCAAGGCTACTCTTTACCTCCTGAAGAAGAC
CTTATCGGGTTGGGAATGTCATCAACAAGCTTTATCCGTGGCATATATTTGCAAAATGCCAAAACTCTCGAATCTTACCA
TCAGAAGATTCTTTCGGGCTCTTTAGCTACAACGAAAAGTAAAATTCTTTCAGAAGATGATAAAATAAGGAAATGGGTAA
TTCATAAGCTGATGTGTACTTTTGTCGTATCAAAAAAAGAATTCATCCAGCTTTTCGGTTATTGTTTTGATGAGTATTTT
GCCGAAAGTCAAGAACGAATAAACAGTATGGAGACTACGGGATTAATTCAAAATAGTTCATCTTTCCTTACCGTAACACC
ATTAGGAGAGCTGTTTGTACGTGTAATTGCTACAACGTTTGATGCCTATTTCTTAAAAACTGTGTCTTCACATCCTAGGT
TTTCAAGATCCATATGA

Upstream 100 bases:

>100_bases
AGTACCTTTCTGTTTTAAAACATCAACCTAAGTACATTTTCAATTCAGGGCATGGTATTCTTCCTGAAACTCCTTTAGAA
AACGTTCAAGCTGCGGTATT

Downstream 100 bases:

>100_bases
AAAAAGCCATTATCATAGGCGCAGGAATTTCAGGGTTATCCACAGCGTGGTGGTTACATAGGAAATTCCCCAATAGCGAA
CTTATAATTATAGATAAGGC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MFNVNFNFLEGLHQPAPRYTSYPTALEWEESDANPAYLAFEYLQKDNSPLSLYFHIPFCQSMCLYCGCSVVINRREDVVE
NYIATLIKEMEYVHTLLGGRRKTSRIHFGGGTPSRLSRKLFETLFSHIHRLFDLSEAEEIAIEFDPRSLRNDDTKAEFIQ
SLGFNRVSLGVQDTQAAVQEAVRRRQSYEESLYAYEKFRELGFESINIDLIYGLPKQTKVTFTQTIADILHMRPDRLALF
SFASVPWIKPHQKAMKESDMPSMEEKFAIYSYARHTLTKAGYQAIGLDHFSLPEDPLSIAFKNKTLIRNFQGYSLPPEED
LIGLGMSSTSFIRGIYLQNAKTLESYHQKILSGSLATTKSKILSEDDKIRKWVIHKLMCTFVVSKKEFIQLFGYCFDEYF
AESQERINSMETTGLIQNSSSFLTVTPLGELFVRVIATTFDAYFLKTVSSHPRFSRSI

Sequences:

>Translated_458_residues
MFNVNFNFLEGLHQPAPRYTSYPTALEWEESDANPAYLAFEYLQKDNSPLSLYFHIPFCQSMCLYCGCSVVINRREDVVE
NYIATLIKEMEYVHTLLGGRRKTSRIHFGGGTPSRLSRKLFETLFSHIHRLFDLSEAEEIAIEFDPRSLRNDDTKAEFIQ
SLGFNRVSLGVQDTQAAVQEAVRRRQSYEESLYAYEKFRELGFESINIDLIYGLPKQTKVTFTQTIADILHMRPDRLALF
SFASVPWIKPHQKAMKESDMPSMEEKFAIYSYARHTLTKAGYQAIGLDHFSLPEDPLSIAFKNKTLIRNFQGYSLPPEED
LIGLGMSSTSFIRGIYLQNAKTLESYHQKILSGSLATTKSKILSEDDKIRKWVIHKLMCTFVVSKKEFIQLFGYCFDEYF
AESQERINSMETTGLIQNSSSFLTVTPLGELFVRVIATTFDAYFLKTVSSHPRFSRSI
>Mature_458_residues
MFNVNFNFLEGLHQPAPRYTSYPTALEWEESDANPAYLAFEYLQKDNSPLSLYFHIPFCQSMCLYCGCSVVINRREDVVE
NYIATLIKEMEYVHTLLGGRRKTSRIHFGGGTPSRLSRKLFETLFSHIHRLFDLSEAEEIAIEFDPRSLRNDDTKAEFIQ
SLGFNRVSLGVQDTQAAVQEAVRRRQSYEESLYAYEKFRELGFESINIDLIYGLPKQTKVTFTQTIADILHMRPDRLALF
SFASVPWIKPHQKAMKESDMPSMEEKFAIYSYARHTLTKAGYQAIGLDHFSLPEDPLSIAFKNKTLIRNFQGYSLPPEED
LIGLGMSSTSFIRGIYLQNAKTLESYHQKILSGSLATTKSKILSEDDKIRKWVIHKLMCTFVVSKKEFIQLFGYCFDEYF
AESQERINSMETTGLIQNSSSFLTVTPLGELFVRVIATTFDAYFLKTVSSHPRFSRSI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=254, Percent_Identity=25.1968503937008, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI87082341, Length=443, Percent_Identity=38.1489841986456, Blast_Score=314, Evalue=6e-87,
Organism=Escherichia coli, GI1789325, Length=400, Percent_Identity=24.25, Blast_Score=106, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 52698; Mature: 52698

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNVNFNFLEGLHQPAPRYTSYPTALEWEESDANPAYLAFEYLQKDNSPLSLYFHIPFCQ
CCCCCHHHHHHHCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHCCCCCEEEEEECHHHH
SMCLYCGCSVVINRREDVVENYIATLIKEMEYVHTLLGGRRKTSRIHFGGGTPSRLSRKL
HHHHHHCCHHEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHH
FETLFSHIHRLFDLSEAEEIAIEFDPRSLRNDDTKAEFIQSLGFNRVSLGVQDTQAAVQE
HHHHHHHHHHHHCCCCCCEEEEEECCHHCCCCCHHHHHHHHCCCCEEECCCHHHHHHHHH
AVRRRQSYEESLYAYEKFRELGFESINIDLIYGLPKQTKVTFTQTIADILHMRPDRLALF
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHH
SFASVPWIKPHQKAMKESDMPSMEEKFAIYSYARHTLTKAGYQAIGLDHFSLPEDPLSIA
HHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCEEE
FKNKTLIRNFQGYSLPPEEDLIGLGMSSTSFIRGIYLQNAKTLESYHQKILSGSLATTKS
ECCCHHHHCCCCCCCCCCCCEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHH
KILSEDDKIRKWVIHKLMCTFVVSKKEFIQLFGYCFDEYFAESQERINSMETTGLIQNSS
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
SFLTVTPLGELFVRVIATTFDAYFLKTVSSHPRFSRSI
CEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MFNVNFNFLEGLHQPAPRYTSYPTALEWEESDANPAYLAFEYLQKDNSPLSLYFHIPFCQ
CCCCCHHHHHHHCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHCCCCCEEEEEECHHHH
SMCLYCGCSVVINRREDVVENYIATLIKEMEYVHTLLGGRRKTSRIHFGGGTPSRLSRKL
HHHHHHCCHHEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHH
FETLFSHIHRLFDLSEAEEIAIEFDPRSLRNDDTKAEFIQSLGFNRVSLGVQDTQAAVQE
HHHHHHHHHHHHCCCCCCEEEEEECCHHCCCCCHHHHHHHHCCCCEEECCCHHHHHHHHH
AVRRRQSYEESLYAYEKFRELGFESINIDLIYGLPKQTKVTFTQTIADILHMRPDRLALF
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHH
SFASVPWIKPHQKAMKESDMPSMEEKFAIYSYARHTLTKAGYQAIGLDHFSLPEDPLSIA
HHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCEEE
FKNKTLIRNFQGYSLPPEEDLIGLGMSSTSFIRGIYLQNAKTLESYHQKILSGSLATTKS
ECCCHHHHCCCCCCCCCCCCEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHH
KILSEDDKIRKWVIHKLMCTFVVSKKEFIQLFGYCFDEYFAESQERINSMETTGLIQNSS
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
SFLTVTPLGELFVRVIATTFDAYFLKTVSSHPRFSRSI
CEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]