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The map label for this gene is hemE

Identifier: 62185447

GI number: 62185447

Start: 979382

End: 980383

Strand: Direct

Name: hemE

Synonym: CAB844

Alternate gene names: 62185447

Gene position: 979382-980383 (Clockwise)

Preceding gene: 62185446

Following gene: 62185448

Centisome position: 85.58

GC content: 39.62

Gene sequence:

>1002_bases
ATGTCGAAATTTTACGACGTGATAAAACCCAAAGCCTCACGTCCACCTGTATGGTTTTTACGGCAAGTAGGCCGATACAT
GCCACAATATAGAGAACTCAAGGGTTCTCAGACATTGAAAGATTTTTTTCACAATACCGAGGCGATTACAGAAGCAACCC
TGTTAGGGCCAAGCTTACTAAAAGTAGATGCTGCGATTCTCTTTGCTGATATTCTTTCACTATTAGATGGCTTCAATATC
TCTTATGATTTTGCTCCGGGCCCGCAAATCTCTTTTTCCCCTAAAGAAGAACTCATTTTTACAAACGATCCTCAAGATAC
GTTTTCCTATCTTCTTAAAGCTATCAAGAATCTCGTCAAACGTTTATCAGTTCCTCTCATTGCGTTTGCGGCATCTCCCT
TTACCATGGCATGTTACCTTTTAGAGGGTGGGGCCTCTAAAGATTTTCCAAAAACTATGGCTTTCTTGTATCAGCATCCC
GAGAGGTTCGACGCACTGCTTAAGCAATTAGCGGAAGCTACTGTCATTTATCTTAAAGAACAAATCCAAGCAGGAGCTTC
AGCTATTCAGTTATTTGAATCTTCTAGCCTACGTTTACCCTCAGCCTTATTTTCTCGTTATGTGACACGACCAAATACCC
AACTCATCACCCAGTTAAAAAACTCGGTTTCGTCTCCTATAAGTTTATTTTGCCGCTGTTTTGATGAAAACTTTATAGAT
CTCTATTCTACGGGAGCGGATACTCTACATCCTGACTACCATGTTAACCTTAGTCAAATCTATACAGCAGTTACACATCC
AGGATCTTTACAAGGAAATATTGATCCCGCACTATTTCTACTTCCTCAAGATCAGTTTCTGAACCACCTTGAAAAGTACC
TTTCTGTTTTAAAACATCAACCTAAGTACATTTTCAATTCAGGGCATGGTATTCTTCCTGAAACTCCTTTAGAAAACGTT
CAAGCTGCGGTATTATGTTTAACGTCAATTTCAACTTCTTAG

Upstream 100 bases:

>100_bases
ACCCTATTCTTTATCCCCCACTCCAGAACTCCTGGTATCTGAAGTGTTGGAATCTATAGAGAAAGCATTTCCTCTAAAAA
CCCCTCGTTAAGGAGGCTCG

Downstream 100 bases:

>100_bases
AAGGTCTTCATCAACCTGCACCGAGATACACAAGCTACCCAACAGCTCTTGAATGGGAGGAATCTGACGCGAATCCTGCC
TACCTTGCTTTTGAGTATCT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MSKFYDVIKPKASRPPVWFLRQVGRYMPQYRELKGSQTLKDFFHNTEAITEATLLGPSLLKVDAAILFADILSLLDGFNI
SYDFAPGPQISFSPKEELIFTNDPQDTFSYLLKAIKNLVKRLSVPLIAFAASPFTMACYLLEGGASKDFPKTMAFLYQHP
ERFDALLKQLAEATVIYLKEQIQAGASAIQLFESSSLRLPSALFSRYVTRPNTQLITQLKNSVSSPISLFCRCFDENFID
LYSTGADTLHPDYHVNLSQIYTAVTHPGSLQGNIDPALFLLPQDQFLNHLEKYLSVLKHQPKYIFNSGHGILPETPLENV
QAAVLCLTSISTS

Sequences:

>Translated_333_residues
MSKFYDVIKPKASRPPVWFLRQVGRYMPQYRELKGSQTLKDFFHNTEAITEATLLGPSLLKVDAAILFADILSLLDGFNI
SYDFAPGPQISFSPKEELIFTNDPQDTFSYLLKAIKNLVKRLSVPLIAFAASPFTMACYLLEGGASKDFPKTMAFLYQHP
ERFDALLKQLAEATVIYLKEQIQAGASAIQLFESSSLRLPSALFSRYVTRPNTQLITQLKNSVSSPISLFCRCFDENFID
LYSTGADTLHPDYHVNLSQIYTAVTHPGSLQGNIDPALFLLPQDQFLNHLEKYLSVLKHQPKYIFNSGHGILPETPLENV
QAAVLCLTSISTS
>Mature_332_residues
SKFYDVIKPKASRPPVWFLRQVGRYMPQYRELKGSQTLKDFFHNTEAITEATLLGPSLLKVDAAILFADILSLLDGFNIS
YDFAPGPQISFSPKEELIFTNDPQDTFSYLLKAIKNLVKRLSVPLIAFAASPFTMACYLLEGGASKDFPKTMAFLYQHPE
RFDALLKQLAEATVIYLKEQIQAGASAIQLFESSSLRLPSALFSRYVTRPNTQLITQLKNSVSSPISLFCRCFDENFIDL
YSTGADTLHPDYHVNLSQIYTAVTHPGSLQGNIDPALFLLPQDQFLNHLEKYLSVLKHQPKYIFNSGHGILPETPLENVQ
AAVLCLTSISTS

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=324, Percent_Identity=31.7901234567901, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI2367337, Length=330, Percent_Identity=30.3030303030303, Blast_Score=169, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6320252, Length=328, Percent_Identity=26.8292682926829, Blast_Score=122, Evalue=9e-29,
Organism=Drosophila melanogaster, GI19921920, Length=327, Percent_Identity=30.5810397553517, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI221330099, Length=327, Percent_Identity=30.5810397553517, Blast_Score=151, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_CHLAB (Q5L510)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_220232.1
- HSSP:   P06132
- ProteinModelPortal:   Q5L510
- SMR:   Q5L510
- GeneID:   3337873
- GenomeReviews:   CR848038_GR
- KEGG:   cab:CAB844
- HOGENOM:   HBG628392
- OMA:   QAGRYHK
- ProtClustDB:   PRK00115
- BioCyc:   CABO218497:CAB844-MONOMER
- BRENDA:   4.1.1.37
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 37315; Mature: 37184

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 70-70 BINDING 139-139 BINDING 194-194 BINDING 309-309

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKFYDVIKPKASRPPVWFLRQVGRYMPQYRELKGSQTLKDFFHNTEAITEATLLGPSLL
CCCHHHHHCCCCCCCCHHHHHHHHHHCHHHHHHCCHHHHHHHHCCHHHHHHHHHCCHHHH
KVDAAILFADILSLLDGFNISYDFAPGPQISFSPKEELIFTNDPQDTFSYLLKAIKNLVK
HHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHH
RLSVPLIAFAASPFTMACYLLEGGASKDFPKTMAFLYQHPERFDALLKQLAEATVIYLKE
HHCCCHHHHHCCCHHHHHHHEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
QIQAGASAIQLFESSSLRLPSALFSRYVTRPNTQLITQLKNSVSSPISLFCRCFDENFID
HHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHCCCHHH
LYSTGADTLHPDYHVNLSQIYTAVTHPGSLQGNIDPALFLLPQDQFLNHLEKYLSVLKHQ
HHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCC
PKYIFNSGHGILPETPLENVQAAVLCLTSISTS
CCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKFYDVIKPKASRPPVWFLRQVGRYMPQYRELKGSQTLKDFFHNTEAITEATLLGPSLL
CCHHHHHCCCCCCCCHHHHHHHHHHCHHHHHHCCHHHHHHHHCCHHHHHHHHHCCHHHH
KVDAAILFADILSLLDGFNISYDFAPGPQISFSPKEELIFTNDPQDTFSYLLKAIKNLVK
HHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHH
RLSVPLIAFAASPFTMACYLLEGGASKDFPKTMAFLYQHPERFDALLKQLAEATVIYLKE
HHCCCHHHHHCCCHHHHHHHEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
QIQAGASAIQLFESSSLRLPSALFSRYVTRPNTQLITQLKNSVSSPISLFCRCFDENFID
HHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHCCCHHH
LYSTGADTLHPDYHVNLSQIYTAVTHPGSLQGNIDPALFLLPQDQFLNHLEKYLSVLKHQ
HHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCC
PKYIFNSGHGILPETPLENVQAAVLCLTSISTS
CCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA