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The map label for this gene is arcD

Identifier: 62185311

GI number: 62185311

Start: 808759

End: 810219

Strand: Direct

Name: arcD

Synonym: CAB698

Alternate gene names: 62185311

Gene position: 808759-810219 (Clockwise)

Preceding gene: 62185310

Following gene: 62185312

Centisome position: 70.67

GC content: 41.62

Gene sequence:

>1461_bases
ATGATTTCTAATGGGAGTAAATCCGGGAAAAATCTCGGAGCCATAGCTTTAGCAGGCATGGTCATTAGCTCCATGATTGG
GGGAGGGATTTTCAGCCTTCCCCAAAATATGGCAGCATCTGCAGGAGTAGGCGCAATTATCTTAGCATGGATCCTAACAG
GCGTAGGCATGTTTTTCATTGCCAATACTTTTAAAATTCTCTCATTAGTACGCCCGGACTTAACGACAGGAATCTATATG
TACAGCCGAGAAGGATTTGGCCCCTACATAGGGTTTACTATCGGCTGGGGATATTGGTTATGCCAGATCTTTGGGAATGT
CGGTTATGCCGTGATGACCATGGATGCATTAAACTATTTTTTCCCTCCCTACTTTCAAGGAGGAAATACTCTACCCGCCA
TTCTAGGGGGCTCCATACTCATCTGGGTTTTCAATTTCATCGTCTTAAAAGGAATCCGTCAGGCATCGTTCATTAACATC
ATCGGCACAGTAGGCAAACTCGTTCCTCTGATTGTATTCATTATCATCACAGCCTTTCTTTTTAAACTTGCGATTTTCAA
AACAGATTTTTGGGGGGATACGGTTACAAAAACACAACCGTTATTAGGATCTATGACTAGTCAGCTGAAAAGCACAATGT
TAGTTACCTTATGGGCTTTCATAGGCATCGAAGGCGCCGTAGTCATGTCCGCACGTGCAAAAAGTCCTAGTGCTGTTGGA
AAAGCGACGATTTTAGGTTTTACTGGGTGTCTCACTGTTTACATACTTTTATCTATCTTACCTTTTGGCTCCTTATTTCA
ACATCAACTCGCCGGTATTGCCAACCCTTCCACCGCGGGAGTATTGGATATTCTCGTAGGAAAATGGGGAGAAATTTTAA
TGAATGTTGGTCTCCTTATTGCCGTACTTTCTAGTTGGTTATCCTGGACTATGATCGTTGCTGAGATCCCGTATTCTGCA
GCAAAAAATGGGACATTCCCAGAGATTTTCGCTATCGAAAATGCGCATCGCTCTCCTAAAGTTTCATTATATGTTACTAG
TGCTCTCATGCAAATCGCTATGCTTCTGGTATACTTTTCAACCGACGCATGGAATACCATGTTGAGCATTACAGGCGTAA
TGGTCTTACCTGCCTATTTCGCAAGTGCCGCTTTTCTTGTGAAGTTTAGTAAAAACAAAAAATACCCAAATAAGGGACCT
ATCAAAGCCTTCACTGCAAAAATTACAGGACTTCTGGGTGCCGTTTATTCTATTTGGCTCATCTATGCTGGAGGGCTGAA
ATATCTACTTATGGCTATCATTCTCTTGGCGTTAGGCATTCCTTTTTACATCGATGCCGGGAAAAAAGGCAGAAATGCAA
AAACATTTTTTGCAAAAAAAGAGGTTACAGAAATTACCATCATTGCTTTTCTAGCCTTATTGGCTATATTCCTCTTTTCA
ACGGAAAAAATCCGTTTATAA

Upstream 100 bases:

>100_bases
CTACATTAACATTAAGCAAAAATATGGTTTCTCATTAACTGCATTAGGGTTTCTCAACTTTGAAAATGCCGATCCGGTAA
CAATTAAGTAAGGAGAATAC

Downstream 100 bases:

>100_bases
CCAAACGATCTAATCACCCTTTGGGAGAGGCCTTTGCGCCTCTCTCATTTATCCTCAGGGGAGATATAGAGTGAATTTCT
AAATTCAGATCCTAGATTTC

Product: putative amino acid permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MISNGSKSGKNLGAIALAGMVISSMIGGGIFSLPQNMAASAGVGAIILAWILTGVGMFFIANTFKILSLVRPDLTTGIYM
YSREGFGPYIGFTIGWGYWLCQIFGNVGYAVMTMDALNYFFPPYFQGGNTLPAILGGSILIWVFNFIVLKGIRQASFINI
IGTVGKLVPLIVFIIITAFLFKLAIFKTDFWGDTVTKTQPLLGSMTSQLKSTMLVTLWAFIGIEGAVVMSARAKSPSAVG
KATILGFTGCLTVYILLSILPFGSLFQHQLAGIANPSTAGVLDILVGKWGEILMNVGLLIAVLSSWLSWTMIVAEIPYSA
AKNGTFPEIFAIENAHRSPKVSLYVTSALMQIAMLLVYFSTDAWNTMLSITGVMVLPAYFASAAFLVKFSKNKKYPNKGP
IKAFTAKITGLLGAVYSIWLIYAGGLKYLLMAIILLALGIPFYIDAGKKGRNAKTFFAKKEVTEITIIAFLALLAIFLFS
TEKIRL

Sequences:

>Translated_486_residues
MISNGSKSGKNLGAIALAGMVISSMIGGGIFSLPQNMAASAGVGAIILAWILTGVGMFFIANTFKILSLVRPDLTTGIYM
YSREGFGPYIGFTIGWGYWLCQIFGNVGYAVMTMDALNYFFPPYFQGGNTLPAILGGSILIWVFNFIVLKGIRQASFINI
IGTVGKLVPLIVFIIITAFLFKLAIFKTDFWGDTVTKTQPLLGSMTSQLKSTMLVTLWAFIGIEGAVVMSARAKSPSAVG
KATILGFTGCLTVYILLSILPFGSLFQHQLAGIANPSTAGVLDILVGKWGEILMNVGLLIAVLSSWLSWTMIVAEIPYSA
AKNGTFPEIFAIENAHRSPKVSLYVTSALMQIAMLLVYFSTDAWNTMLSITGVMVLPAYFASAAFLVKFSKNKKYPNKGP
IKAFTAKITGLLGAVYSIWLIYAGGLKYLLMAIILLALGIPFYIDAGKKGRNAKTFFAKKEVTEITIIAFLALLAIFLFS
TEKIRL
>Mature_486_residues
MISNGSKSGKNLGAIALAGMVISSMIGGGIFSLPQNMAASAGVGAIILAWILTGVGMFFIANTFKILSLVRPDLTTGIYM
YSREGFGPYIGFTIGWGYWLCQIFGNVGYAVMTMDALNYFFPPYFQGGNTLPAILGGSILIWVFNFIVLKGIRQASFINI
IGTVGKLVPLIVFIIITAFLFKLAIFKTDFWGDTVTKTQPLLGSMTSQLKSTMLVTLWAFIGIEGAVVMSARAKSPSAVG
KATILGFTGCLTVYILLSILPFGSLFQHQLAGIANPSTAGVLDILVGKWGEILMNVGLLIAVLSSWLSWTMIVAEIPYSA
AKNGTFPEIFAIENAHRSPKVSLYVTSALMQIAMLLVYFSTDAWNTMLSITGVMVLPAYFASAAFLVKFSKNKKYPNKGP
IKAFTAKITGLLGAVYSIWLIYAGGLKYLLMAIILLALGIPFYIDAGKKGRNAKTFFAKKEVTEITIIAFLALLAIFLFS
TEKIRL

Specific function: Catalyzes the exchange of L-arginine for agmatine. The arginine uptake by the bacterium in the macrophage may be a virulence factor against the host innate immune response

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily

Homologues:

Organism=Escherichia coli, GI1787890, Length=460, Percent_Identity=40.2173913043478, Blast_Score=354, Evalue=9e-99,
Organism=Escherichia coli, GI2367353, Length=437, Percent_Identity=25.629290617849, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1790575, Length=419, Percent_Identity=26.0143198090692, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786908, Length=445, Percent_Identity=25.3932584269663, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AAXC_CHLAB (Q5L5E6)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_220096.1
- GeneID:   3337256
- GenomeReviews:   CR848038_GR
- KEGG:   cab:CAB698
- HOGENOM:   HBG586921
- OMA:   IANTFKI
- PhylomeDB:   Q5L5E6
- ProtClustDB:   CLSK871339
- BioCyc:   CABO218497:CAB698-MONOMER
- GO:   GO:0009405
- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004754
- PANTHER:   PTHR11785
- PIRSF:   PIRSF006060
- TIGRFAMs:   TIGR00905

Pfam domain/function: PF00324 AA_permease

EC number: NA

Molecular weight: Translated: 52473; Mature: 52473

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x403a13f4)-; HASH(0xd48cb9c)-; HASH(0xcc9b530)-; HASH(0xc1e4f48)-; HASH(0xc04c9f0)-; HASH(0xcdc4ccc)-; HASH(0xc1ab900)-; HASH(0xd09cc64)-; HASH(0xc7e2e60)-; HASH(0xc217174)-; HASH(0xd0a5980)-; HASH(0xcf5a634)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCH
>Mature Secondary Structure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CCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA