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The map label for this gene is aaxA

Identifier: 62185309

GI number: 62185309

Start: 806781

End: 808127

Strand: Direct

Name: aaxA

Synonym: CAB696

Alternate gene names: 62185309

Gene position: 806781-808127 (Clockwise)

Preceding gene: 62185308

Following gene: 62185310

Centisome position: 70.5

GC content: 42.69

Gene sequence:

>1347_bases
ATGGCGTCTTTTCGTTCCTCTCTATTATCTGCTCTATGTGCCTATGGCATGATGGTCATGCCTGCCTATGCTATTGATCC
CAATCACCCTAAGCTCCACCATCATAAGTACTCCGAAAGATTGAAAAAAAGGCACACGGAAGATTCGTATCTTTCCTCTT
CCTCGACGCTAGAATCCTCCAAAACCTTCGCCCAAGAACCTCGTCGTCACGTACTTACCCCCATACGTAATGTATTAGCA
GATCGCCCTTGCGAAGAGGGATTGTCGATCTCCAAATTGTTCAACTCCATAGAAAAAGAGACGAACTCTCAAATTTCTGT
GGATTTTACCATTCTTCCTCAGTGGTTTTATCCTAAGAAAGGTTTGCTAAAGGCAGTTGATGAAAAACAGCCGACTTGGC
AATTTTACGTGAGTCCCAACGTTTCTTGGCAACTCTATAACAGCCCTACTGCAGGTGTAGGGAGTATCGATTTCTCCTAT
ACCTTGGTACGTTACTGGAGAAACAACGCGCAAAATGCGAACAACGCTATAGGAATTGCGGGCGGGATTAATGATTATAG
TACTCGAACTAATACGTTATCTCAGCTAACGTTTTCTCAGACATTCCCCGAGAATATCCTTACCATTTCATTTGGCCAAT
ACAGCCTATATTCTATAGATGGGACATTGTACGATAACGACCAACAATCAGGATTCCTAAGTTACGCGTTATCACAAAAT
GCGAGTGCTACGTATTCCTCCGGAAGCGTGGGTGCTTATCTACAATTTACACCTACCCCCTCGATAAATATTCAAGCTGG
TTTCCAAGATGCTTATAATGTTTCAGGTTCTTCTTTTGATCTGTATAACCTTACAAGAAACCGCTATAACTTCTATGGCT
ATGTCTCTTGGGCACCACAAAGTAGTTTAGGTAGTGGGCAATATTCTGCATTAGTCTATTCTACAAGGAAGGTACCTGAA
CAACCTGTGCAAACCACAGGATGGTCACTAAACTTCGGACAGCACCTAGGAGAAAAACTGTATGTATTTGGAAGATGGAA
TGGTGCCACAGGAACAGTGACCAACCTCAACCGCTCTTATGTTCTGGGATTAGCATCAGCAAATCCCATAAATCGCAATC
CTCAAGATCTTTTAGGTGCTGCGTGCTCCATGAGCAAAGTCAATCCTAAAGTAATTACAGAAAAGAAAATCCGCAAATAC
GAAACTGTAATAGAAACATTCGCAACCATAGGATTTGGACCTCACATATCGCTAACTCCAGATCTACAAATCTATATTCA
TCCTGCACGAAGACCCGATAAACGTGCCGCTAAAGTTTACGGCGTCCGAGCGAATTTCTCTACCTAA

Upstream 100 bases:

>100_bases
GATAACAATTCCTCTATTTTCTCCAAAAATGATGGCATAAAAAAAACTTTTTTTTTTAGAGTCACAAAAAAGAACCACGT
ATCTTTTCTTTTGGTAGTTC

Downstream 100 bases:

>100_bases
CATCCTACAACTTGATATCCTTAGGAGTTTGTACATGCCTTACGGAACACGCTACCCGACATTAGCTTTCCATACGGGAG
GAGTCGGTGAATCTGATGAT

Product: hypothetical protein

Products: NA

Alternate protein names: Outer membrane protein AaxA

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MASFRSSLLSALCAYGMMVMPAYAIDPNHPKLHHHKYSERLKKRHTEDSYLSSSSTLESSKTFAQEPRRHVLTPIRNVLA
DRPCEEGLSISKLFNSIEKETNSQISVDFTILPQWFYPKKGLLKAVDEKQPTWQFYVSPNVSWQLYNSPTAGVGSIDFSY
TLVRYWRNNAQNANNAIGIAGGINDYSTRTNTLSQLTFSQTFPENILTISFGQYSLYSIDGTLYDNDQQSGFLSYALSQN
ASATYSSGSVGAYLQFTPTPSINIQAGFQDAYNVSGSSFDLYNLTRNRYNFYGYVSWAPQSSLGSGQYSALVYSTRKVPE
QPVQTTGWSLNFGQHLGEKLYVFGRWNGATGTVTNLNRSYVLGLASANPINRNPQDLLGAACSMSKVNPKVITEKKIRKY
ETVIETFATIGFGPHISLTPDLQIYIHPARRPDKRAAKVYGVRANFST

Sequences:

>Translated_448_residues
MASFRSSLLSALCAYGMMVMPAYAIDPNHPKLHHHKYSERLKKRHTEDSYLSSSSTLESSKTFAQEPRRHVLTPIRNVLA
DRPCEEGLSISKLFNSIEKETNSQISVDFTILPQWFYPKKGLLKAVDEKQPTWQFYVSPNVSWQLYNSPTAGVGSIDFSY
TLVRYWRNNAQNANNAIGIAGGINDYSTRTNTLSQLTFSQTFPENILTISFGQYSLYSIDGTLYDNDQQSGFLSYALSQN
ASATYSSGSVGAYLQFTPTPSINIQAGFQDAYNVSGSSFDLYNLTRNRYNFYGYVSWAPQSSLGSGQYSALVYSTRKVPE
QPVQTTGWSLNFGQHLGEKLYVFGRWNGATGTVTNLNRSYVLGLASANPINRNPQDLLGAACSMSKVNPKVITEKKIRKY
ETVIETFATIGFGPHISLTPDLQIYIHPARRPDKRAAKVYGVRANFST
>Mature_447_residues
ASFRSSLLSALCAYGMMVMPAYAIDPNHPKLHHHKYSERLKKRHTEDSYLSSSSTLESSKTFAQEPRRHVLTPIRNVLAD
RPCEEGLSISKLFNSIEKETNSQISVDFTILPQWFYPKKGLLKAVDEKQPTWQFYVSPNVSWQLYNSPTAGVGSIDFSYT
LVRYWRNNAQNANNAIGIAGGINDYSTRTNTLSQLTFSQTFPENILTISFGQYSLYSIDGTLYDNDQQSGFLSYALSQNA
SATYSSGSVGAYLQFTPTPSINIQAGFQDAYNVSGSSFDLYNLTRNRYNFYGYVSWAPQSSLGSGQYSALVYSTRKVPEQ
PVQTTGWSLNFGQHLGEKLYVFGRWNGATGTVTNLNRSYVLGLASANPINRNPQDLLGAACSMSKVNPKVITEKKIRKYE
TVIETFATIGFGPHISLTPDLQIYIHPARRPDKRAAKVYGVRANFST

Specific function: Facilitates L-arginine uptake, as part of the AaxABC system. The arginine uptake by the bacterium in the macrophage may be a virulence factor against the host innate immune response

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oprB family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AAXA_CHLAB (Q5L5E8)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_220094.1
- GeneID:   3337602
- GenomeReviews:   CR848038_GR
- KEGG:   cab:CAB696
- HOGENOM:   HBG414055
- OMA:   TLYDNDQ
- ProtClustDB:   CLSK871338
- BioCyc:   CABO218497:CAB696-MONOMER
- GO:   GO:0009405
- InterPro:   IPR007049

Pfam domain/function: PF04966 OprB

EC number: NA

Molecular weight: Translated: 50046; Mature: 49914

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASFRSSLLSALCAYGMMVMPAYAIDPNHPKLHHHKYSERLKKRHTEDSYLSSSSTLESS
CCHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCHHHH
KTFAQEPRRHVLTPIRNVLADRPCEEGLSISKLFNSIEKETNSQISVDFTILPQWFYPKK
HHHHHCHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHCCCEEEEEEEEECCCCCCCH
GLLKAVDEKQPTWQFYVSPNVSWQLYNSPTAGVGSIDFSYTLVRYWRNNAQNANNAIGIA
HHHHHHCCCCCCEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEE
GGINDYSTRTNTLSQLTFSQTFPENILTISFGQYSLYSIDGTLYDNDQQSGFLSYALSQN
CCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCEEEEEECCEEECCCCCCCEEEEEECCC
ASATYSSGSVGAYLQFTPTPSINIQAGFQDAYNVSGSSFDLYNLTRNRYNFYGYVSWAPQ
CCCEECCCCCEEEEEECCCCCEEEEECCCHHHCCCCCCEEEEECCCCCEEEEEEEEECCC
SSLGSGQYSALVYSTRKVPEQPVQTTGWSLNFGQHLGEKLYVFGRWNGATGTVTNLNRSY
CCCCCCCEEEEEEECCCCCCCCCCCCCCEEEHHHHCCCEEEEEEECCCCCCEEEECCCEE
VLGLASANPINRNPQDLLGAACSMSKVNPKVITEKKIRKYETVIETFATIGFGPHISLTP
EEEECCCCCCCCCHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHCCCCCEEECC
DLQIYIHPARRPDKRAAKVYGVRANFST
CEEEEEECCCCCCCCCEEEEEEEECCCC
>Mature Secondary Structure 
ASFRSSLLSALCAYGMMVMPAYAIDPNHPKLHHHKYSERLKKRHTEDSYLSSSSTLESS
CHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCHHHH
KTFAQEPRRHVLTPIRNVLADRPCEEGLSISKLFNSIEKETNSQISVDFTILPQWFYPKK
HHHHHCHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHCCCEEEEEEEEECCCCCCCH
GLLKAVDEKQPTWQFYVSPNVSWQLYNSPTAGVGSIDFSYTLVRYWRNNAQNANNAIGIA
HHHHHHCCCCCCEEEEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEE
GGINDYSTRTNTLSQLTFSQTFPENILTISFGQYSLYSIDGTLYDNDQQSGFLSYALSQN
CCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCEEEEEECCEEECCCCCCCEEEEEECCC
ASATYSSGSVGAYLQFTPTPSINIQAGFQDAYNVSGSSFDLYNLTRNRYNFYGYVSWAPQ
CCCEECCCCCEEEEEECCCCCEEEEECCCHHHCCCCCCEEEEECCCCCEEEEEEEEECCC
SSLGSGQYSALVYSTRKVPEQPVQTTGWSLNFGQHLGEKLYVFGRWNGATGTVTNLNRSY
CCCCCCCEEEEEEECCCCCCCCCCCCCCEEEHHHHCCCEEEEEEECCCCCCEEEECCCEE
VLGLASANPINRNPQDLLGAACSMSKVNPKVITEKKIRKYETVIETFATIGFGPHISLTP
EEEECCCCCCCCCHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHCCCCCEEECC
DLQIYIHPARRPDKRAAKVYGVRANFST
CEEEEEECCCCCCCCCEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA