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The map label for this gene is rpiA1

Identifier: 23100064

GI number: 23100064

Start: 2671248

End: 2671922

Strand: Reverse

Name: rpiA1

Synonym: OB2609

Alternate gene names: 23100064

Gene position: 2671922-2671248 (Counterclockwise)

Preceding gene: 23100065

Following gene: 23100063

Centisome position: 73.6

GC content: 36.15

Gene sequence:

>675_bases
GTGAATGAGCAAGATAAATTAAAAAAAGCAGTTGGGGAAAAAGCGGCAACTATGGTGAAGGACGGAATGAAAGTTGGATT
AGGATCAGGATCCACTGTATATTGGATGATTCGTTCATTGGGTGAACGTATTCAACAAGATGGCTTGAAAATTGAAGGCA
TTCCATCTTCAAATCAAACAGCAACATGGGCAGAAGAAGCTGGTATTCCGTTAACAGATTTCTCGAATGTGAAAGAATTA
GATATAACGATTGATGGGGCGGATGAAGTAGATGCTAATAATCATTTGATTAAGGGTGGGGGAGCTGCGCTTTTTCGTGA
AAAAATAATTGCTCAAGCTGCTAAAGAGTTTGTCATAATTGTCGATCAATCAAAAGTAGTAGAGACTCTAGGAGAATTTT
CTCTTCCTGTTGAGGTTCTGCCATTTTCATGGCAACGAACTGCAAATGAAATATCTAAATTAGGTTGTGTTCCTACGGTT
CGTGTTCATGAGGAGGAGCCACTAGTTACCGATAATGGGAATTATATTTTAGATTGTCCTTTTAAAGTTATTCCGCATCC
GGATAAATTAAATAAAGAGATTAAATCAATTGTAGGAGTAATTGAAACGGGCTTATTTATTGATATGGCTACTACGGTAA
TTGTTGGAGAAAAAGATAATATTTATATAAAATAA

Upstream 100 bases:

>100_bases
CTCAATTGTAGGCTTGAATTTTTCAATTATATGCAAATTTAACTTCCAACACCTTTTACGCTATAATGATTACGTATACA
TAATGAGGAGGTAGCTATCG

Downstream 100 bases:

>100_bases
TTTCTAGATACTGTTGAATAGCGGGAAAAGTCATTGGACAATGATTTTTCTTGCTTTTTTTATGTATAGACTAAGAATTT
CTAAATTTTTTATCTTTGAG

Product: ribose-5-phosphate isomerase A

Products: NA

Alternate protein names: Phosphoriboisomerase A 1; PRI 1

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MNEQDKLKKAVGEKAATMVKDGMKVGLGSGSTVYWMIRSLGERIQQDGLKIEGIPSSNQTATWAEEAGIPLTDFSNVKEL
DITIDGADEVDANNHLIKGGGAALFREKIIAQAAKEFVIIVDQSKVVETLGEFSLPVEVLPFSWQRTANEISKLGCVPTV
RVHEEEPLVTDNGNYILDCPFKVIPHPDKLNKEIKSIVGVIETGLFIDMATTVIVGEKDNIYIK

Sequences:

>Translated_224_residues
MNEQDKLKKAVGEKAATMVKDGMKVGLGSGSTVYWMIRSLGERIQQDGLKIEGIPSSNQTATWAEEAGIPLTDFSNVKEL
DITIDGADEVDANNHLIKGGGAALFREKIIAQAAKEFVIIVDQSKVVETLGEFSLPVEVLPFSWQRTANEISKLGCVPTV
RVHEEEPLVTDNGNYILDCPFKVIPHPDKLNKEIKSIVGVIETGLFIDMATTVIVGEKDNIYIK
>Mature_224_residues
MNEQDKLKKAVGEKAATMVKDGMKVGLGSGSTVYWMIRSLGERIQQDGLKIEGIPSSNQTATWAEEAGIPLTDFSNVKEL
DITIDGADEVDANNHLIKGGGAALFREKIIAQAAKEFVIIVDQSKVVETLGEFSLPVEVLPFSWQRTANEISKLGCVPTV
RVHEEEPLVTDNGNYILDCPFKVIPHPDKLNKEIKSIVGVIETGLFIDMATTVIVGEKDNIYIK

Specific function: Nonoxidative branch of the pentose phosphate pathway. [C]

COG id: COG0120

COG function: function code G; Ribose 5-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose 5-phosphate isomerase family

Homologues:

Organism=Homo sapiens, GI94536842, Length=226, Percent_Identity=39.3805309734513, Blast_Score=152, Evalue=3e-37,
Organism=Escherichia coli, GI1789280, Length=220, Percent_Identity=43.1818181818182, Blast_Score=149, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17551758, Length=219, Percent_Identity=38.8127853881278, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6324669, Length=209, Percent_Identity=36.8421052631579, Blast_Score=132, Evalue=6e-32,
Organism=Drosophila melanogaster, GI281364072, Length=204, Percent_Identity=37.2549019607843, Blast_Score=121, Evalue=4e-28,

Paralogues:

None

Copy number: 740 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): RPIA1_OCEIH (Q8EN78)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_693530.1
- ProteinModelPortal:   Q8EN78
- SMR:   Q8EN78
- GeneID:   1015544
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2609
- NMPDR:   fig|221109.1.peg.2608
- HOGENOM:   HBG515603
- OMA:   VFDLNSV
- ProtClustDB:   PRK00702
- BioCyc:   OIHE221109:OB2609-MONOMER
- BRENDA:   5.3.1.6
- HAMAP:   MF_00170
- InterPro:   IPR014036
- InterPro:   IPR004788
- InterPro:   IPR020672
- PANTHER:   PTHR11934
- TIGRFAMs:   TIGR00021

Pfam domain/function: PF00455 DeoR; PF06026 Rib_5-P_isom_A

EC number: =5.3.1.6

Molecular weight: Translated: 24496; Mature: 24496

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEQDKLKKAVGEKAATMVKDGMKVGLGSGSTVYWMIRSLGERIQQDGLKIEGIPSSNQT
CCHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCC
ATWAEEAGIPLTDFSNVKELDITIDGADEVDANNHLIKGGGAALFREKIIAQAAKEFVII
CCHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCEEEE
VDQSKVVETLGEFSLPVEVLPFSWQRTANEISKLGCVPTVRVHEEEPLVTDNGNYILDCP
ECCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCCCEEEEECCCCEEECCCCEEEECC
FKVIPHPDKLNKEIKSIVGVIETGLFIDMATTVIVGEKDNIYIK
EEECCCCHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCEEEC
>Mature Secondary Structure
MNEQDKLKKAVGEKAATMVKDGMKVGLGSGSTVYWMIRSLGERIQQDGLKIEGIPSSNQT
CCHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCC
ATWAEEAGIPLTDFSNVKELDITIDGADEVDANNHLIKGGGAALFREKIIAQAAKEFVII
CCHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCEEEE
VDQSKVVETLGEFSLPVEVLPFSWQRTANEISKLGCVPTVRVHEEEPLVTDNGNYILDCP
ECCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCCCEEEEECCCCEEECCCCEEEECC
FKVIPHPDKLNKEIKSIVGVIETGLFIDMATTVIVGEKDNIYIK
EEECCCCHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376