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The map label for this gene is degU [H]

Identifier: 23099974

GI number: 23099974

Start: 2575855

End: 2576547

Strand: Reverse

Name: degU [H]

Synonym: OB2519

Alternate gene names: 23099974

Gene position: 2576547-2575855 (Counterclockwise)

Preceding gene: 23099975

Following gene: 23099973

Centisome position: 70.97

GC content: 34.92

Gene sequence:

>693_bases
ATGATTACAGAGAAAGAAGTAAGAATTGTATTAATTGATGATCATAAGTTGTTCCGAGAGGGTGTAAAAAGAATACTAGA
TTTTGAACCATCATTTGAAGTAGTAGCTGAAGGTGATGATGGTTCGATGGCATCTAAGCTCGTGAAAGAGAATGCACCAG
ATGTTGTACTTATGGATATTAACATGCCGGAGATTAATGGGGTTCAGGCTACTGCAGATTTAGTAAGGTACTTTCCAAAT
TCAAAGGTTATCATTCTATCTATTCATGATGACGAAAGTTATGTTACTCATGCCTTAAAAACTGGTGCGCAAGGATACTT
ATTAAAAGAGATGGATTCAGACGCTTTAATTGATGCAATTAAAGTAGTAAGCGATGGTGGATCATACCTACACCCTCGTG
TAACACATAACTTAGTAAAAGAATATCGACGCTTGGCTAAAGAAAATTCTTCTAGTATAGCTGATAAAGGAATTGAATAT
CGTAAGCCATTGCATTTACTTACAAAAAGAGAATGTCAAGTACTACAACTGCTTGCTGACGGAAAAAGTAATCGTGCAGT
AGCAGAGACGCTATATATTAGTGAAAAAACTGTAAAAAACCATGTAAGTAATATTTTACAAAAAATGAACGTTAATGATC
GAACTCAAGCTGTTGTATCTGCTATCCGTAAAGGATGGGTAGAAGTAATTTAA

Upstream 100 bases:

>100_bases
ATAATAGAGAATAGATAGAAGAAATAGAATTATTATTTACTGTCATTTCGTGTAGGGAACTATAGAAAGAATTACTATCA
TCGGGAGGGAGTTTTTCCAA

Downstream 100 bases:

>100_bases
CGAAGAAAATAAAAATGCCTTGATGTACATCATCAAGGCATTTTCTGTGTCGATTTTTTATAGGAATTCATGTAAAATAA
ATAACTACAGTTAAAATCGA

Product: two-component response regulator

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MITEKEVRIVLIDDHKLFREGVKRILDFEPSFEVVAEGDDGSMASKLVKENAPDVVLMDINMPEINGVQATADLVRYFPN
SKVIILSIHDDESYVTHALKTGAQGYLLKEMDSDALIDAIKVVSDGGSYLHPRVTHNLVKEYRRLAKENSSSIADKGIEY
RKPLHLLTKRECQVLQLLADGKSNRAVAETLYISEKTVKNHVSNILQKMNVNDRTQAVVSAIRKGWVEVI

Sequences:

>Translated_230_residues
MITEKEVRIVLIDDHKLFREGVKRILDFEPSFEVVAEGDDGSMASKLVKENAPDVVLMDINMPEINGVQATADLVRYFPN
SKVIILSIHDDESYVTHALKTGAQGYLLKEMDSDALIDAIKVVSDGGSYLHPRVTHNLVKEYRRLAKENSSSIADKGIEY
RKPLHLLTKRECQVLQLLADGKSNRAVAETLYISEKTVKNHVSNILQKMNVNDRTQAVVSAIRKGWVEVI
>Mature_230_residues
MITEKEVRIVLIDDHKLFREGVKRILDFEPSFEVVAEGDDGSMASKLVKENAPDVVLMDINMPEINGVQATADLVRYFPN
SKVIILSIHDDESYVTHALKTGAQGYLLKEMDSDALIDAIKVVSDGGSYLHPRVTHNLVKEYRRLAKENSSSIADKGIEY
RKPLHLLTKRECQVLQLLADGKSNRAVAETLYISEKTVKNHVSNILQKMNVNDRTQAVVSAIRKGWVEVI

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=212, Percent_Identity=36.7924528301887, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1788222, Length=219, Percent_Identity=30.1369863013699, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1790102, Length=220, Percent_Identity=32.7272727272727, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1787473, Length=227, Percent_Identity=33.4801762114537, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788712, Length=200, Percent_Identity=29, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1786747, Length=208, Percent_Identity=25.4807692307692, Blast_Score=85, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 25813; Mature: 25813

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITEKEVRIVLIDDHKLFREGVKRILDFEPSFEVVAEGDDGSMASKLVKENAPDVVLMDI
CCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCCEEEEEC
NMPEINGVQATADLVRYFPNSKVIILSIHDDESYVTHALKTGAQGYLLKEMDSDALIDAI
CCCCCCCHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHCCCCCEEEHHCCCHHHHHHH
KVVSDGGSYLHPRVTHNLVKEYRRLAKENSSSIADKGIEYRKPLHLLTKRECQVLQLLAD
HHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
GKSNRAVAETLYISEKTVKNHVSNILQKMNVNDRTQAVVSAIRKGWVEVI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MITEKEVRIVLIDDHKLFREGVKRILDFEPSFEVVAEGDDGSMASKLVKENAPDVVLMDI
CCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCCEEEEEC
NMPEINGVQATADLVRYFPNSKVIILSIHDDESYVTHALKTGAQGYLLKEMDSDALIDAI
CCCCCCCHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHCCCCCEEEHHCCCHHHHHHH
KVVSDGGSYLHPRVTHNLVKEYRRLAKENSSSIADKGIEYRKPLHLLTKRECQVLQLLAD
HHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
GKSNRAVAETLYISEKTVKNHVSNILQKMNVNDRTQAVVSAIRKGWVEVI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]