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The map label for this gene is degS [H]

Identifier: 23099975

GI number: 23099975

Start: 2576652

End: 2577791

Strand: Reverse

Name: degS [H]

Synonym: OB2520

Alternate gene names: 23099975

Gene position: 2577791-2576652 (Counterclockwise)

Preceding gene: 23099977

Following gene: 23099974

Centisome position: 71.0

GC content: 33.33

Gene sequence:

>1140_bases
ATGGCAATCAAAATAACTGATAAAGCTTTGGATCACGTGGTTAATGAAATGGTTGATGTAGTTGAAAACAGTAAAGATGA
AATTTTTAATATAAGTGAAGAGGCCAGAAAAGAGCACGAACACTTAGTTCGGGAGCTTAAATTAACCAAAGAAAAAGTTT
TACGCCACATTCAAAATGGTGACCAACTGGAAGAAAGAGTTCGATTTTCTCGTAAGCGATTAGCAGAAGTGAGTAAATAT
TTCGAAAAATATTCCGAAGATGAAATTCGAGAAGTATATGAAAATACGCATTTAATGCAAACGAAACTCGCTATTTTAAG
GCAAGAAGAAAAATCGCTGAGGGAAAAGAGAGATGAACTTGAACGAAGGTTAATTGGTTTATCACATACTATCAATCGAG
CTGAGAATTTAGCAGGTAAAATTGCTGTTATATTAAATTATCTACAAGATGATTTTCGTCAAGTTAATGAAATGATCGAA
AATGCTAAAGAAAAGCAAGAATTTGGTTTGAAGATTATTGAAGCACAAGAAGAAGAGAGAAGAAAATTATCGAGGGAAAT
TCATGATGGCCCTGCACAAATGCTAGCGAATATGTTACTACGATCAGAAATCCTTGAGAGAACGATAAAAAAAGGAACAC
ATGACCAAGCAATTGAGGAGATTCATAGTGTACGTAAAATGGTTCGCTCATCATTATATGAAGTGAGGAGAATCATTTAC
GATCTTCGTCCAATGGCACTTGATGATTTAGGACTTATACCGACGATTAGAAAATATGTGGAAAGTATTTCAGAATATCA
TTCGATTACAATAAATTTTAATGTTATTGGCGAAGAAAAACGATTGAATCAAAAATATGAAATTGCTCTATTTCGGTTGA
TGCAAGAATCCATTCAAAATGCGATTAAGCATAGTGAAGCTGCATTAATCCAAGTTAAATTAGAGATTCGTAGAGAAAAC
TTAACATTGATTGTGAAAGATGAAGGAAAAGGTTTTGATCAGAATGAAAAAAGTGACAAATCTTTCGGTCTTATTGGGAT
GAGAGAGAGAGTGGAGATGCTTGAGGGAGAATTAAATATAAAATCTGCAATAGGAAAAGGAACATCTATAATAATTAAAG
TTCCATATTCGCCCAGTTAA

Upstream 100 bases:

>100_bases
TAAGGAAGGAATAAATAATATCTTTTGAAATATTCTTAATCTAACCCTTACAAACAGCGAAACGTTACGAATAATTATAA
CATAGGTTGGTGGATGTATT

Downstream 100 bases:

>100_bases
GTATATAATAGAGAATAGATAGAAGAAATAGAATTATTATTTACTGTCATTTCGTGTAGGGAACTATAGAAAGAATTACT
ATCATCGGGAGGGAGTTTTT

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MAIKITDKALDHVVNEMVDVVENSKDEIFNISEEARKEHEHLVRELKLTKEKVLRHIQNGDQLEERVRFSRKRLAEVSKY
FEKYSEDEIREVYENTHLMQTKLAILRQEEKSLREKRDELERRLIGLSHTINRAENLAGKIAVILNYLQDDFRQVNEMIE
NAKEKQEFGLKIIEAQEEERRKLSREIHDGPAQMLANMLLRSEILERTIKKGTHDQAIEEIHSVRKMVRSSLYEVRRIIY
DLRPMALDDLGLIPTIRKYVESISEYHSITINFNVIGEEKRLNQKYEIALFRLMQESIQNAIKHSEAALIQVKLEIRREN
LTLIVKDEGKGFDQNEKSDKSFGLIGMRERVEMLEGELNIKSAIGKGTSIIIKVPYSPS

Sequences:

>Translated_379_residues
MAIKITDKALDHVVNEMVDVVENSKDEIFNISEEARKEHEHLVRELKLTKEKVLRHIQNGDQLEERVRFSRKRLAEVSKY
FEKYSEDEIREVYENTHLMQTKLAILRQEEKSLREKRDELERRLIGLSHTINRAENLAGKIAVILNYLQDDFRQVNEMIE
NAKEKQEFGLKIIEAQEEERRKLSREIHDGPAQMLANMLLRSEILERTIKKGTHDQAIEEIHSVRKMVRSSLYEVRRIIY
DLRPMALDDLGLIPTIRKYVESISEYHSITINFNVIGEEKRLNQKYEIALFRLMQESIQNAIKHSEAALIQVKLEIRREN
LTLIVKDEGKGFDQNEKSDKSFGLIGMRERVEMLEGELNIKSAIGKGTSIIIKVPYSPS
>Mature_378_residues
AIKITDKALDHVVNEMVDVVENSKDEIFNISEEARKEHEHLVRELKLTKEKVLRHIQNGDQLEERVRFSRKRLAEVSKYF
EKYSEDEIREVYENTHLMQTKLAILRQEEKSLREKRDELERRLIGLSHTINRAENLAGKIAVILNYLQDDFRQVNEMIEN
AKEKQEFGLKIIEAQEEERRKLSREIHDGPAQMLANMLLRSEILERTIKKGTHDQAIEEIHSVRKMVRSSLYEVRRIIYD
LRPMALDDLGLIPTIRKYVESISEYHSITINFNVIGEEKRLNQKYEIALFRLMQESIQNAIKHSEAALIQVKLEIRRENL
TLIVKDEGKGFDQNEKSDKSFGLIGMRERVEMLEGELNIKSAIGKGTSIIIKVPYSPS

Specific function: Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=195, Percent_Identity=24.6153846153846, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87082311, Length=227, Percent_Identity=27.7533039647577, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788812, Length=199, Percent_Identity=25.1256281407035, Blast_Score=71, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 44403; Mature: 44272

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKITDKALDHVVNEMVDVVENSKDEIFNISEEARKEHEHLVRELKLTKEKVLRHIQNG
CEEEEHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DQLEERVRFSRKRLAEVSKYFEKYSEDEIREVYENTHLMQTKLAILRQEEKSLREKRDEL
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERRLIGLSHTINRAENLAGKIAVILNYLQDDFRQVNEMIENAKEKQEFGLKIIEAQEEER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHH
RKLSREIHDGPAQMLANMLLRSEILERTIKKGTHDQAIEEIHSVRKMVRSSLYEVRRIIY
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLRPMALDDLGLIPTIRKYVESISEYHSITINFNVIGEEKRLNQKYEIALFRLMQESIQN
HHCCHHHHHCCCHHHHHHHHHHHHHHHEEEEEEEEECCHHHHCHHHHHHHHHHHHHHHHH
AIKHSEAALIQVKLEIRRENLTLIVKDEGKGFDQNEKSDKSFGLIGMRERVEMLEGELNI
HHHHCCHHHEEEEEEEECCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHH
KSAIGKGTSIIIKVPYSPS
HHHCCCCCEEEEECCCCCC
>Mature Secondary Structure 
AIKITDKALDHVVNEMVDVVENSKDEIFNISEEARKEHEHLVRELKLTKEKVLRHIQNG
EEEEHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DQLEERVRFSRKRLAEVSKYFEKYSEDEIREVYENTHLMQTKLAILRQEEKSLREKRDEL
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERRLIGLSHTINRAENLAGKIAVILNYLQDDFRQVNEMIENAKEKQEFGLKIIEAQEEER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHH
RKLSREIHDGPAQMLANMLLRSEILERTIKKGTHDQAIEEIHSVRKMVRSSLYEVRRIIY
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLRPMALDDLGLIPTIRKYVESISEYHSITINFNVIGEEKRLNQKYEIALFRLMQESIQN
HHCCHHHHHCCCHHHHHHHHHHHHHHHEEEEEEEEECCHHHHCHHHHHHHHHHHHHHHHH
AIKHSEAALIQVKLEIRRENLTLIVKDEGKGFDQNEKSDKSFGLIGMRERVEMLEGELNI
HHHHCCHHHEEEEEEEECCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHH
KSAIGKGTSIIIKVPYSPS
HHHCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]